USA flag logo/image

An Official Website of the United States Government

Integrated Architecture for Functional Genomic Measurements

Award Information

Agency:
Department of Defense
Branch:
Army
Award ID:
68272
Program Year/Program:
2004 / SBIR
Agency Tracking Number:
A032-1523
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
3RD MILLENNIUM, INC
3RD MILLENNIUM, INC 391 TOTTEN POND RD, STE 104 WALTHAM, MA 02451
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2004
Title: Integrated Architecture for Functional Genomic Measurements
Agency / Branch: DOD / ARMY
Contract: W81XWH-04-C-0029
Award Amount: $118,892.00
 

Abstract:

The integrated informatics architecture proposed here will facilitate the construction of gene regulatory and other biological pathway models from networks of molecular and phenotypic associations. Current commercial or academic solutions are mostly limited to basic analysis of array data to determine differential expression and do not practically address the advanced analysis of array data to uncover sets of regulatory associations between genes. Moreover, no commercial solutions exist to assist scientists in the critically important task of taking the results of these advanced analyses and assembling testable models from them. The work proposed here will create a next generation informatics architecture that overcomes these deficiencies by providing (1) advanced analytical methods to identify from either Affymetrix or De Novo spotted RNA array data networks of regulatory associations between genes and (2) methods to assist in the interpretation of function genomic results by providing methods to build gene-phenotype association models about which, how and where molecules associate with one another and what are the molecular and phenotypic effects of the association. The components of the architecture will be able with freely exchange information with biological databases, literature mining, analysis and visualization applications to allow better interpretation of the resulting analyses and models.

Principal Investigator:

Jack Pollard
Director of Informatics R
7818904440
jpollard@3rdmill.com

Business Contact:

Eric Meyers
Chief Operations Officer
7818904440
emeyers@3rdmill.com
Small Business Information at Submission:

3RD MILLENNIUM, INC.
400 Totten Pond Road Waltham, MA 02451

EIN/Tax ID: 043217231
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No