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MULTIRESOLUTION AUTOFOCUSING FOR AUTOMATED CYTOGENETICS

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
60114
Program Year/Program:
2002 / SBIR
Agency Tracking Number:
RR016817
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Advanced Digital Imaging Research, LLC
Advanced Digital Imaging Res 2450 S Shore Blvd, Ste 305 League City, TX 77573 0299
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2002
Title: MULTIRESOLUTION AUTOFOCUSING FOR AUTOMATED CYTOGENETICS
Agency: HHS
Contract: 1R43RR016817-01
Award Amount: $91,727.00
 

Abstract:

The goal of this project is to develop innovative digital microscope autofocusing techniques for automated cytogenetics applications. We propose a novel multi-resolution image analysis approach to focus measurement and detection, based on the recently developed mathematical theory of wavelet transform. In comparison to currently available single-resolution techniques, the proposed method overcomes their fundamental limitations and promises considerably more accurate, reliable and faster means to compute and determine in-focus image position for image acquisition. This will significantly increase the ability and efficacy of automated scanning microscope instruments for clinical and cancer cytogenetics applications. In Phase 1 we will investigate the feasibility of the proposed method based on its utilization in fluorescence microscopy. We will develop and implement the algorithm and software for multi-resolution focus function computation and in-focus position determination. We will test and evaluate the new method against the current best-performing algorithms by comparing (1) Accuracy; (2) Range; (3) Insensitivity to other parameters; and (4) Speed. If the new approach achieves superior performance, in Phase 2 the technique will be further developed and extended to bright-field microscopy applications. When fully developed, the new technology will be made available to Applied Imaging (AIC) for integration into the PowerGene cytogenetics automation products.

Principal Investigator:

Qiang Wu
2815351889
QWU@ADIRES.COM

Business Contact:

Kenneth Castleman
2815351889
INFO@ADIRES.COM
Small Business Information at Submission:

ADVANCED DIGITAL IMAGING RESEARCH, LLC
ADVANCED DIGITAL IMAGING RES 2450 S SHORE BLVD, STE 305 LEAGUE CITY, TX 77573

EIN/Tax ID: 752791864
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No