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IMPROVED NON-LINEAR MODELING

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
59871
Program Year/Program:
2002 / SBIR
Agency Tracking Number:
CA094450
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
AISN SOFTWARE
AISN SOFTWARE BOX 449, 11829 E MAPLETON RD MAPLETON, OR 97453
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2002
Title: IMPROVED NON-LINEAR MODELING
Agency: HHS
Contract: 1R43CA094450-01
Award Amount: $200,000.00
 

Abstract:

Dose-response, enzyme kinetics, and other data in the biosciences are often modeled using non-linear least-squares curve-fitting algorithms. These methods are adversely impacted both by outliers and a non- Gaussian error distribution. Misleading confidence intervals on crucial parameters can result. This proposal describes preliminary non-linear optimization technology in the areas of robust fitting and bootstrapping that have shown the ability to substantially improve the accuracy and reliability of biomodeling. Funding is sought for the optimization of the analytic algorithms and the development of the software technology necessary to add these methods to an established commercial software product. Funding is also sought for the support of extensive analysis experiments with both real-world data and Monte-Carlo simulations. In addition to making the innovation available in commercial software, this project will enable the thorough research and development necessary for peer-reviewed publication of these methods. A Phase II project is envisioned which includes extending the robust fitting innovations of Phase I in order to achieve the true maximum-likelihood optimization adaptively, based on the use of a non-linear optimization merit function that adapts to actual experimental error distribution.

Principal Investigator:

Ronald E. Brown
5412681953
RONB@PRESYS.COM

Business Contact:

Ron Brown
5412681954
RONB@PRESYS.COM / REBROWN@HIWAAY.NET
Small Business Information at Submission:

AISN SOFTWARE
AISN SOFTWARE BOX 449, 11829 E MAPLETON RD MAPLETON, OR 97453

EIN/Tax ID: 931123830
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No