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HIGH-SPEED MICRO-CT DETECTOR FOR PHYSIOLOGIC STUDIES

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
59856
Program Year/Program:
2002 / SBIR
Agency Tracking Number:
CA001871
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Radiation Monitoring Devices, Inc.
44 Hunt Street Watertown, MA 02472-4699
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2002
Title: HIGH-SPEED MICRO-CT DETECTOR FOR PHYSIOLOGIC STUDIES
Agency: HHS
Contract: 1R43CA001871-01
Award Amount: $100,000.00
 

Abstract:

Dedicated high-resolution small animal imaging systems have recently emerged as important new tools for cancer research. These systems permit noninvasive screening of animals for mutations or pathologies and to monitor disease progression and response to therapy. One imaging modality, x-ray microcomputed tomography (microCT), shows promise as a cost-effective means for detecting and characterizing soft tissue structures, skeletal abnormalities, and tumors in live animals. The existing CT systems provide high-resolution images with excellent sensitivity to skeletal tissue and soft tissue, particularly when contrast-enhancing media are employed. However, use of this powerful modality for many important functional studies such as first pass bolus-tracking methodology for volumetric tumor perfusion as well as true whole organ physiologic imaging is limited due to their slower speed of operation (5 to 30 minutes) and limited active imaging area. To address these limitations, we propose to develop a high speed, high sensitivity, large area detector for microCT. The detector will be based on a high efficiency structured scintillator coupled to a modified architecture CCD with specially designed readout to accommodate high frame rates. This will enable imaging of tissue vascular physiology and perfusion in organs as well as conducting functional physiologic studies in small animals.

Principal Investigator:

Vivek V. Nagarkar
6179261167
VNAGARKAR@RMDINC.COM

Business Contact:

Gerald Entine
6179261167
GENTINE@RMDINC.COM
Small Business Information at Submission:

RADIATION MONITORING DEVICES, INC.
RADIATION MONITORING DEVICES INC 44 HUNT ST WATERTOWN, MA 02472

EIN/Tax ID: 042546395
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No