Alzheimer's disease (AD) is a common, devastating neurodegenerative disorder characterized by progrcognitive decline. Loss of the cholinergic innervation of limbic structures and the neocortex occursin patients with AD. The degree of cognitive decline has been correlated to the extent of… More

DESCRIPTION (Adapted from applicant's abstract): Chronic pain is an enormous problem in the United States: it is estimated that 30 to 100 million people suffer from it. Often, current treatments are ineffective and the population of sufferers is often described as… More

DESCRIPTION: (Adapted from the Applicant's Abstract) The Mouse is the species of choice for many neuroscientists because of well-characterized molecular biology and chemistry of its brain, the recent widespread use of transgenic and knockout techniques, and the low cost and… More

DESCRIPTION: (Adapted from the Applicant's Abstract) The Mouse is the species of choice for many neuroscientists because of well-characterized molecular biology and chemistry of its brain, the recent widespread use of transgenic and knockout techniques, and the low cost and… More

DESCRIPTION (provided by applicant): SP-SAP, a conjugate between the peptide neurotransmitter substance P, and the ribosome-inactivating protein, saporin, has been shown, through previous NIH funding, to ablate chronic pain transmission in several rat models. Importantly, acute, reflexive pain… More

DESCRIPTION (provided by applicant): SP-SAP, a conjugate between the peptide neurotransmitter substance P, and the ribosome-inactivating protein, saporin, has been shown, through previous NIH funding, to ablate chronic pain transmission in several rat models. Importantly, acute, reflexive pain… More

DESCRIPTION (provided by applicant): In extensive work over the last decade, it has become clear that biologically active molecules can be inserted into specific cell types through targeting to molecules on the cell surface. It is here proposed to direct this technology to specific neuronal cell… More

DESCRIPTION (provided by applicant): Selective Activation in Specific Neuronal Populations Summary: Molecules targeted towards cell surface markers have been used for years to identify specific cell types. It has been demonstrated over the course of the pa st decade that biologically-active… More

DESCRIPTION (provided by applicant): Targeting a Poor Prognosis Marker for Tumor Therapy Summary The purpose of this proposal is to develop a medical treatment for the elimination of metastatic cancers. According to the National Cancer Institute, the s urvival rate for many types of cancer has… More