A number of syntheses of small magnetic particles permittingthe covalent attachment of antibodies will be examined. changes in magnetic resonance (mr) proton relaxation after magnetic antibodies have bound to cell surface antigens willbe utilized to demonstrate the binding of antibody (and magnetic… More

As part of a collaborative effort with the department of radiology at the massachusetts general hospital, advanced magnetics intends to assess the potential of liver-targeted,ferrite-based contrast agents to enhance the potential of magnetic resonance (mr) imaging for detection of liver metastases… More

Diseases of the liver are a major health problem. diagnostic techniques to predict liver failure are interpretable in terms of overall liver function, not in terms of anatomic structure. anatomical information on liver has been obtained by using radioactive colloids. these materials are taken up by… More

The object of this research is to develop an anti-hepatitis b virus pro-drug which will concentrate in the infected liver tissue by binding the hepatic asialoglycoprotein receptor and releasing the active form of the drug in the hepatocyte. toward this end, a number of adenosine… More

The ultimate goal of this research is the development of tissue specific, or directed magnetic resonance umaging (mri) contrast agents. these agents will consist of peptides attached to small, biodegradable superparamagnetic iron oxide colloids. the biodistribution of the superparamagnetic iron… More

Not Available Use of active sonar systems for shallow water anti-submarine warfare and mine warfare is highly attractive owing to its potential for improved target detection and localization. Unfortunately, adverse environmental conditions in shallow water scenarios can degrade the performance of… More