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Company Information:

Company Name: Agave BioSystems, Inc.
City: Ithaca
State: NY
Zip+4: 14850-
Woman-Owned: No
Minority-Owned: Yes
HUBZone-Owned: Yes
Website URL: N/A
Phone: (512) 656-6200

Award Totals:

Program/Phase Award Amount ($) Number of Awards
SBIR Phase I $4,177,057.00 51
SBIR Phase II $18,019,236.00 25
STTR Phase I $1,478,950.00 15
STTR Phase II $5,186,623.00 8

Award List:

Labeless, Reagentless, Biosensor

Award Year / Program / Phase: 1998 / SBIR / Phase I
Agency / Branch: DOD / CBD
Principal Investigator: Dr. Carl A. Batt
Award Amount: $100,000.00
Abstract:
The preponderance of biosensors under development today rely on labeling reagents such as fluorescent, radioisotopic or enzymatic tags. As a result, the added complexity of these reagents and their incorporation into the detection system has resulted in designs that are difficult to implement or… More

N/A

Award Year / Program / Phase: 1999 / SBIR / Phase II
Agency / Branch: DOD / USAF
Principal Investigator: Dr Carl A Batt
Award Amount: $750,000.00

Real Time Automated Screening and Selection of Phage Displayed Antibody

Award Year / Program / Phase: 1999 / SBIR / Phase I
Agency / Branch: DOD / ARMY
Principal Investigator: Carl Batt
Award Amount: $70,000.00
Abstract:
Not Available This Small Business Innovation Research Phase I project features as the main goal demonstration of the feasibility of a single-electron transistor with the following characteristics: 1) a high voltage gain, 2) gain over a significant range of operating voltage, and 3) modulation of… More

RAPID DIAGNOSTIC BIOSENSOR FOR FOODBORNE PATHOGENS

Award Year / Program / Phase: 1999 / SBIR / Phase I
Agency: HHS
Principal Investigator: Carl A. Batt
Award Amount: $100,000.00

N/A

Award Year / Program / Phase: 2000 / STTR / Phase I
Agency / Branch: DOD / ARMY
Research Institution: CORNELL UNIV.
Principal Investigator: Carl A. Batt
Award Amount: $100,000.00
RI Contact: N/A
Abstract:
Not Available VXI-based hardware and software products have now advanced to the point where real-time data acquisition and intensive signal processing on multiple signals can be routinely handled by commercially available products. However, for specialized tasks, such as optimal process control,… More

Fluorogenic Cell-Based Biosensors for Microbial Monitoring

Award Year / Program / Phase: 2001 / SBIR / Phase I
Agency: NASA
Principal Investigator: Joel Tabb, Senior Scientist
Award Amount: $70,000.00
Abstract:
Great strides have been made in developing diagnostic systems for detecting and identifying specific pathogens and their toxins. However, these systems may be too specific and unable to detect newly emerging pathogens whose immunological or genetic profile is different than the normal complement of… More

Miniature Flow Cytometer and Cell Sorter for Use in Low Gravity

Award Year / Program / Phase: 2001 / SBIR / Phase I
Agency: NASA
Principal Investigator: Greg Baxter, Principal Scientist
Award Amount: $70,000.00
Abstract:
Conventional fluorescence-activated cell sorters (FACSs) are widely used to study eukaryotic cell populations. Although they provide impressively efficient sorting, they are costly, mechanically complex, and require large sample volumes and trained personnel for operation and maintenance. In… More

MEMS Biosensor for In Situ Drinking Water Analysis

Award Year / Program / Phase: 2001 / SBIR / Phase I
Agency: EPA
Principal Investigator: Noel Salazar
Award Amount: $0.00
Abstract:
The occurrence of causative agents such as Cryptosporidium parvum and other pathogens in water supplies presents a critical issue. Transmitted through water and animals, these organisms provide a reservoir of infection, which results in the excretion of the environmentally stable cysts or oocysts… More

MEMS Biosensor for In Situ Drinking Water Analysis

Award Year / Program / Phase: 2001 / SBIR / Phase II
Agency: EPA
Principal Investigator: Noel Salazar
Award Amount: $225,000.00
Abstract:
The occurrence of causative agents such as Cryptosporidium parvum and other pathogens in water supplies presents a critical issue. Transmitted through water and animals, these organisms provide a reservoir of infection, which results in the excretion of the environmentally stable cysts or oocysts… More

Phage Array Biosensor for Detection of Biowarfare Agents

Award Year / Program / Phase: 2001 / STTR / Phase I
Agency / Branch: DOD / ARMY
Research Institution: CORNELL UNIV.
Principal Investigator: Tom Klem, Senior Scientist
Award Amount: $100,000.00
RI Contact: Linda Brainard
Abstract:
Agave BioSystems, in collaboration with Professor George Malliaras of Cornell University, proposes to develop a unique and innovative biosensor based on induced luminescence of captured BW bacterial agents and organic light emitting diode (OLED)technology. The system would use an array of… More

Biomolecular Optical Nanostructures

Award Year / Program / Phase: 2001 / SBIR / Phase I
Agency / Branch: DOD / DARPA
Principal Investigator: Joel Tabb, Principal Scientist
Award Amount: $99,000.00
Abstract:
Biology provides a vast number of examples of nanostructures produced at a level of precision that is superior to those that we can produce in the laboratory. The diversity of naturally occurring S-layers suggests that the nature of these self-assembledstructures is genetically controlled and can… More

Rapid Diagnostic Biosensor for Foodborne Pathogens

Award Year / Program / Phase: 2001 / SBIR / Phase II
Agency: HHS
Principal Investigator: Joel Tabb
Award Amount: $749,999.00

Phage Array Biosensor for Detection of Biowarfare Agents

Award Year / Program / Phase: 2002 / SBIR / Phase II
Agency / Branch: DOD / ARMY
Principal Investigator: Joel Tabb, Principal Scientist
Award Amount: $499,999.00
Abstract:
"Agave BioSystems, in collaboration with Professor George Malliaras of Cornell University, proposes to develop a unique and innovative biosensor based on induced luminescence of captured BW bacterial agents and organic light emitting diode (OLED)technology. The system would use an array of… More

