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Novel Membrane System to Automatically Deglycerolize Thawed Frozen Human Blood

Award Information

Agency:
Department of Defense
Branch:
Army
Award ID:
26623
Program Year/Program:
1995 / SBIR
Agency Tracking Number:
26623
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Advanced Haemotechnologies
2828 N. Crescent Ridge Drive The Woodlands, TX 77381
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1995
Title: Novel Membrane System to Automatically Deglycerolize Thawed Frozen Human Blood
Agency / Branch: DOD / ARMY
Contract: N/A
Award Amount: $693,979.00
 

Abstract:

Improved methods for frozen storage of glycerolized red blood cells (RBCs) are needed both tomeet military and civilian needs in periods of high demand. Existing deglycerolization ssytems are labor intensive and considered "open" systems resulting in a maximum storage of 24hrs following washing. The washing of cells with flat sheet membrane filters has been proven effective by the Advanced Haemotechnologies PlateletPlus (TM) Autotransfusion System. They system saves RBCs and reomves >90% of plasma contaminants. If awarded, Phase I activities will include design, construction and testing of three different filter device configurations. They will include multistage continuous flow, single state whole unit, and single stage multibatch devices. Prior to testing the prototype devices, PlateletPlus (TM) filters assembled with various candidate membranes will be tested to select the optimum pore size for deglycerolization. A PlateletPlus (TM) console with modified software will control all filter devices. Tests will be performed using packaged RBCs and frozen glycerolized blood. The major goals of Phase I testing will be to demonstrate that one or more device configurations meet the following requirements: 1. Total processing time <25 minutes 2. Final Hematocrit -- approximately 40% 3. Residual glycerol <1%W/V

Principal Investigator:

Lucas Gordon
7133634949

Business Contact:

Small Business Information at Submission:

Advanced Haemotechnologies
2828 N. Crescent Ridge Drive The Woodlands, TX 77381

EIN/Tax ID:
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No