USA flag logo/image

An Official Website of the United States Government

A Portable Biosensor for Francisella tularensis

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
65952
Program Year/Program:
2003 / SBIR
Agency Tracking Number:
AI055145
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Radiation Monitoring Devices, Inc.
44 Hunt Street Watertown, MA 02472-
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2003
Title: A Portable Biosensor for Francisella tularensis
Agency: HHS
Contract: 1R43AI055145-01
Award Amount: $100,000.00
 

Abstract:

DESCRIPTION (provided by applicant): Radiation Monitoring Devices, Inc. proposes to design and build a portable bacteria sensor to identify Francisella tularensis, a CDC Category A agent of bioterrorism, in the field. The instrument will consist of a disposable microfluidic platform for carrying out the fluorescence labeling and immunocapture steps and a fluorescence detector utilizing our single-photon sensitive Geiger-mode micro avalanche photodiodes (muAPDs). muAPDs are rugged and can be battery-powered due to their low power requirements. The addition of appropriate collectors would permit detection and identification of bacteria in the air, soil, water and clinical material. The proposed Phase I studies include exploratory and optimization experiments in three areas: (1) fluorescent labeling of F. tularensis by non-specific DNA dyes or, if necessary, by fluorescent antibody; (2) selective immunocapture of the labeled bacteria by monoclonal antibody-coated magnetic beads; and (3) construction of a detector and analysis of the fluid flow of the labelled bacteria through poly(dimethylsiloxane) microchannels. Phase II studies will include development and testing of prototype microfluidic devices, final design of the muAPD detection system, integration of the microfluidics platform with the detector, and evaluation of the ability of the integrated prototype instrument to detect and identify F. tularensis.

Principal Investigator:

Clark M. Edson
6176686828
CEDSON@RMDINC.COM

Business Contact:


6179261167
Small Business Information at Submission:

RADIATION MONITORING DEVICES, INC.
RADIATION MONITORING DEVICES INC 44 HUNT ST WATERTOWN, MA 02472

EIN/Tax ID: 042546395
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No