USA flag logo/image

An Official Website of the United States Government

Cancer Detection using Diffuse Luminescence Imaging

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
70593
Program Year/Program:
2004 / SBIR
Agency Tracking Number:
CA105650
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Radiation Monitoring Devices, Inc.
44 Hunt Street Watertown, MA 02472-4699
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2004
Title: Cancer Detection using Diffuse Luminescence Imaging
Agency: HHS
Contract: 1R43CA105650-01
Award Amount: $119,474.00
 

Abstract:

DESCRIPTION (provided by applicant): The focus of the application is in the area of breast cancer imaging and tumor characterization. Imaging in pre-clinical models with injected contrast agents and imaging the oxygen concentration within tissue are important for a number of clinical and scientific reasons. Low oxygen content in tumors is a marker of radiation-resistant tumor regions, and is also correlated with a poor treatment outcome. For basic research applications, it is also very important to understand how hypoxia develops in tumors and how it is correlated with exogenous and endogenous markers of low oxygen. In Phase I, a laboratory prototype, based on frequency domain tomography will be developed to demonstrate the imaging of luminescent antibody complex with a good resolution in phantom tissues and to extract scattering and absorption parameters. It will employ an 8 x 8 mechanically scanned near infrared light excitation-detection system using a high gain avalanche photodiode array. An antibody will be chosen to specifically target neovasculature to identify tumor growth. In Phase II, a prototype will be developed which will have parallel acquisition across a large detector array for high-resolution imaging and improved image reconstruction algorithm. Brief summary: High-resolution optical tomography systems have applications for non-invasive imaging without hazardous ionizing radiation. Breast cancer detection is the primary target application, with the goal of improving diagnostic accuracy of breast cancer screening. Other applications could include brain imaging to monitor cerebral function or cerebral hemorrhage, and monitoring tissue and muscle oxygenation.

Principal Investigator:

Arieh M. Karger
6176686827
AKARGER@RMDINC.COM

Business Contact:

Gerald Entine
6179261167
GENTINE@RMDINC.COM
Small Business Information at Submission:

RADIATION MONITORING DEVICES, INC.
RADIATION MONITORING DEVICES INC 44 HUNT ST WATERTOWN, MA 02472

EIN/Tax ID: 042546395
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No