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Drug Development of a Chronic Pain Therapeutic

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
66558
Program Year/Program:
2003 / SBIR
Agency Tracking Number:
MH056368
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
ADVANCED TARGETING SYSTEMS, INC.
10451 Roselle St #300 SAN DIEGO, CA 92121
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2003
Title: Drug Development of a Chronic Pain Therapeutic
Agency: HHS
Contract: 2R44MH056368-05
Award Amount: $0.00
 

Abstract:

DESCRIPTION (provided by applicant): SP-SAP, a conjugate between the peptide neurotransmitter substance P, and the ribosome-inactivating protein, saporin, has been shown, through previous NIH funding, to ablate chronic pain transmission in several rat models. Importantly, acute, reflexive pain perception remains intact. The conjugate acts by elimination of the small number of substance P receptor-expressing neurons in the superficial laminae of the dorsal horn of the spinal cord after intrathecal injection. The Food and Drug Administration has recommended that the initial patient population for this drug be terminal cancer patients in pain that is refractory to opioids. The purpose of this application is to obtain funding to move this drug closer to clinical trial by establishing Good Manufacturing Practice (GMP)-grade SP-SAP and by taking SP-SAP through toxicology/safety studies in the rat and the dog, as requested by the FDA. Funding is requested for equipment to complete a GMP-level facility, for synthesis of SP-SAP for toxicology/safety (not at GMP level), for the actual toxicology/safety studies (that will be sub-contracted) and for the preparation of protocols that satisfy the FDA request for GMP materials. Finally, GMP-grade SP-SAP will be synthesized in preparation for clinical trial.

Principal Investigator:

Douglas A. Lappi
8586421988
TARGETING@ATSBIO.COM

Business Contact:

Denise Higgins
8586421988
ATS@ATSBIO.COM
Small Business Information at Submission:

ADVANCED TARGETING SYSTEMS, INC.
ADVANCED TARGETING SYSTEMS, INC. 11175-A FLINTKOTE AVE SAN DIEGO, CA 92191

EIN/Tax ID: 330632253
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No