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MAJOR OBJECTIVES OF THIS RESEARCH ARE TO (1) ISOLATE 100 MG OF HOMOGENEOUS…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
4682
Program Year/Program:
1986 / SBIR
Agency Tracking Number:
4682
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Agouron Pharmaceuticals Inc.
505 Coast Blvd La Jolla, CA 92037
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1986
Title: MAJOR OBJECTIVES OF THIS RESEARCH ARE TO (1) ISOLATE 100 MG OF HOMOGENEOUS DIHYDROFOLATE REDUCTASE (DHFR) FROM CANDIDA ALBICANS, (2) CRYSTALLIZE THE ENZYME, AND (3) DETERMINE ITS THREE-DIMENSIONAL STRUCTURE USING X-RAY DIFFRACTION METHODS.
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

MAJOR OBJECTIVES OF THIS RESEARCH ARE TO (1) ISOLATE 100 MG OF HOMOGENEOUS DIHYDROFOLATE REDUCTASE (DHFR) FROM CANDIDA ALBICANS, (2) CRYSTALLIZE THE ENZYME, AND (3) DETERMINE ITS THREE-DIMENSIONAL STRUCTURE USING X-RAY DIFFRACTION METHODS.ARMED WITH THE RESULTING DETAILED KNOWLEDGE OF THE GEOMETRICAL AND TOPOGRAPHICAL PROPERTIES OF CANDIDAS DHFR INRELATION TO THE KNOWN STRUCTURE OF THE CORRESPONDING VERTEBRATE ENZYME, AGOURON TECHNOLOGY WILL DESIGN SPECIFIC, PHARMACOLOGICALLY ACTIVE INHIBITORS THAT SELECTIVELY CRIPPLETHE BACTERIAL REDUCTASE WITHOUT INTERFERING WITH ONE-CARBON METABOLISM IN THE HOST. SUCH NOVEL INHIBITORS WILL ADDRESS THE CURRENT NEED FOR NEW ANTI-INFECTIVE AGENTS WITH ENHANCEDANTI-CANDIDAL ACTIVITY AGAINST CANDIDA ALBICANS.

Principal Investigator:

David a matthews
PRINCIPAL INVESTIGATOR
6194561623

Business Contact:

Small Business Information at Submission:

Agouron Technology Corp
505 Coast Blvd South La Jolla, CA 92037

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No