Biomolecular Construction of Nanostructures

Award Year / Program / Phase: 2002 / SBIR / Phase II
Agency / Branch: DOD / DARPA
Principal Investigator: Joel Tabb, Principal Scientist
Award Amount: $375,000.00
Abstract:
"Biology provides a vast number of examples of nanostructures produced at a level of precision that is superior to those that we can produce in the laboratory The diversity of naturally occurring S-layers suggests these self-assembled structures aregenetically controlled and can therefore be… More

Biomolecular Construction of Optical Nanostructures

Award Year / Program / Phase: 2002 / SBIR / Phase I
Agency: NASA
Principal Investigator: Joel Tabb, Principal Scientist
Award Amount: $70,000.00
Abstract:
Biology provides a vast number of examples of nanostructures produced at a level of precision that is superior to those that we can produce in the laboratory. The diversity of naturally occurring S-layers suggests that the nature of these self-assembled structures is genetically controlled and can… More

Miniature Flow Cytometer and Cell Sorter for Use in Low Gravity

Award Year / Program / Phase: 2002 / SBIR / Phase I
Agency: NASA
Principal Investigator: Greg Baxter, Principal Scientist
Award Amount: $0.00
Abstract:
Conventional fluorescence-activated cell sorters (FACSs) are widely used to study eukaryotic cell populations. Although they provide impressively efficient sorting, they are costly, mechanically complex, and require large sample volumes and trained personnel for operation and maintenance. In… More

Miniature Flow Cytometer and Cell Sorter for Use in Low Gravity

Award Year / Program / Phase: 2002 / SBIR / Phase II
Agency: NASA
Principal Investigator: Greg Baxter, Principal Scientist
Award Amount: $600,000.00
Abstract:
Conventional fluorescence-activated cell sorters (FACSs) are widely used to study eukaryotic cell populations. Although they provide impressively efficient sorting, they are costly, mechanically complex, and require large sample volumes and trained personnel for operation and maintenance. In… More

Fluorogenic Cell-Based Biosensors for Microbial Monitoring

Award Year / Program / Phase: 2002 / SBIR / Phase I
Agency: NASA
Principal Investigator: Joel Tabb, Senior Scientist
Award Amount: $0.00
Abstract:
Great strides have been made in developing diagnostic systems for detecting and identifying specific pathogens and their toxins. However, these systems may be too specific and unable to detect newly emerging pathogens whose immunological or genetic profile is different than the normal complement of… More

Fluorogenic Cell-Based Biosensors for Microbial Monitoring

Award Year / Program / Phase: 2002 / SBIR / Phase II
Agency: NASA
Principal Investigator: Joel Tabb, Senior Scientist
Award Amount: $600,000.00
Abstract:
Great strides have been made in developing diagnostic systems for detecting and identifying specific pathogens and their toxins. However, these systems may be too specific and unable to detect newly emerging pathogens whose immunological or genetic profile is different than the normal complement of… More

RNAi screening for Identification of Compounds to Induce Suspended Animation or Hypometabolism

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency / Branch: DOD / CBD
Principal Investigator: Kathy Wojtas, Staff Scientist
Award Amount: $70,000.00
Abstract:
While the phenomenon of suspended animation has not been widely studied in humans, there are many anecdotal and medically verified examples of humans being in a state that is comparable to suspended animation when they have been accidentally nearly frozenfor short periods of time. There could be… More

N/A

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency: HHS
Principal Investigator: Joel Tabb
Award Amount: $100,000.00

Organic Thin Film Transistor for Microfluidic Flow Cytometry

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency: NASA
Principal Investigator: Joel Tabb
Award Amount: $70,000.00
Abstract:
Agave BioSystems proposes to develop and demonstrate an innovative Organic Thin Film Transistor (OTFT) to detect cell characteristics without the need for cell labeling for use in microfluidic flow cytometers. This sensor would be able to detect count all cells, whether the cells are fluorescently… More

Biological Degradation of Chemical Agents

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency / Branch: DOD / DARPA
Principal Investigator: Mehran Pazirandeh, Staff Scientist
Award Amount: $99,000.00
Abstract:
Current methods used for the destruction of CW agents are cumbersome, require extensive capital equipment such as incinerators and water reactors and pose potential environmental problems themselves. A novel approach for the destruction of CW agentsinvolves genetically engineering microorganisms to… More

Enabling Drug Discovery for Malaria

Award Year / Program / Phase: 2003 / SBIR / Phase II
Agency / Branch: DOD / ARMY
Principal Investigator: Joel Tabb, Principal Scientist
Award Amount: $730,000.00
Abstract:
Agave BioSystems has been highly successful in accomplishing the Phase I objectives. In this Phase II proposal, Agave BioSystems will build upon the results generated in the Phase I to isolate additional shikimate pathway genes. We will continue to usestate-of-the-art-bioinformatics computational… More

Organic Thin Film Transistor for Bioterrorism Pathogen Detection

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency / Branch: DOD / NAVY
Principal Investigator: Joel Tabb, Principal Scientist
Award Amount: $70,000.00
Abstract:
It is clear now that deadly biological materials can easily be spread throughout the U.S., and that there are few methods currently available to rapidly detect and identify these bioterrorist agents. Significant resources have been applied to thedevelopment of DNA diagnostic systems for this… More

Whispering Gallery Mode Resonator Biosensor for Bioterrorist and Biowarfare Agent Detection

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency / Branch: DOD / NAVY
Principal Investigator: Joel Tabb, Principal Scientist
Award Amount: $70,000.00
Abstract:
Agave BioSystems, in collaboration with Dr. Robert Boyd, of the Institute of Optics at the University of Rochester, proposes to develop an ultra sensitive and highly specific biosensor based on whispering gallery mode (WGM) resonator technology forbioterrorist and biowarfare agent detection. This… More

Use of Bioconjugated Quantum Dots in Micro FlowCytometer

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency: HHS
Principal Investigator: Joel S. Tabb
Award Amount: $99,980.00
Abstract:
DESCRIPTION (provided by applicant): Fluorescent semiconductor nanocrystals or quantum dots have many properties that make them superior to traditional dyes as fluorescent markers. Quantum dots have higher extinction coefficients making them brighter than traditional dyes (up to 1000 times… More

