HIGH PERFORMANCE DETECTOR FOR SMALL ANIMAL PET
DESCRIPTION (Verbatim from the Applicant's Abstract): Positron Emission
Tomography (PET) is an in vivo analog of autoradiography, which makes it a
potentially powerful new tool for imaging biological processes in small
laboratory animals. Its critical advantage is that functional data can be
obtained non-invasively, allowing each animal to be studied repeatedly. Thus,
each animal can serve as its own control in studies with a longitudinal design.
Recently, the demand for small animal PET is also driven by the pharmaceutical
industry where in vivo quantification of biological processes to measure an
agent's mechanism of action and its concentration at the site of action is
While the advantages of small animal imaging with PET are obvious, the
challenges are also very significant. The main barriers to using PET in studies
of laboratory animals have traditionally been poor spatial resolution, low
sensitivity, and high cost. To address these deficiencies, we propose to
develop a detector that can achieve extremely fine spatial resolution and high
sensitivity in a cost-effective manner. The detector will be based on finely
pixellated monolithic block of scintillator coupled to a position sensitive
detector. Phase II efforts will focus on the development of a complete
small-animal PET system as a prototype product.
PROPOSED COMMERCIAL APPLICATION:
The demand for small animal PET imagers is being driven both by the biomedical research
community and by the needs of the pharmaceutical industry. In addition to the small animal
PET systems, the detector technology proposed here have direct applications in other areas
of nuclear imaging including whole body PET scanners, gamma cameras, intraoperative
probes, and breast imaging. Additional applications include nuclear physics, and astronomy.
Together these applications represent a large dollar market, a significant fraction of which
would benefit from this research.
Small Business Information at Submission:
Principal Investigator:Vivek V. Nagarkar
RADIATION MONITORING DEVICES INC
44 HUNT ST WATERTOWN, MA 02172
Number of Employees: