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Company Information:

Company Name: Radiation Monitoring Devices, Inc.
City: Watertown
State: MA
Zip+4: 02472-4699
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Website URL: http://www.rmdinc.com
Phone: (617) 668-6810

Award Totals:

Program/Phase Award Amount ($) Number of Awards
SBIR Phase I $45,386,782.52 466
SBIR Phase II $161,792,221.16 226
STTR Phase I $899,808.00 8
STTR Phase II $373,381.00 1

Award List:

LOGGING

Award Year / Program / Phase: 1983 / SBIR / Phase I
Agency: DOE
Principal Investigator: Gerald entine ph.d. , PRESIDENT
Award Amount: $50,000.00
Abstract:
Nuclear techniques are powerful tools for oil well logging but are limited in many ways by the high ambiant temperatures the detectors must withstand. present sensors require either cryogenic cooling or the use of bulky phototubes which are not compatible with modern miniaturizedlogging… More

FOR SOME TIME SILICON AVALANCHE PHOTODETECTORS HAVE BEEN RECOGNIZED AS POTENIALLY HAVING SIGNIFICANT TECHNICAL ADVANTAGES OVER EXISTING DEVICES USED FOR PARTICLE AND CVCMA-RAY DETECTION WITH SCINTILLATOR CRYSTALS.

Award Year / Program / Phase: 1983 / SBIR / Phase I
Agency: NSF
Principal Investigator: Gerald entine, ph.d. , PRINCIPAL INVESTIGATOR
Award Amount: $35,000.00
Abstract:
For some time silicon avalanche photodetectors have been recognized as potenially having significant technical advantages over existing devices used for particle and cvcma-ray detection with scintillator crystals. theses advantages - compactnenn, solid-state stability, room temperature operation,… More

PORTABLE NUCLEAR VENTRICULAR EJECTION FRACTION MONITOR

Award Year / Program / Phase: 1983 / SBIR / Phase I
Agency: NASA
Principal Investigator: Gerald Entine
Award Amount: $50,000.00

SOFT X-RAY WINDOW ENCAPSULENT FOR MERCURIC IODIDE DETECTORS

Award Year / Program / Phase: 1983 / SBIR / Phase I
Agency: NASA
Principal Investigator: Dr. Gerald Entine
Award Amount: $50,000.00

AVALANCHE PHOTODIODES FOR POSITRON EMISSION TOMOGRAPHY

Award Year / Program / Phase: 1983 / SBIR / Phase I
Agency: DOE
Principal Investigator: Gerald Entine Ph.d.
Award Amount: $50,000.00

CRYSTAL IDENTIFICATION SENSORS FOR PET IMAGING

Award Year / Program / Phase: 1983 / SBIR / Phase I
Agency: HHS
Principal Investigator: Gerald Entine
Award Amount: $103,390.00

AVALANCHE PHOTODIODES FOR POSITRON EMISSION TOMOGRAPHY

Award Year / Program / Phase: 1984 / SBIR / Phase II
Agency: DOE
Principal Investigator: Gerald Entine Ph.d.
Award Amount: $496,371.00
Abstract:
Positron emission tomography is a noninvasive nuclear imaging technique which is becoming an important fundamental tool for both clinical diagnosis and medical research. the heart of this instrument is a large array of scintillator-photomultiplier tube detectors. the availability of a compact solid… More

SOFT X-RAY WINDOW ENCAPSULENT FOR MERCURIC IODIDE DETECTORS

Award Year / Program / Phase: 1984 / SBIR / Phase II
Agency: NASA
Principal Investigator: Dr. Gerald Entine
Award Amount: $382,920.00
Abstract:
For many years mercuric iodide has appeared to be an ideal material for use as an uncooled x-ray and gamma-ray detector. it has demonstrated exceptional energy resolutionfor low energy x-rays and has been considered for several nasa space missions. however, mercuric iodide detectors have been… More

CRYSTAL IDENTIFICATION SENSORS FOR PET IMAGING

Award Year / Program / Phase: 1984 / SBIR / Phase II
Agency: HHS
Principal Investigator: Gerald Entine
Award Amount: $495,928.00
Abstract:
"crystal idenification sensors for pet imaging" sbir-drr and/or nimh:brain and body imaging. positron emmission tomography (pet) is a noninvasive medical imaging technique which provides a three dimensional image of radio pharmaceuticals disbursed in the body. it is becoming an important fundamental… More

HYBRIDS

Award Year / Program / Phase: 1984 / SBIR / Phase I
Agency: DOE
Principal Investigator: Gerald entine, ph.d. , PRESIDENT
Award Amount: $50,000.00
Abstract:
The production of hybridomas by cell fusion is an increasingly important aspect of both medical research and clinical protocols. in particular, it has the potential for providing sensitive diagnostic reagents to radiation induced cell damage. we have recently conducted preliminary research on a new… More

PORTABLE NUCLEAR VENTRICULAR EJECTION FRACTION MONITOR

Award Year / Program / Phase: 1984 / SBIR / Phase II
Agency: NASA
Principal Investigator: Gerald Entine
Award Amount: $492,000.00
Abstract:
An important goal of the nasa medical sciences program is to maintain the health of the astronauts both before and during the space missions. two of the most important clinical parameters are the left and right heart ejection fractions. these parameters, which are so central to good vascular… More

WE PROPOSE A PROGRAM OF RESEARCH INTO THE FUNDAMENTAL PROPERTIES OF LIINSE2, A LITTLE-KNOWN SEMICONDUCTOR OF THE I-III-VI FAMILY.

Award Year / Program / Phase: 1984 / SBIR / Phase I
Agency: NSF
Principal Investigator: Gerald entine ph.d. , PRESIDENT
Award Amount: $40,000.00
Abstract:
We propose a program of research into the fundamental properties of liinse2, a little-known semiconductor of the i-iii-vi family. this material promises to become a basis for a revolutionary solid state thermal neutron detector. during phase i, the ternary equilibrium phase diagram will be… More

NEW 2D SOLID STATE X-RAY DETECTOR FOR BIOMEDICAL RESEARCH

Award Year / Program / Phase: 1984 / SBIR / Phase I
Agency: HHS
Principal Investigator: Dr. M. Squillante , Director
Award Amount: $50,000.00

IMPROVED GEL ELECTROPHORESIS SYSTEM FOR MEDICAL RESEARCH

Award Year / Program / Phase: 1984 / SBIR / Phase I
Agency: HHS
Principal Investigator: Gerald Entine , President
Award Amount: $50,000.00

VENTRICULAR FUNCTION MONITOR FOR ACTIVE PATIENTS

Award Year / Program / Phase: 1984 / SBIR / Phase I
Agency: HHS
Principal Investigator: Gerald Entire , President
Award Amount: $49,986.00

PERSONAL DIGITAL NEUTRON DOSIMETER

Award Year / Program / Phase: 1984 / SBIR / Phase I
Agency / Branch: DOD / NAVY
Principal Investigator: Gerald Entine, Phd
Award Amount: $49,896.00

PERSONAL DIGITAL NEUTRON DOSIMETER

Award Year / Program / Phase: 1985 / SBIR / Phase II
Agency / Branch: DOD / NAVY
Principal Investigator: Gerald Entine, Phd
Award Amount: $400,000.00
Abstract:
Over a hundred thousand navy personnel as well as a large number of military and civilian workers are now required to wear nuclear radiation dosimeters. although much of the potential exposure is from neutrons, presently no small electronic neutron dosimeter exists and only passive devices are… More

IMPROVED GEL ELECTROPHORESIS SYSTEM FOR MEDICAL RESEARCH

Award Year / Program / Phase: 1985 / SBIR / Phase II
Agency: HHS
Principal Investigator: Gerald Entine , President
Award Amount: $500,000.00
Abstract:
Gel electrophoresis is one of the most widely used analytical techniques in molecular biology and genetics. typically the separation requires several hours and the gel is then removed and analyzed for the location of the different molecular groups on the surface area of the gel. when used with… More

PERIDONTAL DISEASE IS ONE OF THE MOST WIDESPREAD MEDICAL PROBLEMS FACING THE NATION TODAY.

Award Year / Program / Phase: 1985 / SBIR / Phase I
Agency: HHS
Principal Investigator: Gerald entine , PRINCIPAL INVESTIGATOR
Award Amount: $50,000.00
Abstract:
Peridontal disease is one of the most widespread medical problems facing the nation today. crucial to the successful treatment of this disease is early detection as well as careful monitoring of the progress of the periodontal therapy. there are, however, few effective approaches to this problem… More

TOMOGRAPHY CAMERAS-

Award Year / Program / Phase: 1985 / SBIR / Phase I
Agency: DOE
Principal Investigator: Dr. gerald entine , PRINCIPAL INVESTIGATOR
Award Amount: $49,783.00
Abstract:
Positron emission tomography (pet) is a noninvasive medical imaging technique that provides a three-dimen- sional image of radiopharmaceuticals dispersed in the body. it is becoming an important fundamental tool for both clinical diagnosis and medical research. the heart of this instrument is a… More

AN INP SEMICONDUCTOR NEUTRINO DETECTOR

Award Year / Program / Phase: 1985 / SBIR / Phase I
Agency: DOE
Principal Investigator: Dr. Gerald Entine , Principal Investigator
Award Amount: $50,000.00

ALL SOLID-STATE INTEGRATING DOSIMETER

Award Year / Program / Phase: 1985 / SBIR / Phase I
Agency / Branch: DOD / USAF
Principal Investigator: Dr Gerald Entine
Award Amount: $74,424.00

RAPID NONDESTRUCTIVE DETERMINATION OF RESIN/FIBER CONTENT IN COMPOSITES

Award Year / Program / Phase: 1985 / SBIR / Phase I
Agency / Branch: DOD / ARMY
Principal Investigator: Dr Gerald Entine
Award Amount: $67,406.00

SENSITIVE PROBE FOR INTRAOPERATIVE BONE SCANNING

Award Year / Program / Phase: 1985 / SBIR / Phase I
Agency: HHS
Principal Investigator: Gerald Entine , Principal Investigator
Award Amount: $50,000.00

COMPUTER CONTROLLED COLLIMATORS FOR RADIATION THERAPY

Award Year / Program / Phase: 1985 / SBIR / Phase I
Agency: HHS
Principal Investigator: Gerald Entine , Principal Investigator
Award Amount: $50,000.00

SOLID-STATE TRITIUM SENSOR FOR LABELED SAMPLE MEASUREMENT

Award Year / Program / Phase: 1985 / SBIR / Phase I
Agency: HHS
Principal Investigator: Gerald Entine , Principal Investigator
Award Amount: $49,897.00

SEMICONDUCTOR EXPOSURE CONTROLLER FOR IMPROVED MAMMOGRAPHY

Award Year / Program / Phase: 1985 / SBIR / Phase I
Agency: HHS
Principal Investigator: Michael Squillante , Principal Investigator
Award Amount: $49,452.00

ALL SOLID-STATE INTEGRATING DOSIMETER

Award Year / Program / Phase: 1986 / SBIR / Phase II
Agency / Branch: DOD / USAF
Principal Investigator: Dr Gerald Entine
Award Amount: $500,000.00
Abstract:
Recently, research at several government facilities has resulted in significant advances in both the electronic and detector aspects of integrating radiation dosimeters. one particular approach, the los alamos multidetector radiation monitor, is a microprocessor based instrument, capable of… More

SEMICONDUCTOR EXPOSURE CONTROLLER FOR IMPROVED MAMMOGRAPHY

Award Year / Program / Phase: 1986 / SBIR / Phase II
Agency: HHS
Principal Investigator: Michael Squillante , Principal Investigator
Award Amount: $468,336.00
Abstract:
Cancer of the breast is presently the most common form of cancer in women and early detection of it has become one of the nation's more pressing medical requirements. of the available techniques, mammography is the most widely used approach for the early detecting of the presence of a potential… More

SENSITIVE PROBE FOR INTRAOPERATIVE BONE SCANNING

Award Year / Program / Phase: 1986 / SBIR / Phase II
Agency: HHS
Principal Investigator: Gerald Entine , Principal Investigator
Award Amount: $260,000.00
Abstract:
One of the most critical considerations in the successful treatment of bone tumors and infections is their detection and localization during surgery. although nuclear medicine scanning techniques are a widely accepted and effective approach for imaging, they are very difficult to use in the tight… More

AN INP SEMICONDUCTOR NEUTRINO DETECTOR

Award Year / Program / Phase: 1986 / SBIR / Phase II
Agency: DOE
Principal Investigator: Dr. Gerald Entine , Principal Investigator
Award Amount: $500,000.00
Abstract:
The solar neutrino problem is one of the longest- standing unresolved problems in the understanding of the energy-producing processes in the sun. the observed flux of neutrinos is about one-fourth of that predicted by careful calculations of solar-fusion reactions. the possibility os resolving this… More

RAPID NONDESTRUCTIVE DETERMINATION OF RESIN/FIBER CONTENT IN COMPOSITES

Award Year / Program / Phase: 1986 / SBIR / Phase II
Agency / Branch: DOD / ARMY
Principal Investigator: Dr Gerald Entine
Award Amount: $391,000.00
Abstract:
The advent of fiber reinforced composites has made available new structural materials for use in military hardware. in particular, armor panels made from fiberglass reinforced plastics provide strength to weight ratios significantly superior to those made from metal plate. these new materials are… More

COMPOSITES

Award Year / Program / Phase: 1986 / SBIR / Phase I
Agency / Branch: DOD / USAF
Principal Investigator: Dr gerald entine
Award Amount: $71,456.00
Abstract:
The advent of graphite reinforced composites has led to significant advances in aircraft technology. such composites are essential to modern flight technology becuase of their exceptionally good strength-to-weight ratios and many aircraft and missile components are now made from these materials. an… More

SOLID-STATE TRITIUM SENSOR FOR LABELED SAMPLE MEASUREMENT

Award Year / Program / Phase: 1986 / SBIR / Phase II
Agency: HHS
Principal Investigator: Gerald Entine , Principal Investigator
Award Amount: $491,000.00
Abstract:
Radioisotope labeling of biological compounds is a powerful tool used in many medical research techniques. tritium is an especially useful radioisotope since it can be used to label many biologically active materials. for example, immunologists use tritiated thymidine which can be incorporated into… More

ENERGY COMPENSATED SOLID STATE GAMMA SENSOR

Award Year / Program / Phase: 1986 / SBIR / Phase I
Agency / Branch: DOD / ARMY
Principal Investigator: Dr Gerald Entine
Award Amount: $73,350.00

LEAD IODIDE SEMICONDUCTOR FOR NUCLEAR SENSOR

Award Year / Program / Phase: 1986 / SBIR / Phase I
Agency: NSF
Principal Investigator: Michael R Squillante Ph.
Award Amount: $40,000.00

VENTRICULAR FUNCTION MONITOR FOR ACTIVE PATIENTS

Award Year / Program / Phase: 1987 / SBIR / Phase II
Agency: HHS
Principal Investigator: Gerald Entire , President
Award Amount: $248,000.00
Abstract:
To increase the basic understanding of the cardiac function to improve techniques to aid in the diagnosis of heart disease. we propose to conduct research on an improved method of evaluating myocardial function in active patients. this approach involves the use of a very compact, vestlike instrument… More

NEW 2D SOLID STATE X-RAY DETECTOR FOR BIOMEDICAL RESEARCH

Award Year / Program / Phase: 1987 / SBIR / Phase II
Agency: HHS
Principal Investigator: Dr. M. Squillante , Director
Award Amount: $255,000.00
Abstract:
Two dimensional x-ray detectors are finding increasing use in diffraction studies of biological macromolecules, especially with the advent of high intensity x-ray sources and computer aided analysis systems. currently available detectors all suffer from performance limitations, maintenance… More

COMPUTER CONTROLLED COLLIMATORS FOR RADIATION THERAPY

Award Year / Program / Phase: 1987 / SBIR / Phase II
Agency: HHS
Principal Investigator: Gerald Entine , Principal Investigator
Award Amount: $226,000.00
Abstract:
One of the most important criteria for successful radiation therapy is the ability to deliver the highest possible tumor dose and minimize the dose to normal tissue. most techniques currently used for shaping radiation therapy beams involve the fabrication of custom made, dense alloy blocks. while… More

ON LINE MONITOR FOR METALLIC WEAR PRODUCTS

Award Year / Program / Phase: 1987 / SBIR / Phase I
Agency: NSF
Principal Investigator:
Award Amount: $40,000.00
Abstract:
The useful operating life of most mechanical systems quite often is determined by the continued effectiveness of a variety of tribo-elements. these tribo-elements are the devices and mechanisms that provide for proper lubrication and frictional contact between moving parts. systems which can monitor… More

A BORON PHOSPHIDE SEMICONDUCTOR NEUTRON DETECTOR

Award Year / Program / Phase: 1987 / SBIR / Phase I
Agency: DOE
Principal Investigator: Dr gerald entine
Award Amount: $49,721.00
Abstract:
Since their discovery neutrons have remained one of the most difficult forms of radiation to detect. the most effective neutron detectors in current use are gas filled detectors employing either 3he or bf3 as the detection medium. unfortunately, gas filled detectors suffer from a number of… More

LEAD IODIDE SEMICONDUCTOR NUCLEAR SENSOR

Award Year / Program / Phase: 1987 / SBIR / Phase I
Agency: NSF
Principal Investigator:
Award Amount: $40,000.00
Abstract:
Lead iodide (pbi2) is a little used compound semiconductor. the high atomic numbers of its constituent elements gives itextraordinary photoelectric absorption efficiency for gamma photons, while its 2.5 ev bandgap promises performanceat temperatures up to 250 degrees c. it has shown some promise as… More

ENHANCED ON-LINE GEL ELECTROPHORESIS SYSTEM

Award Year / Program / Phase: 1987 / SBIR / Phase I
Agency: HHS
Principal Investigator: Gerald entine phd
Award Amount: $50,000.00
Abstract:
An understanding of genetic information achieved by sequencing dna is one of the most exciting recent advances in biochemistry. gel electrophoresis is the most widely used method to achieve this important result. typically, the separation of the different molecular-weight fragments in the gel… More

SINGLE SPHERE MULTIPLE DETECTOR NEUTRON SPECTRONMETER

Award Year / Program / Phase: 1987 / SBIR / Phase I
Agency: NSF
Principal Investigator: Gerald entine
Award Amount: $40,000.00
Abstract:
Accurate measurement of neutrons is difficult and requires complex, expensive equipment. it is an especially serious problem for dosimetry where several techmical issues make the accurate dtermination of radiation dose extremely dif- ficult. for example, neutrons occur over a wide range of energies… More

NOVEL PROPORTIONAL PROXIMITY SENSOR FOR AUTONOMOUS, SPACE BASED ROBOTS

Award Year / Program / Phase: 1987 / SBIR / Phase I
Agency: NASA
Principal Investigator:
Award Amount: $50,000.00

INTRAOPERATIVE, REGIONAL MYOCARDIAL BLOOD FLOW MONITOR

Award Year / Program / Phase: 1987 / SBIR / Phase I
Agency: HHS
Principal Investigator: Gerald Entine Phd
Award Amount: $50,000.00

CONTROLLED POLYTYPISM IN A VARIABLE BANDGAP SEMICONDUCTOR

Award Year / Program / Phase: 1987 / SBIR / Phase I
Agency: NSF
Principal Investigator:
Award Amount: $40,000.00

ENERGY COMPENSATED SOLID STATE GAMMA SENSOR

Award Year / Program / Phase: 1988 / SBIR / Phase II
Agency / Branch: DOD / ARMY
Principal Investigator: Dr Gerald Entine
Award Amount: $516,000.00
Abstract:
A key requirement for the success of the new, tactical radiation dosimetry instrumentation now being developed by the army is to have an energy compensated, solid state gamma ray sensor. attemps to use traditional filtering techniques to achieve a flat energy response have not been successful and a… More

NOVEL PROPORTIONAL PROXIMITY SENSOR FOR AUTONOMOUS, SPACE BASED ROBOTS

Award Year / Program / Phase: 1988 / SBIR / Phase II
Agency: NASA
Principal Investigator:
Award Amount: $500,000.00
Abstract:
Robotics is becoming an increasingly important field in research and manufacturing. most robots, however, either perform repetitive preprogrammed operations or are guided by a human operator. this is not practical in many applications where autonomous operation is required, and the most important… More

CONTROLLED POLYTYPISM IN A VARIABLE BANDGAP SEMICONDUCTOR

Award Year / Program / Phase: 1988 / SBIR / Phase II
Agency: NSF
Principal Investigator:
Award Amount: $203,000.00
Abstract:
Lead iodide (pbi2) is a layered semiconductor compound that possesses a number of structural modifications known as polytypes. the formation of these structures is known to be caused by impurities. recently methods for growing this material in very high purity form have been reported in the… More

HIGH RESOLUTION, AVALANCHE DIODE X-RAY SPECTROMETER FOR PLANETARY EXPLORATION

Award Year / Program / Phase: 1988 / SBIR / Phase I
Agency: NASA
Principal Investigator: Dr gerald entine
Award Amount: $50,000.00
Abstract:
One of the most exciting goals of the nasa space program is to land a vehicle on mars and conduct physical and chemical measurements of the martian surface. of the various analytical techniques being considered for the lander mission, x-ray fluorescence analysis offers the possibility of providing… More

A REAL-TIME IMAGING SYSTEM FOR ENHANCING DNA HYBRIDIZATION TECHNOLOGIES

Award Year / Program / Phase: 1988 / SBIR / Phase I
Agency: DOE
Principal Investigator:
Award Amount: $50,000.00
Abstract:
One of the most active and challenging fields in molecular biology today is the genetic study of eukaryotic systems. the preliminary, but often rate limiting, steps in this area are the dna transfer/hybridization technologies associated with gene mapping, and the screening of dna libraries for gene… More

HIGH TEMPERATURE SEMICONDUCTOR SENSOR FOR BORE HOLE LOGGING

Award Year / Program / Phase: 1988 / SBIR / Phase I
Agency: NSF
Principal Investigator: Dr gerald entine
Award Amount: $50,000.00
Abstract:
For many years, nuclear measurement techniques have been an important aspect of downhole geological bore hole logging. approches range from gamma ray backscatter used for gauging density to neutron activation analysis to determine composition. the conditions which severly limit the performance of… More

IMPROVED RFLP ANALYSIS FOR GENETIC LINKAGE MAPPING

Award Year / Program / Phase: 1988 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $50,000.00
Abstract:
One of the most active and challenging fields in molecular biology today is the genetic study of eukaryotic systems. one rapidly growing area in this field is the study of restriction fragment length polymorphisms (rflps). this procedure uses radiolabeled hybridization techniques and autoradiography… More

INTRAOPERATIVE, REGIONAL MYOCARDIAL BLOOD FLOW MONITOR

Award Year / Program / Phase: 1988 / SBIR / Phase II
Agency: HHS
Principal Investigator: Gerald Entine Phd
Award Amount: $444,000.00
Abstract:
Coronary artery bypass is one of the most widely practiced procedures for the treatment of patients with coronary atherosclerosis, yet a simple and rapid method for assessingthe effectiveness of the procedure while it is being performed is not currently available. it would be extremelyuseful if a… More

LEAD IODIDE SEMICONDUCTOR FOR NUCLEAR SENSOR

Award Year / Program / Phase: 1988 / SBIR / Phase II
Agency: NSF
Principal Investigator: Michael R Squillante Ph.
Award Amount: $203,000.00
Abstract:
Lead iodide (pbi2) is a little used compound semiconductor the high atomic numbers of its constituent elements gives itextraordinary photoelectric absorption efficiency ofor gammaphotons, while its 2.5 ev bandgap promises performance at temperatures up to 250 degrees c. it has shown some prom- ise… More

CHARACTERIZATION OF SPRAY PYROLYED THIN FILM SUPERCONDUCTORS

Award Year / Program / Phase: 1988 / SBIR / Phase I
Agency / Branch: DOD / ARMY
Principal Investigator: Dr michael r squillante
Award Amount: $59,503.00
Abstract:
The recent discovery of superconductivity at high temperature (90 deg k) in copper containing ceramics has resulted in a rapid acceleration in superconductor research. production techniques are being examined for the fabrication of bulk and thin film samples. the currently used processes for making… More

SIMULATION OF GAMMA RAY DOSE RATES AND SPECTRA

Award Year / Program / Phase: 1988 / SBIR / Phase I
Agency / Branch: DOD / ARMY
Principal Investigator: Dr gerald entine
Award Amount: $49,895.00
Abstract:
The white sands missile range gamma ray facility is used to qualify military equipment for radiation hardness. isotopic sources of 60 co and 137 cs are used to produce intense gamma ray fields that allow testing of electronic systems in environments that approximate anticipated nuclear battlefield… More

REAL TIME IMAGING SYSTEM FOR SCREENING DNA LIBRARIES

Award Year / Program / Phase: 1988 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $50,000.00

THALLIUM BROMIDE NUCLEAR DETECTORS

Award Year / Program / Phase: 1988 / SBIR / Phase I
Agency: NSF
Principal Investigator: Michael R Squillante Phd
Award Amount: $50,000.00

RENAL BLOOD FLOW MONITOR FOR ICU PATIENTS

Award Year / Program / Phase: 1988 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $50,000.00

THALLIUM BROMIDE NUCLEAR DETECTORS

Award Year / Program / Phase: 1989 / SBIR / Phase II
Agency: NSF
Principal Investigator: Michael R Squillante Phd
Award Amount: $226,232.00
Abstract:
Thallium bromide (t1br) is a new cubic semiconductor. the high atomic numbers of its constituent elements gives it extraordinary photoelectric absorption efficiency for gamma photons, while its 2.5 ev bandgap promises performance at temperatures up to 250xc. it has shown some promise as ahigh… More

REAL TIME IMAGING SYSTEM FOR SCREENING DNA LIBRARIES

Award Year / Program / Phase: 1989 / SBIR / Phase II
Agency: HHS
Principal Investigator:
Award Amount: $496,741.00
Abstract:
One of the most active and challenging fields in molecular biology today is the genetic study of eukaryotic systems. an essential, but often rate limiting step in this area is the screening of dna libraries for gene mapping. this procedure uses radiolabel hybridization techniques and autoradiography… More

RENAL BLOOD FLOW MONITOR FOR ICU PATIENTS

Award Year / Program / Phase: 1989 / SBIR / Phase II
Agency: HHS
Principal Investigator:
Award Amount: $500,000.00
Abstract:
Acute renal failure is a major contributing cause of death in patients in the intensive care unit partly due to the lack of a simple, rapid method of assessing kidney function. it would therefore be extremely useful if a direct measurement of renal function could be performed at regular intervals so… More

POSITRON PROBE FOR CORNEAL TUMOR BIOASSAY

Award Year / Program / Phase: 1989 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $50,000.00
Abstract:
Recently, preliminary research using cyclotron-produced, positron-emitting radiolabels has been conducted at the memorial sloan-kettering cancer center to develop a rabbit/rat corneal implant method to study human tumor angiogenesis and metabolism. this technique is designed to determine the direct… More

HIGH TEMPERATURE SUPERCONDUCTOR RADIATION DETECTOR

Award Year / Program / Phase: 1989 / SBIR / Phase I
Agency: NSF
Principal Investigator: Gerald Entine , Principal Investigator
Award Amount: $50,000.00
Abstract:
Nuclear radiation sensors are used in many important applications in research and industry. good energy resolution is a vital property of nuclear radiation spectrometers. the best contemporary commercial units can discriminate differences about 100 ev. better performance has become available through… More

COMPENDIUM OF RADIATION TREATMENT ACCESSORIES

Award Year / Program / Phase: 1989 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $50,000.00
Abstract:
Radiation therapy has become one of the most important tools for the control of cancer, and an impressive array of supporting technologies has been developed. while many of these accessories are readily available from commercial sources, a very significant number of therapy aids have beendeveloped… More

SOLID-STATE DETECTOR FOR CAPILLARY ELECTROPHORESIS

Award Year / Program / Phase: 1989 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $44,946.00
Abstract:
Gel electrophoresis is one of the most important and widely used analytical techniques for the determination of the sequence of dna. recently, there has been a significant advance in electrophoresis technology through the use of gel geometries involving thin capillary tubes. this technology has been… More

AUTOMATIC CONTROL OF INTERFACE BOUNDARIES IN VERTICAL FREEZEPRODUCTION PROCESSES

Award Year / Program / Phase: 1989 / SBIR / Phase I
Agency: NSF
Principal Investigator: Michael R Squillante , Principal Investigator
Award Amount: $50,000.00

THALLIUM BROMOIODIDE DETECTORS FOR SCINTILLATION SPECTROSCOPY

Award Year / Program / Phase: 1989 / SBIR / Phase I
Agency: DOE
Principal Investigator: Dr Michael R Squillante , Principal Investigator
Award Amount: $50,000.00

A POSITION SENSITIVE NEUTRON DETECTOR USING BORON PHOSPHIDE SEMICONDUCTOR SENSORS

Award Year / Program / Phase: 1989 / SBIR / Phase I
Agency: DOE
Principal Investigator: Dr Gerald Entine , Principal Investigator
Award Amount: $50,000.00

NEW HIGH-Z SEMICONDUCTOR SENSOR FOR POSITRON TOMOGRAPHY

Award Year / Program / Phase: 1989 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $50,000.00

REAL-TIME PORTAL SCANNER/RADIATION THERAPY

Award Year / Program / Phase: 1989 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $50,000.00

A POSITION SENSITIVE NEUTRON DETECTOR USING BORON PHOSPHIDE SEMICONDUCTOR SENSORS

Award Year / Program / Phase: 1990 / SBIR / Phase II
Agency: DOE
Principal Investigator: Dr Gerald Entine , Principal Investigator
Award Amount: $500,000.00
Abstract:
Traditional position-sensitive neutron detectors use either gas filled tubes or scintillator-photomultiplier tube combinations. although both of these technologies have resulted in successful position-sensitive neutron detectors,they have a variety of intrinsic deficiencies. this projectinvolves the… More

NEW HIGH-Z SEMICONDUCTOR SENSOR FOR POSITRON TOMOGRAPHY

Award Year / Program / Phase: 1990 / SBIR / Phase II
Agency: HHS
Principal Investigator:
Award Amount: $500,000.00
Abstract:
Positron emission tomography (pet) is a noninvasive, medical imaging technique that provides an image of a positron-emitting radiopharmaceutical and its distribution in the body on a metabolic level. it is becoming an important fundamental tool for both clinical diagnosis and medical research. the… More

AUTOMATIC CONTROL OF INTERFACE BOUNDARIES IN VERTICAL FREEZEPRODUCTION PROCESSES

Award Year / Program / Phase: 1990 / SBIR / Phase II
Agency: NSF
Principal Investigator: Michael R Squillante , Principal Investigator
Award Amount: $250,000.00
Abstract:
A key consideration in a variety of manufacturing processes is controlling either the position or shape of an interface defined as the boundary between liquid and solid materials of dissimilar composition or density to within certain allowable tolerances. examples of such diverse processes are… More

THALLIUM BROMOIODIDE DETECTORS FOR SCINTILLATION SPECTROSCOPY

Award Year / Program / Phase: 1990 / SBIR / Phase II
Agency: DOE
Principal Investigator: Dr Michael R Squillante , Principal Investigator
Award Amount: $500,000.00
Abstract:
Scintillation detectors remain the leading type of detector in many areas of nuclear physics. although improvements in scintillator crystal technology have extended the utility ofscintillator systems, serious deficiencies in the optical detectors used with scintillation crystals limit the… More

THALLIUM BROMIDE X-RAY PHOTCATHODES

Award Year / Program / Phase: 1990 / SBIR / Phase I
Agency: NSF
Principal Investigator: Dr Michael R Squillante , Director Of Research
Award Amount: $50,000.00
Abstract:
X-ray photocathodes are used in a large number of x-ray imaging systems, mainly in the fields of astronomy and medical imaging. in most applications, x-ray photocathodes are used in conjunction with a microchannel plate (mcp) and a position-sensitive detector. devices incorporating this combination… More

SOLID STATE, ON-LINE DETECTION SYSTEM FOR CAPILLARY ELECTROPHORESIS

Award Year / Program / Phase: 1990 / SBIR / Phase I
Agency: NSF
Principal Investigator: Dr William J Mcgann , Senior Scientist
Award Amount: $50,000.00
Abstract:
Electrophoresis is one of the most important and widely used analytical techniques for the separation and identification of biological molecules. recently, there has been a significant advance in electrophoresis technology through the use of gel geometries involving thin capillary tubes. this… More

LARGE AREA POSITION SENSITIVE DETECTOR FOR SYNCHROTRON X-RAY DIFFRACTION

Award Year / Program / Phase: 1990 / SBIR / Phase I
Agency: DOE
Principal Investigator:
Award Amount: $50,000.00
Abstract:
The availability of high intensity, synchrotron sources to produce high flux, monochromatic x-ray beams has resultedin important advances in the study and determination of the structure of large, fragile biological macromolecules. although these sources represent a major advance in technology, at… More

REAL-TIME PORTAL SCANNER/RADIATION THERAPY

Award Year / Program / Phase: 1990 / SBIR / Phase II
Agency: HHS
Principal Investigator:
Award Amount: $500,000.00
Abstract:
One of the most promising new approaches for rapid portal imaging in radiation therapy is the scanning system under development at johns hopkins medical shcool. this system uses a linear array of diodes to generate an image and has several appealing aspects, including the ability to produce an image… More

A NEW NUCLEAR SURVEY INSTRUMENT WITH IMAGING CAPABILITY

Award Year / Program / Phase: 1990 / SBIR / Phase I
Agency / Branch: DOD / NAVY
Principal Investigator: Dr Michael R Squillante
Award Amount: $58,644.00
Abstract:
Modern military operations have made it necessary for commanders to have radiological information concerning nuclear contamination of occupied areas. this increasing need for more accurate and reliable information for the purpose of locating and identifying potentially hazardous nuclear sources, has… More

SOLID STATE NEUTRON DOSIMETER FOR SPACE APPLICATIONS

Award Year / Program / Phase: 1990 / SBIR / Phase I
Agency: NASA
Principal Investigator: Gerald Entine , President
Award Amount: $50,000.00

INTRAOPERATIVE IMAGING PROBE FOR DELINEATION OF TUMORS

Award Year / Program / Phase: 1990 / SBIR / Phase I
Agency: HHS
Principal Investigator: Gerald Entine
Award Amount: $50,000.00

A NEW SEMICONDUCTOR PHOTOSENSOR FOR SCINTILLATION SPECTROSCOPY

Award Year / Program / Phase: 1990 / SBIR / Phase I
Agency: DOE
Principal Investigator:
Award Amount: $50,000.00

HIGH FIELD, HIGH TC SUPERCONDUCTING MAGNETS

Award Year / Program / Phase: 1990 / SBIR / Phase I
Agency: NASA
Principal Investigator: Michael R. Squillante , Director Of Research
Award Amount: $50,000.00

NEW PHOTOSENSOR FOR POSITRON EMISSION TOMOGRAPHY

Award Year / Program / Phase: 1990 / SBIR / Phase I
Agency: HHS
Principal Investigator: Michael Squillante
Award Amount: $50,000.00

HIGH-SENSITIVITY PHOTOCONDUCTOR FOR XERORADIOGRAPHY

Award Year / Program / Phase: 1990 / SBIR / Phase I
Agency: HHS
Principal Investigator: Michael R Squillante
Award Amount: $49,998.00

RAPID MONITORING OF THE GFR OF PATIENTS IN THE INTENSIVE CARE

Award Year / Program / Phase: 1990 / SBIR / Phase I
Agency: HHS
Principal Investigator: Gerald Entine
Award Amount: $50,000.00

EMBOLI MONITOR TO REDUCE NEUROLOGIC DEFICITS FROM SURGERY

Award Year / Program / Phase: 1990 / SBIR / Phase I
Agency: HHS
Principal Investigator: Gerald Entine
Award Amount: $50,000.00

SOLID STATE NEUTRON DOSIMETER FOR SPACE APPLICATIONS

Award Year / Program / Phase: 1991 / SBIR / Phase II
Agency: NASA
Principal Investigator: Gerald Entine , President
Award Amount: $500,000.00
Abstract:
One of the most important contributions to the radiation exposure of personnel engaged in space flight is the significant flux of high energy neutrons arising from both primary and secondary sources of ionizing radiation. presently, there does not exist a suitable and compact neutron sensor capable… More

HIGH FIELD, HIGH TC SUPERCONDUCTING MAGNETS

Award Year / Program / Phase: 1991 / SBIR / Phase II
Agency: NASA
Principal Investigator: Michael R. Squillante , Director Of Research
Award Amount: $499,975.00
Abstract:
The discovery of superconductivity at high temperatures (90 k) in copper containing ceramics has resulted in the rapid acceleration of superconductor research. much of thisresearch is being directed at producing and examining new compounds both to improve performance characteristics and tobetter… More

A NEW SEMICONDUCTOR PHOTOSENSOR FOR SCINTILLATION SPECTROSCOPY

Award Year / Program / Phase: 1991 / SBIR / Phase II
Agency: DOE
Principal Investigator:
Award Amount: $500,000.00
Abstract:
Scintillation spectrometers are currently the most widely used devices for the detection and spectrometry of energetic photons (x-rays and gamma rays) at room temperature. they are very widely used in nuclear and high energy physics research, medical imaging and industrial gauging applications.… More

LARGE AREA, POSITION SENSITIVE X-RAY DETECTOR

Award Year / Program / Phase: 1991 / SBIR / Phase I
Agency: NSF
Principal Investigator: Michael R. Squillante, Ph , Director Of Research
Award Amount: $50,000.00
Abstract:
High intensity, synchrotron sources are capable of producinga high flux of monochromatic x-rays. this resulted in important advances in the study and determination of the structure of large molecules. although these sources represent such a major advance in technology, at present there are no large… More

INTRAOPERATIVE IMAGING PROBE FOR DELINEATION OF TUMORS

Award Year / Program / Phase: 1991 / SBIR / Phase II
Agency: HHS
Principal Investigator: Gerald Entine
Award Amount: $500,000.00
Abstract:
The surgical removal of tumors is one of the most important medical procedures in the treatment of cancer. recently, radiopharmaceuticals have been developed that achieve improved specificity and efficiency for labeling malignant tissue. these improvements have generated a resurgence of interest in… More

