Microorganism Imprinted Polymers (MOIPs) for Detection of Biological Warfare Agents
Agency / Branch:
DOD / CBD
Radiation Monitoring Device, Inc. (RMD) will develop microorganism imprinted polymers (MOIPs) that purify, concentrate, and identify bacterial and viral wargare agents. In Phase I we will develop polymer formulations and fluorescent labeling strategiesfor MOIPs targeted towards E. coli and B. globigii vegetative cells. We will aslo demonstrate the feasibility of detecting biowarfare agents. In Phase II we will imprint viruses and bacterial spores. The MOIP sensors will be characterized with respect totheir sensitivity, response time, selectivity, stability, and reversibility. To conclude this program, a portable prototype will be designed, fabicated, and tested. The prototype will use an array of MOIPs, housed in a microfluidic format, that will bematched with a PIN photodiode array detector. We will interface the photodiode with an artificial neural network for signal processing. It is anticipated that microorganism imprinted polymers (MOIPs) will be capable of bacterial detection,identification, purification, and concentration. MOIP sensors will be used in portable instruments by combat troops and emergency responders to detect and identify bacterial warfare agents in aerosol samples. For purifying samples, these sensors will beapplicable as the front-end component for instruments, such as a PCR-based detectors. The capability of concentrating microorganisms will increase the sensitivity of biological detectors. Furthermore, MOIPs will identify waterborne pathogens and pollenallergens for water and indoor air quality monitors.
Small Business Information at Submission:
Arieh M. Karger
Group Leader, Sr. Scienti
RADIATION MONITORING DEVICES, INC.
44 Hunt Street Watertown, MA 02472
Number of Employees: