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Company Information:

Name: ADVANCED LIQUID LOGIC
Address: 615 Davis Dr., Suite 800
PO Box 14025
RESEARCH TRIANGLE PARK, NC
Located in HUBZone: No
Woman-Owned: No
Minority-Owned: No
URL: N/A
Phone: (919) 287-9010

Award Totals:

Program/Phase Award Amount ($) Number of Awards
SBIR Phase I $3,187,293.00 17
SBIR Phase II $16,150,721.00 10
STTR Phase I $99,713.00 1

Award List:

Nanoliter Lab-on-a-Chip for Blood Diagnostics

Award Year / Program / Phase: 2004 / SBIR / Phase I
Agency: HHS
Principal Investigator: Michael G. Pollack
Award Amount: $100,000.00
Abstract:
DESCRIPTION (provided by applicant): Large volumes of blood (milliliters) are required for diagnostics with large instruments, latrogenic blood loss or "bleeding into the laboratory" is an important reason for administration of small volume transfusions in very low birth weight, premature infants. A… More

Nanoliter Lab-on-a-chip for Protein Crystallization

Award Year / Program / Phase: 2004 / SBIR / Phase I
Agency: HHS
Principal Investigator: Vamsee K. Pamula
Award Amount: $149,616.00
Abstract:
DESCRIPTION (provided by applicant): The human genome contains at least 30,000 unique open reading frames that may yield >100,000 polypeptide products. These products assemble into more than a million biologically relevant structures of interest per organism. In order to obtain a single protein… More

Nanodroplet PCR Lab-Chip for Clinical Pathogen Detection

Award Year / Program / Phase: 2005 / SBIR / Phase I
Agency: HHS
Principal Investigator: Michael G. Pollack
Award Amount: $165,529.00
Abstract:
DESCRIPTION (provided by applicant): Rapid and accurate detection and identification of pathogens is crucial for the effective management and treatment of infectious disease. While molecular diagnostic techniques including PCR are a promising approach for rapid and sensitive detection of pathogens,… More

Nanoliter Lab-on-a-chip for Protein Crystallization

Award Year / Program / Phase: 2006 / SBIR / Phase II
Agency: HHS
Principal Investigator: Vamsee K. Pamula
Award Amount: $1,835,343.00
Abstract:
DESCRIPTION (provided by applicant): The human genome contains at least 30,000 unique open reading frames that may yield >100,000 polypeptide products. These products assemble into more than a million biologically relevant structures or proteins of interest per organism. Crystallization and X-ray… More

Nanoliter Lab-on-a-Chip for Blood Diagnostics

Award Year / Program / Phase: 2006 / SBIR / Phase II
Agency: HHS
Principal Investigator: Michael G. Pollack
Award Amount: $1,363,593.00
Abstract:
DESCRIPTION (provided by applicant): Latrogenic blood loss or "bleeding into the laboratory" is an important reason for administration of small volume transfusions in very low birth weight premature 6infants. A direct correlation was found between the volume of blood drawn for diagnostics and… More

Portable Programmable Multifunction Body Fluids Analyzer

Award Year / Program / Phase: 2006 / SBIR / Phase I
Agency: NASA
Principal Investigator: Vamsee K. Pamula, Principal Investigator
Award Amount: $69,564.00
Abstract:
Advanced Liquid Logic proposes to develop a very capable analyzer based on its digital microfluidic technology. Such an analyzer would be: Capable of both simple and complex biological assays Small, lightweight, power efficient, and easy to operate Fully programmable and… More

Nanoliter Lab-on-a-Chip for Rapid Parallel Immunoassays

Award Year / Program / Phase: 2006 / SBIR / Phase I
Agency: HHS
Principal Investigator: Vamsee K. Pamula
Award Amount: $159,902.00
Abstract:
DESCRIPTION (provided by applicant): The development of clinically effective cancer vaccines requires reliable analytical methods to evaluate the immune response to vaccination. Immunoassays are among the most sensitive and specific analytical methods that have been used widely in cancer vaccine… More

Lab-on-a-chip for multiplexed newborn screening of lysosomal storage disorders

Award Year / Program / Phase: 2007 / SBIR / Phase I
Agency: HHS
Principal Investigator: Vamsee K. Pamula
Award Amount: $188,364.00
Abstract:
DESCRIPTION (provided by applicant): Newborn screening is currently performed by collecting dried bloodspots from infants and then sending them to a lab for analysis. There is an increasing necessity to screen for a number of disease conditions for which therapies are becoming available.… More

Nanoliter Lab-on-a-Chip for Rapid Parallel Immunoassays

Award Year / Program / Phase: 2008 / SBIR / Phase II
Agency: HHS
Principal Investigator: Vamsee K. Pamula
Award Amount: $1,000,000.00
Abstract:
DESCRIPTION (provided by applicant): The great need for more efficient and effective oncologic drug development has driven the discovery and integration of biomarkers into all phases of clinical research. Further still, biomarkers are entering the clinical arena as early means of determining which… More

