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Genetic Assay for Inhibitors of RNA-Protein Interactions

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
65247
Program Year/Program:
2003 / STTR
Agency Tracking Number:
CA103407
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
ADVANCED GENETIC SYSTEMS, INC.
1554 25TH AVE SAN FRANCISCO, CA 94122-3320
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2003
Title: Genetic Assay for Inhibitors of RNA-Protein Interactions
Agency: HHS
Contract: 1R41CA103407-01
Award Amount: $100,000.00
 

Abstract:

DESCRIPTION (provided by applicant): RNA-protein interactions play critical roles in cellular regulatory processes and in the life cycles of many pathogenic viruses, including HIV, hepatitis C, and West Nile virus, and thus represent attractive targets for therapeutics. Much of our previous work has centered on identifying and characterizing the components of key interactions and developing cell-based reporters to accurately monitor RNA-protein interactions. Here we focus on developing targeted assays for inhibitor screening. The cell-based screens described incorporate a system of genetic reporters designed to recapitulate RNA-protein interactions in a native mammalian environment and to enable screens with high sensitivity and specificity. As proof-of-principle, reporters cell lines will be developed and used to identify inhibitors of the HIV Rev-Rev Response Element (RRE) interaction from combinatorial zinc finger libraries. The development of high-throughput genetic methods to identify specific inhibitors of RNA-protein interactions is expected to help in the discovery of drugs directed against novel therapeutic targets.

Principal Investigator:

Alan D. Frankel
4154769994
FRANKEL@CGL.UCSF.EDU

Business Contact:

Robert Nakamura
4155028442
ROBNAK@ADVANCEDGENETICSYSTEMS.COM
Small Business Information at Submission:

Advanced Genetic Systems
136 S WOLFE RD 136 S WOLFE RD Sunnyvale, CA 94086

EIN/Tax ID: 320080584
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Research Institution Information:
UNIVERSITY OF CALIFORNIA SAN FRANCISCO
500 PARNASSUS AVE
SAN FRANCISCO, CA 94122
RI Type: Nonprofit college or university