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Intraoperative Digital Imaging Probe

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
65272
Program Year/Program:
2003 / SBIR
Agency Tracking Number:
CA083410
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Radiation Monitoring Devices, Inc.
44 Hunt Street Watertown, MA 02472-4699
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 2003
Title: Intraoperative Digital Imaging Probe
Agency: HHS
Contract: 2R44CA083410-02A1
Award Amount: $751,590.00
 

Abstract:

DESCRIPTION (provided by applicant): Nuclear Medicine imaging is being widely used to preoperatively image structures of interest for excisional biopsy. Radioguided intraoperative procedures utilizing radiotracers have established cost effective, highly specific means to locate suspect tissue and access it for pathologic analysis and excision. The ability of intraoperative probes to locate malignancies is based on the fact that the uptake of radiopharmaceutical in tumors is higher compared to healthy tissue. The benefits of radiogiuded surgery include increased tissue specifity obtained for biopsy, minimally accessed incisions and, as a result, reduction of inpatient hospital utilization and improved patient recovery. Most current commercial surgical probes are designed to be used with gamma-emitting radiotracers. The highly penetrating gamma radiation arising from the whole body overwhelms the signal from the region of interest, limiting the practical use of these probes by severely degrading signal-to-noise ratio. Existing counting probes lacking the imaging capability fail to detect small tumors and nodes in the proximity of high radioactivity injection site. We propose to address these limitations by designing a next-generation intraoperative probe utilizing both gamma and gamma radiation from such dual emitters as 131I and 18F. The new probe will rapidly navigate to the malignancy site by detecting long-range gamma rays and then will acquire an image of the region of interest with short-range beta rays. Therefore, the signal registered in the image will be arising only from the area directly in front of the detector. This novel design will fulfill the need for clear delineation of tumors during the surgical procedure and will facilitate decision-making process for the surgeon during the surgery. Furthermore, the new probe will allow inspection of the tumor bed for remaining malignant tissue to confirm the completeness of the excision.

Principal Investigator:

Gerald Entine
6179261167
GENTINE@RMDINC.COM

Business Contact:

Gerald Entine
6179261167
GENTINE@RMDINC.COM
Small Business Information at Submission:

RADIATION MONITORING DEVICES, INC.
RADIATION MONITORING DEVICES INC 44 HUNT ST WATERTOWN, MA 02472

EIN/Tax ID: 042546395
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No