USA flag logo/image

An Official Website of the United States Government

Single Molecule Instrument for Surface Enhanced Raman Optical Activity of…

Award Information

Agency:
National Aeronautics and Space Administration
Branch:
N/A
Award ID:
77692
Program Year/Program:
2006 / SBIR
Agency Tracking Number:
053920
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Radiation Monitoring Devices, Inc.
44 Hunt St. Watertown, MA 02472-4699
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2006
Title: Single Molecule Instrument for Surface Enhanced Raman Optical Activity of Biomolecules
Agency: NASA
Contract: NNA06CA67C
Award Amount: $69,999.00
 

Abstract:

Stereochemistry is an essential element of our organic life. Only certain enantiomers are useful as drugs for the human body. Raman Optical Activity (ROA) and vibrational circular dichroism (VCD) provide stereochemical information down to bond levels. Many biomolecules like proteins and DNA can be studied for understanding their structural chemistry and structure related dynamics. These methods do not require material in the crystalline form and hence can be very useful tools.However, ROA signals are even weaker than the Raman signals. Phase I and Phase II work will focus on enhancing Raman optical Activity (ROA) signals in amino acids and biomolecules, which includes measurement of vibrational circular dichroism by using surface enhanced process involving nanoclusters. The use of nanoparticles is known to enhance Raman signals by several orders of magnitude. Our goal is to achieve similar gains in ROA signals. To achieve it, we will use a sensitive detection system in combination with improved surface enhanced chemistry and microfluidics-based single-molecule detection techniques. This will result in improved precision of measurement and shorten measurement time, which currently takes several hours to days.

Principal Investigator:

Rajan S. Gurjar, PhD
Principal Investigator
6179261167
RGurjar@RMDInc.com

Business Contact:

Gerald Entine, PhD
President
6179261167
GEntine@RMDInc.com
Small Business Information at Submission:

Radiation Monitoring Devices, Inc.
44 Hunt Street Watertown, MA 02472

EIN/Tax ID: 042546395
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No