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SOLUTE-SOLVENT INTERACTIONS IN CHEMISTRY AND BIOLOGY

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
7263
Program Year/Program:
1987 / SBIR
Agency Tracking Number:
7263
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Advanced Technology & Research
14900 Sweitzer Lane Suite 104 Laurel, MD 20707
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Woman-Owned: No
Minority-Owned: Yes
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1987
Title: SOLUTE-SOLVENT INTERACTIONS IN CHEMISTRY AND BIOLOGY
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

THE "SOLVATOCHROMIC PARAMETER" DATABASE WILL BE EXPANDED ANDSOLUBILITY, DISTRIBUTION, AND TOXICOLOGY PROPERTIES (XYZ) OF ORGANIC NONELECTROLYTES WILL BE CORRELATED, RATIONALIZED,AND PREDICTED THROUGH LINEAR SOLVATION ENERGY RELATIONSHIPS OF THE FORM: XYZ = XYZ + MV/100 + S PI* + A ALPHA + B BETA, WHERE V IS A MEASURE OF SOLUTE (TOXICANT) MOLAR VOLUME, AND PI*, ALPHA, AND BETA ARE THE SOLVATOCHROMIC PARAMETERS THAT MEASURE SOLUTE DIPOLARITY/POLARIZABILITY, HYDROGEN-BOND DONOR ACIDITY, AND HYDROGEN-BOND ACCEPTOR BASICITY. PROPERTIES TO BE CORRELATED AND PREDICTED INCLUDE AQUEOUS SOLUBILITIES AND TOXICITIES OF LIQUID AND SOLID SOLUTES, SOLUBILITIES OF LIQUID SOLUTES IN HUMAN BODY TISSUES AND FLUIDS, AND EQUILIBRIUM DISTRIBUTIONS OF LIQUID AND SOLID SOLUTES (INCLUDING CANDIDATE PHARMACEUTICALS AND CARCINOGENS) AMONG THESE TISSUES. THE CORRELATION EQUATIONSWILL PROVIDE SYNTHESIS GUIDELINES FOR "TARGETING" OF CANDIDATE PHARMACEUTICALS TOWARD OR AWAY FROM SPECIFIC BODY ORGANS.

Principal Investigator:

Mortimer j kamlet phd
3014211856

Business Contact:

Small Business Information at Submission:

Advanced Technology & Research
3933 Sandy Spring Road Burtonsville, MD 20866

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No