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POLYETHYLENE OXIDE STAR MOLECULES AS THROMBORESISTANT SURFACES

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
19336
Program Year/Program:
1992 / SBIR
Agency Tracking Number:
19336
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
AST PRODUCTS, INC.
AST PRODUCTS, INC. 9 LINNELL CIR BILLERICA, MA 01821
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1992
Title: POLYETHYLENE OXIDE STAR MOLECULES AS THROMBORESISTANT SURFACES
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

BLOOD IN CONTACT WITH AN ARTIFICIAL SURFACE CAN LEAD TO SHORT-TERM PLATELET DEPOSITION, ACTIVATION AND THROMBOSIS, AND TO COAGULATION VIA ACTIVATION OF THE INTRINSIC CLOTTING SYSTEMS. LONG-TERM EFFECTS MAY RESULT IN COMPLEMENT ACTIVATION. THIS RESEARCH CENTERS ON UTILIZING A NEW CLASS OF PEOP MOLECULES, IN THE FORM OF STARS, TO ACCOMPLISH TWO THINGS: (1) COMPLETELY COVER THE UNDERLYING SUPPORT MATERIAL SO THAT IT CANNOT BE ACCESSED BY ANY OF THE PRECURSORS OF THROMBOSIS, COAGULATION OR COMPLEMENT ACTIVATION. THIS SHOULD PRODUCE A "NON-THROMBOGENIC" SURFACE, BUT NOT AN "ANTI-THROMBOGENIC" SURFACE. (2) TO PROVIDE AT THE SAME TIME MOLECULAR "LEASHES" (I.E,, PEO CHAINS), AT THE ENDS OF WHICH ARE COVALENTLY ATTACHED A MOLECULAR SUCH AS HEPARIN WHICH WILL CARRY OUT A SPECIFIC INTERACTION WITH BLOOD. THIS IS AN EXAMPLE OF A (POTENTIALLY) ANTITHROMBOGENIC SURFACE.

Principal Investigator:

Ih-houng Loh
5086637652

Business Contact:

Small Business Information at Submission:

Advanced Surface
9 Linnell Circle Billerica, MA 01821

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No