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Portable Cell Maintenance System

Award Information

Department of Defense
Award ID:
Program Year/Program:
2004 / STTR
Agency Tracking Number:
Solicitation Year:
Solicitation Topic Code:
Solicitation Number:
Small Business Information
Agave BioSystems, Inc.
401 E. State Street Suite 200 Ithaca, AK 14850-
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Phase 1
Fiscal Year: 2004
Title: Portable Cell Maintenance System
Agency / Branch: DOD / ARMY
Contract: W81XWH-04-C-0140
Award Amount: $98,953.00


Cultured cell-based biosensors offer insight into the physiological action of the agent of interest, which is an advantage over other types of sensors. The development of cell-based biosensors that are field-portable would increase their utility in toxicology and environmental monitoring. One of the most significant issues hampering the development of field portable cell-based biosensors is the maintenance of optimal cultured cell environment under field conditions. A key technology to overcoming this issue is the use of microfluidic systems. A microfluidic based systems would allow assaying small quantities of sample while optimizing storage and transport conditions by minimizing the overall systems size and fluid monitoring requirements. In this Phase I, Agave BioSystems and Cornell University propose to develop a cell maintenance system (CMS) with integrated pH, osmilarity, CO2 and temperature sensors to support multiple vertebrate cells and cell types under field conditions. In addition, a microfluidic cell cartridge suitable for use in hand-held devices and fabricated from biocompatible materials will be developed that is inexpensive and disposable. The proposed CMS would maintain vertebrate cell viability and sterility through transport, storage, and testing and be compatible with interfaces for acquisition and analysis of cell signaling data relevant to toxicity identification.

Principal Investigator:

Theresa Curtis
Staff Scientist

Business Contact:

Noe Salazar
Small Business Information at Submission:

P.O. Box 80010 Austin, TX 78708

EIN/Tax ID: 161551819
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Research Institution Information:
Cornell University
Office of Sponsored Projects, 123 Day Hall
Ithaca, NY 14854
Contact: Linda Brainard
Contact Phone: (607) 255-7123
RI Type: Nonprofit college or university