Enabling Drug Discovery for Malaria

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency / Branch: DOD / ARMY
Principal Investigator: Joel Tabb, Principal Scientist
Award Amount: $119,951.00
Abstract:
Malaria is responsible for 300 million cases a year, resulting in 1 million deaths. From a military perspective, maintaining bases in regions where the disease is endemic puts troops at risk for infection. Whether for civilian or military populations,the fact remains that insecticide tolerant… More

Use of Bioconjugated Quantum Dots in Micro FlowCytometer

Award Year / Program / Phase: 2004 / SBIR / Phase II
Agency: HHS
Principal Investigator: Joel S. Tabb
Award Amount: $644,084.00
Abstract:
DESCRIPTION (provided by applicant): Fluorescent semiconductor nanocrystals or quantum dots have many properties that make them superior to traditional dyes as fluorescent markers. Quantum dots have higher extinction coefficients making them brighter than traditional dyes (up to 1000 times brighter… More

In-line, Real-time monitoring of Arsenic in Drinking Water

Award Year / Program / Phase: 2004 / SBIR / Phase I
Agency / Branch: DOD / USAF
Principal Investigator: Mehran Pazirandeh, Staff Scientist
Award Amount: $100,000.00
Abstract:
In this Phase I, Agave BioSystems proposes a novel approach for the development of a rapid and sensitive detection system for arsenic in drinking water based on the bioluminescent protein aequorin. The simplicity and ruggedness of this technology has the potential for providing low cost, on-line,… More

Environmentally Friendly Luciferase-based Illumination Technology

Award Year / Program / Phase: 2004 / SBIR / Phase I
Agency / Branch: DOD / USAF
Principal Investigator: Kathy Wojtas, Staff Scientist
Award Amount: $100,000.00
Abstract:
Current technologies for marking of landing zones as well as areas for search and rescue have significant drawbacks ranging from the additional weight of batteries for some systems to plastic and metallic debris left behind. There are clear advantages both operationally and environmentally to… More

Respiratory Endothelial Cell Sensor for Real-Time Air Toxicity Monitoring

Award Year / Program / Phase: 2004 / SBIR / Phase II
Agency / Branch: DOD / ARMY
Principal Investigator: Theresa Curtis, Staff Scientist
Award Amount: $730,000.00
Abstract:
Because many chemical and biological toxins selectively target respiratory endothelial cells, a biosensor using these cells in combination with Electric Cell-substrate Impedance Sensing (ECIS) technology has many useful applications for detection and early warning monitoring of a broad range of… More

WGM Resonators for Proteomic Analysis

Award Year / Program / Phase: 2004 / SBIR / Phase I
Agency: NASA
Principal Investigator: Joel Tabb, Principal Investigator
Award Amount: $70,000.00
Abstract:
Due to the extensive amounts of data generated from the genome sequencing projects, the focus of genomics has shifted from elucidating DNA sequence to the interpretation of gene function. In addition, as proteins are most often the targets of drugs, a method of studying the genome at the protein… More

Respiratory Endothelial Cell Sensor for Real-Time Air Toxicity Monitoring

Award Year / Program / Phase: 2004 / SBIR / Phase I
Agency / Branch: DOD / ARMY
Principal Investigator: Theresa Curtis, Staff Scientist
Award Amount: $120,000.00
Abstract:
Because endothelial cells organize to form a tight barrier under normal conditions, several electrical devices have been used to measure the electrical resistance of endothelial cell monolayers. An Electric Cell-substrate Impedance Sensing (ECIS) system can measure the electrical impedance of… More

OTF Transistor Microarray for Cancer Diagnosis

Award Year / Program / Phase: 2004 / SBIR / Phase I
Agency: HHS
Principal Investigator: Joel S. Tabb
Award Amount: $99,617.00
Abstract:
DESCRIPTION (provided by applicant): In response to the solicitation for development of nanotechnologies to improve cancer diagnosis by NCI, Agave BioSystems, in collaboration with Dr. George Malliaras, of the Department of Materials Science and Engineering at Cornell University, proposes to… More

Combinatorial Molecular Array Analysis via MEF/MALDI/MS

Award Year / Program / Phase: 2004 / SBIR / Phase I
Agency: HHS
Principal Investigator: Louis Hom
Award Amount: $99,510.00
Abstract:
DESCRIPTION (provided by applicant): Despite numerous advances in high throughput screening (HTS) and system automation, the identification of specific ligands remains time consuming and resource intensive. A major obstacle to more efficient screening of potential ligands is the current… More

Portable Cell Maintenance System

Award Year / Program / Phase: 2004 / STTR / Phase I
Agency / Branch: DOD / ARMY
Research Institution: Cornell University
Principal Investigator: Theresa Curtis, Staff Scientist
Award Amount: $98,953.00
RI Contact: Linda Brainard
Abstract:
Cultured cell-based biosensors offer insight into the physiological action of the agent of interest, which is an advantage over other types of sensors. The development of cell-based biosensors that are field-portable would increase their utility in toxicology and environmental monitoring. One of… More

Biological Degradation of Chemical Agents

Award Year / Program / Phase: 2005 / SBIR / Phase II
Agency / Branch: DOD / DARPA
Principal Investigator: Mehran Pazirandeh, Staff Scientist
Award Amount: $750,000.00
Abstract:
Current methods used for the destruction of CW agents are cumbersome, require extensive capital equipment such as incinerators and water reactors and pose potential environmental problems themselves. A novel approach for the destruction of CW agents involves genetically engineering microorganisms… More

Environmentally Friendly Luciferase-based Illumination Technology

Award Year / Program / Phase: 2005 / SBIR / Phase II
Agency / Branch: DOD / USAF
Principal Investigator: Kathy Wojtas, Staff Scientist
Award Amount: $750,000.00
Abstract:
Current technologies for marking of landing zones as well as areas for search and rescue have significant drawbacks ranging from the additional weight of batteries for some systems to plastic and metallic debris left behind. There are clear advantages both operationally and environmentally to… More