AN ADDITIVE TO IMPROVE THE PLASTICITY AND DRYING PROPERTIES OF LARGE CERAMICS

Award Year / Program / Phase: 1991 / SBIR / Phase I
Agency: NSF
Principal Investigator: Gerald Entine Ph.d. , President
Award Amount: $50,000.00
Abstract:
This sbir-research addresses a new technique for improving the working properties of water-based ceramic formulations and the production yields for objects manufactured from these materials. this extensively used class of materials is employed in applications ranging from ceramic substrates to… More

NOVEL PHOTODETECTOR FOR SCINTILLATION SPECTROSCOPY

Award Year / Program / Phase: 1991 / SBIR / Phase I
Agency: NSF
Principal Investigator: James C. Lund , Senior Scientist
Award Amount: $50,000.00
Abstract:
Scintillation detectors are the leading type of detector used in many areas of nuclear physics. normally photomultiplier tubes (pmts) are used as the optical detector with scintillation crystals. unfortunately pmts have low efficiency at the output wavelengths of most scintillators and this factor,… More

A NEW VARIABLE BANDGAP SEMICONDUCTOR SYSTEM

Award Year / Program / Phase: 1991 / SBIR / Phase I
Agency: NSF
Principal Investigator: Michael R. Squillante, Ph , Director Of Research
Award Amount: $50,000.00
Abstract:
In recent years the electronics industry has shown considerable interest in semiconducting compounds with specially tailored electrical and optical properties for fabrication of a variety of electro-optic devices such as photodetectors and ir and visible lasers. one method that is commonly used to… More

A SILICON DRIFT PHOTODIODE FOR SCINTILLATION SPECTROSCOPY

Award Year / Program / Phase: 1991 / SBIR / Phase I
Agency: DOE
Principal Investigator: Dr Michael R Squillante , Principal Investigator
Award Amount: $50,000.00
Abstract:
Scintillation detectors have remained the leading type of detector in many areas of nuclear physics. although improvements in scintillator cyystal technology have extended the utility of scintillator-based systems, serious deficiencies in the optical detectors used with the scintillator crystals are… More

MICRODOSIMETRIC SOLID STATE TISSUE EQUIVALENT DETECTOR

Award Year / Program / Phase: 1991 / SBIR / Phase I
Agency: HHS
Principal Investigator: Entine, Gerald , Principal Investigator
Award Amount: $50,000.00
Abstract:
The concern over the potential hazards of low level radiation exposure is increasing as the understanding of its biological effects increases, particularly in assessing the risk to personnel who receive occupational exposure to radiation. current radiation risk assessment methods use global,… More

NOVEL INFRARED FIBER-OPTIC BIOSENSOR

Award Year / Program / Phase: 1991 / SBIR / Phase I
Agency: HHS
Principal Investigator: De Rochemont, L Pierre , Principal Investigator
Award Amount: $50,000.00
Abstract:
Toxic substances in the environment pose a significant threat to humans. to monitor, control and reduce exposure to this health hazard, and to identify individuals needing treatment who have unknowingly been exposed to it, sensitive testing apparatus need to be developed. this need could be met with… More

LARGE AREA HIGH RESOLUTION X-RAY DETECTOR FOR BIOMEDICAL RESEARCH

Award Year / Program / Phase: 1991 / SBIR / Phase I
Agency: HHS
Principal Investigator: Squillante, Michael R , Principal Investigator
Award Amount: $50,000.00
Abstract:
The availability of high intensity, synchrotron sources to produce high flux, monochromatic x-ray beams has resulted in important advances in molecular structure determination studies including the determination of the structure of large, fragile biological macromolecules. although these sources… More

PEDIATRIC XRF BONE LEAD WITH AN X-RAY GENERATOR

Award Year / Program / Phase: 1991 / SBIR / Phase I
Agency: HHS
Principal Investigator: Milder, Fredric L , Principal Investigator
Award Amount: $49,945.00

LOW CAPACITANCE SILICON PHOTODECTOR FOR PET

Award Year / Program / Phase: 1991 / SBIR / Phase I
Agency: HHS
Principal Investigator: Michael Squillante
Award Amount: $50,000.00

BRAGG-FILTERS USING HIGH-SCATTERING EFFICIENCY VOLUME HOLOGRAPHIC RECORDING GLASS

Award Year / Program / Phase: 1991 / SBIR / Phase I
Agency / Branch: DOD / USAF
Principal Investigator: Pierre De Rochemont , Principal Investigator
Award Amount: $61,353.00

A LARGE AREA, REAL-TIME IMAGING SYSTEM FOR SCREEN DNA LIBRARIES

Award Year / Program / Phase: 1991 / SBIR / Phase I
Agency: NSF
Principal Investigator: William J. Mcgann, Ph.d. , Senior Scientist
Award Amount: $50,000.00

NONDESTRUCTIVE ANALYSIS OF GRAPHITE REINFORCED MATERIALS (GRM)

Award Year / Program / Phase: 1992 / SBIR / Phase I
Agency: NASA
Principal Investigator: Dr. Michael R. Squillante
Award Amount: $49,850.00
Abstract:
The advent of graphite reinforced composites has led to major advances in aerospace technology. such composite materials are becoming essential to modern flight technologydue to their exceptionally high strength-to-weight ratios when compared to metals and alloys. many aircraft and rocket components… More

HIGH-SENSITIVITY PHOTOCONDUCTOR FOR XERORADIOGRAPHY

Award Year / Program / Phase: 1992 / SBIR / Phase II
Agency: HHS
Principal Investigator: Michael R Squillante
Award Amount: $499,098.00
Abstract:
Radiography is a primary technique for detection of breast cancer. xeromammography is an important radiological technology because of its ability to highlight microcalcifications, a primary indication of the presence of cancer. this ability is due to the inherent edge enhancement of xerography.… More

NEW PHOTOSENSOR FOR POSITRON EMISSION TOMOGRAPHY

Award Year / Program / Phase: 1992 / SBIR / Phase II
Agency: HHS
Principal Investigator: Michael Squillante
Award Amount: $499,766.00
Abstract:
Positron emission tomography (pet) is an important medical imaging technique that provides an image of the distributionof a positron-emitting radiopharmaceutical in the body on a metabolic level. at the present time, the performance of this important instrument is limited by the sensors used. future… More

RAPID MONITORING OF THE GFR OF PATIENTS IN THE INTENSIVE CARE

Award Year / Program / Phase: 1992 / SBIR / Phase II
Agency: HHS
Principal Investigator: Gerald Entine
Award Amount: $496,000.00
Abstract:
Acute renal failure (arf) is a common lethal complication incritically ill patients; at least 50 percent of patients whodevelop this condition do not recover. it is, therefore, ofparticular importance to devise a means of monitoring renal function in real time so that the efficacy of the commonly… More

EMBOLI MONITOR TO REDUCE NEUROLOGIC DEFICITS FROM SURGERY

Award Year / Program / Phase: 1992 / SBIR / Phase II
Agency: HHS
Principal Investigator: Gerald Entine
Award Amount: $500,000.00
Abstract:
Despite continued improvement in the technical aspects of cardiopulmonary bypass procedures, a majority of cardiac surgical patients demonstrate postoperative cognitive deficits and 3 percent actually suffer frank strokes. although it is not yet proven, the majority of researchers believe that these… More

AVALANCHE PHOTODIODE DETECTORS FOR THE SUPERCONDUCTING SUPER COLLIDER

Award Year / Program / Phase: 1992 / SBIR / Phase I
Agency: DOE
Principal Investigator:
Award Amount: $50,000.00
Abstract:
A high speed avalanche photodiode (apd) is being investigated that would meet the requirements for the central tracker detector system of the superconducting super collider (ssc). the approach would modify existing apd designs to yield a device with lower dark current and faster cycle time when… More

LEAD SULFATE SCINTILLATORS FOR USE IN POSITRON EMISSION TOMOGRAPHY

Award Year / Program / Phase: 1992 / SBIR / Phase I
Agency: DOE
Principal Investigator:
Award Amount: $50,000.00
Abstract:
Positron emission tomography (pet) is emerging as an important fundamental tool for both clinical diagnosis and medical research. pet is a noninvasive medical imaging technique that provides an image of the distribution of a positron-emitting radioisotope in the body. the performance of this… More

INDIUM IODIDE PHOTOCONDUCTIVE DETECTORS FOR USE IN SCINTILLATION SPECTROSCOPY

Award Year / Program / Phase: 1992 / SBIR / Phase I
Agency: DOE
Principal Investigator:
Award Amount: $50,000.00
Abstract:
Currently, scintillation spectrometers are widely used for detection and spectrometry of energetic photons (x-rays and gamma-rays) at room temperature. these spectrometers find extensive application in nuclear and high energy physics experiments, medical imaging systems, and various industrial… More

A NOVEL DETECTOR FOR NEUTRON SPECTROSCOPY

Award Year / Program / Phase: 1992 / SBIR / Phase I
Agency: DOE
Principal Investigator:
Award Amount: $50,000.00
Abstract:
Neutron spectrometers are widely used in nuclear physics research. unfortunately, the performance of existing spectrometers is limited by the technology of the neutron detectors used in them. this research aims to produce a new type of neutron detector that is ideally suited for use in neutron… More

NEW SILICON PHOTODIODE FOR SCINTILLATION SPECTROSCOPY

Award Year / Program / Phase: 1992 / SBIR / Phase I
Agency: NSF
Principal Investigator: Frederick Olschner, M.s.
Award Amount: $50,000.00
Abstract:
Optical detector systems have serious deficiencies in terms of quantum efficiency or signal-to-noise ratio. these silicon drift photodiodes can be made with very low noise and it has been suggested that these devices may be quite useful as scintillation photodecectors. produce silicon drift… More

FIELD EFFECT TRANSISTOR X-RAY SPECTROMETER

Award Year / Program / Phase: 1992 / SBIR / Phase I
Agency: NSF
Principal Investigator: James C. Lund, M.s. , Senior Scientist
Award Amount: $50,000.00
Abstract:
We propose to develop a new type of x-ray detector that utilizes a field effect transistor (fet) structure. this new detector offers the advantage of internal gain, low noise and simple readout electronics. initial studies show that this detector type would have better energy resolution than x-ray… More

A NEW PORTABLE X-RAY FLUORESSCENCE SYSTEM FOR LEAD PAINT ANALYSIS

Award Year / Program / Phase: 1992 / SBIR / Phase I
Agency: HHS
Principal Investigator: Gerald Entine
Award Amount: $50,000.00
Abstract:
Lead poisoning in the united states is a serious health problem which is estimated to affect some 3 to 4 million children under the age of six years old. to prevent this number from growing, the federal government has mandated that all properties subsidized by the department of housing and urban… More

ACOUSTIC SCATTERING BY A VORTEX MODEL OF TURBULENCE

Award Year / Program / Phase: 1992 / SBIR / Phase I
Agency / Branch: DOD / ARMY
Principal Investigator: Dr. Christopher Rollins
Award Amount: $49,777.00
Abstract:
Development of an improved model for acoustic scattering from a turbulent medium is proposed, which will use the self-consistent field approach to multiple scattering. results wil be used to predict acoustic scattering signatures as a function of the acoustic and turbulence properties of the… More

SOLID STATE DETECTOR FOR COMPUTED TOMOGRAPHY

Award Year / Program / Phase: 1992 / SBIR / Phase I
Agency: HHS
Principal Investigator: Gerald Entine
Award Amount: $50,000.00
Abstract:
Computed tomography (ct) is a noninvasive medical imaging technique which provides a complete three dimensional image of the body. at the present time the performance of ct machines are limited by the x-ray sensors used. the research effort will investigate the use of improved cadmium telluride… More

IMPLANTABLE PASSIVE DOSIMETER WITH REMOTE READOUT

Award Year / Program / Phase: 1992 / SBIR / Phase I
Agency: HHS
Principal Investigator: Gerald Entine
Award Amount: $49,999.00
Abstract:
To be effective, a radiation therpay portocol should control the cumulative dose deliverd to a tumor to bettern than 5%, while minimizing the dose to the surrounding tissue. presently, there exists no practical means for acutally measuring in vivo, the cumulative dose received by either the tumor or… More

LOW COST SYSTEM FOR LEAD DETECTION IN LEAD PAINT

Award Year / Program / Phase: 1992 / SBIR / Phase I
Agency: EPA
Principal Investigator: Dr Michael R Squillante , Principal Investigator
Award Amount: $50,000.00
Abstract:
Lead poisoning in the united stated is a serious health problem, estimated to affect some 3 to 4 million children under the age of six years old. to prevent this number from growing, epa has undertaken the role of encouraging the development of techniques to measure the amount of lead in lead paint.… More

LARGE AREA IMAGING DETECTOR FOR TRITIUM SAMPLES

Award Year / Program / Phase: 1992 / SBIR / Phase I
Agency: HHS
Principal Investigator: G Entine
Award Amount: $49,769.00

A NEW FAST HIGH Z SCINTILLATOR FOR PET

Award Year / Program / Phase: 1992 / SBIR / Phase I
Agency: HHS
Principal Investigator: Michael R Squillante
Award Amount: $50,000.00

PHOTODIODE SCINTILLATION DETECTOR FOR ANTI-COINCIDENCE SHIELDING

Award Year / Program / Phase: 1992 / SBIR / Phase I
Agency: NASA
Principal Investigator: Gerald Entine, Ph.d. , President
Award Amount: $50,000.00

A LARGE AREA IMAGING SYSTEM FOR RADIOACTIVE DNA SAMPLES

Award Year / Program / Phase: 1992 / SBIR / Phase I
Agency: HHS
Principal Investigator: William J Mcgann
Award Amount: $49,769.00

HIGH RESOLUTION DIGITAL MAMMOGRAPHY USING CHARGE-COUPLED DEVICES

Award Year / Program / Phase: 1992 / SBIR / Phase I
Agency: HHS
Principal Investigator: Gerald Entine
Award Amount: $50,000.00

A LARGE AREA, REAL-TIME IMAGING SYSTEM FOR SCREEN DNA LIBRARIES

Award Year / Program / Phase: 1993 / SBIR / Phase II
Agency: NSF
Principal Investigator: William J. Mcgann, Ph.d. , Senior Scientist
Award Amount: $250,000.00
Abstract:
One of the most active and challenging fields in molecular biology today is the genetic study of eukaryotic systems. an essential, but often rate limiting step in this area is the screening of dna libraries for gene isolation. this procedure uses radiolabeled hybridization techniques and… More

BRAGG-FILTERS USING HIGH-SCATTERING EFFICIENCY VOLUME HOLOGRAPHIC RECORDING GLASS

Award Year / Program / Phase: 1993 / SBIR / Phase II
Agency / Branch: DOD / USAF
Principal Investigator: Pierre De Rochemont , Principal Investigator
Award Amount: $572,446.00
Abstract:
It has recently been shown that amorphous solids can be utilized as volume holographic recording media using sufficiently intense write beams at appropriate wavelength(s). the commercial potential for passive micro-optical components manufactured form the glassy state is significant. glass can be… More

PEDIATRIC XRF BONE LEAD WITH AN X-RAY GENERATOR

Award Year / Program / Phase: 1993 / SBIR / Phase II
Agency: HHS
Principal Investigator: Milder, Fredric L , Principal Investigator
Award Amount: $500,000.00
Abstract:
X-ray fluorescence is an established technology for measuring the body burden of lead via the bone lead concentration. state-of-the- art measurements have an uncertainty of approximately 5 micrograms lead per gram bone mineral and take 30 minutes. to do mass screening of the high risk pediatric… More

LOW CAPACITANCE SILICON PHOTODECTOR FOR PET

Award Year / Program / Phase: 1993 / SBIR / Phase II
Agency: HHS
Principal Investigator: Michael Squillante
Award Amount: $500,000.00
Abstract:
Positron emission tomography (pet) is a non-invasive medicalimaging technique which provides an image of a positron emitting radio pharmaceutical and its distribution in the body on a metabolic level. at the present time, the performance of this instrument is limited by the nuclear sensors used. the… More

A LARGE AREA IMAGING SYSTEM FOR RADIOACTIVE DNA SAMPLES

Award Year / Program / Phase: 1993 / SBIR / Phase II
Agency: HHS
Principal Investigator: William J Mcgann
Award Amount: $500,098.00
Abstract:
One of the most active and challenging fields in molecular biology today is the genetic study of eukaryotic systems. an essential, but often rate limiting step in this area is the screening of dna libraries for gene isolation. this procedure uses radiolabel hybridization techniques and… More

HIGH RESOLUTION DIGITAL MAMMOGRAPHY USING CHARGE-COUPLED DEVICES

Award Year / Program / Phase: 1993 / SBIR / Phase II
Agency: HHS
Principal Investigator: Gerald Entine
Award Amount: $397,100.00
Abstract:
Breast carcinoma is one of the major causes of death in women, affecting about 1 in 10 north amrican women. it has been shown, however, that the risk of mortality from breast cancer can be reduced with early detection. mammography is the most sensitive technique currently available for the detection… More

LARGE AREA DETECTOR FOR X-RAY DIFFRACTION STUDIES

Award Year / Program / Phase: 1993 / SBIR / Phase I
Agency: NSF
Principal Investigator: Michael R Squillante
Award Amount: $50,000.00
Abstract:
New techniques for digital x-ray imaging have been under investigation for decades. some of the most promising teechniques incorporate solid-state x-ray detectors, which are attractive because of their compactness. high-z semiconductor x-ray detectors have further advantages due to their high… More

A New Type of Multi-element Photomultiplier Tube

Award Year / Program / Phase: 1993 / SBIR / Phase I
Agency: HHS
Principal Investigator: Michael R. Squillante
Award Amount: $50,000.00
Abstract:
Positron Emission Tomography (PET) is an important fundamental tool for both clinical diagnosis and medical research. It is noninvasive medical imaging technique which provides an image of the distribution of a positron emitting radio pharmaceutical in the body. At the present time, the performance… More

PHOTODIODE SCINTILLATION DETECTOR FOR ANTI-COINCIDENCE SHIELDING

Award Year / Program / Phase: 1993 / SBIR / Phase II
Agency: NASA
Principal Investigator: Gerald Entine, Ph.d. , President
Award Amount: $499,715.00

AN INTGRATED VIDEO AND GAMMA RAY IMAGING SYSTEM FOR ROBOTS IN NUCLEAR ENVIRONMENTS

Award Year / Program / Phase: 1993 / SBIR / Phase I
Agency: DOE
Principal Investigator: Dr Michael R Squillante
Award Amount: $75,000.00

Advanced Systems and Technologies for Future Naval Warfare

Award Year / Program / Phase: 1993 / SBIR / Phase I
Agency / Branch: DOD / NAVY
Principal Investigator: Gerald Entine
Award Amount: $50,038.00

A NEW FAST HIGH Z SCINTILLATOR FOR PET

Award Year / Program / Phase: 1994 / SBIR / Phase II
Agency: HHS
Principal Investigator: Michael R Squillante
Award Amount: $530,906.00
Abstract:
Positron emmission tomograhy (pet) is a non-invasive medical imaging technique which provides an image of a positron emitting radio pharmaceutical and its distribution in the body on a metabolic level. at the present time, the performance of this instrument is limited by the nuclear detectors used.… More

AN INTGRATED VIDEO AND GAMMA RAY IMAGING SYSTEM FOR ROBOTS IN NUCLEAR ENVIRONMENTS

Award Year / Program / Phase: 1994 / SBIR / Phase II
Agency: DOE
Principal Investigator: Dr Michael R Squillante
Award Amount: $600,000.00
Abstract:
Robots are becoming increasingly important throughout the nuclear industry. they are commonly used to improve operations and maintenance, lower operating costs, enhance worker safety, and reduce radiation exposure to workers. however, the capabilities of existing robots are limitedby the systems… More

High Resolution X-Ray Imaging Sensor for Real Time Nondestructive Evaluation

Award Year / Program / Phase: 1994 / SBIR / Phase I
Agency / Branch: DOD / USAF
Principal Investigator: Vivek Nagarkar
Award Amount: $60,000.00
Abstract:
The advanced materials and sophisticated designs of metal matrix composite components are being used in modern aircraft designs. To detect flaws and other integrity-reducing anomalies in these new materials and to assure the component reliability and accurate failure rate predictions, nondestructive… More

High-Gain, Avalanche Photodiode Arrays for Deep Space Optical Communications

Award Year / Program / Phase: 1994 / SBIR / Phase I
Agency: NASA
Principal Investigator: Gerald Entine
Award Amount: $70,000.00
Abstract:
Space optical communications techniques are expected to be of great value when communicating at planetary distances. As opposed to RF systems, the high optical power concentration resulting from the small beam divergence will allow smaller diameter telescopes, less power and jam resistant… More

Visible Blind Detectors for UV Surveillance

Award Year / Program / Phase: 1994 / SBIR / Phase I
Agency / Branch: DOD / MDA
Principal Investigator: Gerald Entine, Phd
Award Amount: $50,038.00
Abstract:
ADVANCES IN SEMICONDUCTOR TECHNOLOGY HAVE RESULTED IN VAST NEW TECHNOLOGICAL CAPABILITIES AND HAVE AFFECTED EVERY ASPECT OF MODERN LIFE. ONE SUCH APPLICATION WHERE ADVANCES IN SEMICONDUCTOR MATERIALS CAN HAVE A SIGNIFICANT IMPACT ON SPACE EXPLORATION IS UV DETECTORS. THE IDEAL UV DETECTOR WOULD BE A… More

A ROOM TEMPERATURE,LOW NOISE SILICON PHOTODIODE FOR POSITRON EMISSION TOMOGRAPHY

Award Year / Program / Phase: 1994 / SBIR / Phase I
Agency: DOE
Principal Investigator: Mr Kanai S Shah
Award Amount: $75,000.00
Abstract:
Positron emission tomography (pet) is a non-invasive medical imaging technique, which provides an image of a positron emitting radio pharmaceutical and its distribution in the body on a metabolic level. at the present time, the performance of this instrument is limited by the nuclear sensors used. … More

LOW COST AVALANCHE PHOTODIODES FOR SCINTILLATION DETECTION

Award Year / Program / Phase: 1994 / SBIR / Phase I
Agency: DOE
Principal Investigator: Dr Gerald Entine
Award Amount: $75,000.00
Abstract:
Silicon avalanche photodiodes (apds) have been shown to be nearly an ideal replacement for photomultiplier tubes (pmts) in scintillation detection applications. however, because of their great expense (typically apds cost ten times as much as an equivalent pmt) apds have not been widely used. the… More

A NOVEL SOLID STASTE ULTRAVIOLET DETECTOR FOR SCINTILLATION READOUT

Award Year / Program / Phase: 1994 / SBIR / Phase I
Agency: DOE
Principal Investigator: Dr Chuxin C Zhou
Award Amount: $75,000.00
Abstract:
The overall performance and usefulness of scintillator detectors are often limited by the efficiency of light collection by the photosensor used in conjunction with them. most scintillators that emit in the ultraviolet region (uv) have not been fully exploited, chiefly due to the difficulty of… More

A NOVEL DETECTOR FOR NEUTRON DIFFRACTION STUDIES

Award Year / Program / Phase: 1994 / SBIR / Phase I
Agency: DOE
Principal Investigator: Dr Gerald Entine
Award Amount: $75,000.00
Abstract:
The objective of this project is to develop a new type of large area position sensitive neutron detector for use in diffraction studies. the detector would use a liquid crystal sensing mechnism to provide a large area high resolution (comparable to photographic methods) detectors which would be… More

Portable Lead Iodide Environmental Monitor for Nuclear Radiation

Award Year / Program / Phase: 1994 / SBIR / Phase I
Agency / Branch: DOD / DARPA
Principal Investigator: Michael Squillante
Award Amount: $100,000.00
Abstract:
Environmental monitoring of possible contamination by radioactive materials has created a need for portable measurement systems that can assay low-grade radioactive materials in waste and in process equipment. Currently available instruments for environmental radiation monitoring are either of poor… More

Large Area Digital Imaging System for Mammography

Award Year / Program / Phase: 1994 / SBIR / Phase I
Agency: HHS
Principal Investigator: Jeffrey Gordon
Award Amount: $76,064.00

CDTE Detectors for Simultaneous Emission/Transmission CT

Award Year / Program / Phase: 1994 / SBIR / Phase I
Agency: HHS
Principal Investigator: Michael Squillante
Award Amount: $80,250.00

AVALANCHE PHOTODIODES FOR SCINTILLATING FIBER DETECTORS

Award Year / Program / Phase: 1994 / SBIR / Phase I
Agency: NSF
Principal Investigator: Gerald Entine
Award Amount: $65,000.00

Room Temperature Photosensors for Pet

Award Year / Program / Phase: 1994 / SBIR / Phase I
Agency: HHS
Principal Investigator: Michael Squillante
Award Amount: $80,250.00

Novel Sensor for High Resolution Intraoral Imaging

Award Year / Program / Phase: 1994 / SBIR / Phase I
Agency: HHS
Principal Investigator: Michael Squillante
Award Amount: $75,000.00

High Resolution Sensor for Structural Biology

Award Year / Program / Phase: 1994 / SBIR / Phase I
Agency: HHS
Principal Investigator: Jeffrey Gordon
Award Amount: $81,000.00

Improved Image Quality Film-Cassette for Mammography

Award Year / Program / Phase: 1994 / SBIR / Phase I
Agency: HHS
Principal Investigator: Jeffrey Gordon
Award Amount: $80,249.00

Novel Sensor for High Resolution Intraoral Imaging

Award Year / Program / Phase: 1995 / SBIR / Phase II
Agency: HHS
Principal Investigator: Michael Squillante
Award Amount: $731,863.00
Abstract:
Periodontal disease is a common problem affecting many Americans today. Earliest indicationof periodontal disease in change in bone and tissue mass. Both assessment of bone support and thedetection and measurement of small changes in bone and soft tissues are fundamental tot he intraoralexamination.… More

Improved Image Quality Film-Cassette for Mammography

Award Year / Program / Phase: 1995 / SBIR / Phase II
Agency: HHS
Principal Investigator: Jeffrey Gordon
Award Amount: $750,000.00
Abstract:
Despite advances in other techniques, standard X-ray transmission film mammography is by farthe most common clinical diagnostic tool for detecting breast cancer. Unfortunately, the spatialresolution of mammograms taken with existing systems is still below that needed to allow visualizationof the… More

Real Time Imaging System for Tritiated Biological Sample

Award Year / Program / Phase: 1995 / SBIR / Phase I
Agency: HHS
Principal Investigator: Gerald Entine
Award Amount: $100,000.00
Abstract:
Radioactive labeling of proteins using tritium is a very important technique used in neurological ridentify, isolate, and investigate the expression of proteins in biological systems. It is often necradiolabel for this work because 3H in vivo labeled proteins retain their conformal structure and… More

Silicon Drift Photodiodes for Tritium Detection

Award Year / Program / Phase: 1995 / SBIR / Phase I
Agency: HHS
Principal Investigator: Fred Olschner
Award Amount: $100,000.00
Abstract:
Radioactive labeling of proteins using tritium is a very important technique used in neurological ridentify, isolate, and investigate the expression of proteins in biological systems. It is often necradiolabel for this work because tritium in vivo labeled proteins retain their conformal structure… More

Novel Avalanche Photodiode Arrays for Ultraviolet Light Detection

Award Year / Program / Phase: 1995 / SBIR / Phase I
Agency: DOE
Principal Investigator: Stephan Vasile
Award Amount: $75,000.00

Mcp-Based Photon Counting On Chip Camera

Award Year / Program / Phase: 1995 / SBIR / Phase I
Agency: NASA
Principal Investigator: Frederick Olschner , Sr. Scientist
Award Amount: $70,000.00

High Resolution X-Ray Imaging Sensor for Real Time Nondestructive

Award Year / Program / Phase: 1995 / SBIR / Phase II
Agency / Branch: DOD / DARPA
Principal Investigator:
Award Amount: $740,000.00

A Sensor for Automated Plastics Sorting

Award Year / Program / Phase: 1995 / SBIR / Phase I
Agency: DOE
Principal Investigator: Michael Squillante
Award Amount: $75,000.00

LARGE AREA IMAGING DETECTOR FOR TRITIUM SAMPLES

Award Year / Program / Phase: 1996 / SBIR / Phase II
Agency: HHS
Principal Investigator: G Entine
Award Amount: $750,000.00
Abstract:
Most of the tissue in the human body regenerates after injury. one of the few tissues that are unable to regenerate is the central nervous system (cns). researchers use radioactive tritium (3h) compounds to label these proteins to identify the proteins that may be responsible for the inability of… More

Large Area Digital Imaging System for Mammography

Award Year / Program / Phase: 1996 / SBIR / Phase II
Agency: HHS
Principal Investigator: Jeffrey Gordon
Award Amount: $748,649.00
Abstract:
In mammography, early detection of breast cancer is dependent upon the ability of the imagingsystem to resolve characteristic distributions and shapes of small microcalcifications in the breast tissue,since approximately 80% of excised breast cancers show areas of calcification on… More

Room Temperature Photosensors for Pet

Award Year / Program / Phase: 1996 / SBIR / Phase II
Agency: HHS
Principal Investigator: Michael Squillante
Award Amount: $749,996.00
Abstract:
Positron Emission Tomography (PET) has now reached a degree of maturity where several of itsearly promises have been fulfilled. PET is able to provide information on both structure and function ofdifferent parts of the brain. It is becoming an important fundamental tool for both clinical diagnosis… More

High Resolution Sensor for Structural Biology

Award Year / Program / Phase: 1996 / SBIR / Phase II
Agency: HHS
Principal Investigator: Jeffrey Gordon
Award Amount: $750,000.00
Abstract:
Current research in structural biology is focused on understanding the role of enzymes andproteins in regulating cellular metabolism and the way drugs bind to proteins so that more effective drugswhich can inhibit viral activity may be developed. Macromolecular crystallography provide… More

AVALANCHE PHOTODIODES FOR SCINTILLATING FIBER DETECTORS

Award Year / Program / Phase: 1996 / SBIR / Phase II
Agency: NSF
Principal Investigator: Gerald Entine
Award Amount: $300,000.00
Abstract:
A high speed, high sensitivity avalanche photodiode (apd) array is being investigated to meet the stringent requirements of detectors for high energy physics experiments such as the central tracker vertex detector and calorimeters which are being designed for existing and proposed particle physics… More

High Performance Optical Detectors for Calorimetry

Award Year / Program / Phase: 1996 / SBIR / Phase I
Agency: DOE
Principal Investigator: Dr. Stefan Vasile , Senior Scientist
Award Amount: $75,000.00

LUTETIUM ORTHOALUMINATE SCINTILLATORS FOR PET

Award Year / Program / Phase: 1996 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $99,997.00

Novel Avalanche Photodiode Arrays for Ultraviolet Light Detection

Award Year / Program / Phase: 1996 / SBIR / Phase II
Agency: DOE
Principal Investigator: Stephan Vasile
Award Amount: $750,000.00

NEW GERMANIUM DETECTORS FOR LUNG BURDEN SCREENING

Award Year / Program / Phase: 1996 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $99,998.00

High Resolution Semiconductor Gamma Ray Detectors for Radionuclide Metrology

Award Year / Program / Phase: 1996 / SBIR / Phase I
Agency: DOC
Principal Investigator: Gerald Entine , Principal Investigator
Award Amount: $50,000.00

SBIR Phase I: New Thin N+ Contacts for Germanium Detectors

Award Year / Program / Phase: 1996 / SBIR / Phase I
Agency: NSF
Principal Investigator: Kanai Shah
Award Amount: $75,000.00

SOLID STATE DETECTOR FOR GAS CHROMATOGRAPHY

Award Year / Program / Phase: 1996 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $100,000.00

A Sensor for Automated Plastics Sorting

Award Year / Program / Phase: 1996 / SBIR / Phase II
Agency: DOE
Principal Investigator: Michael Squillante
Award Amount: $750,000.00

CDTE Detectors for Simultaneous Emission/Transmission CT

Award Year / Program / Phase: 1997 / SBIR / Phase II
Agency: HHS
Principal Investigator: Michael Squillante
Award Amount: $748,105.00
Abstract:
A simultaneous Emission/Transmission Computed Tomography (ETCT) system possesses theadvantages of both SPECT and CT by offsetting the individual weakness of each. However, thesuccessful development of ETCT machine must include improved spatial resolution, which currently islimited by the X-ray and… More

High Resolution Semiconductor Gamma Ray Detectors for Radionuclide Metrology

Award Year / Program / Phase: 1997 / SBIR / Phase II
Agency: DOC
Principal Investigator: Gerald Entine , Principal Investigator
Award Amount: $200,000.00
Abstract:
Quantitative, non-invasive X and gamma ray 3-D tomographic assessment of large, irregularly shaped, heterogeneous bodies is essential for efficient progress of environmental waste management. Currently, thousands of sealed containers with low-level radioactive waste are in storage. The material… More

High Performance Optical Detectors for Calorimetry

Award Year / Program / Phase: 1997 / SBIR / Phase II
Agency: DOE
Principal Investigator: Dr. Stefan Vasile , Senior Scientist
Award Amount: $750,000.00
Abstract:
40255 November 6, 1996 Radiation Monitoring Devices, Inc. Silicon avalanche photodiodes (APD) have been studied extensively as a photodetector candidate for the electromagnetic calorimeter readout of the compact muon solenoid (CMS) detector at the Large… More

Low Cost Avalanche Photodiodes and Photodiode Arrays

Award Year / Program / Phase: 1997 / SBIR / Phase I
Agency / Branch: DOD / MDA
Principal Investigator: Michael R. Squillante, Ph
Award Amount: $60,000.00
Abstract:
Silicon avalanche photodiodes are among the most sensitive optical detectors available today. It 11as been shown that large area APDs are potentially an excellent alternative to photomultiplier tubes (PMTs) in applications such as LIDAR, nuclear medicine, physics research and nuclear radiation… More

Room Temperature, Infrared Imaging Array

Award Year / Program / Phase: 1997 / SBIR / Phase I
Agency: NASA
Principal Investigator: Gerald Entine , PRESIDENT
Award Amount: $70,000.00

NOVEL X RAY DIFFRACTION DETECTOR FOR SYNCHROTRON SOURCES

Award Year / Program / Phase: 1997 / SBIR / Phase I
Agency: HHS
Principal Investigator: Nagarkar, vivek
Award Amount: $99,909.00

SBIR Phase I: Sensitive Semiconductor Optical Detector for Bore Hole Logging

Award Year / Program / Phase: 1997 / SBIR / Phase I
Agency: NSF
Principal Investigator: Kanai Shah
Award Amount: $75,000.00

NEW GERMANIUM DETECTORS FOR LUNG BURDEN SCREENING

Award Year / Program / Phase: 1997 / SBIR / Phase II
Agency: HHS
Principal Investigator:
Award Amount: $750,000.00

SBIR Phase I: A Novel Flat Panel Detector for X-Ray Diffraction

Award Year / Program / Phase: 1997 / SBIR / Phase I
Agency: NSF
Principal Investigator: Michael Squillante
Award Amount: $75,000.00

SCINTILLATOR FOR HIGH RESOLUTION MAMMOGRAPHY

Award Year / Program / Phase: 1997 / SBIR / Phase I
Agency: HHS
Principal Investigator: Nagarkar, vivek
Award Amount: $100,000.00

LOW COST AVALANCHE PHOTODIODE GAMMA CAMERA

Award Year / Program / Phase: 1997 / SBIR / Phase I
Agency: HHS
Principal Investigator: Entine, gerald
Award Amount: $100,000.00

Solid-State Neutron Detection with LiZnP

Award Year / Program / Phase: 1998 / SBIR / Phase I
Agency: DOE
Principal Investigator: Mr. Kani S. Shah , Senior Scientist
Award Amount: $75,000.00
Abstract:
50983-98-I Solid-State Neutron Detection with LiZnP--Radiation Monitoring Devices, Inc., 44 Hunt Street, Watertown, MA 02172-4624; (617) 926-1167 Mr. Kani S. Shah, Principal Investigator Dr. Gerald Entine, Business Official DOE Grant No. DE-FG02-98ER82651 Amount: $75,000 Neutron detection and… More

Screen-Printed Solar Cells Based on Nanocrystalline TiO2 Films

Award Year / Program / Phase: 1998 / SBIR / Phase I
Agency: DOE
Principal Investigator: Dr. Micheel R. Squillante , Vice President
Award Amount: $75,000.00
Abstract:
50533-98-I Screen-Printed Solar Cells Based on Nanocrystalline TiO2 Films--Radiation Monitoring Devices, Inc., 44 Hunt Street, , Watertown, MA 02172-4624; (617) 926-1167 Dr. Micheel R. Squillante, Principal Investigator Dr. Gerald Entine, Business Official DOE Grant No. DE-FG02-98ER82649 Amount: … More

APD Arrays for Calorimetric and Tracking Applications

Award Year / Program / Phase: 1998 / SBIR / Phase I
Agency: DOE
Principal Investigator: Dr. Stefan Vasile , Senior Scientist
Award Amount: $75,000.00
Abstract:
50574-98-I APD Arrays for Calorimetric and Tracking Applications--Radiation Monitoring Devices, Inc., 44 Hunt Street, Watertown, MA 02172-4624; (617) 926-1167 Dr. Stefan Vasile, Principal Investigator Dr. Gerald Entine, Business Official DOE Grant No. DE-FG02-98ER82652 Amount: $75,000 Advanced… More

Large Area, Low cost APDs Using Planar Processing

Award Year / Program / Phase: 1998 / SBIR / Phase I
Agency: DOE
Principal Investigator: Dr. Gerald Entine , President
Award Amount: $75,000.00
Abstract:
50811-98-I Large Area, Low Cost APDs Using Planar Processing--Radiation Monitoring Devices, Inc., 44 Hunt Street, Watertown, MA 02172-4624; (617) 926-1167 Dr. Gerald Entine, Principal Investigator Dr. Gerald Entine, Business Official DOE Grant No. DE-FG02-98ER82650 Amount: $75,000 Silicon… More

New Imaging X-Ray Sensor Technology for Real-Time Nondestructive Testing

Award Year / Program / Phase: 1998 / SBIR / Phase I
Agency / Branch: DOD / MDA
Principal Investigator: Kanai S. Shah
Award Amount: $65,000.00
Abstract:
X-ray imaging is an important technique which is used in variety of applications such as general radiology in medicine, astronomical observations, non-destructive testing, X-ray diffraction for materials studies and others. The ability of X-rays to penetrate deep in to matter allows investigation of… More

