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Pneumoreductive Surfactant Therapy for Emphysema

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
71003
Program Year/Program:
2006 / SBIR
Agency Tracking Number:
HL077961
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
AERIS THERAPEUTICS, INC.
AERIS THERAPEUTICS, INC. 10K GILL ST WOBURN, MA 01801 0172
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 2006
Title: Pneumoreductive Surfactant Therapy for Emphysema
Agency: HHS
Contract: 2R44HL077961-02
Award Amount: $855,484.00
 

Abstract:

DESCRIPTION (provided by applicant): Aeris therapeutics is developing a novel medical treatment for patients with advanced emphysema known as Pneumoreductive Surfactant (PRS). PRSs are inhaled drugs that increase lung recoil by safely altering the surface tension properties of native lung surfactant. Unlike existing medical therapies for chronic obstructive pulmonary disease, PRS is the only medical therapy designed specifically to treat emphysema by improving lung recoil and decreasing hyperinflation. During Phase I SBIR funding (9/2004 to 3/2005), Aeris identified two PRS formulations that favorably alter lung surfactant function in vitro, and effectively increase lung recoil in emphysema models in vivo. The best of these preparations has been selected for product development. Dose-response and dose delivery studies demonstrate that PRSs can be effectively delivered to the lung using conventional nebulizer systems. Repeat dosing studies confirm the safety of PRS administration, out to two weeks. GMP sources of raw materials for manufacturing PRS have been identified, and a manufacturing protocol, clinical plan, and regulatory strategy have been developed for advancing this product into clinical testing. Aeris is requesting Phase II SBIR support to advance the development of this exciting new therapeutic product.

Principal Investigator:

Edward P. Ingenito
7819370110
eingenito@aerist.com

Business Contact:

Edward Ingenito
7819370110
EINGENITO@AERIST.COM
Small Business Information at Submission:

AERIS THERAPEUTICS, INC.
AERIS THERAPEUTICS, INC. 10K GILL ST WOBURN, MA 01801

EIN/Tax ID: 043531052
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No