Human Paraoxonase Bioscavenger for Nerve Agents

Award Year / Program / Phase: 2005 / SBIR / Phase I
Agency / Branch: DOD / ARMY
Principal Investigator: Louis Hom, Staff Scientist
Award Amount: $70,000.00
Abstract:
In this Phase I, Agave BioSystems proposes to develop a catalytic organophosphorus bioscavenger based on human paraoxonase 1 (PON1) for the protection of personnel against OP nerve agents. A catalytic bioscavenger that detoxifies multiple organophosphorus (OP) molecules by hydrolysis rather than a… More

ECIS Wound Healing High-Throughput Assay

Award Year / Program / Phase: 2005 / SBIR / Phase I
Agency / Branch: DOD / ARMY
Principal Investigator: Theresa Curtis, Staff Scientist
Award Amount: $70,000.00
Abstract:
Healing of a wound is a complex and protracted process of tissue repair and remodeling in response to injury. Understanding how the body repairs damaged tissue and what genes and biochemical factors influence the wound healing process will have tremendous impact on the treatment of chronic wounds… More

Portable Cell Maintenance System

Award Year / Program / Phase: 2005 / STTR / Phase II
Agency / Branch: DOD / ARMY
Research Institution: CORNELL UNIV.
Principal Investigator: Theresa Curtis, Senior Scientist
Award Amount: $750,000.00
RI Contact: Linda Brainard
Abstract:
Cultured cell-based biosensors offer insight into the physiological action of the agent of interest, which is an advantage over other types of sensors. The development of cell-based biosensors that are field-portable would increase their utility in toxicology and environmental monitoring. One of… More

Inhibition of Biofilm Formation Using Novel Nanostructured Surfaces

Award Year / Program / Phase: 2005 / STTR / Phase I
Agency: NASA
Research Institution: Universities Space Research Association (HQ)
Principal Investigator: Joel S. Tabb
Award Amount: $100,000.00
RI Contact: Noe Salazar
Abstract:
Biofilms are ubiquitous in the environment. Few surfaces resist biofilm formation, most promote it. Biofilm formation poses problems in water systems as they can clog pipes and pores, block filters, reduce heat transfer, and in general restrict flow. Their metabolic products can aid corrosion,… More

Dipstick Assay for Field Detection of Leishmania Parasites using Quantum Dots

Award Year / Program / Phase: 2005 / SBIR / Phase I
Agency / Branch: DOD / OSD
Principal Investigator: Theresa Curtis, Staff Scientist
Award Amount: $100,000.00
Abstract:
A PCR based assay has been developed to detect Leishmania parasites, but PCR requires sophisticated laboratory instruments and trained personnel to interpret the data. The parasite can also be identified in infected sand flies by skillful dissection and microscopic examination but this is… More

Detection of Explosive Materials Using an Encapsulated Fluorescent Bioprobe

Award Year / Program / Phase: 2006 / STTR / Phase I
Agency / Branch: DOD / ARMY
Research Institution: UNIVERSITIES SPACE RESEARCH ASSOC.
Principal Investigator: Joel Tabb
Award Amount: $100,000.00
RI Contact: Randy Vander Wal
Abstract:
The use of explosives over the last 100 years has left up to 16,000 military ranges contaminated with highly toxic compounds. A major challenge to the remediation of these ranges is identifying the location of persistent explosive residues. To meet this challenge, Agave BioSystems in collaboration… More

Microfluidic Optical Biosensor for Detection of Biowarfare Agents

Award Year / Program / Phase: 2006 / STTR / Phase I
Agency / Branch: DOD / ARMY
Research Institution: THE UNIV. OF ROCHESTER
Principal Investigator: Joel Tabb
Award Amount: $100,000.00
RI Contact: Robert Boyd
Abstract:
This STTR Phase I project will develop a microfluidic optical biosensor based on whispering gallery mode resonator technology for the detection of bioterrorism agents. The proposed device will bridge biological sciences with optics and material sciences to develop a commerically useful tool for… More

Carbon Nanotube-Based Adsorbents for Ultrafine Particulate and Volatile Air Contaminants

Award Year / Program / Phase: 2006 / STTR / Phase I
Agency: NASA
Research Institution: Universities Space Research Association
Principal Investigator: Joel S. Tabb, Principal Investigator
Award Amount: $100,000.00
RI Contact: Ron Deacon
Abstract:
While the protective qualities of activated carbon have been enhanced by the addition of specific metal salts, activated carbon technology has changed little over the last 60 years. In this Phase I, Agave BioSystems and the Universities Space Research Association, propose to develop next generation… More

Carbon Nanotube-Based Filters for Aerosol Sample Collection

Award Year / Program / Phase: 2007 / SBIR / Phase I
Agency / Branch: DOD / CBD
Principal Investigator: Joel Tabb, Principal Scientist
Award Amount: $70,000.00
Abstract:
Aerosols represent one of the more efficient methods to distribute biological and chemical agents throughout the atmosphere. Small aerosol droplets can be readily inhaled and easily penetrate deep into the lungs where they lodge in bronchial alveoli. Within the alveoli, chemical and biological… More

CNT-Based Smart Electrostatic Filters for Capturing Nanoparticulate Lunar Regolith

Award Year / Program / Phase: 2007 / SBIR / Phase I
Agency: NASA
Principal Investigator: Joel I. Tabb, Principal Investigator
Award Amount: $100,000.00
Abstract:
The abrasive, reactive, and ubiquitous nature of lunar regolith created significant and serious problems during the Apollo moon missions. In this Phase I, Agave BioSystems, in collaboration with Dr. Randy Vander Wal of the Universities Space Research Association, propose to develop next generation… More

Carbon Nanotube-Based Adsorbents for Volatile Air Contaminants

Award Year / Program / Phase: 2007 / STTR / Phase II
Agency: NASA
Research Institution: Universities Space Research Association
Principal Investigator: Joel S. Tabb, Principal Investigator
Award Amount: $600,000.00
RI Contact: N/A
Abstract:
In completing the Phase I SBIR, Agave BioSystems and the Universities Space Research Association, have successfully demonstrated proof of concept for the use of novel carbon nanotube (CNT)-based structures as next generation smart adsorbents for the adsorption and destruction of potentially toxic… More

