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Genetic Assay for Inhibitors of RNA-Protein Interactions

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
65247
Program Year/Program:
2005 / STTR
Agency Tracking Number:
CA103407
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
ADVANCED GENETIC SYSTEMS, INC.
1554 25TH AVE SAN FRANCISCO, CA 94122-3320
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 2005
Title: Genetic Assay for Inhibitors of RNA-Protein Interactions
Agency: HHS
Contract: 2R42CA103407-02
Award Amount: $820,375.00
 

Abstract:

RNA-protein interactions play critical roles in cellular regulatory processes and in the life cycles of many pathogenic viruses including HIV, hepatitis C, SARS, and West Nile virus, and thus represent attractive targets for therapeutics. We have developed novel cell-based assays to identify drugs that target the RNA-protein interactions. The assays incorporate a system of genetic reporters to accurately recapitulate RNA-protein interactions and enable screens with high sensitivity and specificity. In an initial test of the system, the HIV Rev-RRE interaction was successfully targeted with control inhibitors of the RNA-protein interaction. Experiments to optimize and convert the drug screening assays to high throughput format are currently in progress. The assays will be tested by screening a combinatorial library of RRE-binding peptides to be followed by a high-throughput chemical compound library screen. The development of high-throughput genetic methods to identify specific inhibitors of RNA-protein interactions is expected to help in the discovery of drugs directed against novel therapeutic targets.

Principal Investigator:

Alan D. Frankel
4154769994
FRANKEL@CGL.UCSF.EDU

Business Contact:

Robert Nakamura
4158060187
ROBNAK@ADVANCEDGENETICSYSTEMS.COM
Small Business Information at Submission:

Advanced Genetic Systems, Inc.
Advanced Genetic Systems, Inc. 1554 25Th Ave San Francisco, CA 94122

EIN/Tax ID: 320080584
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Research Institution Information:
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
UNIVERSITY OF CALIFORNIA SAN FRANCISCO
3333 California St., Ste. 315
SAN FRANCISCO, CA 94143
RI Type: Nonprofit college or university