Low Cost Avalanche Photodiodes and Photodiode Arrays

Award Year / Program / Phase: 1998 / SBIR / Phase II
Agency / Branch: DOD / MDA
Principal Investigator: Michael R. Squillante, Ph
Award Amount: $750,000.00
Abstract:
Silicon avalanche photodiodes are among the most sensitive optical detectors available today. It 11as been shown that large area APDs are potentially an excellent alternative to photomultiplier tubes (PMTs) in applications such as LIDAR, nuclear medicine, physics research and nuclear radiation… More

NOVEL NEUTRON SENSOR FOR MACROMOLECULAR CRYSTALLOGRAPHY

Award Year / Program / Phase: 1998 / SBIR / Phase I
Agency: HHS
Principal Investigator: Entine, Gerald
Award Amount: $99,996.00

SOLID STATE DETECTOR FOR GAS CHROMATOGRAPHY

Award Year / Program / Phase: 1998 / SBIR / Phase II
Agency: HHS
Principal Investigator:
Award Amount: $750,000.00

SCINTILLATOR STRUCTURE FOR X-RAY MICROTOMOGRAPHY

Award Year / Program / Phase: 1998 / SBIR / Phase I
Agency: HHS
Principal Investigator: Nagarkar, Vivek V
Award Amount: $100,000.00

DIGITAL MAMMOGRAPHY WITH CMOS READOUT

Award Year / Program / Phase: 1998 / SBIR / Phase I
Agency: HHS
Principal Investigator: Entine, Gerald
Award Amount: $100,000.00

A Novel Flat Panel Detector for X-Ray Diffraction

Award Year / Program / Phase: 1998 / SBIR / Phase II
Agency: NSF
Principal Investigator: Michael Squillante
Award Amount: $400,000.00

DIRECT CONVERSION DETECTOR FOR DIGITAL FLUOROSCOPY

Award Year / Program / Phase: 1998 / SBIR / Phase I
Agency: HHS
Principal Investigator: Squillante, Michael R
Award Amount: $100,000.00

NOVEL, PORTABLE SYSTEM FOR HEMODYNAMIC DIAGNOSTICS

Award Year / Program / Phase: 1998 / SBIR / Phase I
Agency: HHS
Principal Investigator: Vasile, Stefan
Award Amount: $99,575.00

NOVEL SILICON DETECTORS FOR EXAFS STUDIES

Award Year / Program / Phase: 1998 / SBIR / Phase I
Agency: HHS
Principal Investigator: Squillante, Michael R
Award Amount: $100,000.00

COMPACT PET SYSTEM FOR BREAST CANCER IMAGING

Award Year / Program / Phase: 1998 / SBIR / Phase I
Agency: HHS
Principal Investigator: Karger, Arieh
Award Amount: $100,000.00

N/A

Award Year / Program / Phase: 1999 / SBIR / Phase II
Agency: HHS
Principal Investigator: Karger Arieh
Award Amount: $753,118.00

New High Density Scintillator-Based X-ray Imaging System for Nondestructive Evaluation of Composite Structures

Award Year / Program / Phase: 1999 / SBIR / Phase I
Agency / Branch: DOD / NAVY
Principal Investigator: Vivek Nagarkar PhD
Award Amount: $70,000.00
Abstract:
Not Available The objective of this proposal is to demonstrate 1) new principles of sampling and 2) new principles of beam sampling will allow obtaining of up to billion times attenuated replica of the beam. Acousto-optical diffractive gratings in noble gases kept at normal atmospheric pressure and… More

N/A

Award Year / Program / Phase: 1999 / SBIR / Phase II
Agency: DOE
Principal Investigator: Dr Gerald Entine , President
Award Amount: $750,000.00

N/A

Award Year / Program / Phase: 1999 / SBIR / Phase II
Agency: HHS
Principal Investigator: Nagarkar vivek
Award Amount: $754,690.00

N/A

Award Year / Program / Phase: 1999 / SBIR / Phase II
Agency: HHS
Principal Investigator: Entine gerald
Award Amount: $748,623.00

N/A

Award Year / Program / Phase: 1999 / SBIR / Phase II
Agency: HHS
Principal Investigator: Nagarkar vivek
Award Amount: $750,000.00

APD Arrays for Scintillating Fiber Readout

Award Year / Program / Phase: 1999 / SBIR / Phase I
Agency: NASA
Principal Investigator: Kanai Shah, Group Leader
Award Amount: $70,000.00

N/A

Award Year / Program / Phase: 1999 / SBIR / Phase I
Agency: HHS
Principal Investigator: Vivek Nagarkar
Award Amount: $100,000.00
Abstract:
Not Available This SBIR topic is timely and of great importance. It identifies a significant need for both military and civilian applications that will become more and more prevalent in the immediate future. In response to this SBIR topic, we propose here an innovative presentation concept and the… More

N/A

Award Year / Program / Phase: 1999 / SBIR / Phase I
Agency: HHS
Principal Investigator: Gerald Entine
Award Amount: $100,000.00
Abstract:
Not Available In high heat flux applications, typical regeneratively-cooled combustion chambers have very high pressure drops which significantly increase the demands on turbomachinery. These high pressure drops are largely due to high coolant velocities in the regen circuits caused by the use of… More

Advanced Micro-Pixelized Scintillator for Structural Biology

Award Year / Program / Phase: 1999 / SBIR / Phase I
Agency: NSF
Principal Investigator: Vivek Nagarkar
Award Amount: $100,000.00

LOW POWER, HIGH SENSITIVITY, ELEC OLFACTORY SENSORS

Award Year / Program / Phase: 1999 / SBIR / Phase I
Agency: HHS
Principal Investigator: Stefan Vasile
Award Amount: $100,000.00
Abstract:
Not Available Composite materials offer significant benefits for the next generation of lithography tools, including dramatic improvements in weight, vibrational stability, and thermal stability. These advantages lead to higher stage speeds, reduced settling times, improved positional accuracies,… More

LARGE VOLUME CDZNTE GROWTH FOR NUCLEAR IMAGING

Award Year / Program / Phase: 1999 / SBIR / Phase I
Agency: HHS
Principal Investigator: Michael R. Squillante
Award Amount: $100,000.00
Abstract:
Not Available This proposal encompasses a reinforcement alternative to steel rebars that are deteriorating due to corrosion on waterfront constructions. Fiber reinforced polymer reinforcing has been used in the past decade as it offers great potential for use in concrete construction under… More

LOW COST PHOTOCONDUCTOR FOR DIGITAL XRAY IMAGING

Award Year / Program / Phase: 1999 / SBIR / Phase I
Agency: HHS
Principal Investigator: Michael R. Squillante
Award Amount: $100,000.00
Abstract:
Not Available The proposed effort will result in a data formatter that will have the capability to significantly improve the bit rate efficiencies of Pulse Code Modulated data telemetered form test vehicles. The key features of the formatter required to accomplish this are: 1) the ability to… More

Environmental Monitoring Comapct Raman Lidar System Utilizing APD Array Detectors

Award Year / Program / Phase: 1999 / SBIR / Phase I
Agency: EPA
Principal Investigator:
Award Amount: $70,000.00
Abstract:
Not Available We propose to develop a novel, low-cost, amorphous silicon (a-Si:H) based modular to be integrated with a spacecraft thermal blanket for an auxiliary spacecraft power system. This new design is unique from ECD's present multi-junction module design in that an ultralight kapton… More

An Advanced Avalanche-Photodiode Based Spectroscopic Radiation Imager

Award Year / Program / Phase: 1999 / SBIR / Phase I
Agency: DOE
Principal Investigator:
Award Amount: $100,000.00
Abstract:
Not Available The emerging global information infrastructure comprises wire-based and wireless networks of vast complexity that will provide internetworking services using Next Generation Internet (NGI) technologies: revolutionary applications, gigabit capacity wireless networking, internetworking… More

Large Volume Detectors from New CdZnTe Grwoth Process

Award Year / Program / Phase: 1999 / SBIR / Phase I
Agency: DOE
Principal Investigator:
Award Amount: $100,000.00
Abstract:
Not Available Net Squared proposes developing a programming system, or framework, for processing and analyzing audit trails generated by host operating systems. This programming system, called the Audit Workbench, will provide (1) configuration and management for the collection of audit records,… More

Solid-State Neutron Detection Materials

Award Year / Program / Phase: 1999 / SBIR / Phase I
Agency: DOE
Principal Investigator:
Award Amount: $100,000.00
Abstract:
Not Available The Air Force Information Directorate is soliciting innovative technologies for Global Information Exchange that can simultaneously handle command, control, communication, computers, and intelligence data. In response, the Applied Technology Division of Physical Optics Corporation… More

Real-Time Obstacle Detection Ladar System Utilizing Ultra-Sensitive APD Array

Award Year / Program / Phase: 1999 / SBIR / Phase I
Agency / Branch: DOD / ARMY
Principal Investigator: Arieh Karger
Award Amount: $70,000.00
Abstract:
Not Available Sensor developers require the capability to easily generate scenes used to test sensor designs. As with model atmospheres used by MODTRAN/MOSART, the community recognized the need for model terrain materials with full optical/thermal specifications. This database would give users the… More

Miniature, Non-Invasive Sensor for Multi-Site Measurement of Tissue Microvascular Blood Flow

Award Year / Program / Phase: 1999 / SBIR / Phase I
Agency / Branch: DOD / ARMY
Principal Investigator: Stefan Vasile PhD
Award Amount: $70,000.00
Abstract:
Not Available This Small Business Innovative Research Phase I Project develops and demonstrates an electrochemical sensor for detecting and quantifying the concentration level of water in aviation fuel. Sediment and water degrade the quality of aircraft fuel at concentration levels as low as 2 mg/l… More

N/A

Award Year / Program / Phase: 2000 / SBIR / Phase I
Agency: HHS
Principal Investigator: Gerald Entine
Award Amount: $0.00

N/A

Award Year / Program / Phase: 2000 / SBIR / Phase II
Agency: HHS
Principal Investigator: Gerald Entine
Award Amount: $375,005.00

N/A

Award Year / Program / Phase: 2000 / SBIR / Phase I
Agency: NASA
Principal Investigator: Arieh Karger, M.Sci., Group Leader
Award Amount: $70,000.00

N/A

Award Year / Program / Phase: 2000 / SBIR / Phase I
Agency: DOE
Principal Investigator: Mitchell Woodring, Senior Scientist
Award Amount: $100,000.00

N/A

Award Year / Program / Phase: 2000 / SBIR / Phase I
Agency: DOE
Principal Investigator: Arieh Karger, Principal Investigator
Award Amount: $100,000.00

N/A

Award Year / Program / Phase: 2000 / SBIR / Phase I
Agency: DOE
Principal Investigator: Michael R. Squillante, Vice President
Award Amount: $100,000.00

N/A

Award Year / Program / Phase: 2000 / SBIR / Phase I
Agency: DOE
Principal Investigator: Gerald Entine, President
Award Amount: $100,000.00

N/A

Award Year / Program / Phase: 2000 / SBIR / Phase I
Agency: HHS
Principal Investigator: Michael R. Squillante
Award Amount: $100,000.00

N/A

Award Year / Program / Phase: 2000 / SBIR / Phase I
Agency / Branch: DOD / ARMY
Principal Investigator: Arieh Karger, M.Sci.
Award Amount: $120,000.00

N/A

Award Year / Program / Phase: 2000 / SBIR / Phase I
Agency: NSF
Principal Investigator: Vivek Nagarkar
Award Amount: $0.00

N/A

Award Year / Program / Phase: 2000 / SBIR / Phase II
Agency: NSF
Principal Investigator: Vivek Nagarkar
Award Amount: $400,000.00

N/A

Award Year / Program / Phase: 2000 / SBIR / Phase I
Agency: HHS
Principal Investigator: Gerald Entine
Award Amount: $100,000.00

N/A

Award Year / Program / Phase: 2000 / SBIR / Phase I
Agency: HHS
Principal Investigator: Michael R. Squillante
Award Amount: $100,000.00

N/A

Award Year / Program / Phase: 2000 / SBIR / Phase I
Agency: EPA
Principal Investigator: Arieh Karger
Award Amount: $70,000.00
Abstract:
Not Available Morgan Research Corporation proposes to develop a unique non-contact method of mapping the uniformity of carrier concentrations and absorption in binary and tertiary semiconducting compounds of zinc in the temperature range of 300K-77K (Phase I) and 300K-

N/A

Award Year / Program / Phase: 2000 / SBIR / Phase I
Agency: HHS
Principal Investigator: Gerald Entine
Award Amount: $0.00

N/A

Award Year / Program / Phase: 2000 / SBIR / Phase II
Agency: HHS
Principal Investigator: Gerald Entine
Award Amount: $387,706.00

N/A

Award Year / Program / Phase: 2000 / SBIR / Phase I
Agency: HHS
Principal Investigator: Vivek Nagarkar
Award Amount: $0.00

N/A

Award Year / Program / Phase: 2000 / SBIR / Phase II
Agency: HHS
Principal Investigator: Vivek Nagarkar
Award Amount: $405,263.00

N/A

Award Year / Program / Phase: 2000 / SBIR / Phase I
Agency: DOE
Principal Investigator: Mitchell Woodring, R&D Group Leader
Award Amount: $0.00

N/A

Award Year / Program / Phase: 2000 / SBIR / Phase II
Agency: DOE
Principal Investigator: Mitchell Woodring, R&D Group Leader
Award Amount: $750,000.00

Determination of Radionuclide Depth Distribution by Collimated Gamma-Ray Spectroscopy

Award Year / Program / Phase: 2001 / SBIR / Phase I
Agency: DOE
Principal Investigator: Arich Karger, Group Leader
Award Amount: $100,000.00
Abstract:
65584 To meet regulatory and personnel health needs, the Department of Energy (DOE) must monitor radioactive isotopes to determine real-time activity levels over long periods of time. Improvements in sensitivity over current detection systems are required to meet present and future regulatory and… More

Multi-Megawatt Circulator for TE01 Waveguide

Award Year / Program / Phase: 2001 / SBIR / Phase I
Agency: DOE
Principal Investigator: Michael R. Squillante, Vice President
Award Amount: $100,000.00
Abstract:
65458 Scintillation spectrometers, consisting of inorganic scintillation crystals coupled to photomultiplier tubes (PMTs), are an important element of nuclear and elementary particle physics experiments. Performance of the detection systems used in these experiments is often limited by the… More

Axisymmetric, Emittance-Compensated Electron Gun

Award Year / Program / Phase: 2001 / SBIR / Phase I
Agency: DOE
Principal Investigator: Geraldine Entine, President
Award Amount: $100,000.00
Abstract:
65689 For an increasing number of human diseases, smaller animals such as mice and rats can serve as effective models. Accordingly, high-resolution radionuclide imaging, such as positron emission tomography (PET), of small animals can contribute unique information. However, clinical PET scanners… More

Novel Nano-Structured Catalyst for Steam Gasification of Carbonaceous Feedstocks

Award Year / Program / Phase: 2001 / SBIR / Phase I
Agency: DOE
Principal Investigator: Kanai S. Shah, Group Leader
Award Amount: $100,000.00
Abstract:
65526 Current and next-generation experiments in nuclear and particle physics require detectors with high spatial resolution, fast response, and accurate data. However, current technology limits advances made in these areas. This project will develop a position-sensitive detector that provides… More

Novel Wear Resistant and Thermally Insulative Materials

Award Year / Program / Phase: 2001 / SBIR / Phase II
Agency / Branch: DOD / ARMY
Principal Investigator: Arieh Karger, Group Leader
Award Amount: $730,000.00
Abstract:
The Phase I effort successfully integrated micro-APD arrays into a detection system that can accommodate many microscale analysis platforms, including genomic-based systems on glass, silicon, plastic and PDMS (poly-dimethylsiloxane). We demonstrated thefeasibility of our detection platform by… More

A Photon-Counting Spectrometer for Elemental Analysis using LIBS

Award Year / Program / Phase: 2001 / SBIR / Phase I
Agency: NASA
Principal Investigator: Arieh 1. M.Sci., Group Leader
Award Amount: $70,000.00
Abstract:
Scientists have used laser-induced breakdown spectroscopy (LIBS) over the past decade to perform elemental analysis of soil, water and gases. The formation of laser-induced plasma, which produces a localized blackbody source for atomic emissions, enables this technology. Collection of the plasma's… More

NOVEL SILICON DETECTORS FOR EXAFT STUDIES

Award Year / Program / Phase: 2001 / SBIR / Phase I
Agency: HHS
Principal Investigator: Michael R. Squillante
Award Amount: $0.00

NOVEL SILICON DETECTORS FOR EXAFT STUDIES

Award Year / Program / Phase: 2001 / SBIR / Phase II
Agency: HHS
Principal Investigator: Michael R. Squillante
Award Amount: $357,226.00

Advan Scintillator Structure for X-Ray Microtomography

Award Year / Program / Phase: 2001 / SBIR / Phase I
Agency: HHS
Principal Investigator: Vivek V. Nagarkar
Award Amount: $0.00

Advan Scintillator Structure for X-Ray Microtomography

Award Year / Program / Phase: 2001 / SBIR / Phase II
Agency: HHS
Principal Investigator: Vivek V. Nagarkar
Award Amount: $373,961.00

LOW POWER,HIGH SENSITIVITY,ELECTRONIC OLFACTORY SENSORS

Award Year / Program / Phase: 2001 / SBIR / Phase I
Agency: HHS
Principal Investigator: Arieh M. Karger
Award Amount: $0.00

A Fast, High Light Output Scintillator for Gamma Ray and Neutron Detection

Award Year / Program / Phase: 2001 / SBIR / Phase I
Agency: DOE
Principal Investigator: Gerald Entine, President
Award Amount: $0.00
Abstract:
60344 The identification of fast, bright scintillators is a continual goal among scientists who design and manufacture radiation detection systems. Unfortunately, the scintillator is often the limiting technology that impedes product development and adds substantial cost. Many materials… More

LARGE VOLUME CdZnTe DETECTORS FOR NUCLEAR IMAGINGE

Award Year / Program / Phase: 2001 / SBIR / Phase I
Agency: HHS
Principal Investigator: Michael R. Squillante
Award Amount: $0.00

LARGE VOLUME CdZnTe DETECTORS FOR NUCLEAR IMAGINGE

Award Year / Program / Phase: 2001 / SBIR / Phase II
Agency: HHS
Principal Investigator: Michael R. Squillante
Award Amount: $375,000.00

A Fast, High Light Output Scintillator for Gamma Ray and Neutron Detection

Award Year / Program / Phase: 2001 / SBIR / Phase II
Agency: DOE
Principal Investigator: Gerald Entine, President
Award Amount: $750,000.00
Abstract:
60344 The identification of fast, bright scintillators is a continual goal among scientists who design and manufacture radiation detection systems. Unfortunately, the scintillator is often the limiting technology that impedes product development and adds substantial cost. Many materials… More

Advanced Detector Design for Large Area, Ultra-Fast X-ray Imaging

Award Year / Program / Phase: 2001 / SBIR / Phase I
Agency / Branch: DOD / ARMY
Principal Investigator: Vivek Nagarkar, Group Leader
Award Amount: $70,000.00
Abstract:
High speed x-ray imaging is extremely important for several military and civilian applications such as imaging exploding land mines, high speed computed tomography for medical imaging, time resolved x-ray diffraction of biological systems, and drugdevelopment research. The advent of high flux,… More

LOW POWER,HIGH SENSITIVITY,ELECTRONIC OLFACTORY SENSORS

Award Year / Program / Phase: 2001 / SBIR / Phase II
Agency: HHS
Principal Investigator: Arieh M. Karger
Award Amount: $371,423.00

A Comprehensive Hard X-/Soft Gamma-ray Imaging Syst. for Astro. using APD Arrays

Award Year / Program / Phase: 2001 / SBIR / Phase I
Agency: NASA
Principal Investigator: Arieh 1. M.Sci., Group Leader
Award Amount: $0.00
Abstract:
A critically important region of the electromagnetic spectrum is the hard X-ray/soft gamma-ray band from 10 KeV to a few MeVs. In this band, a wealth of astrophysical processes occur in an even greater diversity of astrophysical objects and phenomena, both on a compact and diffuse scale.… More

A Comprehensive Hard X-/Soft Gamma-ray Imaging Syst. for Astro. using APD Arrays

Award Year / Program / Phase: 2001 / SBIR / Phase II
Agency: NASA
Principal Investigator: Arieh 1. M.Sci., Group Leader
Award Amount: $600,000.00
Abstract:
A critically important region of the electromagnetic spectrum is the hard X-ray/soft gamma-ray band from 10 KeV to a few MeVs. In this band, a wealth of astrophysical processes occur in an even greater diversity of astrophysical objects and phenomena, both on a compact and diffuse scale.… More

A Liquid-Desiccant Heating/Cooling System Powered by Solar Energy

Award Year / Program / Phase: 2001 / SBIR / Phase I
Agency: DOE
Principal Investigator: Paul Bennett, Senior Scientist
Award Amount: $100,000.00
Abstract:
65573 The use of neutrons for materials characterization is growing. As more powerful neutron sources become available, corresponding advances in neutron detectors will be required. However, advances in neutron detectors have come slowly, compared to other types of detectors (x-rays, charged… More

High Resolution Imaging Detector for Mammography

Award Year / Program / Phase: 2001 / SBIR / Phase I
Agency: HHS
Principal Investigator: Gerald Entine
Award Amount: $211,416.00
Abstract:
DESCRIPTION (provided by applicant): Breast carcinoma is the leading cause of cancer in women in the U.S. It is well known that if breast cancer is detected when the tumor is small and axillary nodes are not involved, the survival rate is very high. However, if the… More

CZT Arrays for Ultra-fast X-ray Imaging

Award Year / Program / Phase: 2001 / SBIR / Phase I
Agency / Branch: DOD / ARMY
Principal Investigator: Gerald Entine, President
Award Amount: $120,000.00
Abstract:
Cadmium zinc telluride (CZT) is the room temperature x-ray detector of choice for non-destructive imaging applications. Monolithic arrays with high count rate capability (> 1 x 106 counts/pixel) are required for ultra-fast hyperspectral x-ray imaging.Presently, the yield of CZT arrays which can… More

A NOVEL DETECTOR FOR DIGITAL MAMMOGRAPHY

Award Year / Program / Phase: 2001 / SBIR / Phase I
Agency: HHS
Principal Investigator: Vivek V. Nagarkar
Award Amount: $100,000.00
Abstract:
DESCRIPTION (Provided by Applicant): Early detection of breast tumors is critical to the successful treatment of breast cancer. At present, x-ray mammography is the only imaging modality with a proven capability for detecting early-stage breast cancer and reducing… More

INTRAOPERATIVE DIGITAL IMAGING PROBE

Award Year / Program / Phase: 2001 / SBIR / Phase I
Agency: HHS
Principal Investigator: Gerald Entine
Award Amount: $100,000.00

AFTERGLOW Csl(Tl) SCINTILLATOR FOR MEDICAL APPLICATIONS

Award Year / Program / Phase: 2001 / SBIR / Phase I
Agency: HHS
Principal Investigator: Michael R. Squillante
Award Amount: $100,000.00
Abstract:
DESCRIPTION (Provided by Applicant): CsI doped with thallium is one of the most important scintillators currently in use. In terms of conversion of ionizing radiation to visible photons, it is the unquestioned leader in efficiency. Additionally, its high density, high atomic… More

HIGH RESOLUTION/ SENSITIVITY PET IMAGING OF SMALL ANIMAL

Award Year / Program / Phase: 2001 / SBIR / Phase I
Agency: HHS
Principal Investigator: Michael R. Squillante
Award Amount: $276,045.00
Abstract:
DESCRIPTION (provided by applicant): Positron Emission Tomography (PET) is an in vivo analog of autoradiography and has the potential to become a powerful new tool in imaging biological processes in small laboratory animals. With the ever increasing number of human disease… More

N/A

Award Year / Program / Phase: 2001 / SBIR / Phase I
Agency: HHS
Principal Investigator: Gerald Entine
Award Amount: $0.00

N/A

Award Year / Program / Phase: 2001 / SBIR / Phase II
Agency: HHS
Principal Investigator: Gerald Entine
Award Amount: $362,294.00

N/A

Award Year / Program / Phase: 2001 / SBIR / Phase I
Agency: HHS
Principal Investigator: Vivek Nagarkar
Award Amount: $0.00

Linear Avalanche Photodiode Detector Arrays for Gated Spectroscopy with Single-Photon Sensitivity

Award Year / Program / Phase: 2001 / SBIR / Phase I
Agency: DOE
Principal Investigator: Arieh Karger, Group Leader
Award Amount: $0.00
Abstract:
60258 Current high performance, time-resolved spectroscopy systems, used for detecting the proliferation of weapons of mass destruction, usually rely on image intensified charge coupled detector arrays (ICCDs). While ICCDs are capable of single photon sensitivity with nanosecond time… More

Linear Avalanche Photodiode Detector Arrays for Gated Spectroscopy with Single-Photon Sensitivity

Award Year / Program / Phase: 2001 / SBIR / Phase II
Agency: DOE
Principal Investigator: Arieh Karger, Group Leader
Award Amount: $750,000.00
Abstract:
60258 Current high performance, time-resolved spectroscopy systems, used for detecting the proliferation of weapons of mass destruction, usually rely on image intensified charge coupled detector arrays (ICCDs). While ICCDs are capable of single photon sensitivity with nanosecond time… More

LOW-COST, GEIGER-MODE MUAPD ARRAYS FOR CYTOMETRY

Award Year / Program / Phase: 2001 / SBIR / Phase I
Agency: HHS
Principal Investigator: Arieh M. Karger
Award Amount: $100,000.00
Abstract:
DESCRIPTION (abstract, from application): Flow cytometers provide invaluable information for the fields of developmental biology, genetics, hematology, immunology, oncology, microbiology, and parasitology. Multiparameter analysis greatly enhances the capability of flow… More

N/A

Award Year / Program / Phase: 2001 / SBIR / Phase II
Agency: HHS
Principal Investigator: Vivek Nagarkar
Award Amount: $374,737.00

Novel Avalanche Photodiode Arrays for Scintillating Fiber Readout

Award Year / Program / Phase: 2001 / SBIR / Phase I
Agency: DOE
Principal Investigator: Michael R. Squillante, Vice President
Award Amount: $0.00
Abstract:
60615 High energy physics is replete with complex detector systems that record interaction positions, energy deposition, and timing information from thousands of individual elements. Fiber optic tracking is a potentially simpler and less expensive method for large volume detectors that use… More

Novel Avalanche Photodiode Arrays for Scintillating Fiber Readout

Award Year / Program / Phase: 2001 / SBIR / Phase II
Agency: DOE
Principal Investigator: Michael R. Squillante, Vice President
Award Amount: $750,000.00
Abstract:
60615 High energy physics is replete with complex detector systems that record interaction positions, energy deposition, and timing information from thousands of individual elements. Fiber optic tracking is a potentially simpler and less expensive method for large volume detectors that use… More

HIGH PERFORMANCE DETECTOR FOR SMALL ANIMAL PET

Award Year / Program / Phase: 2001 / SBIR / Phase I
Agency: HHS
Principal Investigator: Vivek V. Nagarkar
Award Amount: $100,000.00
Abstract:
DESCRIPTION (Verbatim from the Applicant's Abstract): Positron Emission Tomography (PET) is an in vivo analog of autoradiography, which makes it a potentially powerful new tool for imaging biological processes in small laboratory animals. Its critical advantage is… More

CZT ARrays for Ultra-fast X-ray Imaging

Award Year / Program / Phase: 2002 / SBIR / Phase II
Agency / Branch: DOD / ARMY
Principal Investigator: Gerald Entine, President
Award Amount: $730,000.00
Abstract:
"Cadmium zinc telluride is the room temperature detector of choice for non-destructive imaging applications. Monolithic CZT arrays with high count-rate capability (>1e+6 cps/pixel) are required for ultra-fast hyperspectral x-ray imaging. Presently, theyield of CZT detector arrays that can perform… More

A Novel Position Sensitive Detector for Nuclear Radiation

Award Year / Program / Phase: 2002 / SBIR / Phase I
Agency: DOE
Principal Investigator: Kanai S. Shah
Award Amount: $0.00
Abstract:
65526 Current and next generation experiments in nuclear and particle physics require detectors with high spatial resolution, fast response, and accurate energy information. However, in many nuclear physics experiments, the existing detector technology is the limiting factor. This project… More

A Novel Position Sensitive Detector for Nuclear Radiation

Award Year / Program / Phase: 2002 / SBIR / Phase II
Agency: DOE
Principal Investigator: Kanai S. Shah
Award Amount: $750,000.00
Abstract:
65526 Current and next generation experiments in nuclear and particle physics require detectors with high spatial resolution, fast response, and accurate energy information. However, in many nuclear physics experiments, the existing detector technology is the limiting factor. This project… More

Power Optimizing Petabyte Disk System

Award Year / Program / Phase: 2002 / SBIR / Phase I
Agency: DOE
Principal Investigator: Geraldine Entine
Award Amount: $0.00
Abstract:
65689 For an increasing number of human diseases, smaller animals such as mice and rats can serve as effective models. Accordingly, high-resolution radionuclide imaging, such as positron emission tomography (PET), of small animals can contribute unique information. However, clinical PET scanners… More

A Photon-Counting Spectrometer for Elemental Analysis using LIBS

Award Year / Program / Phase: 2002 / SBIR / Phase I
Agency: NASA
Principal Investigator: Arieh Karger,, Group Leader
Award Amount: $0.00
Abstract:
Scientists have used laser-induced breakdown spectroscopy (LIBS) over the past decade to perform elemental analysis of soil, water and gases. The formation of laser-induced plasma, which produces a localized blackbody source for atomic emissions, enables this technology. Collection of the plasma's… More

A Photon-Counting Spectrometer for Elemental Analysis using LIBS

Award Year / Program / Phase: 2002 / SBIR / Phase II
Agency: NASA
Principal Investigator: Arieh Karger,, Group Leader
Award Amount: $600,000.00
Abstract:
Scientists have used laser-induced breakdown spectroscopy (LIBS) over the past decade to perform elemental analysis of soil, water and gases. The formation of laser-induced plasma, which produces a localized blackbody source for atomic emissions, enables this technology. Collection of the plasma's… More

A High Sensitivity Beta Imaging System for Surface Assessment

Award Year / Program / Phase: 2002 / SBIR / Phase I
Agency: DOE
Principal Investigator: Arich Karger
Award Amount: $0.00
Abstract:
65584 The monitoring of tritium on various surfaces at DOE facilities presents unique challenges for dosimetry and health-risk assessment. Thus, there is a need for a hand-held, direct-reading instrument. So far, the methods proposed for this purpose have not had the sensitivity (or required… More

A Novel Hybrid Imaging Detector

Award Year / Program / Phase: 2002 / SBIR / Phase I
Agency: DOE
Principal Investigator: Kanai S. Shah
Award Amount: $100,000.00
Abstract:
70001 Current and next generation experiments in nuclear and particle physics require detectors with high spatial resolution, fast response, and accurate energy information. In many nuclear physics experiments, existing detector technology is the limiting factor. This project will… More

High Resolution Gamma Ray Spectrometer for Nuclear Non-Proliferation

Award Year / Program / Phase: 2002 / SBIR / Phase I
Agency: DOE
Principal Investigator: Kanai S. Shah
Award Amount: $100,000.00
Abstract:
70062 Gamma ray spectrometers are an important tool for checking the proliferation of the nuclear weapons. The requirements for the ?-ray spectrometers used in this application include good energy resolution, high detection efficiency, compact size, light weight, portability, and low power… More

A High Sensitivity Beta Imaging System for Surface Assessment

Award Year / Program / Phase: 2002 / SBIR / Phase II
Agency: DOE
Principal Investigator: Arich Karger
Award Amount: $749,999.00
Abstract:
65584 The monitoring of tritium on various surfaces at DOE facilities presents unique challenges for dosimetry and health-risk assessment. Thus, there is a need for a hand-held, direct-reading instrument. So far, the methods proposed for this purpose have not had the sensitivity (or required… More

A New Scintillator for Gamma Ray Spectroscopy

Award Year / Program / Phase: 2002 / SBIR / Phase I
Agency: DOE
Principal Investigator: Michael Squillante
Award Amount: $100,000.00
Abstract:
70000 Scintillation spectrometers, consisting of inorganic scintillation crystals coupled to photomultiplier tubes, are an important element of nuclear and elementary particle physics experiments. However, the performance of detection systems used in these experiments is often limited… More

Power Optimizing Petabyte Disk System

Award Year / Program / Phase: 2002 / SBIR / Phase II
Agency: DOE
Principal Investigator: Geraldine Entine
Award Amount: $750,000.00
Abstract:
65689 For an increasing number of human diseases, smaller animals such as mice and rats can serve as effective models. Accordingly, high-resolution radionuclide imaging, such as positron emission tomography (PET), of small animals can contribute unique information. However, clinical PET scanners… More

sbir/sttr phase i: A New Solid State Surgical Imaging Probe

Award Year / Program / Phase: 2002 / SBIR / Phase I
Agency: NSF
Principal Investigator: Gerald Entine
Award Amount: $100,000.00
Abstract:
This Small Business Innovation Research (SBIR) Phase I project proposes to develop a new intraoperative imaging probe based on a solid-state, compact readout sensor coupled to a high resolution, high light output converter. Nuclear Medicine imaging has been widely used to preoperatively image… More

Surface Enhanced Silicon Avalanche Photodiodes for Near-IR Detection

Award Year / Program / Phase: 2002 / SBIR / Phase I
Agency: NASA
Principal Investigator: Arieh M. Karger, Principal Investigator
Award Amount: $70,000.00
Abstract:
This Phase II SBIR builds on the exciting results demonstrated during the Phase I research. Using a new approach for enhancing the near-infrared (IR) sensitivity of high gain avalanche photodiodes (APDs), Radiation Monitoring Devices, Inc. (RMD) will develop a reliable procedure to produce APD… More

Surface Enhanced Silicon Avalanche Photodiodes for Near-IR Detection

Award Year / Program / Phase: 2002 / SBIR / Phase II
Agency: NASA
Principal Investigator: Arieh M. Karger, Principal Investigator
Award Amount: $599,999.00
Abstract:
This Phase II SBIR builds on the exciting results demonstrated during the Phase I research. Using a new approach for enhancing the near-infrared (IR) sensitivity of high gain avalanche photodiodes (APDs), Radiation Monitoring Devices, Inc. (RMD) will develop a reliable procedure to produce APD… More

HIGH PERFORMANCE DETECTOR FOR SMALL ANIMAL PET

Award Year / Program / Phase: 2002 / SBIR / Phase I
Agency: HHS
Principal Investigator: Vivek V. Nagarkar
Award Amount: $0.00
Abstract:
DESCRIPTION (provided by applicant):Positron Emission Tomography (PET) is an in vivo analog of autoradiography, which makes it a potentially powerful new tool for imaging biological processes and molecular targets in small laboratory animals. Its fundamental advantage is that functional data can be… More

HIGH PERFORMANCE DETECTOR FOR SMALL ANIMAL PET

Award Year / Program / Phase: 2002 / SBIR / Phase II
Agency: HHS
Principal Investigator: Vivek V. Nagarkar
Award Amount: $750,000.00
Abstract:
DESCRIPTION (provided by applicant):Positron Emission Tomography (PET) is an in vivo analog of autoradiography, which makes it a potentially powerful new tool for imaging biological processes and molecular targets in small laboratory animals. Its fundamental advantage is that functional data can be… More

HIGH RESOLUTION, LOW COST PET MODULE

Award Year / Program / Phase: 2002 / SBIR / Phase I
Agency: HHS
Principal Investigator: Gerald Entine
Award Amount: $512,803.00
Abstract:
DESCRIPTION (provided by applicant): Positron Emission Tomography (PET) has become an important tool in the fight against cancer. PET is now being used in diverse studies ranging from basic research in animal models of cancer in the mouse, through to diagnosis and staging of cancer patients in the… More

NOVEL DETECTOR FOR SMALL ANIMAL SPECT IMAGING

Award Year / Program / Phase: 2002 / SBIR / Phase I
Agency: HHS
Principal Investigator: Gerald Entine
Award Amount: $213,000.00
Abstract:
Nuclear medicine techniques (such as SPECT) have the potential to become powerful new tools in imaging biological processes in small laboratory animals. With the every increasing number of human disease models, particularly in the smaller animals such as mice and rats, the potential of high… More

SOLID STATE BETA IMAGING SENSOR FOR IMAGE GUIDED SURGERY

Award Year / Program / Phase: 2002 / SBIR / Phase I
Agency: HHS
Principal Investigator: Gerald Entine
Award Amount: $200,000.00
Abstract:
DESCRIPTION (provided by applicant): Nuclear Medicine imaging has been widely used to preoperatively image structures of interest for excisional biopsy. Radio-guided intraoperative procedures utilizing radiotracers have facilitated a cost-effective, highly specific means to locate suspect tissue and… More

BANDWIDTH-SELECTIVE, MLA APD-BASED FLOW CYTOMETER

Award Year / Program / Phase: 2002 / SBIR / Phase I
Agency: HHS
Principal Investigator: Mitchell L. Woodring
Award Amount: $99,902.00
Abstract:
In this Phase I work, we propose to carry out the research necessary to develop, test, and characterize a sophisticated, by avalanche-photodiode (APD) arrangement as a compact, high-performance replacement for photomultiplier tubes used in flow cytomers. Development of a high- performance,… More

HYBRID APD/ASIC DETECTOR MODULE FOR SMALL ANIMAL PET

Award Year / Program / Phase: 2002 / SBIR / Phase I
Agency: HHS
Principal Investigator: Michael R. Squillante
Award Amount: $0.00
Abstract:
DESCRIPTION (provided by applicant):The proposed Phase II research focuses upon an application specific integrated circuit (ASIC) that is necessary to support new avalanche photodiode (APD) and lutetium orthosilicate (LSO) detector module designed for small-animal PET applications. Based on our… More

HYBRID APD/ASIC DETECTOR MODULE FOR SMALL ANIMAL PET

Award Year / Program / Phase: 2002 / SBIR / Phase II
Agency: HHS
Principal Investigator: Michael R. Squillante
Award Amount: $750,000.00
Abstract:
DESCRIPTION (provided by applicant):The proposed Phase II research focuses upon an application specific integrated circuit (ASIC) that is necessary to support new avalanche photodiode (APD) and lutetium orthosilicate (LSO) detector module designed for small-animal PET applications. Based on our… More

