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Biocatalytic Polymer Skin Adhesives

Award Information

Agency:
Department of Defense
Branch:
Army
Award ID:
55389
Program Year/Program:
2001 / STTR
Agency Tracking Number:
A2-0029
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
AGENTASE LLC
3636 Boulevard of the Allies, Suite B-17 Pittsburgh, PA 15213
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 2001
Title: Biocatalytic Polymer Skin Adhesives
Agency / Branch: DOD / ARMY
Contract: DAAD19-02-C-0010
Award Amount: $494,666.00
 

Abstract:

This Phase II STTR proposal describes the development of a prototype enzyme-containing adhesive capable of attaching biocatalytic activity directly to skin. The adhesive, when containing organophosphorus-hydrolyzing enzymes, shall serve to protectunderlying skin from otherwise toxic applications of nerve agents and pesticides. Agentase, a recognized world leader in developing polymer-based carriers for enzyme catalysis, in collaboration with the Midwest Research Institute, shall demonstrate thefeasibility of providing personal protection from hazardous chemicals to individuals via enzyme-based skin adhesives.Having successfully demonstrated the viability of synthesizing biocatalytic adhesives with significant enzyme activity and excellent physical properties during Phase I, Phase II activity is directed at developing a prototype adhesive for protection againstOPs. More specifically, proposed work includes optimization of the processes for applying adhesives in a reproducible and uniform fashion, enhancing their capacity for decontamination, and ensuring polymer as well as polymerization compatibility with skintissues. Phase II research shall also provide a clear demonstration that enzyme-containing skin adhesives can be effectively used to protect a small animal model from the debilitating effects of OP exposures. Successful completion of the aims describedin this Phase II STTR proposal will provide a novel biopolymer skin adhesive for protection against organophosphorus contamination from nerve agents and pesticides. The addition of active biomolecules, such as enzymes, to a skin-compatible biopolymeradhesive has great potential in facilitated wound healing.

Principal Investigator:

Keith LeJeune
4122097298

Business Contact:

Keith LeJeune
4122097298
Small Business Information at Submission:

AGENTASE LLC
3636 Boulevard of the Allies, Suite B-17 Pittsburgh, PA 15213

EIN/Tax ID: 251821159
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Research Institution Information:
MIDWEST RESEARCH INSTITUTE
425 Volker Boulevard
Kansas City, MO 64110
Contact: Jeanette Tombaugh
Contact Phone: (816) 753-7600
RI Type: Domestic nonprofit research organization