USA flag logo/image

An Official Website of the United States Government

Novel Polymer-Coated ION-Exchange Chromatography Support

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
22283
Program Year/Program:
1993 / SBIR
Agency Tracking Number:
22283
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
AST PRODUCTS, INC.
AST PRODUCTS, INC. 9 LINNELL CIR BILLERICA, MA 01821
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1993
Title: Novel Polymer-Coated ION-Exchange Chromatography Support
Agency: HHS
Contract: N/A
Award Amount: $49,962.00
 

Abstract:

This project describes the use radio frequency (RF) plasma induced polymerization for the preparation of new ion exchange support media for High Performance Liquid Chromatography (HPLC) separation of biopolymers. Silica and alumina supports will be uniformly coated with thin layers of polymerizable monomers containing ionizable groups of interest. The dispersed monomer coatings will then be polymerized on the surfaces throughout the pore structure of the supports to form thin, pin hole free chromatographic supports with a high surface density of ionizable groups. Monomers have been selected to allow preparation of both weak and strong cationic and anionic ion-exchange materials. Chromatographic evaluations will be performed using proteins and other biomolecules to characterize the performance of the ion exchange media. The successful completion of Phase I will lead to the evolution of families of highly selective polymer coated separations media of commercial interest for separations, purification and evaluation of complex biological mixtures. The process, although limited here to the preparation of plasma polymer coated silica and alumina HPLC support media, can be generalized to incorporate many different functional monomers and can be applied to other support materials including inorganic and polymeric particulate materials or membranes.

Principal Investigator:

Alan B. Fischer
5086637652

Business Contact:

Small Business Information at Submission:

Advanced Surface Technology,
Nine Linnell Circle Billerica, MA 01821

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No