Multiplexing Cancer Sample Preparation: Indirect Immunomagnetic Enrichment

Award Year / Program / Phase: 2008 / SBIR / Phase I
Agency: HHS
Principal Investigator: Vamsee K. Pamula
Award Amount: $299,554.00
Abstract:
DESCRIPTION (provided by applicant): Biomarkers of clinical activity are critical for targeted anti-cancer therapy development and are becoming important for the care of individual patients. In a prototypical tyrosine kinase pathway, governed by the epider mal growth factor receptor (EGFR),… More

Low-cost and Rapid DNA Sequence for Biometric Applications

Award Year / Program / Phase: 2009 / SBIR / Phase I
Agency: DHS
Principal Investigator: Michael G. Pollack – (919) 287-9010
Award Amount: $99,156.00
Abstract:
A DNA sequencer for biometric applications will be developed. The system will enable rapid and low-cost identification of individuals and kinship verification using a self-contained and portable device. All process steps from DNA extraction to DNA sequencing will be automatically performed within… More

Miniaturized DNA Sequencer for Identification of Microbial Pathogens

Award Year / Program / Phase: 2009 / SBIR / Phase I
Agency: HHS
Principal Investigator: Michael G. Pollack
Award Amount: $178,360.00
Abstract:
DESCRIPTION (provided by applicant): Miniaturized DNA Sequencer for Identification of Microbial Pathogens Abstract. The goal of this project is develop a compact and inexpensive DNA sequencer based on the implementation of sequencing-by-synthesis chemistr y on a droplet-based digital microfluidic… More

Lab-on-a-Chip for Multiplexed Newborn Screening of Lysosomal Storage Disorders

Award Year / Program / Phase: 2009 / SBIR / Phase II
Agency: HHS
Principal Investigator: Vamsee K. Pamula
Award Amount: $1,056,545.00
Abstract:
DESCRIPTION (provided by applicant): Newborn screening is currently performed by collecting dried bloodspots from infants and then sending them to a lab for analysis. Lysosomal storage diseases alone number greater than 40 and there is an increasing necess ity to screen for a number of disease… More

Lab-on-a-chip for Neonatal Hyperbilirubinemia Screening

Award Year / Program / Phase: 2009 / SBIR / Phase I
Agency: HHS
Principal Investigator: Vijay Srinivasan
Award Amount: $189,378.00
Abstract:
DESCRIPTION (provided by applicant): Despite aggressive public health campaigning and strict guidelines for diagnosis and treatment, the estimated incidence of severe hyperbilirubinemia (defined as serum bilirubin levels greater than 99th percentile) is 1: 70. Severe hyperbilirubinemia can cause a… More

Low-cost and Rapid DNA Sequence for Biometric Applications

Award Year / Program / Phase: 2010 / SBIR / Phase II
Agency: DHS
Principal Investigator: Michael G. Pollack
Award Amount: $741,920.00
Abstract:
Advanced Liquid Logic proposes to develop a low-cost and rapid biometric system based on DNA. Using a miniaturized DNA sequencing format the device will enable DNA-based identification of individuals as well as determination of family relationships (kinship) between individuals. The system will be… More

Nanodroplet PCR Lab-Chip for Clinical Pathogen Detection

Award Year / Program / Phase: 2010 / SBIR / Phase II
Agency: HHS
Principal Investigator: Michael G. Pollack
Award Amount: $2,957,902.00
Abstract:
DESCRIPTION (provided by applicant): It is estimated that 2 million health-care associated infections are acquired each year by hospitalized patients resulting in 90,000 deaths and about 4.5 billion in excess health care costs. A large and growing percent age of these infections can be attributed… More

Not Available

Award Year / Program / Phase: 2010 / SBIR / Phase I
Agency: HHS
Principal Investigator: Vamsee Pamula
Award Amount: $168,208.00
Abstract:
Not Available

An automated microfluidic platform for high-throughput newborn SCID screening

Award Year / Program / Phase: 2011 / SBIR / Phase I
Agency: HHS
Principal Investigator: Vijay Srinivasan – 919-287-9010
Award Amount: $179,652.00
Abstract:
DESCRIPTION (provided by applicant): The overall goal of this research collaboration is to develop a high-throughput digital microfluidic instrument capable of screening dozens of newborns simultaneously for severe combined immunodeficiency (SCID). There is a significant need at the state-screening… More

Microfluidic DNA Quality Control Solutions for Biobanks

Award Year / Program / Phase: 2011 / SBIR / Phase I
Agency: HHS
Principal Investigator: Zhishan Hua – 919-287-9010
Award Amount: $152,084.00
Abstract:
DESCRIPTION (provided by applicant): Recent technological advances in genotyping and DNA sequencing platforms have enabled ever larger and more ambitious projects aimed at understanding the genetic basis of human disease. Specialized biobanks have emergedto meet the needs of these studies by… More

