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Kits for 3-Dimensional Histophysiologic Gradient Culture

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
29255
Program Year/Program:
1995 / SBIR
Agency Tracking Number:
29255
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Aeron Biotechnology, Inc.
1933 Davis Street, Suite 310 San Leandro, CA 94577
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1995
Title: Kits for 3-Dimensional Histophysiologic Gradient Culture
Agency: HHS
Contract: 1 R43 CA68873-01,
Award Amount: $98,417.00
 

Abstract:

We will develop a commercial kit so that biologists can readily study tissues under conditions of hgradient culture. Here, as in nature, stratified epithelia adhere to their supporting stroma at a reRenewal of epithelium occurs adjacent to the interface, and all metabolic exchange is by diffusion aculture, a thin, transparent, permeable collagen membrane serves as a "stroma." Cells attach to onethe medium bathes the opposite side, and metabolic exchange for the cells is by diffusion across thethe membrane in contract with the cells is waffled with collagen, which increases the tensile strengthe surface area for cell attachment. The membrane is used in two configurations, as a flat substratchamber closed at both ends. With commercial kits available, a number of basic and clinical biomedicfollow. Processes of tissue remodeling, aging, metaplasia,atrophy, hypertrophy, dysplasia, carcinogeinvasion, and viral propagation can be reconstituted and manipulated. Clinical applications are numediagnosis and treatment,e.g. characterization of cells from a biopsy that will predict the subsequen

Principal Investigator:

Joseph Leighton
51029

Business Contact:

Small Business Information at Submission:

Aeron Biotechnology, Inc.
1933 Davis Street, Suite 310 San Leandro, CA 94577

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No