Xenopus Melanophore-Based Toxicity Sensor for Water

Award Year / Program / Phase: 2007 / STTR / Phase I
Agency / Branch: DOD / ARMY
Research Institution: NORTHWESTERN UNIV.
Principal Investigator: Theresa Curtis, Senior Scientist
Award Amount: $99,999.00
RI Contact: Jamie Young
Abstract:
Deployed armed forces often have to rely on water that is produced from decentralized sources, which presents significant difficulties for assuring the water is free of chemical toxicants. Analysis of these water supplies often requires complex instrumentation that is not practical for field use. … More

Detection of Explosive Materials Using an Encapsulated Fluorescent Bioprobe

Award Year / Program / Phase: 2007 / STTR / Phase II
Agency / Branch: DOD / ARMY
Research Institution: UNIVERSITIES SPACE RESEARCH ASSOCI
Principal Investigator: Joel Tabb, Principal Scientist
Award Amount: $750,000.00
RI Contact: Sophia Hill
Abstract:
The use of explosives over the last 100 years has left up to 16,000 military ranges contaminated with highly toxic compounds. A major challenge to the remediation of these ranges is identifying the location of persistent explosives residues. To meet this challenge, Agave BioSystems in… More

Field Sensor for Measuring Total Trihalomethanes (TTHM) Concentrations in Drinking Water

Award Year / Program / Phase: 2008 / SBIR / Phase I
Agency / Branch: DOD / USAF
Principal Investigator: Mehran Pazirandeh, Staf Scientist
Award Amount: $100,000.00
Abstract:
Rapid detection of the total trihalomethanes (TTHM) in treated drinking water is essential for compliance with the Environmental Protection Agency's (EPA) Stage 2 Disinfectants and Disinfection Byproducts (DBP) Rule, which limits the maximum contaminant level of TTHM in drinking water to 80 parts… More

Multiplex Lyme Disease Diagnostic

Award Year / Program / Phase: 2008 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $100,001.00
Abstract:
DESCRIPTION (provided by investigator): Lyme disease, caused by the gram-negative spirochete Borrelia burgdorferi and transmitted by Ixodid tick species, is the leading vector-borne infectious disease in the United States, with a steady rise in the number of cases reported each year. The most… More

Branched DNA Diagnostic for Malaria Parasites

Award Year / Program / Phase: 2008 / SBIR / Phase I
Agency / Branch: DOD / ARMY
Principal Investigator: Kathie Berghorn, Staff Scientist
Award Amount: $70,000.00
Abstract:
The key to effective management of malaria is accurate diagnosis that is also rapid. The "gold standard" microscopy is time-consuming and labor-intensive and suffers from retirement of microscopic diagnostic experts and inaccurate slide reading. A field-deployable diagnostic method that is… More

Ribozymes for In Vivo Degradation of G-Nerve Agents

Award Year / Program / Phase: 2008 / SBIR / Phase I
Agency / Branch: DOD / CBD
Principal Investigator: Janet Huie, Staff Scientist
Award Amount: $70,000.00
Abstract:
Given the possibility to administer prophylactic doses of protein bioscavengers inactivating OP nerve agents before they reach their acetylcholinesterase target, much attention has been given to proteins such as human butyrylcholinesterase and paraoxonase I. As small nucleic acid catalysts can… More

Collective Protection for Military Working Dogs

Award Year / Program / Phase: 2008 / SBIR / Phase I
Agency / Branch: DOD / CBD
Principal Investigator: Noe Salazar, President
Award Amount: $70,000.00
Abstract:
Shelter enclosures for military working dogs in the event of a CB attack is a technology gap identified by the Joint Requirements Office. Important parameters to consider in the design of protective enclosures include low weight and size to minimize transport requirements; rapid setup; and… More

Organophosphate Degrading Enzymes

Award Year / Program / Phase: 2009 / SBIR / Phase I
Agency: EPA
Principal Investigator: Joel Tabb, Principal Scientist
Award Amount: $70,000.00
Abstract:
Agve BioSystems in collaboration with Carl A. Batt propose to develop decon-nanoparticles which will leverage ongoing opportunities in enzyme engineering and the fabrication of functionalized magnetic nanoparticles. Enhanced performance will be engineered into the system to improve the catalytic… More

Collective Protection for Military Working Dogs

Award Year / Program / Phase: 2009 / SBIR / Phase II
Agency / Branch: DOD / CBD
Principal Investigator: Noe Salazar, President
Award Amount: $750,000.00
Abstract:
Shelter enclosures for military working dogs in the event of a CB attack is a technology gap identified by the Joint Requirements Office. Important parameters to consider in the design of protective enclosures include low weight and size to minimize transport requirements; rapid setup; and… More

Enzymatic Degradation of Rocket Propellant Waste

Award Year / Program / Phase: 2009 / SBIR / Phase I
Agency / Branch: DOD / USAF
Principal Investigator: Mehran Pazirandeh, Staff Scientist
Award Amount: $100,000.00
Abstract:
During the normal course of research, development, and testing by the DOD small quantities of environmentally hazardous waste propellants, explosives, and pyrotechnics (PEP) are produced. The compliance costs and burden associated with open burn/open detonation operations are considerable, including… More

Cell-based High Throughput Screening of Compounds Improving Mitochondrial Energetics

Award Year / Program / Phase: 2009 / STTR / Phase II
Agency / Branch: DOD / ARMY
Research Institution: Cornell University
Principal Investigator: Julien Fey, Staff Scientist
Award Amount: $750,000.00
RI Contact: Ken Packman
Abstract:
Improving age-related decrease in cognitive and physical capabilities has tremendous potential for the civilian population and military personnel, including prolonged aptitude of highly-trained military personnel and lowering of healthcare costs. Mitocho