SPECT/CT IMAGING OF SMALL ANIMALS

Award Year / Program / Phase: 2002 / SBIR / Phase I
Agency: HHS
Principal Investigator: Michael R. Squillante
Award Amount: $505,497.00
Abstract:
DESCRIPTION (provided by applicant): Nuclear medicine techniques (such as SPECT) have the potential to become powerful new tool in imaging biological processes in small laboratory animals. With the ever increasing number of human disease models, particularly in the smaller animals such as mice and… More

HIGH-SPEED MICRO-CT DETECTOR FOR PHYSIOLOGIC STUDIES

Award Year / Program / Phase: 2002 / SBIR / Phase I
Agency: HHS
Principal Investigator: Vivek V. Nagarkar
Award Amount: $100,000.00
Abstract:
Dedicated high-resolution small animal imaging systems have recently emerged as important new tools for cancer research. These systems permit noninvasive screening of animals for mutations or pathologies and to monitor disease progression and response to therapy. One imaging modality, x-ray… More

A NEW FAST HIGH RESOLUTION SCINTILLATOR FOR PET AND CT

Award Year / Program / Phase: 2002 / SBIR / Phase I
Agency: HHS
Principal Investigator: Michael R. Squillante
Award Amount: $0.00
Abstract:
Not Avaialble

A NEW FAST HIGH RESOLUTION SCINTILLATOR FOR PET AND CT

Award Year / Program / Phase: 2002 / SBIR / Phase II
Agency: HHS
Principal Investigator: Michael R. Squillante
Award Amount: $750,495.00
Abstract:
Not Avaialble

A NEW SCINTILLATOR FOR RADIONUCLIDE IMAGING

Award Year / Program / Phase: 2002 / SBIR / Phase I
Agency: HHS
Principal Investigator: Kanai S. Shah
Award Amount: $99,997.00
Abstract:
DESCRIPTION (provided by applicant):Single Photon Emission Computed Tomography (SPECT) is a powerful, non-invasive medical imaging technique which provides an image of the three-dimensional distribution of radionuclide in any slice through an organ under study in the body. These images allow… More

A SIMPLE, HIGH-SPEED, HIGHLY SENSITIVE VIRAL SENSOR

Award Year / Program / Phase: 2002 / SBIR / Phase I
Agency: HHS
Principal Investigator: Arieh M. Karger
Award Amount: $100,000.00
Abstract:
DESCRIPTION (provided by applicant):Radiation Monitoring Devices, Inc. proposes to design a simple, high speed, highly sensitive viral detection instrument. This instrument will measure fluorogenic reporter genes, which hybridize to complementary viral gene target inside a capillary waveguide. Our… More

HIGH RESOLUTION, LOW COST GAMMA CAMERA

Award Year / Program / Phase: 2002 / SBIR / Phase I
Agency: HHS
Principal Investigator: Michael R. Squillante
Award Amount: $100,000.00
Abstract:
DESCRIPTION (provided by applicant):The gamma ray scintillation camera is the instrument of choice for imaging both static and dynamic radioisotope distributions in vivo. Radionuclide imaging conducted using gamma cameras is used to obtain information about functionality, morphology, and metabolic… More

A New Scintillator for Gamma Ray Spectroscopy

Award Year / Program / Phase: 2003 / SBIR / Phase II
Agency: DOE
Principal Investigator: Michael Squillante
Award Amount: $750,000.00
Abstract:
70000S02-II Scintillation spectrometers, consisting of inorganic scintillation crystals coupled to photomultiplier tubes, are an important element of nuclear and elementary particle physics experiments. However, the performance of the detection systems used in these experiments is often limited… More

New N+ Contact for Germanium Strip Detectors

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency: DOE
Principal Investigator: Kanai S. Shah
Award Amount: $100,000.00
Abstract:
72157S03-I Germanium strip detectors are very promising for X-ray and ?-ray imaging with high resolution. However, existing n+ lithium electrodes prevent the full potential of high purity germanium (HPGe) strip detectors from being exploited in nuclear physics experiments as well as in many other… More

A Design of a New Readout Sensor for Spect

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency: DOE
Principal Investigator: Vivek V. Nagarkar
Award Amount: $100,000.00
Abstract:
72486S03-I With the ever increasing number of smaller animals, such as mice and rats, being used as human disease models, the demand for small animal imaging also has increased. In particular, the pharmaceutical industry requires the in vivo quantification of biological processes, to measure the… More

High Performance Pet Detector

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency: DOE
Principal Investigator: Kanai S. Shah
Award Amount: $100,000.00
Abstract:
72199S03-I Proton Emission Tomography (PET) is a powerful imaging tool that can provide diagnosis for symptoms of diseases such as Alzheimer¿s, cancer, head trauma, and stroke. The performance of current clinical PET systems is limited by available detector technology. An urgent need exists to… More

A Novel Design for CZT Gamma Ray Spectrometers

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency: DOE
Principal Investigator: Michael R. Squillante
Award Amount: $100,000.00
Abstract:
72619S03-I Gamma ray spectrometers are an important element of nuclear and elementary particle physics experiments. However, the performance of the detection systems used in these experiments is often limited by the properties of presently available detectors. This project will investigate a new… More

High Resolution Gamma Ray Spectrometer for Nuclear Non-Proliferation

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency: DOE
Principal Investigator: Kanai S. Shah
Award Amount: $0.00
Abstract:
70062S02-II Gamma ray spectrometers are an important tool for checking the proliferation of the nuclear weapons. For this purpose, the ?-ray spectrometers must provide good energy resolution, high detection efficiency, compact size, light weight, portability, and low power requirements. None of… More

High Resolution Gamma Ray Spectrometer for Nuclear Non-Proliferation

Award Year / Program / Phase: 2003 / SBIR / Phase II
Agency: DOE
Principal Investigator: Kanai S. Shah
Award Amount: $750,000.00
Abstract:
70062S02-II Gamma ray spectrometers are an important tool for checking the proliferation of the nuclear weapons. For this purpose, the ?-ray spectrometers must provide good energy resolution, high detection efficiency, compact size, light weight, portability, and low power requirements. None of… More

SBIR Phase I: Advanced Detectors for X-ray Diagnosis

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency: NSF
Principal Investigator: Michael Squillante
Award Amount: $100,000.00
Abstract:
This Small Business Innovation Research Phase I Project will investigate a novel low capacitance design of high purity silicon detectors that offer high-energy resolution, high efficiency, high count-rate operation and straightforward fabrication. By maintaining a low capacitance, the new detectors… More

Microorganism Imprinted Polymers (MOIPs) for Detection of Biological Warfare Agents

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency / Branch: DOD / CBD
Principal Investigator: Arieh M. Karger, Group Leader, Sr. Scienti
Award Amount: $69,996.00
Abstract:
Radiation Monitoring Device, Inc. (RMD) will develop microorganism imprinted polymers (MOIPs) that purify, concentrate, and identify bacterial and viral wargare agents. In Phase I we will develop polymer formulations and fluorescent labeling strategiesfor MOIPs targeted towards E. coli and B.… More

SBIR Phase I: A New High Efficiency, Low Cost Scintillator Screen for Digital Radiography

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency: NSF
Principal Investigator: Vivek Nagarkar
Award Amount: $100,000.00
Abstract:
This Small Business Innovation Research Phase I project aims to develop a new x-ray imaging screen that offers superior properties for digital radiography compared to current materials. Specifically, this new screen will address many of the limitations of digital x-ray imaging by allowing… More

Very Large, High Gain APDs for Particle Physics

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency: DOE
Principal Investigator: Kanai S. Shah
Award Amount: $100,000.00
Abstract:
73066S03-I For several decades photo-multiplier tubes (PMT) have been the key technology for sensing light in most high energy physics research operations. Although extraordinarily successful, PMT technology has a number of limitations: large PMTs cannot be mass produced, they cannot operate… More

Ultra Fast X-Ray Imaging Detector

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency / Branch: DOD / USAF
Principal Investigator: Vivek V. Nagarkar, Group Leader
Award Amount: $0.00
Abstract:
to High speed x-ray imaging is extremely important for several military and civilian applications such as analyzing ballistic impacts, imaging exploding land mines, medical computed tomography, and non-destructive testing. A lack of high-resolutiondetection systems with large active imaging areas… More

Fast, High Resolution Pet Detector

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency: DOE
Principal Investigator: Gerald Entine
Award Amount: $100,000.00
Abstract:
72085S03-I Proton Emission Technology (PET) is a powerful imaging tool that can provide diagnosis for symptoms of diseases such as Alzheimer¿s, cancer, head trauma, and stroke. However, the performance of current clinical PET systems is limited by available detector technology, and improved PET… More

Novel 2-D Digital Imaging Detector for Thermal Neutrons

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency / Branch: DOC / NIST
Principal Investigator: Sameer V. Tipnis
Award Amount: $75,000.00
Abstract:
The use of thermal neutrons has been widespread over the past several decades in many investigations such as non-destructive testing (NDT), neutron radiography and macromolecular crystallography. For some applications such as crystallographic diffraction studies, neutrons are scattered over 4o in… More

Ultra Fast X-Ray Imaging Detector

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency / Branch: DOD / USAF
Principal Investigator: Vivek V. Nagarkar, Group Leader
Award Amount: $100,000.00
Abstract:
High speed X-ray imaging is extremely important for several military and civilian applications such as analyzing ballistic impacts, imaging exploding land mines, medical computed tomography, time resolved X-ray diffraction of biological systems, and drugdevelopment research. The advent of high… More

A New Scintillator for Gamma Ray Spectroscopy

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency: DOE
Principal Investigator: Michael Squillante
Award Amount: $0.00
Abstract:
70000S02-II Scintillation spectrometers, consisting of inorganic scintillation crystals coupled to photomultiplier tubes, are an important element of nuclear and elementary particle physics experiments. However, the performance of the detection systems used in these experiments is often limited… More

Ultra Fast X-Ray Imaging Detector

Award Year / Program / Phase: 2003 / SBIR / Phase II
Agency / Branch: DOD / USAF
Principal Investigator: Vivek V. Nagarkar, Group Leader
Award Amount: $749,000.00
Abstract:
to High speed x-ray imaging is extremely important for several military and civilian applications such as analyzing ballistic impacts, imaging exploding land mines, medical computed tomography, and non-destructive testing. A lack of high-resolutiondetection systems with large active imaging areas… More

Portable, Hand-Held Inspection System for Aircraft Components

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency / Branch: DOD / NAVY
Principal Investigator: Timothy C. Tiernan, Group Director
Award Amount: $69,976.00
Abstract:
New technology is needed for the nondestructive detection and characterization of defects in aerospace structures, particularly those with complex shapes, that are used in high stress environments that accelerate degradation. Existing nondestructiveevaluation (NDE) techniques, based on ultrasonics,… More

NearlR Photon-counting Camera for Optical Tomography

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency: HHS
Principal Investigator: James F. Christian
Award Amount: $100,000.00
Abstract:
DESCRIPTION (provided by applicant): Early detection and routine clinical screening represent the first line of defense for preventing fatalities from cancer, a disease, which claimed 551,833, lives in the U.S. during the year 2000. Significant advances have been made in the medical imaging of… More

A Portable Biosensor for Francisella tularensis

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency: HHS
Principal Investigator: Clark M. Edson
Award Amount: $100,000.00
Abstract:
DESCRIPTION (provided by applicant): Radiation Monitoring Devices, Inc. proposes to design and build a portable bacteria sensor to identify Francisella tularensis, a CDC Category A agent of bioterrorism, in the field. The instrument will consist of a disposable microfluidic platform for carrying out… More

Intraoperative Digital Imaging Probe

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency: HHS
Principal Investigator: Gerald Entine
Award Amount: $0.00
Abstract:
DESCRIPTION (provided by applicant): Nuclear Medicine imaging is being widely used to preoperatively image structures of interest for excisional biopsy. Radioguided intraoperative procedures utilizing radiotracers have established cost effective, highly specific means to locate suspect tissue and… More

High resolution Mammography Sensor

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency: HHS
Principal Investigator: Michael R. Squillante
Award Amount: $219,601.00
Abstract:
DESCRIPTION (provided by applicant): Breast carcinoma is the leading cause of cancer in women in the U.S. It is well known that if breast cancer is detected when the tumor is small and axillary nodes are not involved, the survival rate is very high. However, if the cancer has spread with time, the… More

Intraoperative Digital Imaging Probe

Award Year / Program / Phase: 2003 / SBIR / Phase II
Agency: HHS
Principal Investigator: Gerald Entine
Award Amount: $751,590.00
Abstract:
DESCRIPTION (provided by applicant): Nuclear Medicine imaging is being widely used to preoperatively image structures of interest for excisional biopsy. Radioguided intraoperative procedures utilizing radiotracers have established cost effective, highly specific means to locate suspect tissue and… More

High Resolution Small Animal SPECT

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency: HHS
Principal Investigator: Michael R. Squillante
Award Amount: $100,003.00
Abstract:
DESCRIPTION (provided by applicant): Phase I: SPECT is non-invasive imaging technique which provides an image of the three dimensional distribution of radionuclide in any slice through an organ under study. These images allow investigation of metabolism in the region being studied and are a useful… More

High Sensitivity X-Ray Detector for Small Animal Combined PET/CT

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency: HHS
Principal Investigator: Vivek V. Nagarkar
Award Amount: $99,998.00
Abstract:
DESCRIPTION (provided by applicant): Dedicated high-resolution small animal imaging systems have emerged as important tools for cancer research. These systems permit noninvasive screening of mutations or pathologies, monitor disease progression and response to therapy. MicroPET has demonstrated… More

High Resolution, High Sensitivity PET Imaging of Small *

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency: HHS
Principal Investigator: Michael R. Squillante
Award Amount: $0.00
Abstract:
DESCRIPTION (provided by applicant): Positron Emission Tomography (PET) is an in vivo analog of autoradiography and has the potential to become a powerful new tool in imaging biological processes in small laboratory animals. With the ever increasing number of human disease models (including… More

High Resolution, High Sensitivity PET Imaging of Small *

Award Year / Program / Phase: 2003 / SBIR / Phase II
Agency: HHS
Principal Investigator: Michael R. Squillante
Award Amount: $923,197.00
Abstract:
DESCRIPTION (provided by applicant): Positron Emission Tomography (PET) is an in vivo analog of autoradiography and has the potential to become a powerful new tool in imaging biological processes in small laboratory animals. With the ever increasing number of human disease models (including… More

SBIR Phase II: Detection and Identification Instrument for Single Molecule Analysis

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency: NSF
Principal Investigator: Arieh M. Karger, Mr
Award Amount: $100,000.00
Abstract:
This Small Business Innovation Research (SBIR) Phase II project proposes to develop a novel, low cost laboratory instrument for genetic analysis and single molecule studies. The technology is suitable for the detection and identification of DNA and RNA through fluorescent hybridization probes… More

All-digital, CMOS-based Photodiode Camera

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency: NASA
Principal Investigator: James Christian, Principal Investigator
Award Amount: $70,000.00
Abstract:
CCDs (Charge-Coupled Devices), and more recently, CMOS (complementary-symmetry metal-oxide-semiconductor) APS (Active Pixel Sensor) cameras have revolutionized imaging instrumentation and the many fields that utilize these instruments. Both of these technologies rely on detecting, or integrating,… More

New Imaging X-Ray Sensor Technology for Real-Time Nondestructive Testing

Award Year / Program / Phase: 2003 / SBIR / Phase II
Agency / Branch: DOD / MDA
Principal Investigator: Shah, President
Award Amount: $750,000.00
Abstract:
X-ray imaging is an important technique which is used in variety of applications such as nondestructive evaluation, radiology in medicine, astronomical observations, X-ray diffraction for materials studies, and others. The ability of X-rays to penetratedeep in to matter allows investigation of… More

New Imaging X-Ray Sensor Technology for Real-Time Nondestructive Testing

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency / Branch: DOD / MDA
Principal Investigator: Shah, President
Award Amount: $0.00
Abstract:
X-ray imaging is an important technique which is used in variety of applications such as nondestructive evaluation, radiology in medicine, astronomical observations, X-ray diffraction for materials studies, and others. The ability of X-rays to penetratedeep in to matter allows investigation of… More

High Gain, Position Sensitive, Avalanche Photodiode for Optical Communication

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency: NASA
Principal Investigator: Richard Myers
Award Amount: $70,000.00
Abstract:
This Phase I SBIR describes the fabrication and characterization of a position sensitive detector with internal gain. During this program, Radiation Monitoring Devices (RMD) will fabricate several position sensitive avalanche photodiodes (APDs), including both quadrant and lateral-effect… More

Portable and Environmentally Friendly Trap for Haematophagous Arthropods

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency / Branch: DOD / OSD
Principal Investigator: Stuart Miller, Senior Scientist
Award Amount: $100,000.00
Abstract:
Haematophagous arthropods including ticks and mosquitoes spread many deadly diseases and pose serious threats to people throughout the world. Current measures only mediate the problem, and no solution exists to stop the spread of disease by these vectors.Trapping these arthropods can be a… More

Ultra-Fast, Efficient Scintillator for PET

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency: HHS
Principal Investigator: Kanai S. Shah
Award Amount: $200,000.00
Abstract:
DESCRIPTION (provided by applicant): Positron Emission Tomography (PET) is a nuclear imaging technology that makes use of a range of positron-labeled tracers to provide images that reflect different parameters relevant to tumor biology. PET technology is now playing a prominent and an… More

A New High Performance Detector for Small Animal SPECT

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency: HHS
Principal Investigator: Vivek V. Nagarkar
Award Amount: $203,784.00
Abstract:
DESCRIPTION (provided by applicant): Nuclear medicine techniques, such as SPECT, have a potential to become powerful new tools for imaging biological processes on a cellular or molecular level. With ever increasing number of human disease models, particularly in smaller animals such as mice and… More

Identifying Pathogenic Viruses on Microfluidic Platform

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency: HHS
Principal Investigator: Louis H. Strong
Award Amount: $100,000.00
Abstract:
Abstract. Species-level Identification of Pathogenic Viruses on a Microfluidics Platform Radiation Monitoring Devices, Inc. (RMD) proposes to develop a field-portable, low power and inexpensive instrument for the identification of pathogenic viruses which are collected by an aerosol concentrator. It… More

SBIR Phase II: Advanced Detectors for X-ray Diagnosis

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency: NSF
Principal Investigator: Michael R. Squillante, Dr
Award Amount: $100,000.00
Abstract:
This Small Business Innovation Research (SBIR) Phase II research project involves an innovative gas sensor (DiskFET) based on a commercially available hard drive mechanism, proprietary polymers for sensing, and a modified Field Effect Transistor (FET). The device as envisioned is small, handheld, … More

High Resolution Imaging Detector for Mammography

Award Year / Program / Phase: 2004 / SBIR / Phase II
Agency: HHS
Principal Investigator: Gerald Entine
Award Amount: $1,050,000.00
Abstract:
DESCRIPTION (provided by applicant): Breast carcinoma is the leading cause of cancer in women in the U.S. It is well known that if breast cancer is detected when the tumor is small and axillary nodes are not involved, the survival rate is very high. However, if the cancer has spread with time, the… More

High Performance PET Detector

Award Year / Program / Phase: 2004 / SBIR / Phase II
Agency: DOE
Principal Investigator: Kanai S. Shah, Mr.
Award Amount: $750,000.00
Abstract:
72199-Proton Emission Tomography (PET) is a powerful imaging tool that can provide diagnosis for symptoms of diseases such as Alzheimer¿s, cancer, head trauma, and stroke. The performance of current clinical PET systems is limited by available detector technology. An urgent need exists to improve… More

A Novel Design for CZT Gamma Ray Spectrometers

Award Year / Program / Phase: 2004 / SBIR / Phase II
Agency: DOE
Principal Investigator: Michael R. Squillante, Dr.
Award Amount: $750,000.00
Abstract:
72619-Gamma ray spectrometers are an important element of nuclear and elementary particle physics experiments. However, the performance of the detection systems used in these experiments is often limited by the properties of presently available detectors. This project will investigate a new design… More

Fast, High Resolution PET Detector

Award Year / Program / Phase: 2004 / SBIR / Phase II
Agency: DOE
Principal Investigator: Gerald Entine, Dr.
Award Amount: $750,000.00
Abstract:
72085-Proton Emission Technology (PET) is a powerful imaging tool that can provide diagnosis for symptoms of diseases such as Alzheimer¿s, cancer, head trauma, and stroke. However, the performance of current clinical PET systems is limited by available detector technology, and improved PET… More

A New N+ Contact for Germanium Strip Detectors

Award Year / Program / Phase: 2004 / SBIR / Phase II
Agency: DOE
Principal Investigator: Kanai S. Shah, Mr.
Award Amount: $750,000.00
Abstract:
72157-Germanium strip detectors are very promising for X-ray and g-ray imaging with high resolution. However, existing n+ lithium electrodes prevent the full potential of high purity germanium (HPGe) strip detectors from being exploited in nuclear physics experiments as well as in many other… More

A Design of a New Readout Sensor for SPECT

Award Year / Program / Phase: 2004 / SBIR / Phase II
Agency: DOE
Principal Investigator: Vivek V. Nagarkar, Dr.
Award Amount: $750,000.00
Abstract:
72486-With the ever increasing number of smaller animals, such as mice and rats, being used as human disease models, the demand for small animal imaging also has increased. In particular, the pharmaceutical industry requires the in vivo quantification of biological processes, to measure the… More

High Resolution Positron Emission Mammography

Award Year / Program / Phase: 2004 / SBIR / Phase II
Agency: HHS
Principal Investigator: Gerald Entine
Award Amount: $1,049,938.00
Abstract:
DESCRIPTION (provided by applicant): Positron Emission Tomography (PET) is a nuclear imaging technology that makes use of a range of positron-labeled tracers to provide images that reflect different parameters relevant to tumor biology. Recent developments in PET technology are leading towards… More

Bandwidth-Selective, APD-Based Flow Cytometer

Award Year / Program / Phase: 2004 / SBIR / Phase II
Agency: HHS
Principal Investigator: James F. Christian
Award Amount: $894,653.00
Abstract:
DESCRIPTION (provided by applicant): An ultra-compact, high-performance, multi-laser, many-parameter, bandwidth-selective flow cytometer is the expected result of the research and development proposed here. The cellular analysis typically carried out by a device of this type, through the use of… More

Very Large, High Gain APDs for Particle Physics

Award Year / Program / Phase: 2004 / SBIR / Phase II
Agency: DOE
Principal Investigator: Kanai S. Shah, Mr.
Award Amount: $750,000.00
Abstract:
73066-For several decades, photo-multiplier tubes (PMT) have been the key technology for sensing light in most high energy physics research operations. Although extraordinarily successful, PMT technology has a number of limitations: large PMTs cannot be mass produced, they cannot operate under… More

A New Scintillator for Nuclear Medicine Imaging

Award Year / Program / Phase: 2004 / SBIR / Phase II
Agency: HHS
Principal Investigator: Kanai S. Shah
Award Amount: $854,969.00
Abstract:
DESCRIPTION (provided by applicant): Nuclear medicine imaging modalities such as single photon emission computed tomography (SPECT) and positron emission tomography (PET) are powerful, non-invasive medical imaging techniques that provide an image of the three dimensional distribution of a… More

High Resolution, Low Cost Gamma Camera

Award Year / Program / Phase: 2004 / SBIR / Phase II
Agency: HHS
Principal Investigator: Michael R. Squillante
Award Amount: $750,000.00
Abstract:
DESCRIPTION (provided by applicant): The y-ray scintillation camera is the instrument of choice for imaging static and dynamic radioisotope distributions in vivo and provides information about functionality, morphology, and metabolic activity that is critically needed for medical diagnosis and… More

Portable, Hand-Held Inspection System for Aircraft Components

Award Year / Program / Phase: 2004 / SBIR / Phase II
Agency / Branch: DOD / NAVY
Principal Investigator: Timothy C. Tiernan, Group Director
Award Amount: $749,999.00
Abstract:
New technology is needed for the nondestructive detection and characterization of defects in aerospace structures, particularly those with compex shapes that are used in high stress environments that accelerate degradation. Existing nondestructive evaluation (NDE) techniques, based on ultrasonics,… More

All-Digital, CMOS-Based Photodiode Camera

Award Year / Program / Phase: 2004 / SBIR / Phase II
Agency: NASA
Principal Investigator: James F. Christian, Principal Investigator
Award Amount: $599,971.00
Abstract:
CCDs (Charge-Coupled Devices), and more recently, CMOS (complementary-symmetry metal-oxide-semiconductor) APS (Active Pixel Sensor) cameras have revolutionized imaging instrumentation and the many fields that utilize these instruments. Both these technologies rely on integrating, the analog… More

Microscopic Damage Detection and Remaining Life Assessment of Printed Circuit Boards

Award Year / Program / Phase: 2004 / SBIR / Phase I
Agency / Branch: DOD / NAVY
Principal Investigator: Timothy C. Tiernan, Dir. of Advanced Instrume
Award Amount: $100,000.00
Abstract:
Field inspection of printed circuit boards (PCB), and assessment of their condition is critical for the readiness of military equipment. A new technology is needed that is portable and able to inspect PCBs, yet can perform sophisticated characterization of defects, and predict the remaining life of… More

Novel Scintillator for PET Imaging

Award Year / Program / Phase: 2004 / SBIR / Phase I
Agency: DOE
Principal Investigator: Michael D. Squillante, Dr.
Award Amount: $100,000.00
Abstract:
75530-Positron emission tomography (PET) is a powerful imaging tool that can provide diagnosis for symptoms of diseases such as cancer, Alzheimer's disease, head trauma and stroke. However, the performance of current clinical PET systems is limited by available detector technology, and there is an… More

Fast Microcolumnar Scintillator for Radionuclide Imaging

Award Year / Program / Phase: 2004 / SBIR / Phase I
Agency: DOE
Principal Investigator: Vivek V. Nagarkar, Dr.
Award Amount: $100,000.00
Abstract:
75096-Despite excellent scintillator properties and its use in a wide variety of applications, CsI(Tl) has not been used for radionuclide imaging in medical applications. The primary reason is the presence of a strong afterglow component in its scintillation decay, which reduces the energy… More

A High Purity Silicon X-ray Detector

Award Year / Program / Phase: 2004 / SBIR / Phase I
Agency: DOE
Principal Investigator: Kanai S. Shah, Mr.
Award Amount: $100,000.00
Abstract:
75170-X-ray detectors with high energy resolution, high sensitivity, and high count-rate performance are required in electron beam systems for materials science research. In many X-ray detection studies conducted with electron beam systems, system performance is limited by the characteristics of… More

High Performance Small Animal SPECT Imager

Award Year / Program / Phase: 2004 / SBIR / Phase I
Agency: DOE
Principal Investigator: Kanai S. Shah, Mr.
Award Amount: $100,000.00
Abstract:
75438-With the ever-increasing number of human diseases being modeled in small animals such as mice and rats, the high resolution radionuclide imaging (such as SPECT, single photon emission computed tomography) of these small animals is required. Clinical SPECT scanners used for human imaging are… More

High Resolution Sensor for Nuclear Waste Characterization

Award Year / Program / Phase: 2004 / SBIR / Phase I
Agency: DOE
Principal Investigator: Kanai S. Shah, Mr.
Award Amount: $100,000.00
Abstract:
76325-Gamma ray spectrometers are an important tool in the characterization of radioactive waste, such as found at many DOE sites. These gamma ray spectrometers require good energy resolution, high detection efficiency, compact size, light weight, portability, and low power requirements. No… More

A New Ceramic Scintillator for Neutron Detection

Award Year / Program / Phase: 2004 / SBIR / Phase I
Agency: DOE
Principal Investigator: Jaroslaw Glodo, Dr.
Award Amount: $100,000.00
Abstract:
75745-Neutron beam facilities, used for materials research studies, require high neutron fluxes, but their utilization is often limited by detection systems that use scintillators. None of these scintillators exhibit good neutron detection and energy resolution, fast response, and high light yield… More

High Gain, Position Sensitive, Avalanche Photodiode for Optical Communication

Award Year / Program / Phase: 2004 / SBIR / Phase II
Agency: NASA
Principal Investigator: Richard A. Myers, Principal Investigator
Award Amount: $599,979.00
Abstract:
This Phase II SBIR describes the fabrication and characterization of a position sensitive detector with internal gain. Phase I research demonstrated the fabrication of several position sensitive avalanche photodiodes (APDs), including quadrant and lateral-effect photodiodes. With position resolution… More

Nanofiber LIBS for Nanoparticle Composition

Award Year / Program / Phase: 2004 / STTR / Phase I
Agency / Branch: DOD / ARMY
Research Institution: Harvard University
Principal Investigator: Arieh M. Karger, Pysicist, Group Leader
Award Amount: $100,000.00
RI Contact: Eric Mazur
Abstract:
The pervasiveness of nanoparticles and nanomaterials is rapidly expanding, and determination of their chemical composition can be achieved by Laser-Induced Breakdown Spectroscopy (LIBS) excited through an optical fiber of nanometer dimensions. We propose to develop a LIBS system for nanomaterials… More

Cancer Detection using Diffuse Luminescence Imaging

Award Year / Program / Phase: 2004 / SBIR / Phase I
Agency: HHS
Principal Investigator: Arieh M. Karger
Award Amount: $119,474.00
Abstract:
DESCRIPTION (provided by applicant): The focus of the application is in the area of breast cancer imaging and tumor characterization. Imaging in pre-clinical models with injected contrast agents and imaging the oxygen concentration within tissue are important for a number of clinical and… More

A Detector for Combined SPECT/CT

Award Year / Program / Phase: 2004 / SBIR / Phase I
Agency: DOE
Principal Investigator: Vivek V. Nagarkar, Dr.
Award Amount: $100,000.00
Abstract:
75524-Single photon emission computed tomography (SPECT) maintains an important role in the study of disease models in small animals as well as in patient care. Although rich in physiological information content, interpretation of SPECT data for these studies is challenging because SPECT images… More

A Fast, High Luminosity Scintillator for PET

Award Year / Program / Phase: 2004 / SBIR / Phase I
Agency: HHS
Principal Investigator: Gerald Entine
Award Amount: $100,000.00
Abstract:
DESCRIPTION (provided by applicant): Positron Emission Tomography (PET) is a nuclear imaging modality that makes use of a range of positron-emitting tracers to provide images that reflect different parameters relevant to tumor biology. Tumor cells generally differ from normal cells in many… More

SBIR Phase I: Gamma Ray Detector for Geophysical Exploration

Award Year / Program / Phase: 2004 / SBIR / Phase I
Agency: NSF
Principal Investigator: Gerald Entine, PI
Award Amount: $100,000.00
Abstract:
This Small Business Innovation Research (SBIR) Phase I project is to investigate a new, high performance scintillation detector for eventual use in nuclear borehole logging. Nuclear borehole logging is an important technique for both geophysical research and commercial oil exploration. Well logging… More

Afterglow CsI(Tl) Scintillator for Medical Applications

Award Year / Program / Phase: 2004 / SBIR / Phase I
Agency: HHS
Principal Investigator: Michael R. Squillante
Award Amount: $0.00
Abstract:
DESCRIPTION (provided by applicant): CsI doped with thallium is one of the most important scintillators currently in use. In terms of conversion of ionizing radiation to visible photons, it is the unquestioned leader in efficiency. Additionally, its high density, high atomic number, excellent light… More

Novel Scintillator for Nuclear Physics Studies

Award Year / Program / Phase: 2004 / SBIR / Phase I
Agency: DOE
Principal Investigator: Michael R. Squillante, Dr.
Award Amount: $100,000.00
Abstract:
75416-The performance of nuclear physics detection systems is often limited by the properties of the scintillators that are presently available for neutron and gamma ray detection. This project will develop a new scintillator material that provides excellent light yield for neutrons and also… More

Afterglow CsI(Tl) Scintillator for Medical Applications

Award Year / Program / Phase: 2004 / SBIR / Phase II
Agency: HHS
Principal Investigator: Michael R. Squillante
Award Amount: $750,000.00
Abstract:
DESCRIPTION (provided by applicant): CsI doped with thallium is one of the most important scintillators currently in use. In terms of conversion of ionizing radiation to visible photons, it is the unquestioned leader in efficiency. Additionally, its high density, high atomic number, excellent light… More

In Vivo Molecular Imaging of Cancer in Small Animals

Award Year / Program / Phase: 2005 / SBIR / Phase II
Agency: HHS
Principal Investigator: Gerald Entine
Award Amount: $920,980.00
Abstract:
DESCRIPTION (provided by applicant): Murine models of cancer now have an essential role in formulating modern concepts of carcinogenesis and metastasis, and provide us with a realistic means of developing and evaluating new diagnostic and therapeutic techniques. Moreover, transgenic and knock-out… More

High Resolution Small Animal SPECT

Award Year / Program / Phase: 2005 / SBIR / Phase II
Agency: HHS
Principal Investigator: Michael R. Squillante
Award Amount: $1,043,920.00
Abstract:
DESCRIPTION (provided by applicant): Phase I: SPECT is non-invasive imaging technique which provides an image of the three dimensional distribution of radionuclide in any slice through an organ under study. These images allow investigation of metabolism in the region being studied and are a useful… More

High Sensitivity X-ray Detector for PET/CT

Award Year / Program / Phase: 2005 / SBIR / Phase II
Agency: HHS
Principal Investigator: Vivek V. Nagarkar
Award Amount: $859,764.00
Abstract:
DESCRIPTION (provided by applicant): Dramatic advances in imaging technology, especially for small-animal imaging, have been an important driving force in establishing the field of molecular and genomic imaging. One of these new technologies, microPET, has demonstrated a tremendous potential in… More

SBIR Phase II: Detection and Identification Instrument for Single Molecule Analysis

Award Year / Program / Phase: 2005 / SBIR / Phase II
Agency: NSF
Principal Investigator: Arieh M. Karger, Mr
Award Amount: $500,000.00
Abstract:
This Small Business Innovation Research (SBIR) Phase II project proposes to develop a novel, low cost laboratory instrument for genetic analysis and single molecule studies. The technology is suitable for the detection and identification of DNA and RNA through fluorescent hybridization probes… More

Fast Microcolumnar Scintillator for Radionuclide Imaging

Award Year / Program / Phase: 2005 / SBIR / Phase II
Agency: DOE
Principal Investigator: Vivek V. Nagarkar, Dr.
Award Amount: $749,999.00
Abstract:
75096S Although CsI(Tl) has become the scintillator of choice for a wide variety of applications, it is not been widely used in radionuclide imaging or computed tomography (CT). The primary reason is the presence of an afterglow component in its scintillation decay, which reduces the energy… More

A New Ceramic Scintillator for Neutron Detection

Award Year / Program / Phase: 2005 / SBIR / Phase II
Agency: DOE
Principal Investigator: Jaroslaw Glodo, Dr.
Award Amount: $750,000.00
Abstract:
75745S The utilization of high neutron fluxes (such as at new DOE Spallation Neutron Source, SNS, which is used for materials science studies) is often limited by detection systems, particularly scintillators. For example, the widely-used ZnS:Ag/LiF phosphor, although very bright, is slow and… More

High Performance Small Animal SPECT Imager

Award Year / Program / Phase: 2005 / SBIR / Phase II
Agency: DOE
Principal Investigator: Kanai S. Shah, Mr.
Award Amount: $750,000.00
Abstract:
75438S With the ever-increasing number of human diseases being modeled in small animals such as mice and rats, the high resolution radionuclide imaging (such as SPECT, single photon emission computed tomography) of these small animals is required. Clinical SPECT scanners used for human imaging are… More

Novel Scintillator for PET Imaging

Award Year / Program / Phase: 2005 / SBIR / Phase II
Agency: DOE
Principal Investigator: Michael R. Squillante, Dr.
Award Amount: $750,000.00
Abstract:
75530S Positron emission tomography (PET) is a powerful imaging tool that can provide diagnosis for symptoms of diseases such as cancer, Alzheimer's disease, head trauma and stroke. However, the performance of current clinical PET systems is limited by available detector technology, and there is… More

A Very High Spatial Resolution Detector for Small Animal PET

Award Year / Program / Phase: 2005 / SBIR / Phase I
Agency: DOE
Principal Investigator: Kanai S. Shah, Mr.
Award Amount: $100,000.00
Abstract:
78235S Positron Emission Tomography (PET), an in vivo analog of autoradiography, has the potential to become a powerful new tool for imaging biological processes in small laboratory animals. PET imaging of small animals can provide unique information that can help in the advancement of human… More

High Efficiency, Low Cost Scintillators for PET

Award Year / Program / Phase: 2005 / SBIR / Phase I
Agency: DOE
Principal Investigator: Gerald Entine, Dr.
Award Amount: $100,000.00
Abstract:
78029S Scintillation detectors, consisting of inorganic scintillation crystals coupled to photomultiplier tubes, are an important element of medical imaging applications such as positron emission tomography (PET). Performance as well as cost of these systems is limited by the properties of the… More

Improved Spectroscopic Gamma Ray Detectors

Award Year / Program / Phase: 2005 / SBIR / Phase I
Agency: DHS
Principal Investigator: Gerald Entine
Award Amount: $100,000.00
Abstract:
Spread of the weapons of mass destruction such as nuclear weapons is a serious threat in the world today. Prevention of the spread of radioactive materials and nuclear weapons has reached a state of heightened urgency in recent years, especially since the events on September 11, 2001 and its… More

High Efficiency, Room Temperature Semiconductor Detectors

Award Year / Program / Phase: 2005 / SBIR / Phase I
Agency: DHS
Principal Investigator: William Higgins
Award Amount: $100,000.00
Abstract:
Prevention of the spread of nuclear weapons has reached a state of heightened urgency since the events on September 11, 2001. Gamma ray spectrometers are important tools in homeland security to check the spread of nuclear materials and weapons. Important requirements for gamma ray spectrometers… More

Portable, High Resolution Gamma Ray Imaging System for Radioisotope Detection, Localization and Identification

Award Year / Program / Phase: 2005 / SBIR / Phase I
Agency: DHS
Principal Investigator: Michael R. Squillante, V.P. Research – (617) 668-6808
Award Amount: $99,992.00
Abstract:
Preventing the entry of radioactive materials and nuclear weapons into the United States is at a state of heightened urgency in recent years. Detecting and identifying potentially dangerous radioactive sources is difficult and better spectroscopic gamma ray imaging systems would significantly help… More

