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IMMUNODIRECTABLE MR CONTRAST AGENTS

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
7113
Program Year/Program:
1987 / SBIR
Agency Tracking Number:
7113
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
ADVANCED MAGNETICS, INC.
61 MOONEY ST CAMBRIDGE, MA 02138
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1987
Title: IMMUNODIRECTABLE MR CONTRAST AGENTS
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

A NUMBER OF SYNTHESES OF SMALL MAGNETIC PARTICLES PERMITTINGTHE COVALENT ATTACHMENT OF ANTIBODIES WILL BE EXAMINED. CHANGES IN MAGNETIC RESONANCE (MR) PROTON RELAXATION AFTER MAGNETIC ANTIBODIES HAVE BOUND TO CELL SURFACE ANTIGENS WILLBE UTILIZED TO DEMONSTRATE THE BINDING OF ANTIBODY (AND MAGNETIC LABEL) TO ANTIGENS. THE MAGNETIC LABELS INVESTIGATED WILL POSESS THE MAGNETIC PROPERTIES OF A CRYSTAL (E.G., HIGH MAGNETIC SUSCEPTIBILITY)AND THE SOLUTION PROPERTIES OF SOLUBLE MACROMOLECULES (E.G.,NO SETTLING ON PROLONGED STANDING). ONE ADVANTAGE OF ATTACHING ANTIBODY TO MAGNETIC PARTICLES, OVER THE OFTEN-USED APPROACH OF DERIVATIZING PROTEINS WITH CHELATORS,IS THAT FAR MORE METAL IONS CAN BE ATTACHED PER MOLE OF ANTIBODY. IN ADDITION, UNLIKE RADIOLABELED ANTIBODIES, MAGNETIC LABELS SHOW NO RADIOACTIVE DECAY. HIGHLY MAGNETIC PROTEINS MAY BE USEFUL AGENTS FOR IMMUNODIRECTABLE MR CONTRAST AGENTS.

Principal Investigator:

Lee josephson md
6174972070

Business Contact:

Small Business Information at Submission:

Advanced Magnetics Inc
61 Mooney Street Cambridge, MA 02138

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No