Point-of-Care Diagnostic for Acute Q Fever using LAMP

Award Year / Program / Phase: 2009 / SBIR / Phase I
Agency / Branch: DOD / ARMY
Principal Investigator: Janet Huie, Staff Scientist
Award Amount: $70,000.00
Abstract:
Q fever is caused by the bacterium Coxiella burnetii and presents with acute symptoms indistinguishable from many other blood infections. Chronic infection, however, can result in endocarditis, with a high mortality rate (up to 60% of chronic Q fever cases) and requiring open-heart surgery to… More

Malarial Vaccines Utilizing Antigen/Adjuvant Display on Viral-Like Particles

Award Year / Program / Phase: 2009 / SBIR / Phase I
Agency / Branch: DOD / ARMY
Principal Investigator: Mehran Pazirandeh, Staff Scientist
Award Amount: $70,000.00
Abstract:
Development of an effective malarial vaccine has been slow, although recent success in vaccine development has been achieved by using the Plasmodium falciparum circumsporozoite surface protein (CSP)-hepatitis B surface antigen fusions, in conjunction with hepatitis B particles (the RTS, S… More

Water Toxicity Detection using Genetically Engineered Yeast

Award Year / Program / Phase: 2009 / SBIR / Phase I
Agency / Branch: DOD / ARMY
Principal Investigator: Kathie Berghorn, Staff Scientist
Award Amount: $70,000.00
Abstract:
The rapid evaluation of drinking water toxicity in the field is a necessity for the safety of our soldiers. To achieve field portability and sensitive screening for identification of toxic industrial chemicals (TICs) a handheld device that is biologically-based and easy to use with components that… More

Field Sensor for Measuring Total Trihalomethanes (TTHM) Concentrations in Drinking Water

Award Year / Program / Phase: 2009 / SBIR / Phase II
Agency / Branch: DOD / USAF
Principal Investigator: Mehran Pazirandeh, Staff Scientist
Award Amount: $540,000.00
Abstract:
Rapid detection of the total trihalomethanes (TTHM) in treated drinking water is essential for compliance with the Environmental Protection Agency's (EPA) Stage 2 Disinfectants and Disinfection Byproducts (DBP) Rule, which limits the maximum contaminant level of TTHM in drinking water. The current… More

Food Toxicity Detection Using C. elegans

Award Year / Program / Phase: 2010 / SBIR / Phase I
Agency / Branch: DOD / OSD
Principal Investigator: Kathie Berghorn, Staff Scientist
Award Amount: $100,000.00
Abstract:
Current toxicity testing of foodstuffs involves mass spectrometry analysis which requires a >24 h turnaround time in deployed military operations. This length of time is dangerous for personnel. Rapid identification of toxic industrial chemicals (TICs) in food using a sensor that is… More

A High-Throughput Blood Esterase Panel Assay

Award Year / Program / Phase: 2010 / SBIR / Phase I
Agency / Branch: DOD / CBD
Principal Investigator: Julien Fey, Senior Scientist
Award Amount: $70,000.00
Abstract:
Organophosphorus chemical warfare nerve agents (OP-CWA) are attractive to terrorist groups and rogue states as an inexpensive and accessible technology for chemical warfare. OP-CWA and organophosphate pesticides cause severe neurological symptoms and death by inhibiting the enzyme… More

Point-of-Care Diagnostic for Acute Q Fever using LAMP

Award Year / Program / Phase: 2010 / SBIR / Phase II
Agency: DOD
Principal Investigator: Janet Huie, Staff Scientist – (607) 272-0002
Award Amount: $730,000.00
Abstract:
Q fever, caused by the bacterium Coxiella burnetii, presents with acute symptoms indistinguishable from many other blood infections. Chronic infection, more frequently developing in immunocompromised individuals, presents a high mortality rate (up to 60% of chronic cases) and often requires… More

Water Toxicity Detection using Genetically Engineered Yeast

Award Year / Program / Phase: 2010 / SBIR / Phase II
Agency / Branch: DOD / ARMY
Principal Investigator: Kathie Berghorn, Staff Scientist
Award Amount: $730,000.00
Abstract:
The rapid evaluation of drinking water toxicity in the field is a necessity for the safety of our soldiers. To achieve field portability and sensitive screening for identification of toxic industrial chemicals (TICs) a handheld device that is biologically-based and easy to use with components that… More

A Point-of-Care Field Assay for Dengue Viruses

Award Year / Program / Phase: 2010 / SBIR / Phase I
Agency / Branch: DOD / ARMY
Principal Investigator: Janet Huie, Staff Scientist
Award Amount: $70,000.00
Abstract:
Dengue viruses are transmitted by mosquito vectors throughout tropical and subtropical regions of Asia, Africa, and Central and South America. Four serotypes circulate, DEN-1 through -4, and immunity to one type does not preclude illness from another type and can exacerbate subsequent disease with… More

Water Toxicity Detection using Genetically Engineered Yeast

Award Year / Program / Phase: 2010 / SBIR / Phase II
Agency / Branch: DOD / ARMY
Principal Investigator: Kathie Berghorn, Staff Scientist – (607) 272-0002
Award Amount: $1,291,865.00
Abstract:
The rapid evaluation of drinking water toxicity in the field is a necessity for the safety of our soldiers. To achieve field portability and sensitive screening for identification of toxic industrial chemicals (TICs) a handheld device that is biologically-based and easy to use with components that… More

High-capacity and Cost-effective Manufacture of Chloroperoxidase

Award Year / Program / Phase: 2011 / STTR / Phase I
Agency / Branch: DOD / ARMY
Research Institution: Cornell University
Principal Investigator: John Ramsey, Staff Scientist – (607) 272-0002
Award Amount: $100,000.00
RI Contact: Linda Brainard
Abstract:
The chloroperoxidase enzyme from the filamentous fungus Caldariomyces fumago has applications in industrial chemical synthesis and the detection and inactivation of chemical warfare agents. Chloroperoxidase is capable of regio- and enantioselective oxygenations and halogenations of organic… More

Specific Epigenetic Molecules Involved in Wound Healing and Repair

Award Year / Program / Phase: 2011 / STTR / Phase I
Agency / Branch: DOD / ARMY
Research Institution: Rutgers University
Principal Investigator: Kathie Berghorn, Staff Scientist – (607) 272-0002
Award Amount: $99,999.00
RI Contact: Diane Ambrose
Abstract:
The ability to direct the wound pathways following injury could provide a critical path in wound care at crucial times during the progression of healing. A promising field of study in wound healing is epigenetics; alterations in gene expression caused by mechanisms other than changes in DNA… More

