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Detection of Explosive Materials Using an Encapsulated Fluorescent Bioprobe

Award Information

Agency:
Department of Defense
Branch:
Army
Award ID:
77852
Program Year/Program:
2007 / STTR
Agency Tracking Number:
A064-025-0256
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Agave BioSystems, Inc.
P.O. Box 100 Ithaca, NY -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 2007
Title: Detection of Explosive Materials Using an Encapsulated Fluorescent Bioprobe
Agency / Branch: DOD / ARMY
Contract: W9132V-07-C-0017
Award Amount: $750,000.00
 

Abstract:

The use of explosives over the last 100 years has left up to 16,000 military ranges contaminated with highly toxic compounds. A major challenge to the remediation of these ranges is identifying the location of persistent explosives residues. To meet this challenge, Agave BioSystems in collaboration with Universities Space Research Agency (USRA) is developing an encapsulated fluorescent bioprobe for in situ detection of explosive materials. The bioprobe developed uses a displacement immunoassay and fluorescence quenching to detect the presence of specific explosives residues. In the Phase I, a bioprobe was developed specifically for TNT (2,4,6-trinitrotoluene). This fluorescent bioprobe is encapsulated within novel nanoporous silica microspheres. Encapsulation within nanometer-sized pores in the microspheres provides a protective structure to stabilize the bioprobes and minimize environmental influences. Protecting the bioprobes from micron-sized clays and other materials present in soil will allow development of a robust and sensitive detection system. In the Phase I effort Agave BioSystems successfully demonstrated probe development, encapsulation, and detection of TNT. The Phase II effort will focus on scale up of materials, developing assays to detect multiple agents, and adapting the assay for stand-off detection of explosives residues under field conditions.

Principal Investigator:

Joel Tabb
Principal Scientist
6072720002
jtabb@agavebio.com

Business Contact:

Noe Salazar
President
5126566200
nsalazar@agavebio.com
Small Business Information at Submission:

AGAVE BIOSYSTEMS, INC.
P.O. Box 80010 Austin, TX 78708

EIN/Tax ID: 161551819
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Research Institution Information:
UNIVERSITIES SPACE RESEARCH ASSOCI
10211 Wincopin Circle ste 500
Columbia, MD 21044
Contact: Sophia Hill
Contact Phone: (410) 730-2656
RI Type: Domestic nonprofit research organization