DESCRIPTION (provided by applicant): An automated piezoelectric monitoring system is proposed for high-throughput screening (HTS) of sleep and other behaviors in mice. Piezoelectric surfaces on the floor of a cage can detect very small movements with great ease. During sleep, the primary movement is… More

DESCRIPTION (provided by applicant): Agents acting at G-protein coupled receptors (GPCRs) have been the most successful targets for drug development. Every new GPCR identified is immediately examined for their potential clinical applications. Likewise all novel endogenous neuropeptides are viewed as… More

DESCRIPTION (provided by applicant): Neurobehavioral assessments, including arousal activity level and sleep pattern, are endpoints of global nervous system function. Virtually all pathological conditions, particularly neuropsychological disorders such as anxiety and depression, and a variety of… More

DESCRIPTION (provided by applicant): The querying of biological databases by biomedical researchers is hampered by the absence of metadata, which describe the "why" and "how" of the data generated by an experiment. Consequently, it is difficult for researchers to query for experiments stored in… More

DESCRIPTION (provided by applicant): 6. Project Summary-Abstract Modern societies face a mounting epidemic that cuts across all age groups: daily sleep loss. Cumulative sleep loss induces excessive daytime sleepiness and impairs cognitive performance. Amon g its many financial and physical… More

DESCRIPTION (provided by applicant): Millions of people suffer chronic neurodegeneration, leading to Alzheimer's disease and other dementias. Millions more suffer acute cognitive impairment from sleep deprivation, stress, circadian disturbances, and psychi atric disorders. Many medication side… More

DESCRIPTION (provided by applicant): Recent surveys indicate that approximately 26 - 27 million individuals in the US suffer from moderate to severe chronic pain. A key pathophysiology of chronic pain is neurogenic inflammation, which is primarily elicited by activation of unmyelinated sensory… More

DESCRIPTION (provided by applicant): Tracing techniques have long been used to analyze specific neural pathways but do not reveal their function. Lesion techniques have also long been employed to analyze the function of neural pathways but are not very sel ective. Current lesion methods use… More

DESCRIPTION (provided by applicant): This application is in response to NIH/PSH 2010-2 'Omnibus solicitation for SBIR/STTR Grant Application' under NIDA 2, Development of Alternate Drug Delivery Dosage Forms for Drugs Abuse Studies . Through the use of tobacco, nicotine is one of the most… More

DESCRIPTION (provided by applicant): Development of automated neurobehavioral assay for rodent stroke model assessment Millions of elderly people suffer from stroke, which is the third leading cause of death in the US, after heart disease and cancer. Stroke survivors suffer from motor and cognitive… More

DESCRIPTION (provided by applicant): Neuropathic pain is a complex, chronic pain state that is usually initiated by tissue injury and maintained, in part, by subsequent dysfunction of damaged peripheral nerve fibers or fibers that innervate that injured tissue. The impact of nerve fiber damage… More