A New Scintillator for Time-of-Flight PET

Award Year / Program / Phase: 2005 / SBIR / Phase I
Agency: DOE
Principal Investigator: Gerald Entine, Dr.
Award Amount: $100,000.00
Abstract:
78035S Scintillation detectors, consisting of inorganic scintillation crystals coupled to PMTs, are an important element of medical imaging applications such as positron emission tomography (PET). Yet, the performance of these systems is limited by the properties of the currently available… More

Microscopic Damage Detection and Remaining Life Assessment of Printed Circuit Boards

Award Year / Program / Phase: 2005 / SBIR / Phase II
Agency / Branch: DOD / NAVY
Principal Investigator: Timothy C. Tiernan, Group Leader
Award Amount: $600,000.00
Abstract:
Inspection of printed circuit boards (PCB) to detect and repair defects is critical for the readiness of military equipment. A new technology is needed to perform sophisticated characterization of defects, and predict the remaining life of electronics without costly, PCB and IC specific hardware… More

Compact, Multipulse Agile Laser for Spectrochemical Applications

Award Year / Program / Phase: 2005 / SBIR / Phase I
Agency / Branch: DOD / ARMY
Principal Investigator: Arieh M. Karger, Group Leader
Award Amount: $70,000.00
Abstract:
High-energy, tunable, pulsed lasers are vital components in many state-of-the-art optical systems, including Laser Induced Breakdown Spectroscopy (LIBS) for standoff spectrochemical detection and analysis of explosives and other chemicals. In order to enhance the signal and improve repeatability, it… More

Novel Scintillator for Nuclear Physics Studies

Award Year / Program / Phase: 2005 / SBIR / Phase II
Agency: DOE
Principal Investigator: Michael R. Squillante, Dr.
Award Amount: $700,000.00
Abstract:
75416S Inorganic scintillation crystals are a very important element of current and next generation experiments in. Scintillators are the most common detectors used In nuclear and particle physics experiments, the perfomance of the detection systems is often limited by the properties of the… More

A Fast, High Luminosity Scintillator for PET

Award Year / Program / Phase: 2005 / SBIR / Phase II
Agency: HHS
Principal Investigator: Gerald Entine
Award Amount: $356,136.00
Abstract:
DESCRIPTION (provided by applicant): Positron Emission Tomography (PET) is a nuclear imaging modality that makes use of a range of positron-emitting tracers to provide images that reflect different parameters relevant to tumor biology. Tumor cells generally differ from normal cells in many… More

Low-cost Individual Digital Dosimeters using Solid State Photomultipliers

Award Year / Program / Phase: 2005 / SBIR / Phase I
Agency / Branch: DOD / DTRA
Principal Investigator: James F. Christian, Group Leader, Senior Scientist
Award Amount: $100,000.00
Abstract:
U.S. forces working in low-level radiation environments have unsatisfactory choices for monitoring radiation exposure. The currently available A/UDR-13 pocket dosimeter is able to meet sensitivity requirements, but is cost prohibitive at ~$400 per unit, and it fails in the high temperature… More

High Resolution, Room Temperature Semiconductor Detectors

Award Year / Program / Phase: 2005 / SBIR / Phase I
Agency / Branch: DOD / DTRA
Principal Investigator: Kanai S. Shah, Director of Research
Award Amount: $100,000.00
Abstract:
Proliferation of the weapons of mass destruction such as nuclear weapons is a serious threat in the world today. Prevention of the spread of nuclear weapons has reached a state of heightened urgency in recent years, especially since the events on September 11, 2001 and its aftermath. Gamma ray… More

Nondestructive Inspection (NDI) of Small-Diameter Titanium Tubing

Award Year / Program / Phase: 2005 / SBIR / Phase I
Agency / Branch: DOD / NAVY
Principal Investigator: Timothy C. Tiernan, Group Leader, Adv. Instrumentation
Award Amount: $80,000.00
Abstract:
New technology is needed for the nondestructive inspection (NDI) of microscopic defects in the thin-wall, titanium alloy hydraulic lines used on aircraft. Once mounted on an aircraft, these tubes are difficult to access externally, making inspection of the tube from the inside the most practical… More

Digital Fluoroscopy for Cardiac Imaging

Award Year / Program / Phase: 2005 / SBIR / Phase I
Agency: HHS
Principal Investigator: Gerald Entine
Award Amount: $100,000.00
Abstract:
DESCRIPTION (provided by applicant): Real-time or dynamic radiographic imaging (fluoroscopy) provides vital information concerning internal organ structure, flow of contrast agents and in-vivo instrument positioning. Fluoroscopy is a very important modality for cardiac and vascular imaging… More

Direct Conversion Dental Sensor

Award Year / Program / Phase: 2005 / SBIR / Phase I
Agency: HHS
Principal Investigator: Paul R. Bennett
Award Amount: $100,000.00
Abstract:
DESCRIPTION (provided by applicant): Radiation Monitoring Devices (RMD) proposes to develop a new dental x-ray imager that will have all the advantages of a digital technology and retain the most desirable aspects of image quality that film emulsions provide. The device will be a blend of two… More

Digital 2-D Neutron Detector for Protein Function Sudies

Award Year / Program / Phase: 2005 / SBIR / Phase I
Agency: HHS
Principal Investigator: Irina Shestakova
Award Amount: $100,000.00
Abstract:
DESCRIPTION (provided by applicant): Information on the structure and function of proteins is important for unveiling the biological processes taking place on a molecular level. X-ray crystallography has been successful in determining protein structure, however is not well suited for analyzing… More

High Sensitivity, 2-D Solid State Sensor Array/Rapid MCG

Award Year / Program / Phase: 2005 / SBIR / Phase I
Agency: HHS
Principal Investigator: Timothy C. Tiernan
Award Amount: $100,000.00
Abstract:
DESCRIPTION (provided by applicant): Magnetocardiography (MCG) has been shown to offer powerful disease detection and diagnostic capabilities in both humans and animals not readily achieved with standard ECG and echocardiography, including the ability to map ischemic regions in the heart, and… More

Fast, Dense, Low Cost Scintillator for Nuclear Physics

Award Year / Program / Phase: 2005 / SBIR / Phase I
Agency: DOE
Principal Investigator: Gerald Entine, Dr.
Award Amount: $100,000.00
Abstract:
78004S Inorganic scintillators are one of the most common detectors used in nuclear and particle physics experiments. Among the important requirements for scintillators are high light output, high sensitivity, low cost, fast response, and good stability. None of the available scintillators… More

Multi-modal, Non-contact, Automated Test Equipment (ATE) for PCBs

Award Year / Program / Phase: 2005 / SBIR / Phase I
Agency / Branch: DOD / USAF
Principal Investigator: Timothy C. Tiernan, Director of Advanced Instrumentatio
Award Amount: $100,000.00
Abstract:
The accurate assessment of the electrical and physical characteristics of a PCB (printed circuit board) to determine its condition, operational status and to analyze defects is a difficult challenge. Multi-function, high speed and exceedingly small PCBs point to a need for versatile new automated… More

High Resolution Gamma Ray Spectrometer for Nuclear Physics

Award Year / Program / Phase: 2005 / SBIR / Phase I
Agency: DOE
Principal Investigator: Kanai S. Shah, Mr.
Award Amount: $100,000.00
Abstract:
78028S Scintillation spectrometers, consisting of inorganic scintillation crystals coupled to photomultiplier tubes, are an important element of nuclear and elementary particle physics experiments. Performance of the detection systems used in these experiments is often limited by the properties of… More

Self-Assembled DNA: A Template for Constructing Electronic Devices

Award Year / Program / Phase: 2005 / SBIR / Phase I
Agency / Branch: DOD / ARMY
Principal Investigator: Louis H. Strong, Senior Scientist/Microbiologist
Award Amount: $70,000.00
Abstract:
In order to increase the performance of electronic devices, much technical effort is being devoted towards shrinking the size of the individual components. However, it is uncertain whether the current pace of miniaturization may be continued since fundamental limits of the photolithographic… More

Next-Generation Active Pixel Sensor Device with CMOS Avalanche Photodiodes

Award Year / Program / Phase: 2005 / SBIR / Phase I
Agency: DOE
Principal Investigator: James F. Christian, Dr.
Award Amount: $100,000.00
Abstract:
78820S Modern high-energy physics experiments that explore the fundamental properties of matter rely on large, sophisticated instruments for tracking particle decay events with large detector arrays. However, the performance of these instruments is limited by available detector technology. … More

SBIR Phase II: Advanced Detectors for X-ray Diagnosis

Award Year / Program / Phase: 2005 / SBIR / Phase II
Agency: NSF
Principal Investigator: Michael R. Squillante, Dr
Award Amount: $500,000.00
Abstract:
This Small Business Innovation Research (SBIR) Phase II research project involves an innovative gas sensor (DiskFET) based on a commercially available hard drive mechanism, proprietary polymers for sensing, and a modified Field Effect Transistor (FET). The device as envisioned is small, handheld, … More

An Instrument for Detecting Protein Expression Under Radiation and Microgravity

Award Year / Program / Phase: 2005 / SBIR / Phase I
Agency: NASA
Principal Investigator: Louis Strong, Principal Investigator
Award Amount: $70,000.00
Abstract:
An understanding of the basic cellular mechanisms organisms use to cope with extreme environments is important as we search for life in other parts of the universe and seek to adapt terrestrial life beyond earth. Radiation Monitoring Devices, Inc. proposes to build an automated, high-throughput… More

Solid State Beta Imaging Sensor for Radioguided Surgery

Award Year / Program / Phase: 2006 / SBIR / Phase II
Agency: HHS
Principal Investigator: Gerald Entine
Award Amount: $985,949.00
Abstract:
DESCRIPTION (provided by applicant): Advances in radiopharmaceutical have dramatically escalated the use of intraoperative gamma probes in surgery. Such probes provide benefits of increased tissue specificity obtained for biopsy, minimally accessed incisions, and the reduction of inpatient hospital… More

NearIR Photon-counting Camera for Diffuse Optical Tomography

Award Year / Program / Phase: 2006 / SBIR / Phase II
Agency: HHS
Principal Investigator: James F. Christian
Award Amount: $829,949.00
Abstract:
DESCRIPTION (provided by applicant): Early detection and routine clinical screening represent the first line of defense for managing cancer, a disease that claimed over 570,280 lives in the U.S. during the year 2005. Significant advances have been made in the medical imaging of tumors; however, many… More

Species Level Identification of Pathogenic Viruses on a Microfluidic Platform

Award Year / Program / Phase: 2006 / SBIR / Phase II
Agency: HHS
Principal Investigator: Louis H. Strong
Award Amount: $830,260.00
Abstract:
DESCRIPTION (provided by applicant): Radiation Monitoring Devices, Inc. (RMD) proposes to develop a field-portable instrument for the detection and identification of pathogenic viruses that are collected by an aerosol concentrator. It will incorporate modular, microfluidic platforms designed to… More

A New Scintillator for Time-of-Flight PET

Award Year / Program / Phase: 2006 / SBIR / Phase II
Agency: DOE
Principal Investigator: Gerald Entine, Dr.
Award Amount: $750,000.00
Abstract:
Scintillation detectors, consisting of inorganic scintillation crystals coupled to photomultiplier tubes, are an important element of medical imaging applications such as positron emission tomography (PET). Yet, the performance of these systems is limited by the properties of the currently… More

SBIR Phase II: Gamma Ray Detector for Geophysical Exploration

Award Year / Program / Phase: 2006 / SBIR / Phase II
Agency: NSF
Principal Investigator: Gerald Entine, Dr
Award Amount: $479,410.00
Abstract:
This Small Business Innovation Research (SBIR) Phase II research project aims to produce a radiation detector technology that will be able to provide a completely new level of performance for demanding industrial applications. Three different scintillator materials - LaBr3, LaCl3 and CeBr3 - have… More

High Resolution, Room Temperature Semiconductor Detectors

Award Year / Program / Phase: 2006 / SBIR / Phase II
Agency / Branch: DOD / DTRA
Principal Investigator: Kanai S. Shah, DIRECTOR OF RESEARCH
Award Amount: $353,250.00
Abstract:
Proliferation of the weapons of mass destruction such as nuclear weapons is a serious threat in the world today. Prevention of the spread of nuclear weapons has reached a state of heightened urgency in recent years, especially since the events on September 11, 2001 and its aftermath. Gamma ray… More

Nondestructive Inspection (NDI) of Small-Diameter Tubing

Award Year / Program / Phase: 2006 / SBIR / Phase II
Agency / Branch: DOD / NAVY
Principal Investigator: Timothy C. Tiernan, Group Leader, Senior Scie
Award Amount: $750,000.00
Abstract:
New technology is needed for the nondestructive inspection (NDI) of microscopic defects in the thin-wall, titanium alloy hydraulic lines used on aircraft. Once mounted on an aircraft, these tubes are difficult to access externally, making inspection of the tube from the inside the most practical… More

High Resolution Gamma Ray Spectrometer for Nuclear Physics

Award Year / Program / Phase: 2006 / SBIR / Phase II
Agency: DOE
Principal Investigator: Kanai S. Shah, Mr.
Award Amount: $750,000.00
Abstract:
Scintillation spectrometers, which consist of inorganic scintillation crystals coupled to photomultiplier tubes, are an important element of nuclear and elementary particle physics experiments. However, the performance of the detection systems used in these experiments is often limited by the… More

Fast, Dense, Low Cost Scintillator for Nuclear Physics

Award Year / Program / Phase: 2006 / SBIR / Phase II
Agency: DOE
Principal Investigator: Gerald Entine, Dr.
Award Amount: $749,999.00
Abstract:
Although inorganic scintillators are one of the most common detectors used in nuclear and particle physics experiments, the properties of currently available scintillator materials limit the performance and increase the cost of these systems. This project will develop a new class of scintillation… More

Portable High Resolution Imaging for NDI of Hot Section Aero Turbine Components

Award Year / Program / Phase: 2006 / STTR / Phase I
Agency / Branch: DOD / NAVY
Research Institution: NORTHEASTERN UNIV.
Principal Investigator: Timothy Tiernan, Group Leader
Award Amount: $69,999.00
RI Contact: Nian Sun
Abstract:
New technology is needed for the nondestructive evaluation (NDE) of defects in gas turbine engines. While these defects adversely affect hot-section performance and reduce component life, they are difficult to detect and characterize without destructive inspection. The lack of detailed flaw… More

Single Molecule Instrument for Surface Enhanced Raman Optical Activity of Biomolecules

Award Year / Program / Phase: 2006 / SBIR / Phase I
Agency: NASA
Principal Investigator: Rajan S. Gurjar, PhD, Principal Investigator
Award Amount: $69,999.00
Abstract:
Stereochemistry is an essential element of our organic life. Only certain enantiomers are useful as drugs for the human body. Raman Optical Activity (ROA) and vibrational circular dichroism (VCD) provide stereochemical information down to bond levels. Many biomolecules like proteins and DNA can… More

Modular, High Precision, Digital Measurement System for Hypervelocity Projectiles

Award Year / Program / Phase: 2006 / SBIR / Phase I
Agency / Branch: DOD / USAF
Principal Investigator: Vivek Nagarkar, Group Leader, Senior Scientist
Award Amount: $100,000.00
Abstract:
The high penetration power of X-rays permit imaging through smoke, fire and metal, and enables precise recording of a test event under the harshest conditions. The advent of high flux flash x-ray systems has enabled a unique method of imaging very fast events on a 20 to 50 nanosecond scale that… More

Microfluidic Cytometer for Complete Blood Count Analysis

Award Year / Program / Phase: 2006 / SBIR / Phase I
Agency: NASA
Principal Investigator: Louis H. Strong, PhD, Principal Investigator
Award Amount: $70,000.00
Abstract:
RMD proposes to develop a MEMS based complete blood count (CBC) instrument that can be used aboard a spacecraft. We will produce a microfluidic scale combination cell counter-flow cytometer for CBC analyses that can be communicated to ground bases by telemetry. The blood analyzer will utilize… More

High Quantum Efficiency, Fast Detectors for the Readout of Scintillators for Gamma-Ray Detection

Award Year / Program / Phase: 2006 / SBIR / Phase I
Agency: DHS
Principal Investigator: Kanai S. Shah, Mr.
Award Amount: $150,000.00
Abstract:
Gamma-ray spectrometers consisting of inorganic scintillators coupled to optical detectors such as photomultiplier tubes (PMTs) are an important element of the systems that are used to monitor and prevent the spread of special nuclear materials. Two very important requirements for the scintillation… More

Parallel Detection of Multiple Biomarkers During Spaceflight

Award Year / Program / Phase: 2006 / SBIR / Phase I
Agency: NASA
Principal Investigator: Daniel B. Hall, PhD, Principal Investigator
Award Amount: $69,999.00
Abstract:
Maintaining the health of astronauts during extended spaceflight is critical to the success of the mission. Radiation Monitoring Devices, Inc. (RMD) proposes an instrument to monitor astronauts' physiological responses to stress, microgravity, radiation, infection, and pharmaceutical agents through… More

E-tongue Sensor Array For Shipyard Water Monitoring

Award Year / Program / Phase: 2006 / SBIR / Phase I
Agency / Branch: DOD / NAVY
Principal Investigator: Senerath Palamakumbura, Staff Scientist
Award Amount: $70,000.00
Abstract:
Navy program office is seeking capability to monitor known pollutants in shipyard waste water discharges to comply with local environmental discharge limits. The pollutants of concern are heavy metal ions but petroleum hydrocarbons and semi volatile organics are also of interest. The monitoring… More

Low-cost Individual Digital Dosimeters using Solid State Photomultipliers

Award Year / Program / Phase: 2006 / SBIR / Phase II
Agency / Branch: DOD / DTRA
Principal Investigator: James Christian, Group Leader
Award Amount: $353,250.00
Abstract:
U.S. forces working in low-level radiation environments have unsatisfactory choices for monitoring radiation exposure. A solid-state photomultiplier (SSPM) uses an array of silicon based avalanche photodiodes (APD) to collect light and produce a signal proportional to the amount of light collected.… More

New, Bright, High Resolution Scintillators

Award Year / Program / Phase: 2006 / SBIR / Phase I
Agency: DOE
Principal Investigator: Kanai S. Shah, Mr.
Award Amount: $100,000.00
Abstract:
Proliferation of weapons of mass destruction, such as nuclear weapons, is a serious threat in the world today. Although gamma-ray detectors are an important component of systems used to prevent nuclear proliferation, the performance of such systems is currently limited by the characteristics of… More

LIBS: An Alternative to Commercial Instruments for Measurement of Lead

Award Year / Program / Phase: 2006 / SBIR / Phase I
Agency: DHS
Principal Investigator: Michael R. Squillante, Vice President
Award Amount: $140,607.00
Abstract:
Radioactive materials are used in commercially important analytical instruments because of the ability of ionizing radiation to excite characteristic x-ray fluorescence lines. Radiation sources are often the most practical method for portable instruments, such as analyzers for lead paint in homes.… More

High-Throughput Single Molecule Analysis Instrument

Award Year / Program / Phase: 2006 / SBIR / Phase I
Agency: DOE
Principal Investigator: Rajan S. Gurjar, Dr.
Award Amount: $100,000.00
Abstract:
The analysis and control of single macromolecules is an important goal of the DOE¿s Genome-to-Life Program. However, single molecule assays that use fluorescent dyes are not photostable, have low quantum yield, and have broad emission spectra. Conventional, confocal, fluorescence correlation… More

Low-Cost SSPM-Based Digital Radiation Monitor

Award Year / Program / Phase: 2006 / SBIR / Phase I
Agency: DOE
Principal Investigator: James F. Christian, Dr.
Award Amount: $100,000.00
Abstract:
Many facilities throughout the DOE Complex will reside in a safe storage, or surveillance and maintenance mode, until such time that funding resources are available to perform decontamination and demolition. Therefore, long-term monitoring systems are required to ensure against a contaminant… More

PET Detector for Cardiac Imaging of Small Animals

Award Year / Program / Phase: 2006 / SBIR / Phase I
Agency: HHS
Principal Investigator: Kanai S. Shah
Award Amount: $124,018.00
Abstract:
DESCRIPTION (provided by applicant): Positron emission tomography (PET) of small animals is emerging as a very powerful tool for advancing our understanding of human diseases such as heart disease and cancer. Due to the small (sub-millimeter) feature sizes, dedicated, high resolution PET systems are… More

High Sensitivity Pesticide and Nerve Agent Detector

Award Year / Program / Phase: 2006 / SBIR / Phase I
Agency: HHS
Principal Investigator: Senerath Palamakumbura
Award Amount: $132,551.00
Abstract:
DESCRIPTION (provided by applicant): RMD Inc. proposes to develop direct reading, highly sensitive, reusable point sensors for detecting organophosphate and carbomate pesticide and nerve agent contamination in liquid and air. The sensors can be made for visual detection and handheld instrument… More

Low Cost Co Doped Scintillator for Medical CT

Award Year / Program / Phase: 2006 / SBIR / Phase I
Agency: HHS
Principal Investigator: Michael R. Squillante
Award Amount: $119,407.00
Abstract:
DESCRIPTION (provided by applicant): Although CsI:TI is one of the most desirable scintillators for a broad range of medical and industrial diagnostics, it has never been applicable to X-ray computerized tomography (CT). Despite the otherwise superb properties of CsI, it suffers from a persistent… More

HIGH RESOLUTION NUCLEAR CARDIAC IMAGING

Award Year / Program / Phase: 2006 / SBIR / Phase I
Agency: HHS
Principal Investigator: Gerald Entine
Award Amount: $100,000.00
Abstract:
DESCRIPTION (provided by applicant): Nuclear medicine imaging modalities such as single photon emission computed tomography (SPECT) and positron emission tomography (PET) are powerful, non-invasive medical imaging techniques that provide an image of the three dimensional distribution of a… More

High Spatial Resolution Structured Plastic Scintillator

Award Year / Program / Phase: 2006 / SBIR / Phase I
Agency: HHS
Principal Investigator: Irina Shestakova
Award Amount: $134,460.00
Abstract:
DESCRIPTION (provided by applicant): The goal of this Phase I project is to develop a fast high spatial resolution scintillator for time-resolved neutron crystallography. Neutron crystallography compliments x-ray crystallography in its ability to precisely locate hydrogen atoms in protein molecules.… More

High Resolution PET Detectors for Combined PET-MR Small Animal Imaging

Award Year / Program / Phase: 2006 / SBIR / Phase I
Agency: HHS
Principal Investigator: Kanai S. Shah
Award Amount: $100,003.00
Abstract:
DESCRIPTION (provided by applicant): The ideal biological imaging system would provide non-invasive, high-resolution, high-sensitivity, three-dimensional (3D) images of living systems. Positron Emission Tomography (PET) offers high sensitivity to a range of biological processes through the use of… More

Novel, Needle-Shapred Scintillator for Emission Transmission Tomography

Award Year / Program / Phase: 2006 / SBIR / Phase I
Agency: DOE
Principal Investigator: Vivek V. Nagarkar, Dr.
Award Amount: $100,000.00
Abstract:
With the ever-increasing number of human disease models, particularly in smaller animals, high-resolution, emission/transmission tomography techniques have become extremely important. The main barriers to using existing modalities in studies of laboratory animals have traditionally been poor… More

An Efficient, Solid State Detector for Nuclear Medicine

Award Year / Program / Phase: 2006 / SBIR / Phase I
Agency: DOE
Principal Investigator: Michael R. Squillante, Dr.
Award Amount: $100,000.00
Abstract:
Nuclear medicine techniques such as Positron Emission Tomography and Single Photon Emission Computed Tomography have become powerful new tools in imaging biological processes in small laboratory animals. However, the performance of these systems is often limited by the properties of the detectors… More

Multibeam Healing for Laser Micromachining in Manufacturing

Award Year / Program / Phase: 2006 / SBIR / Phase I
Agency: HHS
Principal Investigator: Bipin Singh
Award Amount: $198,585.00
Abstract:
DESCRIPTION (provided by applicant): There is a considerable interest in using laser-manufacturing methods for medical applications due to their potential to reduce cost. In fact, the precision and low-force signature of lasers makes them very attractive alternatives to traditional machining methods… More

High Resolution, High-Count-Rate Silicon X-Ray Detector

Award Year / Program / Phase: 2006 / SBIR / Phase I
Agency: DOE
Principal Investigator: Kanai S. Shah, Mr.
Award Amount: $100,000.00
Abstract:
X-ray detectors with high resolution, high sensitivity, and high count-rate are required for the electron beam systems used for materials science research at DOE facilities. In many studies conducted with electron beam systems, the characteristics of available X-ray detectors limit the system… More

Sensitive High Speed Detector for Synchrotron Applications

Award Year / Program / Phase: 2006 / SBIR / Phase I
Agency: DOE
Principal Investigator: Gerald Entine, Dr.
Award Amount: $100,000.00
Abstract:
Advanced Photon Sources have proven to be outstanding facilities for x-ray diffraction and scattering of non-crystalline biological materials. The biggest problem is finding a detector that can provide multiple frames of detailed structural information, with the required millisecond time scales and… More

Fast Neutron Imaging Scintillator with Low Sensitivity to Gamma Radiation

Award Year / Program / Phase: 2006 / SBIR / Phase I
Agency: DOE
Principal Investigator: Irina Shestakova, Dr.
Award Amount: $100,000.00
Abstract:
Neutron crystallography compliments x-ray crystallography in its ability to precisely locate hydrogen and light atoms in various materials. This information is important for biological applications (for example, monitoring protein dynamics), and material research and security applications (for… More

Advanced Photodetector for Dark Matter Studies

Award Year / Program / Phase: 2006 / SBIR / Phase I
Agency: DOE
Principal Investigator: Gerald Entine, Dr.
Award Amount: $99,999.00
Abstract:
Optical detectors are a very important component of both existing and future particle physics experiments, including those being developed for dark matter studies. However, for dark matter studies, the expected performance of experimental systems is limited by the properties of presently available… More

A Dual Modality Imaging System for Small Animal Imaging

Award Year / Program / Phase: 2006 / SBIR / Phase I
Agency: DOE
Principal Investigator: Gerald Entine, Dr.
Award Amount: $100,000.00
Abstract:
The ideal biological imaging system would provide non-invasive, high-resolution, high-sensitivity three-dimensional (3D) images of living systems. Positron Emission Tomography (PET) offers high sensitivity to a range of biological processes through the use of targeted radiolabeled probes. … More

Internal-gain CMOS APS Camera for SPECT Imaging of Small Animals

Award Year / Program / Phase: 2006 / SBIR / Phase I
Agency: HHS
Principal Investigator: James F. Christian
Award Amount: $159,915.00
Abstract:
DESCRIPTION (provided by applicant): Nuclear medicine techniques such as SPECT and PET are powerful tools for functional imaging of biological processes in vivo. Recently, there have been significant advances in development of human disease models in small animals. A critical advantage of SPECT and… More

A Fast, High Gain Photodetector for PET

Award Year / Program / Phase: 2006 / SBIR / Phase I
Agency: DOE
Principal Investigator: Kanai S. Shah, Mr.
Award Amount: $100,000.00
Abstract:
Positron Emission Tomography (PET) is a functional imaging technique that has the potential to quantify the rates of biological processes in vivo. PET imaging can provide diagnoses for symptoms such diseases as Alzheimer¿s, head trauma, cancer, and stroke. However, the performance of existing PET… More

SBIR Phase I: New Sensors for Biological Instrumentation

Award Year / Program / Phase: 2006 / SBIR / Phase I
Agency: NSF
Principal Investigator: Kanai S. Shah, Mr
Award Amount: $100,000.00
Abstract:
This Small Business Innovation Research (SBIR) Phase I project will undertake a study of new materials that will find application as scintillation detectors in nuclear medicine instrumentation (PET and SPECT imaging). Work will progress by starting with rare earth halide compositions that are known… More

Bright, Fast Scintillator for Nuclear Studies

Award Year / Program / Phase: 2006 / SBIR / Phase I
Agency: DOE
Principal Investigator: Kanai S. Shah, Mr.
Award Amount: $100,000.00
Abstract:
Scintillation spectrometers, which consist of inorganic scintillation crystals coupled to photomultiplier tubes, are an important element of nuclear and elementary particle physics experiments. The performance of the detection systems used in these experiments is often limited by the properties of… More

Magnetic Imaging And Current Mapping For NDE Of Aluminum Components On Ships

Award Year / Program / Phase: 2006 / SBIR / Phase I
Agency / Branch: DOD / NAVY
Principal Investigator: Timothy C. Tiernan, Group Leader
Award Amount: $70,000.00
Abstract:
New technology is needed for nondestructive evaluation (NDE) of defects in aluminum structures on ships. Fatigue cracks at weldments where defects may be hidden under paints, rough surfaces and other materials are especially problematic. An NDE technology capable of imaging defects in welds under a… More

Improved Molecular Barcodes by Lifetime Discrimination

Award Year / Program / Phase: 2006 / SBIR / Phase I
Agency: HHS
Principal Investigator: Daniel B. Hall
Award Amount: $127,960.00
Abstract:
DESCRIPTION (provided by applicant): DNA microarrays have advanced our understanding of cellular biology by their ability to simultaneously measure mRNA levels for thousands of genes. However, these microarrays are expensive to produce and quality control is a problem due to technical issues… More

Bright Low Persistance Scintillator for Radionuclide/X-Ray Imaging

Award Year / Program / Phase: 2006 / SBIR / Phase I
Agency: DOE
Principal Investigator: Gerald Entine, Dr.
Award Amount: $100,000.00
Abstract:
Due to its excellent properties,CsI:Tl has become the scintillator of choice for a wide variety of applications; however, it has not been widely used in radionuclide imaging in the medical field. The primary reason for this is the presence of a strong afterglow component in its scintillation decay,… More

SBIR Phase I: Improved Substrates for Single Molecule Detection

Award Year / Program / Phase: 2006 / SBIR / Phase I
Agency: NSF
Principal Investigator: Rajan Gurjar, Dr
Award Amount: $99,990.00
Abstract:
This Small Business Innovation Research Phase I project will develop substrates for enhancing the fluorescence signal from nearby analytes. This will be achieved by utilizing two-dimensional arrays of regularly spaced metallic nanoparticles thereby generating propagating modes of surface plasmons.… More

IMPROVED SPECTROSCOPIC GAMMA RAY DETECTORS

Award Year / Program / Phase: 2007 / SBIR / Phase II
Agency: DHS
Principal Investigator: Gerald Entine, PRESIDENT
Award Amount: $749,999.00
Abstract:
Spread of the weapons of mass destruction such as nuclear weapons is a serious threat in the world today. Prevention of the spread of radioactive materials and nuclear weapons has reached a state of heightened urgency in recent years, especially since the events of September 11, 2001 and its… More

Rapid Generation of High-affinity Aptamers for Quantification of Protein Biomarkers

Award Year / Program / Phase: 2007 / SBIR / Phase I
Agency / Branch: DOD / ARMY
Principal Investigator: Daniel Hall, Staff Scientist
Award Amount: $70,072.00
Abstract:
The generation of genomic and proteomic data with the goal of biomarker discovery for disease diagnostics or prognosis is a powerful approach. However, biomarkers identified from a typically small sample size must be validated on a large population. A limiting factor is the availability of… More

Augmented Reality Maintenance System (ARMS) for Complex Military Assets

Award Year / Program / Phase: 2007 / SBIR / Phase I
Agency / Branch: DOD / NAVY
Principal Investigator: Timothy C. Tiernan, Group Leader
Award Amount: $69,995.00
Abstract:
Currently, equipment maintenance requires highly trained individuals and is labor intensive, expensive and inefficient. The Marine Corps and DOD use written technical manuals and Interactive Electronic Technical Manuals (IETM) to direct technicians through complex maintenance procedures for land… More

Improved Solid-State Neutron Detector

Award Year / Program / Phase: 2007 / SBIR / Phase I
Agency: DHS
Principal Investigator: James Christian, Group Leader, Instrument R & D
Award Amount: $149,999.00
Abstract:
The use and applications of radiological sources, for power, medical, and defense applications, continuously increases with time. Illicit nuclear materials represent a threat for the safety of the American citizens and the detection and interdiction of a nuclear weapon is a national problem that has… More

High Performance X-Ray Detectors

Award Year / Program / Phase: 2007 / SBIR / Phase I
Agency: DOE
Principal Investigator: Gerald Entine, Mr
Award Amount: $99,996.00
Abstract:
X-ray detector arrays with high energy resolution, high sensitivity, and high count rate are required for synchrotron beamline studies. In many studies conducted with synchrotron beamlines, the characteristics of available X-ray detectors limit overall system performance. This project will… More

Developing CZT for Single Element Spectrometers

Award Year / Program / Phase: 2007 / SBIR / Phase I
Agency: DOE
Principal Investigator: Paul R. Bennett, Dr
Award Amount: $100,000.00
Abstract:
Large volume CdZnTe gamma ray detectors would improve radiation detection capabilities in support of the nonproliferation of nuclear weapons. However, scientific and commercial interest in large volume CdZnTe gamma-ray detectors has been obstructed by a lack of consistent, high-quality crystalline… More

Novel Parallax Free Sensor for Molecular Imaging

Award Year / Program / Phase: 2007 / SBIR / Phase I
Agency: DOE
Principal Investigator: Vivek Nagarkar, Dr
Award Amount: $99,947.00
Abstract:
With the ever-increasing number of human disease models, particularly in smaller animals, high resolution emission/transmission tomography techniques have become extremely important. The main barriers to using existing modalities in studies of laboratory animals have traditionally been poor spatial… More

Novel Ceramic Scintillators for PET

Award Year / Program / Phase: 2007 / SBIR / Phase I
Agency: DOE
Principal Investigator: Alexander Lempicki, Dr
Award Amount: $99,998.00
Abstract:
Scintillation detectors, consisting of inorganic scintillation crystals coupled to photomultipliers, are an important element of medical imaging applications, such as positron emission tomography (PET). However, the performance, as well as the cost, of these systems is limited by the properties of… More

SSPM Detector for Polarized Target Scintillator Readout

Award Year / Program / Phase: 2007 / SBIR / Phase I
Agency: DOE
Principal Investigator: James Christian, Dr
Award Amount: $100,000.00
Abstract:
Nuclear and high-energy physics experiments often require detectors to face harsh environments, such as milli-Kelvin temperatures of a helium dilution refrigerator in high magnetic field of a few Tesla. Photomultipliers will not function in these magnetic fields, and existing silicon… More

High Sensitivity Multi-Well Plate Reader Based on an Array of Photon Counting Det

Award Year / Program / Phase: 2007 / SBIR / Phase I
Agency: HHS
Principal Investigator: William Lawrence
Award Amount: $135,001.00
Abstract:
DESCRIPTION (provided by applicant): Title: High throughput and high sensitivity multi-well plate reader Project Summary/Abstract: The multi-well or microwell plate has become ubiquitous in research and clinical laboratories for processing multiple samples with high speed and reproducibility. These… More

Rapid Detection and Monitoring of Biomarkers for Traumatic Brain Injury

Award Year / Program / Phase: 2007 / SBIR / Phase I
Agency: HHS
Principal Investigator: William Lawrence
Award Amount: $91,724.00
Abstract:
DESCRIPTION (provided by applicant): Over 370,000 people in the US are hospitalized for traumatic brain injury (TBI) each year. In the US, the cost associated with the treatment, hospitalization and rehabilitation of TBI are estimated to be 48.3 billion a nnually. A fast, easy, accurate and… More

Bright and Fast Sensor for Time Resolved X-Ray Diffraction Studies

Award Year / Program / Phase: 2007 / SBIR / Phase I
Agency: HHS
Principal Investigator: Vivek V. Nagarkar
Award Amount: $135,116.00
Abstract:
DESCRIPTION (provided by applicant): Recent extraordinary developments in synchrotron radiation sources have enabled the growth of powerful research techniques such as time-resolved X-ray diffraction studies for understanding dynamic biological phenomena a nd recovering phase information in X-ray… More

Low-Cost Instrument for Long-Term Monitoring of Hazardous Contaminants in Drinking Water

Award Year / Program / Phase: 2007 / SBIR / Phase I
Agency: EPA
Principal Investigator: John Ford, Senior Scientist
Award Amount: $70,000.00
Abstract:
The EPA has stated a need for technologies and instruments to monitor and warn of the presence of toxic contaminants in drinking water. An innovative device that could detect, identify and localize hazardous chemical contaminants in drinking water would be immensely valuable to water utility… More

Tissue-Equivalent Radiation Dosimeter-On-A-Chip

Award Year / Program / Phase: 2007 / SBIR / Phase I
Agency: NASA
Principal Investigator: James E. Christian, PhD, Principal Investigator
Award Amount: $99,999.00
Abstract:
Many commercially available digital dosimeters are bulky and are unable to properly measure dose for space radiation. The complexity of space flight design requires reliable, fault-tolerant equipment with the capability of providing real-time dose readings during a mission, which is not feasible… More

New Detector for Gamma-Ray and Neutron Studies

Award Year / Program / Phase: 2007 / SBIR / Phase I
Agency: DOE
Principal Investigator: Kanai S. Shah, Mr
Award Amount: $99,999.00
Abstract:
Inorganic scintillation crystals are a very important element of the detection systems for current and next generation experiments in nuclear and particle physics. However, the performance of these detection systems is often limited by the properties of scintillators now available for neutron and… More

A Novel Microfluidic Detector with Position Sensitivity

Award Year / Program / Phase: 2007 / SBIR / Phase I
Agency: DOE
Principal Investigator: Kanai S. Shah, Mr
Award Amount: $99,992.00
Abstract:
Microfluidic chips, fabricated from low cost polymers, are a promising, emerging technology for the synthesis and study of new molecular imaging probes. These chips can contain a variety of microcircuitry and microwells, and are capable of manipulating nanoliter samples of reagents and solvents. … More

Single Molecule Instrument for Surface Enhanced Raman Optical Activity of Biomolecules

Award Year / Program / Phase: 2007 / SBIR / Phase II
Agency: NASA
Principal Investigator: Rajan R. Gurjar, Principal Investigator
Award Amount: $559,992.00
Abstract:
Stereochemistry is an essential element of our organic life. Only certain enantiomers are useful as drugs for the human body. Raman optical activity (ROA) provides stereochemical information down to the bond levels. Many biomolecules like proteins and DNA can be studied to understand their… More