Multiplex Microsphere Assay for Botulinum Neutralizing Antibodies

Award Year / Program / Phase: 2011 / SBIR / Phase I
Agency: DOD
Principal Investigator: Kathie Berghorn, Staff Scientist – (607) 272-0002
Award Amount: $100,000.00
Abstract:
Currently, the accepted standard experimental model for measuring protective efficacy against botulism is the Mouse Lethality Neutralization (MLN) assay. Botulism poisoning is a life threatening condition that is not only a public health concern, but could also be a potential biological weapon. … More

Luminescent Coordination Polymer-Based VOC Monitoring System

Award Year / Program / Phase: 2011 / SBIR / Phase I
Agency: DOD
Principal Investigator: Omar Green, Staff Scientist – (607) 272-0002
Award Amount: $100,000.00
Abstract:
ABSTRACT: Volatile Organic Compounds (VOCs) serve an important role in manufacturing processes as solvents. However, once these products reach the marketplace the industrial solvents are released into the ambient air, causing them to concentrate in enclosed work spaces such as office buildings.… More

Novel Toxicity Sensor using Genetically Engineered, Permeabilized, Freeze-Dried Bacteria

Award Year / Program / Phase: 2011 / SBIR / Phase I
Agency: DOD
Principal Investigator: Julien Fey, Senior Scientist – (607) 272-0002
Award Amount: $70,000.00
Abstract:
Field testing of water samples is needed for broad and sensitive detection of toxic industrial chemicals, or TICs. The use of unicellular organisms in cell-based detection systems is particularly advantageous both because these organisms have developed a natural ability to respond to environmental… More

A High-Throughput Blood Esterase Panel Assay

Award Year / Program / Phase: 2011 / SBIR / Phase II
Agency: DOD
Principal Investigator: Julien Fey, Senior Scientist – (607) 272-0002
Award Amount: $750,000.00
Abstract:
Organophosphorus chemical warfare nerve agents (OP-CWA) are attractive to terrorist groups and rogue states as an inexpensive and accessible technology for chemical warfare. OP-CWA and organophosphate pesticides cause severe neurological symptoms and death by inhibiting the enzyme… More

Food Toxicity Detection Using C. elegans

Award Year / Program / Phase: 2011 / SBIR / Phase II
Agency: DOD
Principal Investigator: Kathie Berghorn, Staff Scientist – (607) 272-0002
Award Amount: $750,000.00
Abstract:
Current toxicity testing of foodstuffs involves mass spectrometry analysis which requires a>24 h turnaround time in deployed military operations. This length of time is dangerous for personnel. Rapid identification of toxic industrial chemicals (TICs) in food using a sensor that is… More

Enzymatic Degradation of Rocket Propellant Waste

Award Year / Program / Phase: 2011 / SBIR / Phase II
Agency: DOD
Principal Investigator: Mehran Pazirandeh, Staff Scientist – (607) 272-0002
Award Amount: $733,786.00
Abstract:
ABSTRACT: During the normal course of research, development, and testing by the DOD small quantities of environmentally hazardous waste propellants, explosives, and pyrotechnics (PEP) are produced. The compliance costs and burden associated with open burn/open detonation operations are… More

Malarial Vaccines Utilizing Antigen/Adjuvant Display on Viral-Like Particles

Award Year / Program / Phase: 2011 / SBIR / Phase II
Agency: DOD
Principal Investigator: Mehran Pazirandeh, Staff Scientist – (607) 272-0002
Award Amount: $629,510.00
Abstract:
Recent studies have suggested the potential of improved malarial vaccines by use of the viral-like particle (VLP)-linked immunogen approach. The VLP technology is being utilized for the development of vaccines for a variety of diseases. Agave BioSystems is creating a novel platform for development… More

A Point-of-Care Field Assay for Dengue Viruses

Award Year / Program / Phase: 2011 / SBIR / Phase II
Agency / Branch: DOD / ARMY
Principal Investigator: Joel Tabb, Principal Scientist – (607) 272-0002
Award Amount: $780,000.00
Abstract:
Dengue viruses are transmitted by mosquito vectors throughout tropical and subtropical regions of Asia, Africa, and Central and South America. Four serotypes circulate, DEN-1 through -4, and immunity to one type does not preclude illness from another type and can exacerbate subsequent disease with… More

Intracellular Detection of Small Molecules in Live Cells

Award Year / Program / Phase: 2012 / STTR / Phase I
Agency / Branch: DOD / USAF
Research Institution: Cornell University
Principal Investigator: Joel Tabb, Principal Scientist – (607) 272-0002
Award Amount: $100,000.00
RI Contact: Linda Brainard
Abstract:
ABSTRACT: The extreme toxicity of organophosphate (OP) chemical warfare agents (CWA) is due to their specific, rapid, and irreversible reaction with cholinesterase enzymes. A significant portion of this reactive nature of OP agents is directly due to the unique metabolically active environment… More

Ionic Liquid-Based Dried Biological Specimen Materials

Award Year / Program / Phase: 2012 / SBIR / Phase I
Agency: DOD
Principal Investigator: Joel Tabb, Principal Scientist – (607) 272-0002
Award Amount: $100,000.00
Abstract:
Dried blood spots (DBS) analysis has many advantages over standard liquid blood sample testing including: small sample size, ease of blood sampling, room temperature storage, minimal storage size requirement, and ease of shipping. Although these advantages are significant, there are still problems… More

PNA-Based Rapidly Adaptable Anti-Microbial Nanoparticles

Award Year / Program / Phase: 2012 / SBIR / Phase I
Agency / Branch: DOD / DARPA
Principal Investigator: Joel Tabb, Principal Scientist – (607) 272-0002
Award Amount: $100,000.00
Abstract:
Agave BioSystems proposed to develop a system of Rapidly Adaptable Nanotherapeutics (RANT) by combining advanced bioformatics, with DNA-based nanoparticles, peptide nucleic acid (PNA) antisense oligonucleotides, and cell permeating peptides (CPPs). Advanced bioinformatics computing will allow for… More

