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Miniature Flow Cytometer and Cell Sorter for Use in Low Gravity

Award Information

National Aeronautics and Space Administration
Award ID:
Program Year/Program:
2002 / SBIR
Agency Tracking Number:
Solicitation Year:
Solicitation Topic Code:
Solicitation Number:
Small Business Information
Agave BioSystems, Inc.
401 E. State Street Suite 200 Ithaca, AK 14850-
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Phase 2
Fiscal Year: 2002
Title: Miniature Flow Cytometer and Cell Sorter for Use in Low Gravity
Agency: NASA
Contract: NAS2-02045
Award Amount: $600,000.00


Conventional fluorescence-activated cell sorters (FACSs) are widely used to study eukaryotic cell populations. Although they provide impressively efficient sorting, they are costly, mechanically complex, and require large sample volumes and trained personnel for operation and maintenance. In addition, the footprint per unit separation is considerable and they typically require large input populations. Inexpensive devices that rapidly sort live cell, particles and even single molecules would greatly facilitate screening of combinatorial chemical, biochemical or biological libraries taking advantage of the enormous power of in vitro evolution. Moreover, such devices would have wide applications in clinical medicine and basic research. Current systems are also not well suited for use in low gravity environments or impose a significant cost in payload size and weight. Agave BioSystems proposes to develop a miniature flow cytometer/ fluorescent cell sorter (nanoSort) based on a novel micropumping system with an integrated optical waveguide that will eliminate these shortcomings. The microfabricated system will be ideal for use in low gravity environments as well as typical laboratory settings and will be both compact and lightweight.

Principal Investigator:

Greg Baxter
Principal Scientist

Business Contact:

Noe Salazar
Small Business Information at Submission:

Agave BioSystems, Inc.
PO Box 80010 Austin, TX 78708

EIN/Tax ID: 161551819
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No