Development of a Biochip Device for In Vitro Toxicology
DESCRIPTION (provided by applicant): Accurate prediction of human
responsiveness to chemical exposure is difficult, often unreliable, and
invariably expensive. Thus, Aegen Biosciences is developing a microfluidic
biochip device called the Animal Chip. The Animal Chip system is a biochip
device containing living cells segregated into discrete yet interconnected
organ compartments. The organ compartments consist of a microfluidic array of
channels that contain cultured mammalian cells selected to mimic key metabolic
functions of different animal or human organ systems. The fluidics is designed
such that the primary elements of the circulatory system of the animal are
mimicked accurately. Test compounds are added to the re-circulating culture
medium, interacting with the cells in the various organ compartments. The
effects of these compounds and/or their metabolites on the various cell types
are detected by measuring key indicators of cytotoxicity or drug efficacy.
Unlike traditional in vitro assays, the Animal Chip more faithfully mimics the
complex multi-tissue, multi-organ biology of the animal or human body. We
believe that this device will greatly decrease dependency on expensive, time
consuming and unpopular animal testing by predicting a priori which compounds
are potentially toxic to humans.
PROPOSED COMMERCIAL APPLICATION:
There is a pressing need in the pharmaceutical, chemical, and consumer products industries for new technologies that can accurately predict which compounds have the potential to be toxic to humans early in the development process. Refer to Section B5, Page 18.
Small Business Information at Submission:
Principal Investigator:Gregory T. Baxter
AEGEN BIOSCIENCES, INC.
105 MC INTYRE PL ITHACA, NY 14850
Number of Employees: