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Small Molecule Blockers of B. anthracis Toxin

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
60465
Program Year/Program:
2004 / SBIR
Agency Tracking Number:
AI052894
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
INNOVATIVE BIOLOGICS, INC
INNOVATIVE BIOLOGICS, INC 13455 SUNRISE VALLEY DR, STE 200 HERNDON, VA 20171 3296
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 2004
Title: Small Molecule Blockers of B. anthracis Toxin
Agency: HHS
Contract: 2R44AI052894-02
Award Amount: $1,703,293.00
 

Abstract:

DESCRIPTION (provided by investigator): Results from our SBIR Phase I project demonstrated that beta-cyclodextrin derivatives designed to block the trans-membrane channel formed by B. anthracis protective antigen (PA) can inhibit the cytotoxic effects of anthrax toxin at low micromolar concentrations. Based on successful completion of the feasibility study, the overall goal of our Phase II project is to select the best drug candidates for anthrax treatment. To achieve this goal we will perform large-scale design, synthesis and screening of chemical libraries, and test the best candidates in small animal studies. The specific aims of this Phase II study are: (1) Utilize crystallographic coordinates and initial testing data in concert with computational chemistry to design additional beta-cyclodextrin derivatives with increased affinity to the PA pore. (2) Optimize a cell-based assay to screen the inhibition of the anthrax toxin cytotoxic effect, establish and validate cell-based and biochemical assays to test chemical compounds for the ability to block the PA channel. (3) Synthesize representative libraries of beta-cyclodextrin analogues, and screen them using biochemical and cell-based assays. (4) Perform toxicity and efficacy tests in mice using at least five compounds with inhibitory activity at nanomolar concentrations to select drug candidates. Long term goals include subsequent preclinical and clinical studies that will lead to the development of a new anti-anthrax treatment.

Principal Investigator:

Vladimir A. Karginov
7036225749
vak@innovbio.com

Business Contact:

Vladimir Karginov
2025464367
vak@innovbio.com
Small Business Information at Submission:

INNOVATIVE BIOLOGICS, INC
INNOVATIVE BIOLOGICS, INC 13455 SUNRISE VALLEY DR, STE 200 HERNDON, VA 20171

EIN/Tax ID: 113427236
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No