Combinatorial PNA-CPP Molecules Targeting Plasmid Transfer and Replication to Control Antibiotic Resistance

Award Year / Program / Phase: 2012 / SBIR / Phase I
Agency: DOD
Principal Investigator: Zoey Ni, Staff Scientist – (607) 272-0002
Award Amount: $99,999.00
Abstract:
One major cause of the widespread of drug-resistant and virulent bacteria pathogen is the horizontal gene transfer of resistance and virulence genes in the form of plasmids. As proof-of concept for this Phase I effort, Agave BioSystems proposes to develop combinatorial therapeutics by inhibiting… More

Antimicrobial Drug Targeted to Essential Bacterial Genes in Wound Infection Pathogens

Award Year / Program / Phase: 2012 / SBIR / Phase I
Agency: DOD
Principal Investigator: Mehran Pazirandeh, Staff Scientist – (607) 272-0002
Award Amount: $100,000.00
Abstract:
Wounds infected with drug-resistant Gram-negative bacteria can increase morbidity, hospital length of stay and cost. Among these Klebsiella pneumoniae and Pseudomonas aeruginosa have become important causes of concern in military personnel wounded in battlefield. New classes of antimicrobial agents… More

Yeast-Based High-Throughput Screens for Inhibitors of Key Flaviviral Enzymes

Award Year / Program / Phase: 2012 / SBIR / Phase I
Agency: DOD
Principal Investigator: Julien Fey, Senior Scientist – (607) 272-0002
Award Amount: $100,000.00
Abstract:
With no clinically approved antiviral therapy available for treatment of flavivirus infections, the development of efficient vaccines and antiviral agents for prevention and treatment of infections is an urgent health priority. A combination of structure-based in silico models, in vitro and… More

Multiplex Immunoassays in the Development of Vaccines Against Enteric Pathogens

Award Year / Program / Phase: 2012 / SBIR / Phase I
Agency: DOD
Principal Investigator: Kathie Berghorn, Staff Scientist – (607) 272-0002
Award Amount: $99,999.00
Abstract:
Bacterial enteric pathogens causing travelers"diarrhea (TD) in developing countries include enterotoxigenic E. coli (50%), Camplyobacter jejuni, Shigella sonnei and Shigella flexneri, while Norovirus is a common viral cause. High risk regions for TD include areas where US service members are… More

Novel Toxicity Sensor using Genetically Engineered, Permeabilized, Freeze-Dried Bacteria

Award Year / Program / Phase: 2012 / SBIR / Phase II
Agency / Branch: DOD / ARMY
Principal Investigator: Julien Fey, Senior Scientist – (607) 272-0002
Award Amount: $780,000.00
Abstract:
Field testing of water samples is needed for broad and sensitive detection of toxic industrial chemicals, or TICs. The use of unicellular organisms in cell-based detection systems is particularly advantageous both because these organisms have developed a natural ability to respond to environmental… More

High-capacity and Cost-effective Manufacture of Chloroperoxidase

Award Year / Program / Phase: 2013 / STTR / Phase II
Agency / Branch: DOD / ARMY
Research Institution: Cornell University
Principal Investigator: John Ramsey, Staff Scientist – (607) 272-0002
Award Amount: $374,999.00
RI Contact: Linda Brainard
Abstract:
The chloroperoxidase enzyme from the filamentous fungus Caldariomyces fumago has applications in industrial chemical synthesis and the detection and inactivation of chemical warfare agents. Chloroperoxidase is capable of regio- and enantioselective oxygenations and halogenations of organic… More

Multiplex Immunoassays in the Development of Vaccines Against Enteric Pathogens

Award Year / Program / Phase: 2013 / SBIR / Phase II
Agency: DOD
Principal Investigator: Kathie Berghorn, Senior Scientist – (607) 272-0002
Award Amount: $1,149,993.00
Abstract:
Bacterial enteric pathogens causing travelers"diarrhea (TD) in developing countries include enterotoxigenic E. coli (50%), Camplyobacter jejuni, Shigella sonnei and Shigella flexneri, while Norovirus is a common viral cause. High risk regions for TD include areas where US service members are… More

Probiotics for Maintaining Dolphin (Tursiops truncatus) Health and the Readiness of the U.S. Navy"s Marine Mammal Systems

Award Year / Program / Phase: 2013 / STTR / Phase I
Agency / Branch: DOD / NAVY
Research Institution: Mote Marine Laboratory
Principal Investigator: John Ramsey, Staff Scientist – (607) 272-0002
Award Amount: $79,999.00
RI Contact: Kimberly Ritchie
Abstract:
Agave BioSystems, with their academic partners at the Mote Marine Laboratory, proposes to develop probiotic pharmaceuticals from indigenous commensal microbes to enhance gastrointestinal health in the bottlenose dolphin (Tursiops truncatus). The dolphin gastrointestinal microbiome will be… More

PNA-Based Rapidly Adaptable Anti-Microbial Nanoparticles

Award Year / Program / Phase: 2013 / SBIR / Phase II
Agency / Branch: DOD / DARPA
Principal Investigator: Joel Tabb, Principal Scientist – (607) 272-0002
Award Amount: $1,000,000.00
Abstract:
Wound management becomes increasingly challenging due to bacterial infections, especially from epidemic drug-resistant strains. To address this problem, Agave BioSystems proposes to develop a RANT (Rapidly Adaptable Nanotherapeutics) breadboard system built upon the modules successfully established… More

Intracellular Detection of Small Molecules in Live Cells

Award Year / Program / Phase: 2014 / STTR / Phase II
Agency / Branch: DOD / USAF
Research Institution: Cornell University
Principal Investigator: Joel Tabb, Principal Scientist – (607) 272-0002
Award Amount: $711,624.00
RI Contact: Ilene lambiase
Abstract:
ABSTRACT: Protection of first responders who are exposed to hazards including chemical warfare agents (CWAs) is a very critical need. The need is derived from not only their welfare but their ability to respond, protect the community and provide logistical support to the response. A simple… More