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HEPATIC DIRECTED ANTIVIRAL AGENTS

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
18969
Program Year/Program:
1992 / SBIR
Agency Tracking Number:
18969
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
ADVANCED MAGNETICS, INC.
61 MOONEY ST CAMBRIDGE, MA 02138
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1992
Title: HEPATIC DIRECTED ANTIVIRAL AGENTS
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

THE OBJECT OF THIS RESEARCH IS TO DEVELOP AN ANTI-HEPATITIS B VIRUS PRO-DRUG WHICH WILL CONCENTRATE IN THE INFECTED LIVER TISSUE BY BINDING THE HEPATIC ASIALOGLYCOPROTEIN RECEPTOR AND RELEASING THE ACTIVE FORM OF THE DRUG IN THE HEPATOCYTE. TOWARD THIS END, A NUMBER OF ADENOSINE ARABINOFURANOSIDE/ARABINOGALACTAN CONJUGATES WILL BE SYNTHESIZED. THE CONJUGATES WILL BE EVALUATED AS SUITABLE PRODRUGS BY SEVERAL CRITICAL TESTS. INTERACTION WITH THE HEPATICASIALOGLYCOPROTEIN RECEPTOR IN VITRO WILL BE DETERMINED IN A COMPETITIVE BINDING ASSAY USING ISOLATED RAT HEPATOCYTES. THE RELEASE OF ADENOSINE ARABINOFURANOSIDE, OR IN SOME INSTANCES, ITS ALSO ACTIVE 5 MONOPHOSPHATE DERIVATIVE, WILL BE MEASURED IN VITRO ALSO USING A HEPATOCYTE CELL CULTURE A PRELIMINARY TOXICOLOGICAL EXAMINATION OF THE CONJUGATE CONSIDERED MOST SUITABLE AS A PRO-DRUG WILL BE CONDUCTED. THE RESEARCH IS EXPECTED TO LEAD TO AN ANTIVIRAL PRO-DRUG OF ADENOSINE ARABINOFURANOSIDE POSSESSING A GREATER POTENCY AND LOWERTOXICITY RELATIVE TO THE FREEDRUG.

Principal Investigator:

Philip M Enriquez
6174972070

Business Contact:

Small Business Information at Submission:

Advanced Magnetics Inc
61 Mooney Street Cambridge, MA 02138

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No