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Company Information:

Company Name: AFASCI, INC.
City: REDWOOD CITY
State: CA
Zip+4: 94063-3848
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Website URL: http://www.afasci.com
Phone: N/A

Award Totals:

Program/Phase Award Amount ($) Number of Awards
SBIR Phase I $3,315,490.00 10
SBIR Phase II $2,713,899.00 3
STTR Phase I $232,068.00 1
STTR Phase II $852,597.00 1

Award List:

High-throughput screening of behavior using piezo system

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency: HHS
Principal Investigator: Xinmin S. Xie
Award Amount: $100,000.00
Abstract:
DESCRIPTION (provided by applicant): An automated piezoelectric monitoring system is proposed for high-throughput screening (HTS) of sleep and other behaviors in mice. Piezoelectric surfaces on the floor of a cage can detect very small movements with great ease. During sleep, the primary movement is… More

Novel Neuropeptides as Targets for Psychiatric Disorders

Award Year / Program / Phase: 2004 / SBIR / Phase I
Agency: HHS
Principal Investigator: Xinmin S. Xie
Award Amount: $500,000.00
Abstract:
DESCRIPTION (provided by applicant): Agents acting at G-protein coupled receptors (GPCRs) have been the most successful targets for drug development. Every new GPCR identified is immediately examined for their potential clinical applications. Likewise all novel endogenous neuropeptides are viewed as… More

High throughput screen of behavior using piezo-imaging

Award Year / Program / Phase: 2005 / SBIR / Phase II
Agency: HHS
Principal Investigator: Xinmin S. Xie
Award Amount: $744,109.00
Abstract:
DESCRIPTION (provided by applicant): Neurobehavioral assessments, including arousal activity level and sleep pattern, are endpoints of global nervous system function. Virtually all pathological conditions, particularly neuropsychological disorders such as anxiety and depression, and a variety of… More

AUTOMATED EXTRACTION OF METADATA FROM EXPERIMENT DESIGNS

Award Year / Program / Phase: 2005 / SBIR / Phase I
Agency: HHS
Principal Investigator: Yannick Pouliot
Award Amount: $92,093.00
Abstract:
DESCRIPTION (provided by applicant): The querying of biological databases by biomedical researchers is hampered by the absence of metadata, which describe the "why" and "how" of the data generated by an experiment. Consequently, it is difficult for researchers to query for experiments stored in… More

Development of Automated Noninvasive DiskTreadmills for Sleep Deprivation in Mice

Award Year / Program / Phase: 2007 / STTR / Phase I
Agency: HHS
Research Institution: PENN STATE UNIV HERSHEY MED CT
Principal Investigator: Jidong Fang
Award Amount: $232,068.00
RI Contact: N/A
Abstract:
DESCRIPTION (provided by applicant): 6. Project Summary-Abstract Modern societies face a mounting epidemic that cuts across all age groups: daily sleep loss. Cumulative sleep loss induces excessive daytime sleepiness and impairs cognitive performance. Amon g its many financial and physical… More

Automated Touchscreen-Piezo Monitoring of Mouse Cognition, Activity and Sleep

Award Year / Program / Phase: 2007 / SBIR / Phase I
Agency: HHS
Principal Investigator: Xinmin S. Xie
Award Amount: $400,742.00
Abstract:
DESCRIPTION (provided by applicant): Millions of people suffer chronic neurodegeneration, leading to Alzheimer's disease and other dementias. Millions more suffer acute cognitive impairment from sleep deprivation, stress, circadian disturbances, and psychi atric disorders. Many medication side… More

Microneedle patches deliver a CGRP antagonist for neurogenic inflammatory pain

Award Year / Program / Phase: 2008 / SBIR / Phase I
Agency: HHS
Principal Investigator: Xinmin S. Xie
Award Amount: $199,171.00
Abstract:
DESCRIPTION (provided by applicant): Recent surveys indicate that approximately 26 - 27 million individuals in the US suffer from moderate to severe chronic pain. A key pathophysiology of chronic pain is neurogenic inflammation, which is primarily elicited by activation of unmyelinated sensory… More

