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NOVEL CHROMATOGRAPHIC SUPPORTS: METHODS AND PROCESSES

Award Information

Agency:
National Science Foundation
Branch:
N/A
Award ID:
17254
Program Year/Program:
1992 / SBIR
Agency Tracking Number:
17254
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
AST PRODUCTS, INC.
AST PRODUCTS, INC. 9 LINNELL CIR BILLERICA, MA 01821
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1992
Title: NOVEL CHROMATOGRAPHIC SUPPORTS: METHODS AND PROCESSES
Agency: NSF
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

THE OBJECTIVE OF THIS PROPOSAL IS TO USE PLASMA INDUCED POLYMERIZATION FOR THE PREPARATION OF NEW HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC) SUPPORTS. WE WILL POLYMERIZE MONOMERS ON SILICA SURFACES TO FORM THIN, PIN HOLE FREE CHROMATOGRAPHIC SUPPORTS WHOSE SILANOL SITES ARE DEACTIVATEDBY THE POLYMER COATING. OTHER RIGID SUPPORTS, SUCH AS ALUMINA, WILL BE EVALUATED WITH THE OBJECTIVE TO PREPARE ALKALI STABLE CHROMATOGRAPHIC SUPPORTS. CHROMATOGRAPHIC EVALUATIONS WILL BE PERFORMED USING BOTH SMALL MOLECULE AND LARGE MOLECULE STANDARD PROBES. THE PROPOSING PROCESS, UNLIKE CONVENTIONAL SILANE BONDING, DOES NOT REQUIRE A LARGE CHEMICAL FACILITY, OR THE USE OF LARGE QUANTITIES OF REACTANTS AND WASH SOLVENTS, OR LONG REACTION TIMES. IN ADDITION, THE RESULTING NOVEL CHROMATOGRAPHIC SUPPORTS SHOULD HAVE BETTER SEPARATION EFFICIENCIES WITH IMPROVED STABILITY, REPRODUCIBILITY, AND BE SCALEABLE FROM ANALYTICAL TO PREPARATIVE SEPARATION MODES.

Principal Investigator:

Henry S. Kolesinski
0

Business Contact:


5086637652
Small Business Information at Submission:

Advanced Surface Technology
85 Rangeway Road N. Billerica, MA 01862

EIN/Tax ID:
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No