Microfluidic Cytometer for Complete Blood Count Analysis

Award Year / Program / Phase: 2007 / SBIR / Phase II
Agency: NASA
Principal Investigator: Louis B. Strong, Principal Investigator
Award Amount: $599,965.00
Abstract:
We will fabricate and test microfluidic designs for a micro-electromechanical system based complete blood count (CBC) analysis in separate modules and integrate them into a working prototype. A first module constitutes a hydrodynamic focusing injector and cell impedance meter. A second module… More

System for Analyzing Microscopic Defects and Defect Propagation Due to Aging

Award Year / Program / Phase: 2007 / SBIR / Phase I
Agency: NASA
Principal Investigator: Timothy L. Tiernan, Principal Investigator
Award Amount: $100,000.00
Abstract:
New technology is needed for sensing and characterizing incipient defects, and assessing the effects of aging in aerospace components. Next generation materials, including nickel-based superalloys that are exceedingly difficult to inspect with existing technology are being adopted by designers and… More

An Efficient, Solid State Detector for Nuclear Medicine

Award Year / Program / Phase: 2007 / SBIR / Phase II
Agency: DOE
Principal Investigator: Michael R. Squillante, Dr
Award Amount: $750,000.00
Abstract:
80498S06 Nuclear medicine techniques such as Positron Emission Tomography and Single Photon Emission Computed Tomography have become powerful new tools for imaging biological processes in small laboratory animals. However, the performance of these systems is limited by the properties of the… More

Active Interrogation System for Detecting and Identifying SNM

Award Year / Program / Phase: 2007 / SBIR / Phase I
Agency / Branch: DOD / DTRA
Principal Investigator: Michael Squillante, Vice President of Research
Award Amount: $99,941.00
Abstract:
Active interrogation holds the most promise for detecting heavily shielded materials at a distance. This effort will use pulsed neutron excitation of fission reactions in the target being inspected in conjunction with an imaging detector. Special nuclear material (SNM) that is present will undergo… More

Novel, Needle-Shaped Scintillator for Emission Transmission Tomography

Award Year / Program / Phase: 2007 / SBIR / Phase II
Agency: DOE
Principal Investigator: Vivek V. Nagarkar, Dr
Award Amount: $749,996.00
Abstract:
80495S06 With the ever-increasing number of human disease models, particularly in smaller animals, high resolution emission/transmission tomography techniques have become extremely important. Such advanced imaging requires advanced detectors, and although detector technologies have improved… More

High Resolution, High-Count-Rate Silicon X-Ray Detector

Award Year / Program / Phase: 2007 / SBIR / Phase II
Agency: DOE
Principal Investigator: Kanai S. Shah, Mr
Award Amount: $750,000.00
Abstract:
81289S06 In many studies conducted with electron beam systems, the characteristics of available X-ray detectors limit the system performance. This project will investigate a novel low-capacitance design of high purity silicon detectors, which offers high energy resolution, high efficiency, high… More

Eddy Current Braking Technology for Aircraft Catapult Systems

Award Year / Program / Phase: 2007 / STTR / Phase I
Agency / Branch: DOD / NAVY
Research Institution: WORCESTER POLYTECHNIC INSTITUTE
Principal Investigator: Timothy C. Tiernan, Principal Investigator
Award Amount: $69,999.00
RI Contact: Francois D. Lemire
Abstract:
The Navy uses steam powered catapults to launch aircraft from naval vessels. Currently, after the aircraft is launched, the massive catapult mechanism is slowed to a stop by a complex water braking system. This water braking system has many moving parts and experiences high stresses during… More

Scintillation Detector with Fast-Neutron/Gamma ray Discrimination

Award Year / Program / Phase: 2007 / SBIR / Phase I
Agency / Branch: DOD / DTRA
Principal Investigator: Edgar Van Loef, Staff Scientist
Award Amount: $99,996.00
Abstract:
The proliferation of weapons of mass destruction such as nuclear missiles and "dirty bombs" are a serious threat in the world today and especially to the well-being of the United States. Preventing the spread of these nuclear weapons has reached a state of heightened urgency in recent years, more… More

Sensitive High Speed Detector for Synchrotron Applications

Award Year / Program / Phase: 2007 / SBIR / Phase II
Agency: DOE
Principal Investigator: Gerald Entine, Dr
Award Amount: $749,993.00
Abstract:
Third-generation synchrotron sources, such as the Advanced Photon Source (APS), are outstanding facilities for X-ray diffraction and scattering of non-crystalline biological materials. However, their full potential has not been realized because of the lack of detectors that can provide multiple… More

Advanced Photodetector for Dark Matter Studies

Award Year / Program / Phase: 2007 / SBIR / Phase II
Agency: DOE
Principal Investigator: Gerald Entine, Dr
Award Amount: $650,000.00
Abstract:
Optical detectors are very important components of existing and future particle physics experiments, including those being developed for dark matter studies. However, the performance of experimental systems used in dark matter studies is limited by the properties of presently-available optical… More

New Bright High Resolution Scintillators

Award Year / Program / Phase: 2007 / SBIR / Phase II
Agency: DOE
Principal Investigator: Kanai S. Shah, Mr
Award Amount: $750,000.00
Abstract:
80613S06 Proliferation of the weapons of mass destruction such as nuclear weapons is a serious threat in the world today. Gamma-ray detectors are an important component of systems used to prevent nuclear proliferation. However, the performance of such systems is currently limited by the… More

Improvements in Scintillation Technology for Detection of Nuclear Radiation

Award Year / Program / Phase: 2007 / SBIR / Phase I
Agency / Branch: DOD / DTRA
Principal Investigator: Vivek Nagarkar, Director, Advanced Imaging Division
Award Amount: $100,000.00
Abstract:
High-resolution scintillation crystals and crystal arrays are important components of current and future handheld and arrayed detectors (used for DOD applications) and scintillation spectrometers (routinely used in high energy physics research, medical imaging, diffraction, homeland security,… More

Fast Neutron Imaging Scintillator with Low Sensitivity to Gamma Radiation

Award Year / Program / Phase: 2007 / SBIR / Phase II
Agency: DOE
Principal Investigator: Irina Shestakova, Dr
Award Amount: $749,999.00
Abstract:
The detectors available for neutron radiation are still inadequate, primarily limited by the available scintillators. Scintillators that can simultaneously provide high spatial resolution, high neutron detection efficiency, low gamma sensitivity, and fast response time do not exist. This project… More

Low-Cost SSPM-Based Digital Radiation Monitor

Award Year / Program / Phase: 2007 / SBIR / Phase II
Agency: DOE
Principal Investigator: James F. Christian, Dr
Award Amount: $749,996.00
Abstract:
81146S06 Many contaminated facilities throughout the DOE complex will reside in a safe storage or surveillance and maintenance (S&M) mode until such time that funding resources are available to perform decontamination and demolition. Long-term monitoring systems are required to ensure against a… More

Bright, Fast Scintillator for Nuclear Studies

Award Year / Program / Phase: 2007 / SBIR / Phase II
Agency: DOE
Principal Investigator: Kanai S. Shah, Mr
Award Amount: $750,000.00
Abstract:
Scintillation spectrometers, which consist of inorganic scintillation crystals coupled to photomultiplier tubes, are an important element of nuclear and elementary particle physics experiments. However, the performance of the detection systems used in these experiments is often limited by the… More

New Neutron Detectors with Pulse Shape Discrimination

Award Year / Program / Phase: 2007 / SBIR / Phase I
Agency: DHS
Principal Investigator: Jaroslav Glodo, Senior Scientist
Award Amount: $150,000.00
Abstract:
Proliferation of weapons of mass destruction such as nuclear weapons is a serious threat in the world today. Preventing the spread of nuclear weapons has reached a state of heightened urgency in recent years, especially since the events on September 11, 2001 and its aftermath. One way to passively… More

HIGH PERFORMANCE NEUTRON DETECTOR FOR PROTEIN CRYSTALLOGRAPHY

Award Year / Program / Phase: 2007 / SBIR / Phase I
Agency: HHS
Principal Investigator: Jaroslaw Glodo
Award Amount: $99,999.00
Abstract:
DESCRIPTION (provided by applicant): Recently, with the increase in number of new neutron sources, stationary as well as portable, there has been growing utilization of neutrons in a similar manner. Contrary to X- and ?-rays, the probability of interaction of neutrons with matter does not depend on… More

Diffused Optical Tomography using Oxygen-sensitive Luminescent Contrast Agent for

Award Year / Program / Phase: 2007 / STTR / Phase I
Agency: HHS
Research Institution: UNIVERSITY OF MICHIGAN
Principal Investigator: Rajan Gurjar
Award Amount: $210,345.00
RI Contact: N/A
Abstract:
DESCRIPTION (provided by applicant): Molecule specific targeting and improving image contrast have been recognized as important research areas in cancer imaging. Goal of cancer diagnosis and prognosis research is to develop new imaging techniques to detect lesions with certainty in early stages so… More

Instrument to Identify Hazardous Children's Products that Could Cause Lead Poison

Award Year / Program / Phase: 2007 / SBIR / Phase I
Agency: HHS
Principal Investigator: Michael R. Squillante
Award Amount: $150,000.00
Abstract:
DESCRIPTION (provided by applicant): Summary Lead and its compounds have been rated as one of the leading chemicals posing the greatest threat to human health. Significant amounts of lead are found in a multitude of consumer goods, ranging from electronics , household goods, to toys. In 1997, the… More

High-Performance Transparent Optical Ceramic Scintillators through Nanotechnology

Award Year / Program / Phase: 2007 / SBIR / Phase I
Agency: HHS
Principal Investigator: Alexander Lempicki
Award Amount: $144,547.00
Abstract:
DESCRIPTION (provided by applicant): LSO is generally recognized as the ideal scintillator for PET. It has high stopping power for 511 keV gamma rays, high light yield of over 20000 photons/MeV, and rapid decay of 32 ns. It achieves high coincidence timing resolution and energy resolution. But… More

SBIR Phase I: A Protein Probe for High-Throughput SNP Screening

Award Year / Program / Phase: 2007 / SBIR / Phase I
Agency: NSF
Principal Investigator: Daniel G. Hall, DPhil
Award Amount: $99,994.00
Abstract:
This Small Business Small Business Innovation Research (SBIR) Phase I research project aims to develop a reagent that binds specifically to DNA mismatches for use in a microarray-based single nucleotide polymorphism (SNP) assay. Directed evolution will be used to isolate variants of a DNA repair… More

Solid-State Photosensor for PET

Award Year / Program / Phase: 2007 / SBIR / Phase I
Agency: HHS
Principal Investigator: Gerald Entine
Award Amount: $100,000.00
Abstract:
DESCRIPTION (provided by applicant): Positron Emission Tomography (PET) is a functional imaging technique with potential to quantify the rates of biological processes in vivo. The availability of short lived positron-emitting isotopes of carbon, nitrogen, oxygen and especially fluorine allows… More

High-Speed Micro CT Detector for Physiologic Studies

Award Year / Program / Phase: 2007 / SBIR / Phase II
Agency: HHS
Principal Investigator: Vivek V. Nagarkar
Award Amount: $777,227.00
Abstract:
DESCRIPTION (provided by applicant): Dedicated high-resolution small animal imaging systems have recently emerged as important new tools for cancer research. Of these systems, x-ray microcomputed tomography (microCT) shows promise as a cost-effective means for detecting and characterizing soft… More

HIGH RESOLUTION NUCLEAR CARDIAC IMAGING

Award Year / Program / Phase: 2007 / SBIR / Phase II
Agency: HHS
Principal Investigator: Gerald Entine
Award Amount: $852,925.00
Abstract:
DESCRIPTION (provided by applicant): Nuclear medicine imaging modalities such as single photon emission computed tomography (SPECT) and positron emission tomography (PET) are powerful, non-invasive medical imaging techniques that provide an image of the t hree dimensional distribution of a… More

High Resolution PET Detectors for Combined PET-MR Small Animal Imaging

Award Year / Program / Phase: 2007 / SBIR / Phase II
Agency: HHS
Principal Investigator: Kanai S. Shah
Award Amount: $984,997.00
Abstract:
DESCRIPTION (provided by applicant): The ideal biological imaging system would provide non-invasive, high-resolution, high-sensitivity, three-dimensional (3D) functional and anatomic images of living systems. Positron Emission Tomography (PET) offers high sensitivity to a range of biological… More

Digital 2-D Neutron Detector for Protein Function Studies

Award Year / Program / Phase: 2007 / SBIR / Phase II
Agency: HHS
Principal Investigator: Irina Shestakova
Award Amount: $830,250.00
Abstract:
DESCRIPTION (provided by applicant): Information on the structure and function of proteins is important for unveiling biological processes taking place on a molecular level. X-ray crystallography has been successful in determining protein structure, howeve r, it is not well suited for analyzing… More

CVD Diamond Neutron Detectors with Pulse Shape Discrimination

Award Year / Program / Phase: 2008 / SBIR / Phase I
Agency: DHS
Principal Investigator: Leonard J. Cirignano, Principal Investigator
Award Amount: $150,000.00
Abstract:
Proliferation of nuclear weapons is a serious threat in the world today. One way to determine the presence of nuclear weapons is to detect neutrons emitted by special nuclear material(SNM) such as highly enriched uranium and weapons grade plutonium. The purpose of this project is to develop improved… More

Inspection of Subsurface Flaws around Fasteners on Aircraft

Award Year / Program / Phase: 2008 / SBIR / Phase I
Agency / Branch: DOD / USAF
Principal Investigator: Timothy Tiernan, Director of Adv. Instrumentation
Award Amount: $99,993.00
Abstract:
New technology is needed for nondestructive inspection (NDI) of defects in metallic components on aircraft. Small cracks and flaws in multilayer components near rivets and fasteners are a particular concern. Other problems include detecting and characterizing small defects in highly confined areas.… More

High Quantum Efficiency, Fast Detectors for the Readout of Scintillators for Gamma-Ray Detection

Award Year / Program / Phase: 2008 / SBIR / Phase II
Agency: DHS
Principal Investigator: Kanai S. Shah, Group Leader
Award Amount: $993,316.00
Abstract:
Gamma-ray spectrometers consisting of inorganic scintillators coupled to optical detectors such as photomultiplier tubes (PMTs) are an important element of the systems that are used to monitor and prevent the spread of special nuclear materials. Two very important requirements for the scintillation… More

High Resolution Mammography Sensor

Award Year / Program / Phase: 2008 / SBIR / Phase II
Agency: HHS
Principal Investigator: Michael R. Squillante
Award Amount: $977,915.00
Abstract:
DESCRIPTION (provided by applicant): Radiation Monitoring Devices ( RMD') is developing a digital radiographic imaging technology that is based upon a semiconductor x-ray receptor. The more specific, targeted application is mammographic imaging (including breast tomosynthesis) for which the… More

Tissue-Equivalent Radiation Dosimeter-On-A-Chip

Award Year / Program / Phase: 2008 / SBIR / Phase II
Agency: NASA
Principal Investigator: James Christian, Principal Investigator
Award Amount: $599,951.00
Abstract:
Available digital dosimeters are bulky and unable to provide real-time monitoring of dose for space radiation. The complexity of space-flight design requires reliable, fault-tolerant equipment capable of providing real-time dose readings during a mission, which is not feasible with the existing… More

Improvements in Scintillation Technology for Detection of Nuclear Radiation

Award Year / Program / Phase: 2008 / SBIR / Phase II
Agency / Branch: DOD / DTRA
Principal Investigator: Vivek Nagarkar, Group Leader
Award Amount: $749,989.00
Abstract:
OBJECTIVE: Develop innovative scintillator materials for the detection of gamma-ray or neutron radiation for a variety of applications. For handheld and arrayed detectors criteria for improvement include better energy resolution; higher light output (photons per MeV); improved linearity of light… More

CMOS-Based Neutron Spectroscopic Dosimeter (CNSD)

Award Year / Program / Phase: 2008 / SBIR / Phase I
Agency: NASA
Principal Investigator: James Christian, Principal Investigator
Award Amount: $99,996.00
Abstract:
Monitoring space radiation and the dose received by astronauts is important, especially for future long-duration missions. Neutrons contribute a significant component to the total radiation dose during solar events. We propose to develop a rugged, compact, lightweight, non-hazardous CMOS-based… More

Compact Unit for Eye-Safe Standoff Explosive Detection

Award Year / Program / Phase: 2008 / SBIR / Phase I
Agency / Branch: DOD / ARMY
Principal Investigator: Richard Myers, Senior Scientist
Award Amount: $69,997.00
Abstract:
The goal of this work is to develop a novel Raman scattering spectrometer for advance standoff detection of IEDs and suicide bomber threats. When using the proposed instrument, we will obtain rapid, chemical-specific analysis at standoff distances of up to 30 m. This instrument will have… More

Lidar-radar heterodyne receiver for underwater imaging applications

Award Year / Program / Phase: 2008 / SBIR / Phase I
Agency / Branch: DOD / NAVY
Principal Investigator: Madhavi Seetamraju, Principal Investigator
Award Amount: $79,999.00
Abstract:
High spatial resolution, LIDAR images of underwater targets from air and submersed platforms are plagued by poor signal-to-noise ratios (SNR), arising from strong scattering in the turbid media of seawater. A hybrid system that combines the detection and coherent signal processing techniques of… More

Portable High Resolution Imaging for NDI of Hot Section Aero Turbine Components

Award Year / Program / Phase: 2008 / STTR / Phase II
Agency / Branch: DOD / NAVY
Research Institution: NORTHEASTERN UNIV.
Principal Investigator: Timothy Tiernan, Group Director
Award Amount: $373,381.00
RI Contact: Nian Sun
Abstract:
New technology is needed for the nondestructive inspection (NDI) of defects in gas turbine engines. This is particularly true for components such as turbine blades with fretting fatigue defects that are difficult to detect and characterize with existing NDI equipment. The lack of detailed flaw… More

A Novel High Resolution Photon Counting Detector for X-Ray Inspections

Award Year / Program / Phase: 2008 / SBIR / Phase I
Agency / Branch: DOD / ARMY
Principal Investigator: Vivek Nagarkar, Group Leader
Award Amount: $69,997.00
Abstract:
Current state-of-the-art X-ray imaging detectors use energy integration, where the simple integration of X-ray events during the exposure period forms images. Unfortunately, such indiscriminate operation is sub-optimal for digital radiography or CT imaging because of its inability to reject… More

Near-IR Enhanced CMOS Sensor for LADAR Imaging

Award Year / Program / Phase: 2008 / SBIR / Phase I
Agency / Branch: DOD / MDA
Principal Investigator: Richard Myers, Senior Scientist
Award Amount: $99,993.00
Abstract:
Radiation Monitoring Devices, Inc. (RMD), in collaboration with Harvard University and Raytheon, proposes to develop a silicon-based focal plane array with single-photon responsivity at 1064-nm, with the goal of creating next-generation LADAR receivers. This Phase I effort will demonstrate the… More

Position Sensitive Microfluidic Detector

Award Year / Program / Phase: 2008 / SBIR / Phase I
Agency: HHS
Principal Investigator: Gerald Entine
Award Amount: $100,000.00
Abstract:
DESCRIPTION (provided by applicant): Microfluidic chips, fabricated from low cost polymers, are a promising, emerging technology for synthesis and study of new molecular imaging probes. These chips can contain a variety of microcircuitry and microwells and are capable of manipulating nanoliter… More

Modular, High Precision, Digital Measurement System for Hypervelocity Projectiles

Award Year / Program / Phase: 2008 / SBIR / Phase II
Agency / Branch: DOD / USAF
Principal Investigator: Vivek Nagarkar, Principal Investigator
Award Amount: $749,987.00
Abstract:
High flux flash X-ray systems provide unique methods of imaging ultra-fast events that cannot be captured using normal photographic techniques. X-ray images can be obtained in 20 to 50 nanoseconds, even through smoke, fire, and metal, and enable precise recording of details of test events under the… More

Novel Parallax Free Sensor for Molecular Imaging

Award Year / Program / Phase: 2008 / SBIR / Phase II
Agency: DOE
Principal Investigator: Vivek Nagarkar, Dr
Award Amount: $749,999.00
Abstract:
With the ever-increasing number of human disease models, particularly models in smaller animals, high-resolution emission/transmission tomography techniques have become extremely important. The barriers to using existing modalities in studies of laboratory animals have traditionally been poor… More

Improved Solid-State Neutron Detector

Award Year / Program / Phase: 2008 / SBIR / Phase II
Agency: DHS
Principal Investigator: James Christian
Award Amount: $463,736.00
Abstract:
The use and applications of radiological sources, for power, medical, and defense applications, continuously increases with time. Illicit nuclear materials represent a threat for the safety of the American citizens and the detection and interdiction of a nuclear weapon is a national problem that has… More

New Neutron Detectors with Pulse Shape Discrimination

Award Year / Program / Phase: 2008 / SBIR / Phase II
Agency: DHS
Principal Investigator: Jaroslav Glodo
Award Amount: $999,998.00
Abstract:
Proliferation of the weapons of mass destruction such as nuclear weapons is a serious threat in the world today. Preventing the spread of nuclear weapons has reached a state of heightened urgency in recent years, especially since the events on September 11, 2001 and its aftermath. One way to… More

A New High Performance Detector for Small Animal SPECT

Award Year / Program / Phase: 2008 / SBIR / Phase II
Agency: HHS
Principal Investigator: Vivek V. Nagarkar
Award Amount: $962,923.00
Abstract:
DESCRIPTION (provided by applicant): Among the various functional imaging techniques, SPECT maintains an important role in the study of disease models in small animals as well as in patient care. Many SPECT-labeled imaging probes that have highly specific distributions with very little background… More

Continuous Phoswich Detector for Molecular Imaging

Award Year / Program / Phase: 2008 / SBIR / Phase I
Agency: HHS
Principal Investigator: Vivek V. Nagarkar
Award Amount: $179,999.00
Abstract:
DESCRIPTION (provided by applicant): Positron Emission Tomography (PET) imaging systems used in Nuclear Medicine can suffer from loss of spatial resolution due to parallax effects, called radial elongation. A scintillation detector that allows depth-of- in teraction (DOI) determination would be an… More

High Resolution Detectors for Single Photon Cardiac Imaging

Award Year / Program / Phase: 2008 / SBIR / Phase I
Agency: HHS
Principal Investigator: Gerald Entine
Award Amount: $135,000.00
Abstract:
DESCRIPTION (provided by applicant): High Resolution Detectors for Single Photon Cardiac Imaging Single photon emission computed tomography (SPECT) is a powerful, noninvasive medical imaging modality that mathematically reconstructs the three dimensional d istribution of a radionuclide throughout… More

Practical Anti-Thrombotic Catheters for Improved Patient Outcome

Award Year / Program / Phase: 2008 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $137,486.00
Abstract:
DESCRIPTION (provided by applicant): Venous catheters play critical roles in the administration of chemotherapy, antibiotics, blood, blood products and total parenteral nutrition essential for the successful treatment of many chronic afflictions. Recent ad vances in catheter technology have enabled… More

Cancer Detection Using Diffuse Luminescence Imaging

Award Year / Program / Phase: 2008 / SBIR / Phase II
Agency: HHS
Principal Investigator:
Award Amount: $1,080,222.00
Abstract:
DESCRIPTION (provided by applicant): The focus of the proposal is in the area of breast cancer imaging and tumor characterization using oxygen sensitive phosphorescent labels and hybrid imaging modality. We propose to use simultaneous diffuse optical tomog raphy (DOT) and magnetic resonance imaging… More

Reduced Afterglow Scintillator Films for High Speed Medical Imaging

Award Year / Program / Phase: 2008 / SBIR / Phase I
Agency: HHS
Principal Investigator: Vivek V. Nagarkar
Award Amount: $1,550,305.00
Abstract:
DESCRIPTION (provided by applicant): While many exotic new scintillation materials are now being developed, few even come close to CsI:Tl in performance and versatility. Widely available commercially at low cost, CsI:Tl not only has superb scintillation ef ficiency, but also can readily be… More

Novel Detector for Molecular Imaging Studies

Award Year / Program / Phase: 2008 / SBIR / Phase I
Agency: HHS
Principal Investigator: Michael R. Squillante
Award Amount: $99,999.00
Abstract:
DESCRIPTION (provided by applicant): Microfluidic devices are a promising, emerging technology for molecular imaging studies. These chips can contain a variety of microcircuitry and microwells, and are capable of manipulating nanoliter samples of reagents and solvents. The microfluidic chips have… More

Near Infrared Detector for Advanced Opthamology

Award Year / Program / Phase: 2008 / SBIR / Phase I
Agency: HHS
Principal Investigator: Gerald Entine
Award Amount: $180,000.00
Abstract:
DESCRIPTION (provided by applicant): Some of the most useful tools for diagnosis and understanding of blinding retinal diseases rely on the use of spectral reflectance. Improvements to these tools, especially over the past decade, have greatly advanced our ability to achieve extremely… More

SSPM Detector for Polarized Target Scintillator Readout

Award Year / Program / Phase: 2008 / SBIR / Phase II
Agency: DOE
Principal Investigator: James Christian, Dr
Award Amount: $749,996.00
Abstract:
Nuclear physics investigations require photodetectors that operate in harsh conditions (e.g., temperatures of 5 K and below, and magnetic fields greater than 1 T); yet existing methods of photodetection cannot provide the needed quality of data at a reasonable cost. This project will develop a… More

New Detector for Gamma-Ray and Neutron Studies

Award Year / Program / Phase: 2008 / SBIR / Phase II
Agency: DOE
Principal Investigator: Kanai S. Shah, Mr
Award Amount: $750,000.00
Abstract:
Inorganic scintillation crystals are a very important element of the current and the next generation experiments in nuclear and particle physics. Performance of the nuclear physics detection systems is often limited by the properties of scintillators available for neutron and gamma ray detection. … More

Low Cost Co-Doped Scintillator for Medical CT

Award Year / Program / Phase: 2008 / SBIR / Phase II
Agency: HHS
Principal Investigator: Michael R. Squillante
Award Amount: $1,011,614.00
Abstract:
DESCRIPTION (provided by applicant): Venous catheters play critical roles in the administration of chemotherapy, antibiotics, blood, blood products and total parenteral nutrition essential for the successful treatment of many chronic afflictions. Recent ad vances in catheter technology have enabled… More

Developing CZT for Single Element Spectrometers

Award Year / Program / Phase: 2008 / SBIR / Phase II
Agency: DOE
Principal Investigator: Paul R. Bennett, Dr
Award Amount: $750,000.00
Abstract:
Cadmium zinc telluride (CZT) detectors have the potential to be a powerful and versatile tool in the tracking and control of nuclear materials. However, despite well over a decade of development, yield of spectrometer grade material remains low. This project will investigate the traveling heater… More

High Performance X-Ray Detectors

Award Year / Program / Phase: 2008 / SBIR / Phase II
Agency: DOE
Principal Investigator: Gerald Entine, Mr
Award Amount: $750,000.00
Abstract:
X-ray detector arrays with high energy resolution, high sensitivity and high count-rate performance are required for synchrotron beamline studies. However, in many studies conducted with synchrotron beamlines, the characteristics of available X-ray detectors limit the overall system performance. … More

A Novel Microfluidic Detector with Position Sensitivity

Award Year / Program / Phase: 2008 / SBIR / Phase II
Agency: DOE
Principal Investigator: Kanai S. Shah, Mr
Award Amount: $750,000.00
Abstract:
Microfluidic chips, fabricated from low cost polymers, are a promising, emerging technology for synthesis and study of new molecular imaging probes. These chips can contain a variety of microcircuitry and microwells, and are capable of manipulating nanoliter samples of reagents and solvents. The… More

Novel Ceramic Scintillators for PET

Award Year / Program / Phase: 2008 / SBIR / Phase II
Agency: DOE
Principal Investigator: Alexander Lempicki, Dr
Award Amount: $750,000.00
Abstract:
Scintillation detectors, consisting of inorganic scintillation crystals coupled to photomultipliers, are an important element of medical imaging applications such as positron emission tomography (PET). Performance as well as cost of these systems is limited by the properties of the scintillation… More

New Approach for Lanthanide Halide Crystal Growth

Award Year / Program / Phase: 2008 / SBIR / Phase I
Agency: DOE
Principal Investigator: William Higgins, Mr.
Award Amount: $99,999.00
Abstract:
Gamma-ray spectrometers based on lanthanide halide scintillators are a very promising class of detectors for nuclear nonproliferation monitoring. They provide excellent energy resolution and fast response. However, the growth of large crystals of lanthanide halide scintillators using traditional… More

Structured Scintillator for High Resolution, High Efficiency Neutron Imaging

Award Year / Program / Phase: 2008 / SBIR / Phase I
Agency: DOE
Principal Investigator: Vivek V. Nagarkar, Dr.
Award Amount: $100,000.00
Abstract:
The development of new high-intensity neutron sources such as the Spallation Neutron Source (SNS) will place demanding requirements on detector performance, because current state-of-the-art detectors are limited by the characteristics of the phosphor screen used to convert the incident neutron flux… More

Novel Approach for Depth-of-Interaction Encoding in PET

Award Year / Program / Phase: 2008 / SBIR / Phase I
Agency: DOE
Principal Investigator: Kanai Shah, Mr.
Award Amount: $100,000.00
Abstract:
Depth-of-Interaction (DOI) encoding is an important requirement in clinical as well as small animal Positron Emission Tomography (PET). At present, almost all commercial PET scanners do not have DOI encoding capability, and, as a result, these scanners exhibit parallax error, which degrades their… More

Advanced Detectors for PET

Award Year / Program / Phase: 2008 / SBIR / Phase I
Agency: DOE
Principal Investigator: Purushottam Dokhale, Dr.
Award Amount: $99,999.00
Abstract:
Positron Emission Tomography (PET) is a functional imaging technique with the potential to quantify the rates of biological processes in vivo. PET imaging can provide diagnosis for symptoms of diseases such as Alzheimer¿s disease, head trauma, cancer, and stroke. However, the performance of… More

Development of Real-time Coal Monitoring Instrument

Award Year / Program / Phase: 2008 / SBIR / Phase I
Agency: DOE
Principal Investigator: Rajan Gurjar, Dr.
Award Amount: $99,998.00
Abstract:
Optimized extraction of heat content from various blends of coal fuel, in combination with a reduction in harmful constituents and byproducts, will be necessary if reliance on coal energy is desired. Therefore, it is important to have a real-time instrument that (1) provides relevant information… More

Optical Detector with Integrated ADC for Digital Readout

Award Year / Program / Phase: 2008 / SBIR / Phase I
Agency: DOE
Principal Investigator: James Christian, Dr.
Award Amount: $99,999.00
Abstract:
Most nuclear physics experiments use PMTs coupled to scintillators, which require a readout using BNC cables, HV cables, HV suppliers, analog-to-digital converters (ADCs), and possibly additional modular electronics and mainframes for signal processing. These items tend to account for a significant… More

Fast, Low Noise Photodetectors for Nuclear Physics

Award Year / Program / Phase: 2008 / SBIR / Phase I
Agency: DOE
Principal Investigator: Kanai Shah, Mr.
Award Amount: $100,000.00
Abstract:
Current and next generation experiments in nuclear and particle physics require detectors with high signal-to-noise ratio, fast response, accurate energy information and high spatial resolution. This project will investigate a compact detector design that can be operated with very high gain. This… More

High Resolution Scintillators for SPECT

Award Year / Program / Phase: 2008 / SBIR / Phase I
Agency: DOE
Principal Investigator: Gerald Entine, Dr.
Award Amount: $99,998.00
Abstract:
Single photon emission computed tomography (SPECT) is a powerful, noninvasive medical imaging modality that mathematically reconstructs the three dimensional distribution of a radionuclide throughout the body of a human patient or research animal. At present, the performance of available SPECT… More

A Novel, High Resolution PET Detector

Award Year / Program / Phase: 2008 / SBIR / Phase I
Agency: DOE
Principal Investigator: Jaroslaw Glodo, Dr.
Award Amount: $99,998.00
Abstract:
Positron Emission Tomography (PET) is a powerful imaging technique with a potential to quantify the rates of biological processes in vivo. However, the performance of PET systems is limited by presently available detector technology. Next generation gamma-ray detectors will be based on bright, fast… More

High Performance Neutron Detector

Award Year / Program / Phase: 2008 / SBIR / Phase I
Agency: DOE
Principal Investigator: Jaroslaw Glodo, Dr.
Award Amount: $99,999.00
Abstract:
With the increase in the number of new neutron sources, stationary as well as portable, there has been growing utilization of neutrons in materials science and other fields. However, available neutron detectors are not able to extract the full potential of the new neutron sources being built. This… More

Advanced Scintillation Detector for Synchrotron Facilities

Award Year / Program / Phase: 2008 / SBIR / Phase I
Agency: DOE
Principal Investigator: Vivek V. Nagarkar, Dr.
Award Amount: $100,000.00
Abstract:
Recent developments in synchrotron radiation sources have enabled the growth of powerful techniques, such as time-resolved X-ray diffraction for understanding dynamic biological phenomena and the Multi-wavelength Anomalous Dispersion (MAD) method for recovering phase information in X-ray… More

Generation of bivalent aptamers with high affinity and selectivity for detection of viruses and bacteria from environmental samples

Award Year / Program / Phase: 2009 / SBIR / Phase I
Agency: DHS
Principal Investigator: Daniel Hall
Award Amount: $99,999.00
Abstract:
Better methodologies for the rapid detection of pathogenic bacteria and viruses are needed. A problem with current antibody-based assays is cross-reactivity with similar, but harmless, species. RMD, Inc., proposes developing nucleic acid-based affinity reagents (aptamers) against the spore coat of… More

Autonomous Vehicle Awareness Sensor

Award Year / Program / Phase: 2009 / SBIR / Phase I
Agency / Branch: DOD / USAF
Principal Investigator: Richard Myers, Ph.D., Design Engineer
Award Amount: $99,999.00
Abstract:
Radiation Monitoring Devices, Inc. (RMD) in collaboration with Munro Ranging, LLC will develop an active laser sensor for autonomous satellite awareness systems. The instrument will be based on two innovative technologies developed by Munro Ranging and RMD to allow accurate and timely situation… More

A Novel High Resolution Photon Counting Detector for X-Ray Inspections

Award Year / Program / Phase: 2009 / SBIR / Phase II
Agency / Branch: DOD / ARMY
Principal Investigator: Vivek Nagarkar, Group Leader
Award Amount: $729,995.00
Abstract:
Current state-of-the-art X-ray imaging detectors use energy integration, where the simple integration of X-ray events during the exposure period forms images. Unfortunately, such indiscriminate operation is sub-optimal for digital radiography or CT imaging because of its inability to reject… More

Low Cost Large Volume Lanthanide Halide Scintillators

Award Year / Program / Phase: 2009 / SBIR / Phase I
Agency: DOE
Principal Investigator: Bipin Singh, Dr.
Award Amount: $99,996.00
Abstract:
New cerium-doped lanthanide halide scintillators have shown a strong potential to move beyond their familiar role in conventional gamma ray spectroscopy, toward fulfilling the needs of other highly demanding applications. However, issues related to the reliable, large volume manufacturing of these… More

Bright Selenium Based Quantum Dot Scintillators

Award Year / Program / Phase: 2009 / SBIR / Phase I
Agency: DOE
Principal Investigator: Vivek Nagarkar, Dr.
Award Amount: $99,997.00
Abstract:
High-resolution scintillation crystals and crystal arrays are important components of current and future nuclear physics instruments and experiments. Unfortunately, the performance of the systems used in these experiments is often limited by the properties of the scintillation detectors presently… More

Augmented Reality Maintenance System (ARMS) for Complex Military Assets

Award Year / Program / Phase: 2009 / SBIR / Phase II
Agency: DOD
Principal Investigator: Timothy Tiernan, Director Advanced Instrum – (617) 668-6800
Award Amount: $1,146,067.00
Abstract:
Currently, equipment maintenance requires highly trained individuals and is labor intensive, expensive and inefficient. The Marine Corps and DoD use written technical manuals and Interactive Electronic Technical Manuals (IETM) to direct technicians through complex maintenance procedures for land… More

A Novel Cost Effective Method for Growing High Performance Radiation Sensors

Award Year / Program / Phase: 2009 / SBIR / Phase I
Agency / Branch: DOD / DTRA
Principal Investigator: Vivek Nagarkar, Group Leader
Award Amount: $99,999.00
Abstract:
We seek proposals to develop, design and build inexpensive radiation detectors capable of crude gamma spectroscopy. Ideally these detectors will be simple and inexpensive enough to be deployed in large numbers and essentially disposable. DESCRIPTION: In DTRA's efforts to prevent the spread… More

High Reliability, Miniature Personal Hypoxia Monitoring System

Award Year / Program / Phase: 2009 / SBIR / Phase I
Agency / Branch: DOD / NAVY
Principal Investigator: Rajan Gurjar, Senior Scientist
Award Amount: $79,998.00
Abstract:
Accidental reduction in the oxygen available to a fighter pilot at high altitudes can lead to insidious hypoxia, where symptoms are almost unnoticeable before loss of consciousness in less than a minute. Under such situations, an accurate hypoxia monitoring unit that can predict the early onset of… More

High Performance Neutron Detector

Award Year / Program / Phase: 2009 / SBIR / Phase II
Agency: DOE
Principal Investigator: Jaroslaw Glodo, Dr.
Award Amount: $749,996.00
Abstract:
Neutrons are invaluable to the characterization of materials in the physical, chemical, and biological sciences. To realize the full potential of present and future neutron facilities, improvements are needed for neutron detectors with respect to detection efficiency, high counting rate capability,… More

Novel Approach for Depth-of-Interaction Encoding in PET

Award Year / Program / Phase: 2009 / SBIR / Phase II
Agency: DOE
Principal Investigator: Kanai Shah, Mr.
Award Amount: $749,995.00
Abstract:
Depth-of-interaction (DOI) encoding is an important requirement in clinical as well as small-animal positron emission tomography (PET). At present, almost none of the commercial PET scanners have DOI encoding capability, and, as a result, these scanners show parallax error, which degrades their… More