Retrograde Tracers with Suicide Enzyme?Prodrug to Study Specific Neural Circuits

Award Year / Program / Phase: 2009 / SBIR / Phase I
Agency: HHS
Principal Investigator: Xinmin S. Xie
Award Amount: $595,044.00
Abstract:
DESCRIPTION (provided by applicant): Tracing techniques have long been used to analyze specific neural pathways but do not reveal their function. Lesion techniques have also long been employed to analyze the function of neural pathways but are not very sel ective. Current lesion methods use… More

Nicotine delivery to rodents with lung alveolar region-targeted aerosol tech

Award Year / Program / Phase: 2011 / SBIR / Phase I
Agency: HHS
Principal Investigator: Xinmin S. Xie – 650-995-7320
Award Amount: $240,384.00
Abstract:
DESCRIPTION (provided by applicant): This application is in response to NIH/PSH 2010-2 'Omnibus solicitation for SBIR/STTR Grant Application' under NIDA 2, Development of Alternate Drug Delivery Dosage Forms for Drugs Abuse Studies . Through the use of tobacco, nicotine is one of the most… More

Development of automated neurobehavioral assay for rodent stroke model assessment

Award Year / Program / Phase: 2011 / SBIR / Phase I
Agency: HHS
Principal Investigator: Xinmin S. Xie – 650-995-7320
Award Amount: $253,114.00
Abstract:
DESCRIPTION (provided by applicant): Development of automated neurobehavioral assay for rodent stroke model assessment Millions of elderly people suffer from stroke, which is the third leading cause of death in the US, after heart disease and cancer. Stroke survivors suffer from motor and cognitive… More

Treat Neuropathic Pain with Dissolvable Microneedles Containing Anti-CGRP Peptide

Award Year / Program / Phase: 2012 / SBIR / Phase II
Agency: HHS
Principal Investigator: Xinmin S. Xie – 650-995-7320
Award Amount: $979,131.00
Abstract:
DESCRIPTION (provided by applicant): Neuropathic pain is a complex, chronic pain state that is usually initiated by tissue injury and maintained, in part, by subsequent dysfunction of damaged peripheral nerve fibers or fibers that innervate that injured tissue. The impact of nerve fiber damage… More

Development of an automated noninvasive system for sleep restriction in rodents

Award Year / Program / Phase: 2013 / STTR / Phase II
Agency: HHS
Research Institution: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
Principal Investigator: Jidong Fang – 717-531-5435
Award Amount: $852,597.00
RI Contact:
Abstract:
DESCRIPTION (provided by applicant): Sleep deprivation (SD) occurs universally in modern societies and causes significant social and financial harm. Numerous human and animal studies indicate that various forms of SD are deleterious to mental and physicalhealth. Therefore, SD has been recognized as… More

Development of Montelukast Delivery System for Childhood Asthma

Award Year / Program / Phase: 2013 / SBIR / Phase I
Agency: HHS
Principal Investigator: Xinmin S. Xie – 650-995-7320
Award Amount: $596,058.00
Abstract:
DESCRIPTION (provided by applicant): Development of Novel Tricyclic Pyrone Drugs for Treatment of Alzheimer's Disease Alzheimer's disease (AD) afflicts approximately 35 million people worldwide and is the most common cause of dementia in the elderly. Thereis an unmet medical need for new… More

Nicotine delivery to rodent with lung alveolar region-targeted aerosol technology

Award Year / Program / Phase: 2013 / SBIR / Phase II
Agency: HHS
Principal Investigator: Xinmin S. Xie – 650-995-7320
Award Amount: $990,659.00
Abstract:
DESCRIPTION (provided by applicant): Our completed SBIR Phase I project (R43 DA031578) was in response to NIH PA11-096, PHS 2011-02 'Omnibus solicitation for SBIR/STTR Grant Application' under NIDA 2, Development of Alternate Drug Delivery Dosage Forms for Drugs Abuse Studies. We have… More

IGF::OT::IGF: FY13: Phenotypic Screening of Smoking Cessation Drugs, N43DA-13-7

Award Year / Program / Phase: 2013 / SBIR / Phase I
Agency: HHS
Principal Investigator: Xinmin S. Xie – 650-784-5658
Award Amount: $338,884.00
Abstract:
Under this Small Business Innovation Research (SBIR) Phase I project, Research Topic 149, the Contractor shall develop predictive in vivo screening systems for phenotypic drug discovery for smoking cessation. The Contractor shall accomplish this throughthe following objectives: Objective 1-… More