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Malarial Vaccines Utilizing Antigen/Adjuvant Display on Viral-Like Particles

Award Information

Agency:
Department of Defense
Branch:
Army
Award ID:
92223
Program Year/Program:
2009 / SBIR
Agency Tracking Number:
A092-107-1383
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Agave BioSystems, Inc.
P.O. Box 100 Ithaca, NY -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2009
Title: Malarial Vaccines Utilizing Antigen/Adjuvant Display on Viral-Like Particles
Agency / Branch: DOD / ARMY
Contract: W81XWH-10-C-0005
Award Amount: $70,000.00
 

Abstract:

Development of an effective malarial vaccine has been slow, although recent success in vaccine development has been achieved by using the Plasmodium falciparum circumsporozoite surface protein (CSP)-hepatitis B surface antigen fusions, in conjunction with hepatitis B particles (the RTS, S formulation). The results of these studies suggest the potential of improved malarial vaccines by use of the viral-like particle (VLP)-linked immunogen approach. The VLP technology is being utilized for the development of vaccines for a variety of diseases. Agave BioSystems proposes to develop a novel platform for development of malarial vaccines consisting of a VLP displayed malarial antigen/adjuvant based on the Norwalk virus (NV) capsid protein. The NV-VLP will be engineered to express a candidate antigen in combination with a peptide adjuvant. These VLPs will be characterized, purified and delivered for testing of efficacy to stimulate cellular and humoral immune responses.

Principal Investigator:

Mehran Pazirandeh
Staff Scientist
6072720002
mehranp@agavebio.com

Business Contact:

Noe Salazar
President
5126566200
nsalazar@agavebio.com
Small Business Information at Submission:

AGAVE BIOSYSTEMS, INC.
P.O. Box 100 Ithaca, NY 14850

EIN/Tax ID: 161551819
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No