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Human Paraoxonase Bioscavenger for Nerve Agents

Award Information

Agency:
Department of Defense
Branch:
Army
Award ID:
73698
Program Year/Program:
2005 / SBIR
Agency Tracking Number:
A043-180-0989
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Agave BioSystems, Inc.
P.O. Box 100 Ithaca, NY -
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2005
Title: Human Paraoxonase Bioscavenger for Nerve Agents
Agency / Branch: DOD / ARMY
Contract: W81XWH-05-C-0023
Award Amount: $70,000.00
 

Abstract:

In this Phase I, Agave BioSystems proposes to develop a catalytic organophosphorus bioscavenger based on human paraoxonase 1 (PON1) for the protection of personnel against OP nerve agents. A catalytic bioscavenger that detoxifies multiple organophosphorus (OP) molecules by hydrolysis rather than a single OP molecule like Hu-BuChE greatly reduces the amount of protein required, making administration of the scavenger to large numbers of individuals safer and less expensive. PON1 is a serum protein found in humans and other animals which has been shown to catalytically inactivate paraoxon and other organophosphorus compounds. While the wild type human enzyme possesses too little activity to protect against large doses of OP agents, preliminary studies of chimeric PON1 mutants have identified a number of sequence changes that increase phosphotriesterase (PTE) activity significantly. A human PON1 (huPON1) with enhanced PTE activity could provide full protection against otherwise lethal exposures to OP agents and would still be compatible with the human immune system, allowing multiple doses to be administered.

Principal Investigator:

Louis Hom
Staff Scientist
6072720002
lhom@agavebio.com

Business Contact:

Noe Salazar
President
5126711369
nsalazar@agavebio.com
Small Business Information at Submission:

AGAVE BIOSYSTEMS, INC.
P.O. Box 80010 Austin, TX 78708

EIN/Tax ID: 161551819
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No