Optical Detector with Integrated ADC for Digital Readout

Award Year / Program / Phase: 2009 / SBIR / Phase II
Agency: DOE
Principal Investigator: James Christian, Dr.
Award Amount: $749,999.00
Abstract:
Many nuclear physics experiments use photomultiplier tubes (PMTs) coupled to scintillators, which require a readout using BNC cables, HV cables, HV suppliers, analog-to-digital converters (ADCs), and possibly additional modular electronics and mainframes for signal processing. These items tend to… More

Advanced Detectors for PET

Award Year / Program / Phase: 2009 / SBIR / Phase II
Agency: DOE
Principal Investigator: Purushottam Dokhale, Dr.
Award Amount: $749,994.00
Abstract:
Positron Emission Tomography (PET) is a functional imaging technique with the potential to quantify the rates of biological processes in vivo. PET imaging can provide diagnosis for symptoms of diseases such as Alzheimer¿s disease, head trauma, cancer, and stroke. However, the performance of… More

Advanced Scintillation Detector for Synchrotron Facilities

Award Year / Program / Phase: 2009 / SBIR / Phase II
Agency: DOE
Principal Investigator: Vivek V. Nagarkar, Dr.
Award Amount: $749,999.00
Abstract:
Recent developments in synchrotron radiation sources have enabled the growth of powerful techniques, such as time-resolved X-ray diffraction studies for understanding dynamic biological phenomena and the Multi-wavelength Anomalous Dispersion (MAD) method for recovering phase information in X-ray… More

High Resolution Scintillators for SPECT

Award Year / Program / Phase: 2009 / SBIR / Phase II
Agency: DOE
Principal Investigator: Gerald Entine, Dr.
Award Amount: $749,993.00
Abstract:
Positron Emission Tomography (PET) is a functional imaging technique with the potential to quantify the rates of biological processes in vivo. PET imaging can provide diagnosis for symptoms of diseases such as Alzheimer¿s disease, head trauma, cancer, and stroke. However, the performance of… More

New Approach for Lanthanide Halide Crystal Growth

Award Year / Program / Phase: 2009 / SBIR / Phase II
Agency: DOE
Principal Investigator: William Higgins, Mr.
Award Amount: $749,995.00
Abstract:
Gamma-ray spectrometers based on lanthanide halide and related scintillators are a very promising class of detectors for nuclear non-proliferation monitoring, providing excellent energy resolution and fast response. However, the growth of large crystals of lanthanide halide scintillators, using… More

Low Cost, High Speed, High Sensitivity Detector for Material Science Studies

Award Year / Program / Phase: 2009 / SBIR / Phase I
Agency: DOE
Principal Investigator: Gerald Entine, Dr.
Award Amount: $99,997.00
Abstract:
Advanced photon sources are capable of providing extremely high X-ray intensities and have proven to be outstanding resources for X-ray scattering and time-resolved diffraction of materials. The problem, however, is in finding a detector that can provide multiple frames of detailed structural… More

High Performance Detectors for SPECT

Award Year / Program / Phase: 2009 / SBIR / Phase I
Agency: HHS
Principal Investigator: Michael R. Squillante
Award Amount: $136,293.00
Abstract:
DESCRIPTION (provided by applicant): High Performance Detectors for SPECT P.I.: Dr. Michael R. Squillante Abstract Single photon emission computed tomography (SPECT) is a powerful, noninvasive medical imaging modality that mathematically reconstructs the t hree dimensional distribution of a… More

NIR Instrument for Singlet Oxygen Mapping during PDT

Award Year / Program / Phase: 2009 / SBIR / Phase I
Agency: HHS
Principal Investigator: Madhavi Seetamraju
Award Amount: $168,029.00
Abstract:
DESCRIPTION (provided by applicant): The focus of the proposal is in the area of dosimetry for photodynamic therapy (PDT), especially for breast cancer treatment. It is crucial that the optimal dosage of the three PDT components - photosensitizer, light fl uence, and oxygen - be involved for the… More

New Solid-State Photosensor for PET

Award Year / Program / Phase: 2009 / SBIR / Phase II
Agency: HHS
Principal Investigator: Gerald Entine
Award Amount: $1,285,160.00
Abstract:
DESCRIPTION (provided by applicant): New, Solid-State Photosensor for PET Positron Emission Tomography (PET) is a functional imaging technique with potential to quantify the rates of biological processes in vivo. The availability of short lived positron-em itting isotopes of carbon, nitrogen, oxygen… More

Bright Quantum Dot Scintillator for High Frame Rate Imaging

Award Year / Program / Phase: 2009 / SBIR / Phase I
Agency: DOE
Principal Investigator: Vivek Nagarkar, Dr.
Award Amount: $99,997.00
Abstract:
As synchrotron radiation has become a ubiquitous tool across a broad area of science, the DOE supports collaborative research centers for synchrotron radiation science. Recent developments in synchrotron radiation sources have enabled the growth of powerful techniques, such as time-resolved X-ray… More

New Design of a Photon Counting Detector for Breast CT

Award Year / Program / Phase: 2009 / SBIR / Phase I
Agency: HHS
Principal Investigator: Vivek V. Nagarkar
Award Amount: $191,501.00
Abstract:
DESCRIPTION (provided by applicant): Breast cancer is a serious disease that accounts for approximately 40,000 deaths per year in the United States alone. Unfortunately, there is no simple, easily addressed cause of breast cancer, and until the root causes can be identified and eliminated, the best… More

Sesquoxide Laser Hosts for Electron Accelerators

Award Year / Program / Phase: 2009 / SBIR / Phase I
Agency: DOE
Principal Investigator: Rajan Gurjar, Dr.
Award Amount: $99,998.00
Abstract:
Ultrafast high power lasers are now employed in electron accelerators to generate X-rays or to inject highly accelerated electrons for further applications. However, the current lasers used are inefficient, due to the high power needed to pump the gain medium using indirect pumping. Recently it… More

High Bandwidth Optical Detector for Scanning Probe Microscopy

Award Year / Program / Phase: 2009 / SBIR / Phase I
Agency: DOE
Principal Investigator: Richard Myers, Dr.
Award Amount: $99,999.00
Abstract:
Rapid advancements in nanosciences are pushing the limits of surface probe microscopy (SPM) technology. Of particular interest is the ability to extend the SPM bandwidth of detection, which would provide more specific molecular recognition and allow studies of interaction chemistry that, to date,… More

Magneto-optical Technology for Screening Receptor Libraries

Award Year / Program / Phase: 2009 / SBIR / Phase I
Agency: HHS
Principal Investigator: Gyula Varadi
Award Amount: $180,001.00
Abstract:
DESCRIPTION (provided by applicant): Radiation Monitoring Devices, Inc. (RMD) proposes to develop a platform technology and device capable of high throughput screening of the association between biologically/pharmacologically active molecules and their cog nate receptors. RMD has demonstrated that… More

High Resolution Detectors for Single Photon Cardiac Imaging

Award Year / Program / Phase: 2009 / SBIR / Phase II
Agency: HHS
Principal Investigator: Gerald Entine
Award Amount: $880,002.00
Abstract:
DESCRIPTION (provided by applicant): High Resolution Detectors for Single Photon Cardiac Imaging Single photon emission computed tomography (SPECT) is a powerful, noninvasive medical imaging modality that mathematically reconstructs the three dimensional d istribution of a radionuclide throughout… More

Novel Photon Counting Detector for Small Animal SPECT/MRI

Award Year / Program / Phase: 2009 / SBIR / Phase I
Agency: DOE
Principal Investigator: Gerald Entine, Dr.
Award Amount: $99,999.00
Abstract:
Single photon emission computed tomography (SPECT) maintains an important role in the study of disease models in small animals. Although rich in physiological information content, the interpretation of SPECT data is challenging because SPECT images lack anatomical information. While… More

New Detectors for Small Animal SPECT

Award Year / Program / Phase: 2009 / SBIR / Phase I
Agency: DOE
Principal Investigator: Leonard Cirignano, Mr.
Award Amount: $99,998.00
Abstract:
Single Photon Emission Computed Tomography (SPECT) has become a powerful new tool in imaging biological processes in small laboratory animals. However, the performance of this modality is limited by the properties of the detectors available at present. This project will investigate a new solid… More

High Performance, Low Cost Scintillators for PET

Award Year / Program / Phase: 2009 / SBIR / Phase I
Agency: DOE
Principal Investigator: Charles Brecher, Dr.
Award Amount: $99,996.00
Abstract:
Scintillation detectors, which consist of inorganic scintillation crystals coupled to photomultiplier tubes (PMTs), are an important element of medical imaging applications such as positron emission tomography (PET). However, both the performance and cost-effectiveness of these systems is limited… More

Dual Modality Small Animal Imaging

Award Year / Program / Phase: 2009 / SBIR / Phase I
Agency: DOE
Principal Investigator: Purushottam Dokhale, Dr.
Award Amount: $99,997.00
Abstract:
The ideal biological imaging system would provide non-invasive, high-resolution, high sensitivity, three-dimensional (3D) images of living systems. Positron Emission Tomography (PET), which offers high sensitivity to a range of biological processes, through the use of targeted radio labeled probes,… More

Fast, Low Noise Photodetectors for Nuclear Physics

Award Year / Program / Phase: 2009 / SBIR / Phase II
Agency: DOE
Principal Investigator: Kanai Shah, Mr.
Award Amount: $749,994.00
Abstract:
Current and next generation experiments in nuclear and particle physics require detectors with high signal-to-noise ratio, fast response, accurate energy information, and high spatial resolution. This project will investigate a promising compact detector design that can be operated with very high… More

Low Cost High Frame Rate Detector for Macromolecular Diffraction and Scattering

Award Year / Program / Phase: 2009 / SBIR / Phase I
Agency: HHS
Principal Investigator: Vivek V. Nagarkar
Award Amount: $136,816.00
Abstract:
DESCRIPTION (provided by applicant): Advanced photon sources are capable of providing extremely high X-ray intensities and have proven to be outstanding resources for X-ray scattering and time-resolved diffraction of materials such as organic semiconductor s used in electronics, photodiode, and… More

Fast, Photon Counting Detector Arrays with Internal Gain

Award Year / Program / Phase: 2009 / SBIR / Phase I
Agency: DOE
Principal Investigator: Richard Farrell, Mr.
Award Amount: $99,995.00
Abstract:
Third generation x-ray synchrotron facilities, such as Argonne National Laboratory¿s Advanced Photon Source, create high-brilliance x-ray beams that are focused to small spot sizes on a wide variety of materials and biological samples. The efficient use of these expensive facilities requires that… More

Tunable Wavelength, High Efficiency Scintillator for Neutron Crystallography

Award Year / Program / Phase: 2009 / SBIR / Phase I
Agency: HHS
Principal Investigator: Vivek V. Nagarkar
Award Amount: $197,548.00
Abstract:
DESCRIPTION (provided by applicant): Despite their unique advantages and great promise for elucidating the structure of proteins, neutron techniques have been underutilized compared to X-ray measurement techniques, primarily because of the lack of adequate neutron sources and suitable imaging… More

High Spatial Resolution Structured Plastic Scintillator

Award Year / Program / Phase: 2009 / SBIR / Phase II
Agency: HHS
Principal Investigator: Vivek V. Nagarkar
Award Amount: $1,229,941.00
Abstract:
DESCRIPTION (provided by applicant): Neutron techniques complement X-ray diffraction techniques in their ability to precisely locate hydrogen and light atoms in various materials. This information is critical for determining the structure and function of p roteins and for the discovery of biological… More

Ultra-Fast, Bright Scintillators for PET

Award Year / Program / Phase: 2009 / SBIR / Phase I
Agency: DOE
Principal Investigator: Jaroslaw Glodo, Dr.
Award Amount: $99,997.00
Abstract:
Scintillation detectors, consisting of inorganic scintillation crystals coupled to photomultiplier tubes (PMTs), are an important element of medical imaging applications such as positron emission tomography (PET). However, the performance of these systems is limited by the properties of the… More

Next Generation SPECT Detectors

Award Year / Program / Phase: 2009 / SBIR / Phase I
Agency: DOE
Principal Investigator: Michael Squillante, Dr.
Award Amount: $99,999.00
Abstract:
Single photon emission computed tomography (SPECT) is a powerful, noninvasive medical imaging modality that mathematically reconstructs the three dimensional distribution of a radionuclide throughout the body of a human patient or research animal. At present, the performance of available SPECT… More

Bright and Fast Sensor for Time Resolved X-Ray Diffraction Studies

Award Year / Program / Phase: 2009 / SBIR / Phase II
Agency: HHS
Principal Investigator: Vivek V. Nagarkar
Award Amount: $1,207,979.00
Abstract:
DESCRIPTION (provided by applicant): Recent extraordinary developments in synchrotron radiation sources have enabled the growth of powerful research techniques such as time-resolved X-ray diffraction studies, essential for understanding dynamic biological phenomena and recovering phase information… More

CVD Diamond Neutron Detectors with Pulse Shape Discrimination

Award Year / Program / Phase: 2009 / SBIR / Phase II
Agency: DHS
Principal Investigator: Leonard J. Cirignano
Award Amount: $999,597.75
Abstract:
Proliferation of nuclear weapons is a serious threat in the world today. One way to determine the presence of nuclear weapons is to detect neutrons emitted by special nuclear material (SNM) such as highly enriched uranium and weapons grade plutonium. The purpose of this project is to develop… More

A Novel High Resolution Photon Counting Detector for X-Ray Inspections

Award Year / Program / Phase: 2009 / SBIR / Phase II
Agency / Branch: DOD / ARMY
Principal Investigator: Vivek Nagarkar, Group Leader – (617) 668-6800
Award Amount: $1,729,213.00
Abstract:
Current state-of-the-art X-ray imaging detectors use energy integration, where the simple integration of X-ray events during the exposure period forms images. Unfortunately, such indiscriminate operation is sub-optimal for digital radiography or CT imaging because of its inability to reject… More

Instrumentation for Nanoscale Spectroscopy

Award Year / Program / Phase: 2010 / STTR / Phase I
Agency / Branch: DOD / USAF
Research Institution: University of Nebraska
Principal Investigator: Rajan Gurjar, Senior Scientist
Award Amount: $99,999.00
RI Contact: Yongfeng Lu
Abstract:
We propose to develop a combination Tip-Enhanced Raman Scattering and Shear-Force Microscopy (TERS-SFM) instrument to study the composition and morphology of nanoparticles, surfaces, and biofilms on any substrate material. The instrument developed during Phase I will rely upon Scanning Tunneling… More

Generation of bivalent aptamers with high affinity and selectivity for detection of viruses and bacteria from environmental samples

Award Year / Program / Phase: 2010 / SBIR / Phase II
Agency: DHS
Principal Investigator: Daniel Hall
Award Amount: $749,945.00
Abstract:
  Better methodologies for the rapid detection of pathogenic bacteria and viruses are needed. A particular problem with current antibody-based assays is cross-reactivity with similar, but harmless, species. Radiation Monitoring Devices, Inc. proposes developing nucleic acid-based affinity… More

Semiconductor Neutron Detectors

Award Year / Program / Phase: 2010 / SBIR / Phase I
Agency: DHS
Principal Investigator: William Higgins
Award Amount: $149,999.00
Abstract:
In the proposed program we plan to investigate novel semiconductor neutron detectors based on the wide bandgap, lithium containing compositions LiMgP LiMgAs and LiZnP. The goal of the program is to produce detector quality crystals and to demonstrate efficient thermal neutron detection, with the… More

New Wide Bandgap Semiconductor Materials for Neutron Detection

Award Year / Program / Phase: 2010 / SBIR / Phase I
Agency: DHS
Principal Investigator: Joshua Tower
Award Amount: $149,999.00
Abstract:
In the proposed program, we plan to investigate novel semiconductor neutron detectors based on the wide bandgap lithium containing compositions LiGaSe2, LiGaTe2, LiInS2, and LiInSe2. The goal of the program is to produce detector quality crystals and to demonstrate efficient thermal neutron… More

New Scintillator for Neutron Detection

Award Year / Program / Phase: 2010 / SBIR / Phase I
Agency: DHS
Principal Investigator: Jaroslaw Glodo
Award Amount: $149,999.00
Abstract:
Neutron detection is one of the methods used in revealing illicit nuclear materials. Currently, there is an ongoing search for new and better neutron detectors prompted by anticipated shortages of He-3 that is used in many of the current detection systems. This effort proposes and investigation and… More

Low Cost, Large Volume 3He Replacement Neutron Detector

Award Year / Program / Phase: 2010 / SBIR / Phase I
Agency: DHS
Principal Investigator: Vivek Nagarkar
Award Amount: $149,999.00
Abstract:
Nuclear instrumentation for the detection of thermal neutrons relies heavily upon 3He because of its desirable nuclear properties and physical characteristics. The decline in production combined with increased demand has depleted the 3He stockpile and the supply of 3He is presently insufficient for… More

High Performance Detectors for SPECT

Award Year / Program / Phase: 2010 / SBIR / Phase II
Agency: HHS
Principal Investigator: Michael R. Squillante
Award Amount: $1,189,589.00
Abstract:
DESCRIPTION (provided by applicant): High Performance Detectors for SPECT P.I.: Dr. Michael R. Squillante Abstract Single photon emission computed tomography (SPECT) is a powerful, noninvasive medical imaging modality that mathematically reconstructs the t hree dimensional distribution of a… More

Fast Neutron Dosimeter for the Space Environment

Award Year / Program / Phase: 2010 / SBIR / Phase I
Agency: NASA
Principal Investigator: James Christian, Ph.D., Principal Investigator
Award Amount: $99,998.00
Abstract:
Secondary neutrons make a significant contribution to the total absorbed dose received by space crews during long duration space missions However, only a limited number of measurements of the dose contribution from secondary neutrons have been made. In part this is due to an inability to easily… More

High Speed and High Sensitivity Quadrant Photo Detector

Award Year / Program / Phase: 2010 / SBIR / Phase I
Agency / Branch: DOC / NIST
Principal Investigator: Richard Myers
Award Amount: $89,999.00
Abstract:
To further advance the characterization and utility of microcantilevers, next generation optical detectors with higher frequency response, improved displacement resolution and lower noise for weak signal detection are needed. Consequently, Radiation Monitoring Devices, Inc. (RMD) will develop a… More

Photonic Bandgap Structures for Improved Timing and Spatial Resolution in PET Det

Award Year / Program / Phase: 2010 / SBIR / Phase I
Agency: HHS
Principal Investigator: Bipin Singh
Award Amount: $179,995.00
Abstract:
DESCRIPTION (provided by applicant): Scintillation crystals coupled to photomultiplier tubes or silicon diodes are the most common detectors for X-ray/3-ray detection. Imaging modalities such as positron emission tomography (PET), single photon emission co mputed tomography (SPECT), digital… More

New Design of a Sensor for Ultrahigh Performance SPECT Imaging

Award Year / Program / Phase: 2010 / SBIR / Phase I
Agency: HHS
Principal Investigator: Vivek V. Nagarkar
Award Amount: $181,387.00
Abstract:
DESCRIPTION (provided by applicant): Among the various functional imaging techniques, SPECT maintains an important and growing role in the study of disease models in small animals as well as in patient care. Many SPECT-labeled imaging probes that have high ly specific distributions with very little… More

Simultaneous PET-MR Small Animal Imaging

Award Year / Program / Phase: 2010 / SBIR / Phase I
Agency: HHS
Principal Investigator: Gerald Entine
Award Amount: $149,352.00
Abstract:
DESCRIPTION (provided by applicant): Simultaneous PET-MR Small Animal Imaging Principal Investigator: Dr. Gerald Entine, Ph.D. Abstract: The ideal biological imaging system would provide non-invasive, high-resolution, high-sensitivity, three-dime nsional (3D) images of living systems.… More

Hand held Eddy Current Tester for Accurate Depth Measurement of Case Hardening in Aerospace Materials

Award Year / Program / Phase: 2010 / SBIR / Phase I
Agency / Branch: DOD / NAVY
Principal Investigator: Timothy Tiernan, Group Leader
Award Amount: $79,996.00
Abstract:
New technology is needed for nondestructive inspection (NDI) of the interface depth on case hardened aerospace components such as gears and drive trains. At this time, the standard method of measurement is destructive and sample dependent - cross sectioning and traverse-hardness testing. An NDI… More

A Novel Cost Effective Method for Growing High Performance Radiation Sensors

Award Year / Program / Phase: 2010 / SBIR / Phase II
Agency: DOD
Principal Investigator: Vivek Nagarkar, Group Leader – (617) 668-6800
Award Amount: $749,963.00
Abstract:
OBJECTIVE: We seek proposals to develop, design and build inexpensive radiation detectors capable of crude gamma spectroscopy. Ideally these detectors will be simple and inexpensive enough to be deployed in large numbers and essentially disposable. DESCRIPTION: In DTRA"s efforts to… More

DEVELOPMENT A PROPRIETARY TIP-ENHANCED RAMAN SPECTROSCOPY

Award Year / Program / Phase: 2010 / SBIR / Phase I
Agency: HHS
Principal Investigator: David Wolf
Award Amount: $149,999.00
Abstract:
Mutation of genetic DNA is a major factor causing cancer. Locating these changes in the DNA sequence of single molecules is difficult because they cannot be assayed by conventional sequencing techniques. This project will demonstrate sequencing capabilities for single stranded DNA and RNA… More

Improved Continuous Autologus Blood Reinfusion Device Using an Ultrasonic System

Award Year / Program / Phase: 2010 / SBIR / Phase I
Agency: HHS
Principal Investigator: Timothy C. Tiernan
Award Amount: $178,996.00
Abstract:
DESCRIPTION (provided by applicant): Surgeons face several challenges associated with intra- and post-operative blood loss. A limited supply of blood available for transfusion and injurious results involving transfusion reactions and disease transmission u sing allogenic blood, make blood component… More

Multi-Channel Electronics for Solid-State Photodetectors

Award Year / Program / Phase: 2010 / STTR / Phase I
Agency: DOE
Research Institution: Lawrence Berkeley National Laboratory
Principal Investigator: Gerald Entine, Dr.
Award Amount: $99,998.00
RI Contact: Susan Hedley
Abstract:
New solid-state photomultipliers (SSPMs) need compact integrated circuitry for readout if such photodetectors are going to be implemented in high-energy physics, nuclear physics, or nuclear medical imaging applications. The aim of this work is to significantly improve the bandwidth in reading out… More

Low Cost Photon Counting Detector for Synchrotron Applications

Award Year / Program / Phase: 2010 / SBIR / Phase I
Agency: HHS
Principal Investigator: Gerald Entine
Award Amount: $174,056.00
Abstract:
Recognizing the ability of synchrotron sources to deliver increasingly higher photon fluxes and the correspondingly rising, demanding needs of time-resolved applications, along with the limitations of current imaging modalities, the need for the developmen t of an innovative detector technology for… More

Novel Concepts for Handheld Radioisotope Identifiers

Award Year / Program / Phase: 2010 / SBIR / Phase I
Agency: DOE
Principal Investigator: Kanai Shah, Mr.
Award Amount: $99,998.00
Abstract:
Proliferation of the weapons of mass destruction such as nuclear weapons is a serious threat in the world today. Prevention of the spread of nuclear weapons has reached a state of heightened urgency in recent years. Handheld radioisotope identifiers incorporating gamma-ray spectrometers are an… More

Non-Cubic Ceramic Scintillators for Nuclear Non-Proliferation

Award Year / Program / Phase: 2010 / SBIR / Phase I
Agency: DOE
Principal Investigator: Jaroslaw Glodo, Dr.
Award Amount: $99,996.00
Abstract:
Proliferation of the weapons of mass destruction such as nuclear weapons is a serious threat in the world today. Prevention of the spread of nuclear weapons has reached a state of heightened urgency in recent years. Scintillator based gamma-ray spectrometers are an important tool in checking the… More

Novel Polycrystalline Scintillators for Nuclear Non-Proliferation

Award Year / Program / Phase: 2010 / SBIR / Phase I
Agency: DOE
Principal Investigator: Jaroslaw Glodo, Dr.
Award Amount: $99,999.00
Abstract:
Proliferation of the weapons of mass destruction such as nuclear weapons is a serious threat in the world today. Prevention of the spread of nuclear weapons has reached a state of heightened urgency in recent years. Scintillator based gamma-ray spectrometers are an important tool in checking the… More

Bright Quantum Dot Scintillator for High Frame Rate Imaging

Award Year / Program / Phase: 2010 / SBIR / Phase II
Agency: DOE
Principal Investigator: Vivek Nagarkar, Dr.
Award Amount: $999,974.00
Abstract:
Recent significant improvements in synchrotron radiation sources have enabled the growth of powerful techniques such as time-resolved X-ray diffraction studies for use in understanding dynamic phenomena in materials, including those in biological systems. To make the most effective use of… More

Low Cost, High Speed, High Sensitivity Detector for Material Science Studies

Award Year / Program / Phase: 2010 / SBIR / Phase II
Agency: DOE
Principal Investigator: Gerald Entine, Dr.
Award Amount: $977,448.00
Abstract:
Advanced photon sources, capable of providing extremely high X-ray intensities, have proven to be outstanding resources for X-ray scattering and time-resolved diffraction studies of materials such as organic semiconductors used in electronics, photodiode, and photovoltaic applications, and… More

Dual Modality Small Animal Imaging

Award Year / Program / Phase: 2010 / SBIR / Phase II
Agency: DOE
Principal Investigator: Purushottam Dokhale, Dr.
Award Amount: $749,998.00
Abstract:
The ideal biological imaging system would provide non-invasive, high-resolution, high-sensitivity, three-dimensional (3D) images of living systems. Positron Emission Tomography (PET) offers high sensitivity to a range of biological processes through the use of targeted radiolabeled probes. … More

High Bandwidth Optical Detector for Scanning Probe Microscopy

Award Year / Program / Phase: 2010 / SBIR / Phase II
Agency: DOE
Principal Investigator: Richard Myers, Dr.
Award Amount: $996,322.00
Abstract:
The rapid advancements in nanosciences are pushing the limits of surface probe microscopy (SPM) technology. Of particular interest is the ability to extend the SPM bandwidth of detection. This would provide more specific molecular recognition and allow studies of interaction chemistry that, to… More

Growth of Semiconductors for Room Temperature Gamma-Ray Detection

Award Year / Program / Phase: 2010 / SBIR / Phase I
Agency: DOE
Principal Investigator: Leonard Cirignano, Mr.
Award Amount: $99,999.00
Abstract:
There is a critical need for low cost, high performance gamma-ray detectors for identification and localization of special nuclear materials (SNM) such as plutonium and weapons grade uranium. Gamma ray spectrometers are an important tool in checking the proliferation of nuclear weapons. Cadmium zinc… More

Novel Concept in PET Imaging

Award Year / Program / Phase: 2010 / SBIR / Phase I
Agency: DOE
Principal Investigator: Purushottam Dokhale, Dr.
Award Amount: $99,998.00
Abstract:
Positron Emission Tomography (PET) is a functional imaging technique with potential to quantify the rates of biological processes in vivo. PET imaging can provide diagnosis for symptoms of diseases such as Alzheimer

Fast, Photon Counting Detector Arrays with Internal Gain

Award Year / Program / Phase: 2010 / SBIR / Phase II
Agency: DOE
Principal Investigator: Richard Farrell, Mr.
Award Amount: $999,998.00
Abstract:
Third generation x-ray synchrotron facilities such as Argonne National Laboratory

New Room Temperature Semiconductor Detectors for Small Animal SPECT

Award Year / Program / Phase: 2010 / SBIR / Phase I
Agency: DOE
Principal Investigator: Michael Squillante, Dr.
Award Amount: $99,999.00
Abstract:
Single Photon Emission Computed Tomography (SPECT) is an in vivo analog of autoradiography and is emerging as a powerful new tool in imaging biological processes in small laboratory animals. With the ever increasing number of human disease models (including cancer) in small laboratory animals such… More

New Detectors for Small Animal SPECT

Award Year / Program / Phase: 2010 / SBIR / Phase II
Agency: DOE
Principal Investigator: Leonard Cirignano, Mr.
Award Amount: $749,998.00
Abstract:
Single Photon Emission Computed Tomography has become a powerful new tool in imaging biological processes in small laboratory animals. Performance of this modality is limited by the properties of the detectors available at present. The goal of the proposed project is to investigate a new solid… More

Low Cost, High Performance SPECT Detectors

Award Year / Program / Phase: 2010 / SBIR / Phase I
Agency: DOE
Principal Investigator: Edgar Van Loef, Dr.
Award Amount: $99,999.00
Abstract:
Scintillation detectors, consisting of inorganic scintillation crystals coupled to PMTs, are an important element of medical imaging applications such as single photon emission computed tomography (SPECT). Performance as well as cost of these systems is limited by the properties of the scintillation… More

Next Generation SPECT Detectors

Award Year / Program / Phase: 2010 / SBIR / Phase II
Agency: DOE
Principal Investigator: Michael Squillante, Dr.
Award Amount: $749,998.00
Abstract:
Single photon emission computed tomography (SPECT) is a powerful, noninvasive medical imaging modality that mathematically reconstructs the three dimensional distribution of a radionuclide throughout the body of a human patient or research animal. At present, the performance of the available SPECT… More

High-Performance, CMOS Solid-State Photomultiplier

Award Year / Program / Phase: 2010 / SBIR / Phase I
Agency: DOE
Principal Investigator: Erik Johnson, Dr.
Award Amount: $100,000.00
Abstract:
The present CMOS SSPMs use a large feature size process to maximum the silicon die area for a low-cost solution, but this low-cost solution limits the performance of the SSPM, as well as the amount of on-chip circuitry that can be incorporated into the device. Existing SSPMs provide may provide a… More

New High Resolution, Large Area Detector for Synchrotron Applications

Award Year / Program / Phase: 2010 / SBIR / Phase I
Agency: DOE
Principal Investigator: Tapan Gupta, Dr.
Award Amount: $99,999.00
Abstract:
Synchrotron radiation is a powerful tool for measuring structural properties of materials. Important applications of higher energy synchrotron X-rays include measurement of strain and material evolution during processing, studies of composite materials and studies of layered systems. Detector… More

Solid-State Sensor to Directly Replace Coils for Improved Eddy Current Testing (ECT)

Award Year / Program / Phase: 2010 / SBIR / Phase I
Agency: DOE
Principal Investigator: Timothy Tiernan, Mr.
Award Amount: $99,998.00
Abstract:
Degradation of reactor components, heat exchangers, and piping systems in nuclear power plants subjected to heat, high pressure and corrosion has been estimated to cost the electric power industry $17.3 billion dollars annually. Eddy current testing (ECT) is a widely practiced, and critically… More

High Resolution High Sensitivity Sensor for Radionuclide Imaging

Award Year / Program / Phase: 2010 / SBIR / Phase I
Agency: DOE
Principal Investigator: Gerald Entine, Dr.
Award Amount: $99,998.00
Abstract:
Among the various functional imaging techniques, SPECT maintains an important and growing role in the study of disease models in small animals as well as in patient care. These applications require excellent spatial resolution, not only because of the small scale of the details to be imaged, but… More

Eu2 Doped CsBaI3 and CsBa2I5 Scintillators

Award Year / Program / Phase: 2011 / SBIR / Phase I
Agency: DHS
Principal Investigator: Kanai Shah
Award Amount: $149,998.00
Abstract:
The proliferation of weapons of mass destruction such as nuclear missiles and “dirty bombs” is a serious threat in the world today. Preventing the spread of these nuclear weapons has reached a state of heightened urgency in recent years, more so since the events on September 11, 2001 and its… More

Mixed Barium Halide Scintillators for Gamma Ray Spectroscopy

Award Year / Program / Phase: 2011 / SBIR / Phase I
Agency: DHS
Principal Investigator: Kanai Shah
Award Amount: $149,998.00
Abstract:
The proliferation of weapons of mass destruction such as nuclear missiles and “dirty bombs” is a serious threat in the world today. Preventing the spread of these nuclear weapons has reached a state of heightened urgency in recent years, more so since the events on September 11, 2001 and its… More

Hand-held Neutron Detectors

Award Year / Program / Phase: 2011 / SBIR / Phase I
Agency: DHS
Principal Investigator: Jaroslaw Glodo
Award Amount: $149,998.00
Abstract:
Proliferation of the weapons of mass destruction such as nuclear weapons is a serious threat and prevention of their spread has reached a state of heightened urgency in recent years. One of the ways to passively determine the presence of nuclear weapons is to detect and identify characteristic… More

High Speed and High Sensitivity Quadrant Photodetector

Award Year / Program / Phase: 2011 / SBIR / Phase II
Agency / Branch: DOC / NIST
Principal Investigator: Richard Myers – (617) 668-6800
Award Amount: $299,995.00
Abstract:
To further advance the characterization and utility of microcantilevers, next generation optical detectors with higher frequency response, improved displacement resolution and lower noise for weak signal detection are needed. Consequently, Radiation Monitoring Devices, Inc. (RMD) will develop a… More

Optical Surgical Probe for Assessing Human Oral Mucosa Graft Vascularization

Award Year / Program / Phase: 2011 / SBIR / Phase I
Agency: HHS
Principal Investigator: David E. Wolf – 617-668-6810
Award Amount: $196,853.00
Abstract:
DESCRIPTION (provided by applicant): This proposal's main objective is the development of a novel Perfusion Monitoring Device (PMD) based upon diffuse correlation spectroscopy (DCS), which will enable microsurgeons to assess the level of vascularization ofburied (prelaminated) flaps and the… More

Device for Measuring Capillary Blood Flow and the Onset of Shock

Award Year / Program / Phase: 2011 / SBIR / Phase I
Agency: HHS
Principal Investigator: David E. Wolf – 617-668-6810
Award Amount: $220,639.00
Abstract:
DESCRIPTION (provided by applicant): The onset of hemorrhagic shock is a major cause of death in emergency departments and trauma centers. Currently there is no clinically accepted quantitative monitor of the onset of hemorrhagic shock. Death from hemorrhagic shock results from diminished capillary… More

High Performance, Low Cost PET Scintillators

Award Year / Program / Phase: 2011 / SBIR / Phase I
Agency: HHS
Principal Investigator: Kanai S. Shah – 617-668-6855
Award Amount: $189,406.00
Abstract:
DESCRIPTION (provided by applicant): Positron Emission Tomography (PET) is a functional imaging technique with the potential to quantify the rates of biological processes in vivo. The availability of short-lived positron-emitting isotopes of carbon, nitrogen, oxygen and especially fluorine allows… More

Fast Neutron Dosimeter for the Space Environment

Award Year / Program / Phase: 2011 / SBIR / Phase II
Agency: NASA
Principal Investigator: James Christian, Principal Investigator
Award Amount: $599,993.00
Abstract:
Model calculations and risk assessment estimates indicate that secondary neutrons, with energies ranging between 0.5 to >150 MeV, make a significant contribution to the total absorbed dose received by space crews during long duration space missions [1-3]. Advanced scintillation materials, which… More

Instrument to Identify Hazardous Children's Products that Could Cause Lead Poison

Award Year / Program / Phase: 2011 / SBIR / Phase II
Agency: HHS
Principal Investigator: Michael R. Squillante – 617-668-6808
Award Amount: $951,056.00
Abstract:
DESCRIPTION (provided by applicant): The goal of Phase II is to develop the world's first safe, inexpensive, and easy to operate lead detector for consumers that can reliably detect dangerous levels of lead in toys and other products. It will be based on ahigh sensitivity yet inexpensive X-ray… More

Simultaneous PET-MR Small Animal Imaging

Award Year / Program / Phase: 2011 / SBIR / Phase II
Agency: HHS
Principal Investigator: Purushottam Dokhale – 617-668-6801
Award Amount: $1,187,392.00
Abstract:
DESCRIPTION (provided by applicant): Simultaneous PET-MR Small Animal Imaging Principal Investigator: Dr. Gerald Entine, Ph.D. Abstract: The ideal biological imaging system would provide non-invasive, high-resolution, high-sensitivity, three-dimensional (3D) images of living systems.… More

Multibeam Healing for Laser Micromachining in Manufacturing

Award Year / Program / Phase: 2011 / SBIR / Phase II
Agency: HHS
Principal Investigator: Bipin Singh – 617-668-6934
Award Amount: $1,592,997.00
Abstract:
DESCRIPTION (provided by applicant): There is considerable interest in new and innovative manufacturing methods for medical imaging technologies to enhance performance while reducing cost. The precision and low-force signature of lasers makes them very attractive alternatives to traditional… More

Efficient, Long-Lived Radioisotope Power Generator

Award Year / Program / Phase: 2011 / SBIR / Phase I
Agency: NASA
Principal Investigator: Noa M. Rensing, Principal Investigator
Award Amount: $99,999.00
Abstract:
Radiation Monitoring Devices, Inc., (RMD) proposes to develop an alternative very long term, radioisotope power source with thermoelectric power conversion with greater than 10% energy efficiency for deep space applications. The proposed technology is based on a betavoltaic generator which can be… More

Wireless, Low Mass, High Sensitivity Sensing Sheet for Structural Sensing and Long Term Analysis

Award Year / Program / Phase: 2011 / SBIR / Phase I
Agency: NASA
Principal Investigator: Timothy Tiernan, Principal Investigator
Award Amount: $100,000.00
Abstract:
NASA needs sensor systems to inspect space structures with minimum human interaction. These systems must be highly integrated and self-sufficient, low mass, simple to operate, provide reliable information, and use little command processing power.Eddy current testing (ECT) is a widely practiced and… More

High-Resolution Detector for At-Wavelength Metrology of X-Ray Optics

Award Year / Program / Phase: 2011 / SBIR / Phase I
Agency: NASA
Principal Investigator: Vivek Nagarkar, Principal Investigator
Award Amount: $99,997.00
Abstract:
Since the launch of the first X-ray focusing telescope in 1963, the development of grazing incidence X-ray optics has been crucial to the development of the field of X-ray astronomy. The recent Decadal Survey also highlights the important contribution that X-ray astronomy can make in addressing… More

New Wide Bandgap Semiconductor Materials for Neutron Detection

Award Year / Program / Phase: 2011 / SBIR / Phase II
Agency: DHS
Principal Investigator: Joshua Tower
Award Amount: $999,998.00
Abstract:
In the proposed program, we plan to investigate novel semiconductor neutron detectors based on the wide bandgap lithium containing compositions LiGaSe2, LiGaTe2, LiInS2, and LiInSe2. The goal of the program is to produce detector quality crystals and to demonstrate efficient thermal neutron… More

