LUNG DRUG DELIVERY WITH CARBON DIOXIDE AEROSOL INHALERS
DESCRIPTION (Adapted from the Investigator's Abstract): The chlorofluorocarbon
(CFC) propellants currently being used in metered dose inhalers for pulmonary
drug delivery are being phased out due to their high ozone depletion potential.
An international pharmaceutical industry consortium has proposed that the
zero-ozone depletion potential hydrofluoroalkane (HFA) propellants will replace
CFCs in metered dose inhalers. There remain, however, crucial reasons to find
other drug aerosolization alternatives. Potential problems with the HFA
propellants include toxicity, incompatibility with devices, incompatibility
with FDA approved inhaler surfactants and reduced bioavailability of some
drugs. The investigators have patented a method for the pulmonary aerosol
delivery of pharmaceuticals using supercritical fluid carbon dioxide as an
inhaler propellant, and have demonstrated its potential usefulness in vivo in
several laboratory studies. The investigators have designed a number of inhaler
prototypes that use carbon dioxide as a propellant and are seeking funding for
additional research and development of these devices. This technology has
several advantages including zero-ozone depletion potential propellant, low
toxicity of carbon dioxide, and the ability to administer to the lungs
lipophilic drugs which cannot currently be delivered by any other method. The
investigators propose to improve and thoroughly test a new form of metered dose
inhaler which uses carbon dioxide as a propellant.
PROPOSED COMMERCIAL APPLICATION:
1. This ozone-friendly technology may replace existing MDI propellants.
2. Aerosol delivery of antibiotics may reduce death from pneumonia.
3. This inhaler may prove to be better than needle injection of insulin.
4. This is an excellent surfactant delivery system to reduce acute lung injury.
5. This may deliver drugs that cannot be administered by any other method.
Small Business Information at Submission:
Principal Investigator:Brian N. Hansen
401 MOUNTAIN VIEW AVE LONGMONT, CO 80501
Number of Employees: