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A SIMPLE, HIGH-SPEED, HIGHLY SENSITIVE VIRAL SENSOR

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
60549
Program Year/Program:
2002 / SBIR
Agency Tracking Number:
AI052547
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
RADIATION MONITORING DEVICES, INC.
44 HUNT ST WATERTOWN, MA 02472-4699
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2002
Title: A SIMPLE, HIGH-SPEED, HIGHLY SENSITIVE VIRAL SENSOR
Agency: HHS
Contract: 1R43AI052547-01
Award Amount: $100,000.00
 

Abstract:

DESCRIPTION (provided by applicant):Radiation Monitoring Devices, Inc. proposes to design a simple, high speed, highly sensitive viral detection instrument. This instrument will measure fluorogenic reporter genes, which hybridize to complementary viral gene target inside a capillary waveguide. Our single-photon sensitive Geiger-mode, microavalanche photodiodes (micro-APDs) will enable low limits of detection of viruses. The micro-APD :an be battery-powered because of its low voltage requirement and rugged characteristics. We will also use active quenching circuitry, which allows measurement of a large dynamic range (-10 E 6), needed for continuous monitoring through exponential nucleic acid amplification. In Phase I, we will design the waveguide sensor, the micro-APD detection system, and establish fluorogenic probe chemistry. In Phase I, we will design a system for viral load detection, array formatting, establish nucleic acid amplification reactions, test a virus, and explore the instrument's versatility.

Principal Investigator:

Arieh M. Karger
6179261167
AKARGER@RMDINC.COM

Business Contact:

Gerald Entine
6179261167
GENTINE@RMDINC.COM
Small Business Information at Submission:

RADIATION MONITORING DEVICES, INC.
RADIATION MONITORING DEVICES INC 44 HUNT ST WATERTOWN, MA 02472

EIN/Tax ID: 042546395
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No