New Scintillator for Neutron Detection

Award Year / Program / Phase: 2011 / SBIR / Phase II
Agency: DHS
Principal Investigator: Jaroslaw Glodo
Award Amount: $999,997.00
Abstract:
Neutron detection is one of the methods used in revealing illicit nuclear materials. Currently, there is an ongoing search for new and better neutron detectors prompted by anticipated shortages of He-3 that is used in many of the current detection systems. This effort proposes and investigation… More

Engineering High Resolution Scintillator for Next-Generation High Frame Rate Detectors

Award Year / Program / Phase: 2011 / SBIR / Phase I
Agency: DOE
Principal Investigator: Michael Squillante, Dr. – 617-668-6800
Award Amount: $149,998.00
Abstract:
Recent developments in synchrotron radiation sources have generated an urgent need for high performance X-ray detectors. While new imaging devices have been developed that employ high performance CCD sensors, what is currently lacking in these detectors is an adequate X-ray-to-light converter that… More

High Efficiency High Resolution Sensor for Hard X-Ray Microtomography

Award Year / Program / Phase: 2011 / SBIR / Phase I
Agency: DOE
Principal Investigator: Charles Brecher, Dr. – 617-668-6800
Award Amount: $149,999.00
Abstract:
X-ray microtomography (XMT) is a powerful tool for researchers in a wide range of fields, allowing 3D imaging at the micron scale. Many of the DOE synchrotron tomography facilities are involved in research that requires hard X-rays (high energy, up to 100 keV) in order to get better penetration into… More

Ultra-High Resolution High Sensitivity PET for Plant Imaging

Award Year / Program / Phase: 2011 / SBIR / Phase I
Agency: DOE
Principal Investigator: Purushottam Dokhale, Dr. – 617-668-6800
Award Amount: $149,999.00
Abstract:
PET is a very powerful functional imaging technology and has the capacity to measure the transport and distribution of radionuclides, labeled photoassimilates in plants in 3D. PET Imaging of plants will help scientist to understand how plants respond to environmental stresses, and have many… More

High Z Semiconductor Gamma-Ray Detector for Nuclear Non-Proliferation

Award Year / Program / Phase: 2011 / SBIR / Phase I
Agency: DOE
Principal Investigator: Leonard Cirignano, Mr. – 617-668-6800
Award Amount: $149,999.00
Abstract:
There is a critical need for low cost, high performance gamma-ray detectors for identification and localization of special nuclear materials (SNM) such as plutonium and weapons grade uranium. Cadmium zinc telluride (Cd1-xZnxTe or & quot;CZT & quot;) has emerged as the leading room… More

Non-Contact, High Speed Inspection of Zirconium Power Plant Components

Award Year / Program / Phase: 2011 / SBIR / Phase I
Agency: DOE
Principal Investigator: Timothy Tiernan, Mr. – 617-668-6800
Award Amount: $149,992.00
Abstract:
Advanced sensors and measurement techniques are needed to increase resolution, and sensitivity to defects while reducing the intrusiveness and cost of inspection at nuclear power plants. Zirconium, a metal with a low neutron absorption cross section, is widely used in nuclear power plants and close… More

Low Cost, Efficient, Room Temperature Semiconductor Gamma-Ray Detectors

Award Year / Program / Phase: 2011 / SBIR / Phase I
Agency: DOE
Principal Investigator: Leonard Cirignano, Mr. – 617-668-6800
Award Amount: $149,999.00
Abstract:
Gamma ray spectrometers provide detection and spectroscopy of energetic photons (-rays), and are expected to be an important component of the future nuclear physics experiments including those being planned for the Facility for Rare Isotope Beams (FRIB) that is being funded by the Department of… More

Solid-State Sensor to Directly Replace Coils for Improved Eddy Current Testing (ECT)

Award Year / Program / Phase: 2011 / SBIR / Phase II
Agency: DOE
Principal Investigator: Timothy Tiernan, Mr.
Award Amount: $999,998.00
Abstract:
Degradation of reactor components, heat exchangers, and piping systems in nuclear power plants subjected to heat, high pressure and corrosion has been estimated to cost the electric power industry $17.3 billion dollars annually. Eddy current testing is a widely practiced, and critically important… More

Novel Polycrystalline Scintillators for Nuclear Non-Proliferation

Award Year / Program / Phase: 2011 / SBIR / Phase II
Agency: DOE
Principal Investigator: Jaroslaw Glodo, Dr.
Award Amount: $999,998.00
Abstract:
Proliferation of the weapons of mass destruction such as nuclear weapons is a serious threat in the world today. Prevention of the spread of nuclear weapons has reached a state of heightened urgency in recent years. Scintillator based gamma-ray spectrometers are an important tool in checking the… More

Growth of Semiconductors for Room Temperature Gamma-Ray Detection

Award Year / Program / Phase: 2011 / SBIR / Phase II
Agency: DOE
Principal Investigator: Leonard Cirignano, Mr.
Award Amount: $999,998.00
Abstract:
There is a critical need for low cost, high performance gamma-ray detectors for identification and localization of special nuclear materials (SNM) such as plutonium and weapons grade uranium. Gamma ray spectrometers are an important tool in checking the proliferation of nuclear weapons. Cadmium zinc… More

Novel Concept in PET Imaging

Award Year / Program / Phase: 2011 / SBIR / Phase II
Agency: DOE
Principal Investigator: Purushottam Dokhale, Dr.
Award Amount: $999,998.00
Abstract:
Positron Emission Tomography (PET) offers high sensitivity to a range of biological processes through the use of targeted radiolabeled probes. PET imaging can provide diagnosis for symptoms of diseases such as Alzheimers disease, head trauma, cancer, and stroke. In recent years, there has been… More

New High Resolution, Large Area Detector for Synchrotron Applications

Award Year / Program / Phase: 2011 / SBIR / Phase II
Agency: DOE
Principal Investigator: Tapan Gupta, Dr.
Award Amount: $999,998.00
Abstract:
Synchrotron radiation is a powerful tool for measuring structural properties of materials. Important applications of higher energy synchrotron X-rays include measurement of strain and material evolution during processing, studies of composite materials and studies of layered systems. Detector… More

Enhanced Beta-Batteries: A Long Life Power Source for Sensors Monitoring WMD Materials

Award Year / Program / Phase: 2011 / SBIR / Phase I
Agency: DOD
Principal Investigator: Noa M. Rensing, Sr. Scientist – (617) 668-6943
Award Amount: $99,994.00
Abstract:
OBJECTIVE: To provide innovative technologies and system components which increase the lifetime and utility of various systems within DTRA"s Tag, Track, and Locate (TTL) portfolio to combat weapons of mass destruction (WMD). The specific innovations sought under this topic are improved… More

Severe Space Weather Satellite Protection

Award Year / Program / Phase: 2011 / SBIR / Phase I
Agency: DOD
Principal Investigator: James Christian, Group Leader – (617) 668-6897
Award Amount: $99,995.00
Abstract:
ABSTRACT: Modern space electronics used for military space communications are susceptible to highly energized charged particles such as electrons and protons originating from coronal mass ejections that create geomagnetic storms. There is a need for advanced protection measures that can help… More

Flexible, Compatible, Solid-State Eddy Current Probe for Detection of Defects Near Edges of Curved Components

Award Year / Program / Phase: 2011 / SBIR / Phase I
Agency: DOD
Principal Investigator: Timothy Tiernan, Group Leader – (617) 668-6856
Award Amount: $99,997.00
Abstract:
Eddy current testing (ECT) is a widely practiced and critically important nondestructive evaluation (NDE) method used in aerospace, yet it relies on decades-old, wire-coil sensors. Flexible sensors are needed to inspect curved surfaces near the edges of components including wheel bead seats on… More

Full Spectrum Solar Cell Using Novel Material

Award Year / Program / Phase: 2011 / SBIR / Phase I
Agency: DOD
Principal Investigator: Michael Squillante, Vice President – (617) 668-6800
Award Amount: $69,995.00
Abstract:
The goal of the proposed Phase I is to demonstrate the feasibility of fabricating cost-competitive intermediate band light-harvesting solar cells with high conversion efficiency, through a combination of intermediate band physics and the unique structure of our proposed material. The most efficient… More

UV-Enhanced APD Receiver for Free Space Optical Communications

Award Year / Program / Phase: 2011 / SBIR / Phase I
Agency: DOD
Principal Investigator: Richard Myers, Senior Scientist – (617) 668-6801
Award Amount: $99,993.00
Abstract:
Free space optical communication (FSOC) systems offer rapid data transfer rates, allowing practical wireless relay of complex data sets. To further promote the use of this technology for medium-range optical communication links operating with eye-safe ultra-violet (UV) sources, compact and robust… More

TIBr Spectrometers with Improved Long Term Stability at Room Temperature

Award Year / Program / Phase: 2012 / SBIR / Phase I
Agency: DHS
Principal Investigator: Leonard Cirignano
Award Amount: $149,999.00
Abstract:
The ideal semiconductor detector for the nuclear non-proliferation application should have good energy resolution, high detection efficiency, compact size, light weight, easy portability, low power requirments and low cost. In the proposed effort, we plan to continue our development of thallium… More

High Efficiency TlBr Gamma-Ray Detector Module

Award Year / Program / Phase: 2012 / SBIR / Phase I
Agency: DHS
Principal Investigator: Leonard Cirignano
Award Amount: $149,999.00
Abstract:
The ideal semiconductor detector for nuclear monitoring should have good energy resolution, high detection efficiency, compact size, light weight, easy portability and low cost. In the proposed effort, we plan to develop a detector module for nuclear monitoring based on thallium bromide (TlBr), a… More

Hand-held Neutron Detector

Award Year / Program / Phase: 2012 / SBIR / Phase II
Agency: DHS
Principal Investigator: Kanai Shah – (617) 926-9980
Award Amount: $999,994.00
Abstract:
Proliferation of the weapons of mass destruction such as nuclear weapons is a serious threat. Prevention of their spread has reached a state of heightened urgency in recent years. One of the ways to passively determine the presence of nuclear weapons is to detect and identify characteristic… More

Eu2 Doped CSBal3 and CsBa215 Scintillators for Gamma-Ray Spectroscopy

Award Year / Program / Phase: 2012 / SBIR / Phase II
Agency: DHS
Principal Investigator: Kanai Shah
Award Amount: $749,997.00
Abstract:
The proliferation of weapons of mass destruction such as nuclear missiles and “dirty bombs” is a serious threat in the world today. Preventing the spread of these nuclear weapons has reached a state of heightened urgency in recent years, more so since the events on September 11, 2001 and its… More

Non-invasive Continuous Hemodynamic Monitor

Award Year / Program / Phase: 2012 / STTR / Phase I
Agency / Branch: DOD / DARPA
Research Institution: Mayo Clinic
Principal Investigator: David Wolf, Group Leader, Optics and Photonics – (617) 668-6800
Award Amount: $99,997.00
RI Contact: Michael J. Joyner, M.D.
Abstract:
Emergency departments, trauma centers, and military field physicians have a critical need for a simple, easy-to-use, and reliable method of monitoring the onset of hemorrhagic shock that is able to predict onset during the compensatory phase, before syncope and cardiac collapse signaled by a rapid… More

High-Resolution Detector for At-Wavelength Metrology of X-Ray Optics

Award Year / Program / Phase: 2012 / SBIR / Phase II
Agency: NASA
Principal Investigator: Vivek Nagarkar, Principal Investigator
Award Amount: $749,956.00
Abstract:
Since the launch of the first X-ray focusing telescope in 1963, the development of grazing incidence X-ray optics has been crucial to the development of the field of X-ray astronomy. The recent Decadal Survey also highlights the important contribution that X-ray astronomy can make in addressing… More

Modified High Gain APDs for Multi-beam Ladar Instrumentation

Award Year / Program / Phase: 2012 / SBIR / Phase I
Agency: NASA
Principal Investigator: Richard Myers, Principal Investigator
Award Amount: $124,935.00
Abstract:
In this effort, Radiation Monitoring Devices, Inc. (RMD) addresses NASA's request for sensitive, high quantum efficiency (QE) optical detectors for space- and ground-based light detection and ranging (Lidar) instruments. We propose to address this need by utilizing our latest designs in solid… More

Next Generation Gamma/Neutron Detectors for Planetary Science.

Award Year / Program / Phase: 2012 / SBIR / Phase I
Agency: NASA
Principal Investigator: James Christian, Principal Investigator
Award Amount: $124,962.00
Abstract:
Gamma ray and neutron spectroscopy are well established techniques for determining the chemical composition of planetary surfaces, and small cosmic bodies such as asteroids and comets; however, new technologies with the potential to significantly improve the performance of planetary nuclear… More

High Performance, Low Cost PET Scintillators

Award Year / Program / Phase: 2012 / SBIR / Phase II
Agency: HHS
Principal Investigator: Kanai S. Shah – 617-668-6855
Award Amount: $1,164,766.00
Abstract:
DESCRIPTION (provided by applicant): Positron Emission Tomography (PET) is a functional imaging technique with the potential to quantify the rates of biological processes in vivo. The availability of short-lived positron-emitting isotopes of carbon, nitrogen, oxygen and especially fluorine allows… More

Near Infrared Detector for Advanced Ophthalmology

Award Year / Program / Phase: 2012 / SBIR / Phase II
Agency: HHS
Principal Investigator: Richard Myers – 617-668-6800
Award Amount: $1,370,876.00
Abstract:
DESCRIPTION (provided by applicant): Some of the most useful tools for diagnosis and understanding of blinding retinal diseases rely on the use of spectral reflectance. Improvements to these tools, especially over the past decade, have greatly advanced ourability to achieve extremely high-resolution… More

Engineering a High Resolution Scintillator for Next-Generation High Frame Rate Detectors

Award Year / Program / Phase: 2012 / SBIR / Phase II
Agency: DOE
Principal Investigator: Michael Squillante, Dr. – 617-668-6800
Award Amount: $1,009,998.00
Abstract:
Recent improvements in synchrotron radiation sources have generated an urgent need for high-performance X-ray detectors. While new imaging devices have been developed that employ high-performance CCD sensors, what is currently lacking in these detectors is an adequate X-ray-to-light converter … More

High Efficiency High Resolution Sensor for Hard X-Ray Microtomography

Award Year / Program / Phase: 2012 / SBIR / Phase II
Agency: DOE
Principal Investigator: Charles Brecher, Dr. – 617-668-6800
Award Amount: $1,009,740.00
Abstract:
X-ray microtomography (XMT) is a powerful tool for researchers in a wide range of fields, enabling 3D imaging at the micron scale. Many of the DOE synchrotron tomography facilities are involved in research that requires hard X-rays (high energy, up to 100 keV) in order to get better penetration… More

Non-contact, High Speed Inspection of Zirconium Power Plant Components

Award Year / Program / Phase: 2012 / SBIR / Phase II
Agency: DOE
Principal Investigator: Timothy Tiernan, Mr. – 617-668-6800
Award Amount: $1,009,940.00
Abstract:
Advanced sensors and measurement techniques are needed to increase resolution, and sensitivity to defects while reducing the intrusiveness and cost of inspection at nuclear power plants. Zirconium, a metal with a low neutron absorption cross section, is widely used in nuclear power plants.… More

Manufacturing High Efficiency,yet High Resolution, Scintillator for Wide-Band X-Ray Analysis

Award Year / Program / Phase: 2012 / SBIR / Phase I
Agency: DOE
Principal Investigator: Vivek Nagarkar, Dr. – 617-668-6801
Award Amount: $149,994.00
Abstract:
High-resolution CCD/CMOS area detectors coupled to scintillators are commonly used at synchrotrons for a wide range of experiments. While various detectors satisfy resolution, efficiency, speed of operation, and large active area needs for low-energy X-rays (8 to 12 keV), none are suitable for the… More

Low Noise, High Rate X-Ray Spectrometer for Synchrotron Applications

Award Year / Program / Phase: 2012 / SBIR / Phase I
Agency: DOE
Principal Investigator: Leonard Cirignano, Mr. – 617-668-6801
Award Amount: $149,999.00
Abstract:
X-ray detector arrays with high energy resolution, high sensitivity and high count- rate performance are required for synchrotron beam-line studies. In many studies conducted with synchrotron beam-lines, the characteristics of available X-ray detectors limit the overall system performance. The… More

Low Radioactivity NaI for Dark Matter Studies

Award Year / Program / Phase: 2012 / SBIR / Phase I
Agency: DOE
Principal Investigator: William Higgins, Dr. – 617-668-6801
Award Amount: $149,999.00
Abstract:
Dark Matter accounts for nearly 90 percent of all matter in the universe, yet its identity remains one of the biggest mysteries of modern science. Although Dark Matter is invisible to telescopes, astronomers know it is there from the gravitational influence it exerts over galaxies. Using sensitive… More

Multi-Modality Nuclear Spectroscopy

Award Year / Program / Phase: 2012 / SBIR / Phase I
Agency: DOE
Principal Investigator: Edgar van Loef, Dr. – 617-668-6801
Award Amount: $150,000.00
Abstract:
Current radiation detectors used in nuclear physics are typically capable of detecting only one type of radiation well. Therefore, the systems in use require a number of individual detectors for each type of radiation. Furthermore, fast neutron spectroscopy is often very challenging. The research… More

Advanced Plastic Scintillators for Nuclear Non-Proliferation Monitoring

Award Year / Program / Phase: 2012 / SBIR / Phase I
Agency: DOE
Principal Investigator: Edgar Van Loef, Dr. – 617-668-6800
Award Amount: $149,998.00
Abstract:
The proliferation of weapons of mass destruction such as nuclear missiles and dirty bombs are a serious threat in the world today. Preventing the spread of these nuclear weapons has reached a state of heightened urgency in recent years. Neutron detection is an important component of the overall… More

Solid-State Neutron Detector for Nuclear Material Accounting

Award Year / Program / Phase: 2012 / SBIR / Phase I
Agency: DOE
Principal Investigator: Kanai Shah, Dr. – 617-668-6800
Award Amount: $149,999.00
Abstract:
Neutron detectors, traditionally pressurized He-3 tubes, are a common instrument used in nuclear material accounting within the domestic nuclear fuel cycle. Due to the worldwide shortage and high demand of 3He supply, low-cost alternative neutron detection technologies are required to replace He-3… More

New 3He Replacement Sensors for DOE Material Control and Accountability

Award Year / Program / Phase: 2012 / SBIR / Phase I
Agency: DOE
Principal Investigator: Vivek Nagarkar, Dr. – 617-668-6800
Award Amount: $149,999.00
Abstract:
Implementing nuclear material control and accountability (MC & amp;A) programs at DOE facilities requires new techniques and equipment that maximize material loss detection sensitivity, increase the quality of accountability measurements, minimize material holdup, and reduce the magnitude of… More

A New High Sensitivity High Resolution Sensor for X-Ray CT

Award Year / Program / Phase: 2012 / SBIR / Phase I
Agency: DOD
Principal Investigator: Vivek Nagarkar, Group Leader – (617) 668-6801
Award Amount: $149,999.00
Abstract:
In field hospitals in/near theatres of operations, and even in smaller mobile medical units, X-ray CT can provide crucial information to first responding providers about soldiers"injuries and allow for quick yet comprehensive blunt and penetrating trauma assessments, which can expedite… More

Eddy Current Sensors for Failure Analysis

Award Year / Program / Phase: 2012 / SBIR / Phase I
Agency: DOD
Principal Investigator: Timothy Tiernan, Principal Investigator – (617) 668-6800
Award Amount: $79,998.00
Abstract:
There is a need for a non-destructive, in-situ method to determine the root cause of cracking in aircraft components, and specifically to distinguish between fatigue cracks, cracks due to overload conditions, and cracks caused by corrosion. RMD proposes to develop a system based on an array of eddy… More

Severe Space Weather Satellite Protection

Award Year / Program / Phase: 2012 / SBIR / Phase II
Agency: DOD
Principal Investigator: James Christian, Group Leader – (617) 668-6800
Award Amount: $749,878.00
Abstract:
ABSTRACT: Modern electronics used for military space communications are susceptible to highly energized charged particles such as electrons and protons originating from coronal mass ejections that create geomagnetic storms. There is a need for advanced protection measures that can help minimize… More

Flexible, Compatible, Solid-State Eddy Current Probe for Detection of Defects Near Edges of Curved Components

Award Year / Program / Phase: 2012 / SBIR / Phase II
Agency: DOD
Principal Investigator: Timothy Tiernan, Director Advanced Instrum – (617) 668-6800
Award Amount: $749,992.00
Abstract:
ABSTRACT: Eddy current testing (ECT) is a widely practiced and critically important nondestructive evaluation (NDE) method used in aerospace, yet it relies on decades-old, wire-coil sensors. Flexible sensors are needed to inspect curved surfaces near the edges of components including wheel bead… More

Full Spectrum Solar Cell Using Novel Material

Award Year / Program / Phase: 2012 / SBIR / Phase II
Agency: DOD
Principal Investigator: Michael Squillante, Vice President, Research – (617) 668-6800
Award Amount: $720,000.00
Abstract:
Phase I demonstrated the feasibility of fabricating cost-competitive intermediate band light-harvesting solar cells with high conversion efficiency, through a combination of intermediate band physics and the unique structure of our proposed material. Phase II will continue the research, produce… More

Enhanced Beta-Batteries: A Long Life Power Source for Sensors Monitoring WMD

Award Year / Program / Phase: 2012 / SBIR / Phase II
Agency: DOD
Principal Investigator: Michael Squillante, Vice President – (617) 668-6800
Award Amount: $999,989.00
Abstract:
While many applications may have access to harvestable energy in the form of solar radiation (or other ambient light), wind, environmental vibration, or wave motion, not all do. In this proposal, RMD targets the most challenging applications, sensors that must operate for many months or years and… More

Dual Mode, Hand-held Intraoperative Imager

Award Year / Program / Phase: 2012 / SBIR / Phase I
Agency: HHS
Principal Investigator: Vivek V. Nagarkar – 617-668-6937
Award Amount: $301,875.00
Abstract:
DESCRIPTION (provided by applicant): Radionuclide-guided intraoperative probes increase the specificity of tissue biopsies, enable minimal- access incisions, reduce inpatient hospital utilization, and contribute to improved patient recovery. At present, most such probes on the market are… More

Novel Technology for Screening Receptor and Compound Libraries in Drug Discovery

Award Year / Program / Phase: 2012 / SBIR / Phase I
Agency: HHS
Principal Investigator: Daniel B. Hall – 617-926-1167
Award Amount: $155,459.00
Abstract:
DESCRIPTION (provided by applicant): Discovery research in the pharmaceutical/biotech industries utilizes high throughput, label-free drug binding cell-based assays, many of which are functional assays. In such instances, the receptor-ligand interaction isonly an indirect measurement of binding and… More

Instrument for Single Molecule Sequencing of Alzheimer's-Relevant Genomic Oxidati

Award Year / Program / Phase: 2012 / SBIR / Phase I
Agency: HHS
Principal Investigator: David E. Wolf – 617-668-6854
Award Amount: $299,996.00
Abstract:
DESCRIPTION (provided by applicant): DNA damage threatens the longevity and functionality of cells, and is common to the pathogenesis of many diseases. Better tools are needed for clinical identification and research into mechanisms underlying DNA oxidation, deamination, and hyper/hypomethylation,… More

OTHER FUNCTIONS - NOVEL TECHNOLOGIES FOR ASSESSING LIPOPROTEIN SUB-FRACTIONS

Award Year / Program / Phase: 2012 / SBIR / Phase I
Agency: HHS
Principal Investigator: Velasco Guillermo – 617-668-6801
Award Amount: $149,963.00
Abstract:
Global analysis of serum lipoprotein subclasses requires a platform that measures size distributions of lipoprotein particles identified by apoprotein content. We propose to employ an innovative methodology based on superparamagnetic and birefringent nanoparticles that bind to supramacromolecular… More

Accountability Instrument Using a New Neutron-Gamma Sensor

Award Year / Program / Phase: 2013 / SBIR / Phase I
Agency: DOE
Principal Investigator: Jaroslaw Glodo, Dr.
Award Amount: $224,901.00
Abstract:
DOEs mission of nuclear material control and accountability (NMC & amp;A) requires adequate tools, therefore, the development of new sensor materials and measurement techniques for NMC & amp;A is important for the future of the U.S. nuclear fuel cycle. These techniques will reduce… More

Solid-State Sensors and Sensor Arrays for Advanced Pipe Inspection

Award Year / Program / Phase: 2013 / SBIR / Phase I
Agency: DOE
Principal Investigator: Timothy Tiernan, Mr.
Award Amount: $224,989.00
Abstract:
Nuclear power is an important part of the Nations energy security providing 20 percent of U.S. electricity generation without the emission of gases associated with global climate change and air pollution. The DOE would like to improve and optimize the performance of nuclear power plants by improving… More

Thermoelectric Power Platform for In-Situ Monitoring of Nuclear Spent Fuel Storage

Award Year / Program / Phase: 2013 / SBIR / Phase I
Agency: DOE
Principal Investigator: Kanai Shah, Dr.
Award Amount: $224,757.00
Abstract:
Dry storage systems are designed to safely confine the used nuclear fuel by providing radiation shielding, heat dissipation and protection of fuel assemblies from outside elements. To avoid dry storage system breach due to material deterioration or other factors, sensors can be sealed inside to… More

Plastic Scintillatos with Gamma-Neutron PSD

Award Year / Program / Phase: 2013 / SBIR / Phase I
Agency: DOE
Principal Investigator: Edgar Van Loef, Dr.
Award Amount: $149,999.00
Abstract:
The proliferation of weapons of mass destruction such as nuclear missiles and dirty bombs is a serious threat in the world today. Fast-neutron detectors are an important tool in monitoring the proliferation of nuclear weapons. Discrimination between fast neutrons and gamma rays is typically… More

Theory-Based High-QE Photocathode Development

Award Year / Program / Phase: 2013 / SBIR / Phase I
Agency: DOE
Principal Investigator: Vivek Nagarkar, Dr.
Award Amount: $149,953.00
Abstract:
While substantial advancements have been made in realizing tube based large area detectors such as the Large Area Picosecond Photo-Detector (LAPPD), there is widespread agreement in the cathode community that a higher QE bialkali cathode is possible, and that the present understanding is largely… More

Corrosion-Resistant AR Coating of High Energy Alkali Laser Components Using Refractory Materials

Award Year / Program / Phase: 2013 / SBIR / Phase I
Agency: DOD
Principal Investigator: Vivek Nagarkar, Director Imaging Systems – (617) 668-6800
Award Amount: $149,989.00
Abstract:
Realization of high-performance compact lasers will require the development of substrates and advancements in optical coatings that can withstand the harsh environments of corrosive gases, high temperatures, and high energy densities. Toward this end we intend to undertake the development of novel… More

Approaching Single Crystal Properties Enhancement of Bulk Properties of Polycrystalline Materials by Orientational Control of their Microstructure

Award Year / Program / Phase: 2013 / SBIR / Phase I
Agency: DOD
Principal Investigator: Gary Baldoni, Senior Scientist – (617) 668-6801
Award Amount: $99,922.00
Abstract:
The goal of this program is to develop a process for producing ceramic materials with properties approaching or, possibly in some aspects, exceeding those of single crystals. Ceramic processing provides important benefits including lower cost, higher yield, relaxed constraints on size and shape,… More

Rapid biodosimetry for accurate assessment of individual radiation exposure levels

Award Year / Program / Phase: 2013 / SBIR / Phase I
Agency: DOD
Principal Investigator: Richard Myers, Principla Investigator – (617) 668-6800
Award Amount: $99,995.00
Abstract:
In the event of an intentional or accidental release of ionizing radiation, it will be critical to have rapid triage assessment tools to evaluate the health of mission-critical personnel and to make effective use of available medical and emergency resources. However, assessment of whole body… More

Energy Saving Through Advanced Photovoltaic Materials and Manufacturing Technology

Award Year / Program / Phase: 2013 / SBIR / Phase I
Agency: DOE
Principal Investigator: Vladimir Gelfandbein, Mr.
Award Amount: $149,996.00
Abstract:
Todays conventional solar energy conversion technologies face serious problems, because of their combination of moderate efficiencies and high photovoltaic complexities, and because they are burdened with high manufacturing costs. For solar cells to be cost-competitive with other primary sources of… More

Solid State Sensor System for Inspection of Prestressed Concrete Pressure Pipe

Award Year / Program / Phase: 2013 / SBIR / Phase I
Agency: EPA
Principal Investigator: Noa Rensing – 617-668-6943
Award Amount: $80,000.00
Abstract:
An important type of water pipe is the Prestressed Concrete Cylinder Pipe (PCCP). There are thousands of miles of PCCP installed in the US in sections with length up to 20 feet and diameter for 2 to 14 feet. The large size of the pipes, the thickness of the concrete (up to 10 inches) and the… More

Advanced Plastic Scintillators for Nuclear Non-Proliferation Monitoring

Award Year / Program / Phase: 2013 / SBIR / Phase II
Agency: DOE
Principal Investigator: Edgar VanLoef, Dr.
Award Amount: $998,282.00
Abstract:
The proliferation of weapons of mass destruction (WMD) is a serious threat. Preventing the spread of these nuclear weapons has reached a state of heightened urgency in recent years. Neutron detection is an important component of the overall detection techniques used in identifying WMDs.… More

Solid-State Neutron Detector for Nuclear Material Accounting

Award Year / Program / Phase: 2013 / SBIR / Phase II
Agency: DOE
Principal Investigator: Kanai Shah, Dr.
Award Amount: $999,979.00
Abstract:
Nuclear material accounting within the nuclear fuel cycle includes preventing and detecting theft or diversion of special nuclear material. Neutron detection by use of pressurized He-3 tubes is a critical component within the scheme of safeguarding nuclear materials. Due to the worldwide shortage … More

New 3He Replacement Sensors for DOE Material Control and Accountability

Award Year / Program / Phase: 2013 / SBIR / Phase II
Agency: DOE
Principal Investigator: Vivek Nagarkar, Dr.
Award Amount: $999,988.00
Abstract:
Nuclear material control and accountability (MC & amp;A) programs at DOE facilities require new techniques that maximize material loss detection sensitivity, increase the quality of accountability measurements, minimize material holdup, and reduce the magnitude of inventory… More

Next Generation Gamma/Neutron Detectors for Planetary Science

Award Year / Program / Phase: 2013 / SBIR / Phase II
Agency: NASA
Principal Investigator: James Christian, Principal Investigator
Award Amount: $666,612.00
Abstract:
Gamma-ray and neutron spectroscopy are well established techniques for determining the chemical composition of planetary surfaces, and small cosmic bodies such as asteroids and comets; however, new technologies with the potential to significantly improve the performance of planetary nuclear… More

A New High Sensitivity High Resolution Sensor for X-Ray CT

Award Year / Program / Phase: 2013 / SBIR / Phase II
Agency: DOD
Principal Investigator: Vivek Nagarkar, Director, Imaging Tech.& – (617) 668-6800
Award Amount: $999,997.00
Abstract:
To address issues of sub-optimal performance of current X-ray CT scanners used by the first re-sponding providers to expedite diagnosis and triage, we are developing a novel scintillator that offers a unique promise to achieve high-sensitivity, high-resolution X-ray imaging through its integration… More

TlBr Spectrometers with Improved Long Term Stability at Room Temperature

Award Year / Program / Phase: 2013 / SBIR / Phase II
Agency: DHS
Principal Investigator: Kanai Shah
Award Amount: $999,929.52
Abstract:
The ideal semiconductor detector for the nuclear non-proliferation application should have good energy resolution, high detection efficiency, compact size, light weight, easy portability, low power requirements and low cost. In the proposed effort, we plan to continue our development of thallium… More

High Efficiency TlBr Gamma-Ray Detector Module

Award Year / Program / Phase: 2013 / SBIR / Phase II
Agency: DHS
Principal Investigator: Kanai Shah
Award Amount: $999,807.89
Abstract:
The ideal semiconductor detector for nuclear monitoring should have good energy resolution, high detection efficiency, compact size, light weight, easy portability and low cost. In the proposed effort, we plan to develop a detector module for nuclear monitoring based on thallium bromide (TlBr), a… More

Conformal Passivation of High Aspect Ratio HgCdTe Surfaces by ALD Using a Novel Cd-Precursor

Award Year / Program / Phase: 2013 / STTR / Phase I
Agency / Branch: DOD / ARMY
Research Institution: Illinois Institute of Technology
Principal Investigator: Harish B. Bandari, Ph.D., Senior Scientist – (617) 668-6800
Award Amount: $149,471.00
RI Contact: Adam H. Ph.D.
Abstract:
The goal of the proposed program is to identify an effective passivation material and develop a capable passivation methodology to protect highly reticulated HgCdTe surfaces. The proposed passivation material and technique using highly conformal atomic layer deposition (ALD) will allow the DOD to… More

Optical Communications for Control of Unmanned Ground Vehicles

Award Year / Program / Phase: 2013 / SBIR / Phase I
Agency: DOD
Principal Investigator: Richard Myers, Senior Scientist – (617) 668-6863
Award Amount: $99,995.00
Abstract:
Free space optical communication (FSOC) systems offer rapid data transfer rates, allowing wireless relay of complex data sets. To further promote the use of this technology for short-range covert communication links and non-line-of-sight (NLOS) data transfer, compact and robust transmitter/receiver… More

Smartphone Enabled Spectroscopic Gamma-Neutron Radiation Sensor

Award Year / Program / Phase: 2014 / SBIR / Phase I
Agency: DHS
Principal Investigator: Kanai Shah, President – (617) 668-6853
Award Amount: $149,615.86
Abstract:
RMD is proposing the development of Smart-Phone Enabled Radionuclide Identifier (SERI), a new detection instrument designed to take full advantage of smartphone / tablet technology. The hardware platform will include a new advanced scintillator that will provide both high gamma-ray efficiency and… More

Hard X-ray Area Detector Using Direct Converter Layer

Award Year / Program / Phase: 2014 / SBIR / Phase I
Agency: DOE
Principal Investigator: Paul Bennett, Mr.
Award Amount: $147,192.03
Abstract:
Synchrotron radiation is a powerful tool for measuring structural properties of materials. Important applications of higher energy synchrotron X-rays include measurement of strain and material evolution during processing, studies of composite materials and studies of layered systems such as… More

Fast-Timing Large-Area Detector for Neutron Scattering

Award Year / Program / Phase: 2014 / SBIR / Phase I
Agency: DOE
Principal Investigator: Vivek Nagarkar, Dr.
Award Amount: $149,999.00
Abstract:
The two reflectometers at SNS serve rapidly growing communities in the fields of nanoscience, membrane bioscience, surfactant chemistry. Unique capabilities of these instruments include ultrahigh neutron intensity for in-plane diffraction and off-specular/grazing- incidence small-angle scattering… More

Neutron-Gamma Scintillation Detector for Emergency Response

Award Year / Program / Phase: 2014 / SBIR / Phase I
Agency: DOE
Principal Investigator: Andrey Gueorguiev, Mr.
Award Amount: $149,997.00
Abstract:
Current radiation detectors are typically capable of detecting only one type of radiation. Therefore, the current detection systems require a number of individual detectors to be used for each type of radiation. The development of the proposed nuclear detector significantly improves the capability… More

Supperlattice Doped APDs for Improved UV Sensitivity in Scintillator Calorimetry

Award Year / Program / Phase: 2014 / SBIR / Phase I
Agency: DOE
Principal Investigator: Mickel McClish, Mr.
Award Amount: $149,999.00
Abstract:
One of the proposed next generation Intensity Frontier experiments is Mu2e. Mu2e will directly probe the Intensity Frontier as well as aid research on the Energy and Cosmic frontiers with precision measurements required to characterize the properties and interactions of new particles discovered at… More

Solid-State Neutron Detectors with Integrated Electronics for Nuclear Physics

Award Year / Program / Phase: 2014 / SBIR / Phase I
Agency: DOE
Principal Investigator: Christopher Stapels, Dr.
Award Amount: $149,999.00
Abstract:
At present, detectors of fast neutrons use liquid scintillators liquid scintillators can be dangerous to handle due to their low flash points and bulkiness, and the readout of the liquid scintillator by large PMTs limits the available position resolution and ability to operate in high magnetic… More

Composite Neutron-Gamma Detector

Award Year / Program / Phase: 2014 / SBIR / Phase I
Agency: DOE
Principal Investigator: Andrey Gueorguiev, Mr.
Award Amount: $149,985.56
Abstract:
Current radiation detectors are typically capable of detecting only one type of radiation. Therefore, the detection systems require a number of individual detectors to be used for each type of radiation. Also the performance to cost ratio of the currently available scintillators is high which… More

High Efficiency and Bright Neutron Converter Screens

Award Year / Program / Phase: 2014 / SBIR / Phase I
Agency: DOE
Principal Investigator: Gary Baldoni, Dr.
Award Amount: $224,977.53
Abstract:
The DOE is planning to restart work at one or both of the research reactors at Idaho National Laboratory (Transient Reactor Test Facility) and Sandia National Laboratories (Annular Core Research Reactor). Neutron radiography plays a large role in the work done at these facilities and there is a… More

High Resolution Digital Imaging Platform for NDE Transient Testing

Award Year / Program / Phase: 2014 / SBIR / Phase I
Agency: DOE
Principal Investigator: Vivek Nagarkar, Dr.
Award Amount: $224,999.75
Abstract:
Neutron radiography using the foil-film transfer method is currently employed for the quantitative evaluation of the geometric and compositional characteristics of nuclear fuel burn-up distribution, visualization of cracks and void formations, fuel location determination, pellet-clad and… More

Robust Kr-85 Detectors for New Waste Cask Design

Award Year / Program / Phase: 2014 / SBIR / Phase I
Agency: DOE
Principal Investigator: Paul Bennett, Mr.
Award Amount: $149,976.79
Abstract:
Dry cask storage systems (DCSS) are used to store spent nuclear fuel from nuclear power plants. Without a long term storage solution in place, storage for decades in casks may be required. High burnup fuel rods may become brittle over time presenting problems for eventual transport of the spent fuel… More

Theory-Based High-QE Photocathode Development

Award Year / Program / Phase: 2014 / SBIR / Phase II
Agency: DOE
Principal Investigator: Vivek Nagarkar, Dr.
Award Amount: $999,998.00
Abstract:
While substantial advancements have been made in realizing tube based large area detectors such as the Large Area Picosecond Photo-Detector (LAPPD), there is widespread agreement in the cathode community that a higher QE bialkali cathode is possible, and that the present understanding is… More