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RETARDATION

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
4828
Program Year/Program:
1986 / SBIR
Agency Tracking Number:
4828
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Agouron Pharmaceuticals Inc.
505 Coast Blvd La Jolla, CA 92037
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1986
Title: RETARDATION
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

THIS PROJECT DESCRIBES THE ISOLATION OF DNA PROBES LINKED TOTHE SITE IN THE HUMAN X CHROMOSOME INVOLVED IN FRAGILITY OF THE CHROMOSOME UNDER SOME GROWTH CONDITIONS ("FRAGILE X SITE") AND KNOWN TO BE ASSOCIATED WITH A HIGH INCIDENCE OF MENTAL RETARDATION. SUCH SEQUENCES MAY BE USEFUL IN UNDER- STANDING THE MOLECULAR DEFECTS RESPONSIBLE FOR CHROMOSOMAL FRAGILITY, IN ELUCIDATING THE PATHOGENESIS OF THE CENTRAL NERVOUS SYSTEM DISORDER, AND IN PROVIDING TOOLS FOR ITS DETECTION. RESEARCHERS WILL INVESTIGATE THE POSSIBILITY THAT LARGE REGIONS OF THE HUMAN AND MOUSE X CHROMOSOMES HAVESIMILAR OR IDENTICAL GENETIC ORGANIZATION AND DETERMINE THE FINE STRUCTURE GENETIC MAP OF THE REGION OF THE MOUSE X CHROMOSOME HOMOLOGOUS TO THE HUMAN FRAGILE SITE AND ITS FLANKING REGIONS. A COMBINATION OF IN SITU HYBRIDIZATION, MAPPING IN RECOMBINANT INBRED (RI) MOUSE STRAINS, AND LINKAGE ANALYSIS IN HUMAN PEDIGREES WILL BE USED TO TEST ANDPROVE TIGHT LINKAGE OF PROBES TO THE FRAGILE X SITE. THE NEW METHODS OF CHROMOSOME "WALKING" WILL THEN BE USED TO ISOLATE SEQUENCES THAT SPAN THS SITE ITSELF.

Principal Investigator:

Cila blatt
PRINCIPAL INVESTIGATOR
6194561623

Business Contact:

Small Business Information at Submission:

Agouron Technology Corp
505 Coast Blvd South La Jolla, CA 92037

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No