USA flag logo/image

An Official Website of the United States Government

Selective Inhibitors of Pancreatic Cholesterol Esterase

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
54422
Program Year/Program:
2001 / SBIR
Agency Tracking Number:
1R43DK058440-01A1
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
ALBUQUERQUE AVIAN EXOTIC
AND SMALL ANIMAL CLINIC, P.C. 8414 4TH ST NW ALBUQUERQUE, NM 87114
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2001
Title: Selective Inhibitors of Pancreatic Cholesterol Esterase
Agency: HHS
Contract: N/A
Award Amount: $70,342.00
 

Abstract:

DESCRIPTION (Scanned from the Applicant's Abstract): The specific aim of this esterase (CE) inhibitor in an acute cholesterol absorption assay. Hamsters will be gavage fed 3H-labeled cholesterol with CE-inhibitor ranging from 20-200 umoles. Twenty-four hours later, hepatic and serum cholesterol absorption will be assayed. Hepatic and serum cholesterol levels will be determined in a subchronic hamster assay. CE-inhibitor from 20-200 umoles will be fed in chow supplemented with 0.2 percent cholesterol and 0.1 percent cholic acid for 4 days. Hepatic and serum cholesterol will be determined. In a third study, toxicity will be determined following a 30 day feeding trial of CE inhibitor. The optimum dose of CE-inhibitor determined in the previous two experiments and 200 umoles will be added to chow supplemented with 1 percent cholesterol and 0.5 percent cholic acid. Clinical chemistry, hepatic and serum cholesterol, urinalysis and histopathology will be obtained.

Principal Investigator:

John E. Heidrich

Business Contact:


5058978200
LCONTOS@UNM.EDU
Small Business Information at Submission:

ALBUQUERQUE AVIAN EXOTIC
AND SMALL ANIMAL CLINIC, P.C. 8414 4TH ST NW ALBUQUERQUE, NM 87114

EIN/Tax ID: 850382209
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No