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Nanoliter Lab-on-a-Chip for Blood Diagnostics

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
71553
Program Year/Program:
2006 / SBIR
Agency Tracking Number:
DK066956
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
ADVANCED LIQUID LOGIC
615 Davis Dr., Suite 800 PO Box 14025 RESEARCH TRIANGLE PARK, NC -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 2006
Title: Nanoliter Lab-on-a-Chip for Blood Diagnostics
Agency: HHS
Contract: 2R44DK066956-02
Award Amount: $1,363,593.00
 

Abstract:

DESCRIPTION (provided by applicant): Latrogenic blood loss or "bleeding into the laboratory" is an important reason for administration of small volume transfusions in very low birth weight premature 6infants. A direct correlation was found between the volume of blood drawn for diagnostics and subsequent volume transfused. In neonatal infants, there may not be enough collected blood sample to perform all the necessary tests. Conventional laboratory analysis of blood samples while in the field (accidents, disasters, battlefield, etc.) is impractical. A handheld, automated, inexpensive, multi-analyte and multiplexed blood chemistry analyzer will help reduce the blood analysis volume from milliliters to nanoliters, reduce the need for further transfusions, and make the analyzer available at the point-of-care (clinics, operating & emergency rooms, intensive care units, and in the field). In Phase I, we have successfully demonstrated a digital microfluidic platform for manipulation of nanoliter-sized droplets of reagents and sample for dispensing from on-chip reservoirs, high speed transport, mixing, splitting and dilution, and colorimetric measurement of glucose, lactate, and creatinine. In phase II, a disposable lab-on-a-chip for blood chemistry will be developed where 0.5 microliters of human blood will be the input to the digital microfluidic system and it outputs the measurements of metabolites, proteins, electrolytes, gases, hematocrit, and enzymes in a completely automated fashion.

Principal Investigator:

Michael G. Pollack
9192879010
MGP@LIQUID-LOGIC.COM

Business Contact:

Vamsee Pamula
9192879010
VKP@LIQUID-LOGIC.COM
Small Business Information at Submission:

ADVANCED LIQUID LOGIC
ADVANCED LIQUID LOGIC 615 Davis Dr., Suite 800 RESEARCH TRIANGLE PARK, NC 27709

EIN/Tax ID: 200461851
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No