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Rapid In-vivo Cancer Detection via Multispectral Confocal Cellular Imaging

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
88850
Program Year/Program:
2010 / SBIR
Agency Tracking Number:
CA124036
Solicitation Year:
N/A
Solicitation Topic Code:
NCI
Solicitation Number:
N/A
Small Business Information
OMEGA OPTICAL INC.
OMEGA OPTICAL INC. 21 OMEGA DR BRATTLEBORO, VT -
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 2010
Title: Rapid In-vivo Cancer Detection via Multispectral Confocal Cellular Imaging
Agency: HHS
Contract: 4R44CA124036-02
Award Amount: $749,933.00
 

Abstract:

DESCRIPTION (provided by applicant): A fast, cost-effective multispectral confocal imaging capability for high-resolution mapping in vivo will be created during this project. This new approach will be based on fiber Bragg gratings, a technology not utiliz ed previously in biomedical imaging, and will ultimately enable the early in vivo detection and treatment of cancer at the cellular level. The central innovation in this effort involves coupling a fast optical fiber-based spectrum analyzer with confocal sp atial scanning optics - both interfaced with endoscopes for in-vivo detection and potential treatments. This fiber optic imaging spectrometer can acquire spectra in microseconds - fast enough to collect one spectrum for each resolved spot in a confocal spa tial scan. As a result, datacubes containing spatial images for many wavelengths can be acquired in real-time. Multispectral confocal imaging in milliseconds will eliminate the effects of motion in biological systems. One can envisage acquiring multiple sp atially registered simultaneous movies, comparing one channel with another (by subtraction or normalization). Further, biomedical researchers could use this new technology to catalog more extensive libraries of spectral images showing tumor growth, angiogenesis and subsequent metastasis. These enhanced libraries will lead to several applications in surgical pathology, oncology labs, and clinics. Clinicians will use the technology to take optical biopsies, perform treatments, and monitor long-term re sults. Patients will have access to real-time diagnosis and treatment. In addition to cancer interventions, other potential multispectral applications include: neural imaging, intra-cellular proteomics, micro-vascular testing, plaque detection, foodstuff t esting, and the evaluation of pharmaceutical products. Our planned phases for this program will successively (a) create a fast fiber grating based spectrometer, (b) integrate the spectrometer with confocal scanning optics, (c) evaluate the integrat ed system with representative ex-vivo and in-vivo tissue samples (normal and abnormal), and (d) deliver the final product optimized for intrasurgical imaging to the biomedical community. The project will rely heavily on the unique and complementary experti se of the two participating groups/organizations.

Principal Investigator:

Gary E. Carver
8022517346
GCARVER@OMEGAFILTERS.COM

Business Contact:

Gary E. Carver
gcarver@omegafilters.com
Small Business Information at Submission:

OMEGA OPTICAL INC.
OMEGA OPTICAL INC. 21 OMEGA DR BRATTLEBORO, VT -

EIN/Tax ID: 103022367
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No