Lab-on-a-chip for Neonatal Hyperbilirubinemia Screening

Award Year / Program / Phase: 2011 / SBIR / Phase II
Agency: HHS
Principal Investigator: Vijay Srinivasan – 919-287-9010
Award Amount: $1,484,378.00
Abstract:
DESCRIPTION (provided by applicant): Severe hyperbilirubinemia (defined as serum bilirubin levels greater than 99th percentile) can cause a spectrum of neurologic dysfunction, of which kernicterus has the most devastating neurologic consequences. Kernicterus manifests as a life-long movement… More

Miniaturized DNA Sequencer for Identification of Microbial Pathogens

Award Year / Program / Phase: 2011 / SBIR / Phase II
Agency: HHS
Principal Investigator: Michael G. Pollack – 919-287-9010
Award Amount: $1,454,210.00
Abstract:
DESCRIPTION (provided by applicant): The ultimate goal of this project is to develop an extremely compact and inexpensive DNA sequence for applications in laboratory and clinical settings. The device will implement pyrosequencing on a disposable droplet based digital microfluidic cartridge and… More

Lab-on-a-Chip for Multiplexed Newborn Screening of Lysosomal Storage Disorders

Award Year / Program / Phase: 2012 / SBIR / Phase II
Agency: HHS
Principal Investigator: Vamsee K. Pamula – 919-287-9010
Award Amount: $2,983,089.00
Abstract:
DESCRIPTION (provided by applicant): Newborn screening is currently performed by collecting dried bloodspots from infants and then sending them to a lab for analysis. It is primarily performed to detect disorders which lead to severe physical and mental disabilities. There is an increasing necessity… More

Multiplex platform for point of care newborn screening of hyperbilirubinemia

Award Year / Program / Phase: 2012 / SBIR / Phase I
Agency: HHS
Principal Investigator: Vamsee K. Pamula – 919-287-9010
Award Amount: $468,008.00
Abstract:
DESCRIPTION (provided by applicant): Jaundice is the most common condition that requires urgent medical attention in some newborns and is the result of elevation in circulating unconjugated bilirubin. The unbound unconjugated bilirubin can be specificallyneurotoxic and, if untreated, is associated… More

Droplet-Based Automation of Complex Workflows for Synthetic Biology

Award Year / Program / Phase: 2013 / STTR / Phase I
Agency / Branch: DOD / DARPA
Research Institution: Stanford University
Principal Investigator: Brent Lutz, President and CEO – (919) 287-9010
Award Amount: $99,713.00
RI Contact: Mark Horowitz
Abstract:
Large-scale genome engineering represents a broad group of technologies, all of which stand to impact the manufacturing of a range of biological and chemical products. While the power of these methods to increase the production of biologically-driven manufacturing processes has been previously… More

Automated Sample Preparation for Next Generation Sequencing Cancer Diagnostics

Award Year / Program / Phase: 2013 / SBIR / Phase I
Agency: HHS
Principal Investigator: Nicholas Trotta – 919-287-9010
Award Amount: $240,201.00
Abstract:
DESCRIPTION (provided by applicant): As more diverse genetic links are established with cancer, the utility of one-gene-one-test diagnostics is diminished. In addition, biopsies are mixed populations of tumor and normal tissue, requiring deconvolution oftumor and non-tumor genoptypes to accurately… More

Distributed REMD Simulation for Probing Alzheimer Molecular Mechanisms

Award Year / Program / Phase: 2013 / SBIR / Phase I
Agency: HHS
Principal Investigator: Nicholas Trotta
Award Amount: $181,049.00
Abstract:
DESCRIPTION: Mass spectrometry is a multiplex technology for high-throughput analysis of biomolecules in newborn screening and clinical laboratories. Complexity in sample preparation has been recognized as the main bottleneck in well-established MS methods. Digital microfluidics is a rapidly… More

Point-of-Care Nucleic Acid Test for Cytomegalovirus for Newborn Hearing Screening

Award Year / Program / Phase: 2013 / SBIR / Phase I
Agency: HHS
Principal Investigator: Vamsee K. Pamula – 919-287-9010
Award Amount: $198,668.00
Abstract:
DESCRIPTION (provided by applicant): Universal newborn hearing screening is mandated in the US and is performed in the postpartum hospital setting. Current physiology-based hearing screening tests are unable to detect late-onset hearing loss caused by cytomegalovirus (CMV) infection. Therefore, a… More

Point-of-Care Nucleic Acid Test for Cytomegalovirus for Newborn Hearing Screening

Award Year / Program / Phase: 2013 / SBIR / Phase II
Agency: HHS
Principal Investigator: Vamsee K. Pamula – 919-287-9010
Award Amount: $1,273,741.00
Abstract:
DESCRIPTION (provided by applicant): Universal newborn hearing screening is mandated in the US and is performed in the postpartum hospital setting. Current physiology-based hearing screening tests are unable to detect late-onset hearing loss caused by cytomegalovirus (CMV) infection. Therefore, a… More