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PET Detector for Cardiac Imaging of Small Animals

Award Information

Department of Health and Human Services
Award ID:
Program Year/Program:
2006 / SBIR
Agency Tracking Number:
Solicitation Year:
Solicitation Topic Code:
Solicitation Number:
Small Business Information
Radiation Monitoring Devices, Inc.
44 Hunt St. Watertown, MA 02472-4699
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Phase 1
Fiscal Year: 2006
Title: PET Detector for Cardiac Imaging of Small Animals
Agency: HHS
Contract: 1R43HL083503-01
Award Amount: $124,018.00


DESCRIPTION (provided by applicant): Positron emission tomography (PET) of small animals is emerging as a very powerful tool for advancing our understanding of human diseases such as heart disease and cancer. Due to the small (sub-millimeter) feature sizes, dedicated, high resolution PET systems are required to obtain sufficiently detailed images of organs of interest. In particular, sub-millimeter spatial resolution is required for detailed, functional heart imaging of mice. Currently, the detectors for most PET systems are based on arrays of dense scintillators (i.e. indirect detectors). Simulations have shown that the pitch of the scintillator arrays is the dominant factor limiting spatial resolution. However, fabricating and accurately decoding scintillators with element size much smaller than 1-mm is very challenging. In addition, as the scintillator element size decreases, the light collection decreases and consequently the energy and timing resolution of the system decreases. Therefore there is a need for an alternative approach for developing an improved detector for small animal PET imaging. The main objective of the Phase I research is to demonstrate the feasibility of producing very high- resolution PET detectors for small animal imaging using a direct detection approach with room temperature CdTe and CZT detectors. The overall detector design that we plan to use in the proposed effort is expected to satisfy all major requirements for small animal imaging including very high spatial resolution, reasonably high sensitivity, and good timing and DOI resolution. Excellent energy resolution can also be expected from the proposed design. The proposed effort is expected to have a lasting value both in terms of its research potential as well as its commercial scope. The most direct application addressed here is that of small animal PET imaging which is showing enormous promise for increasing our understanding of human disease models. Other selected human high-resolution PET applications for breast, brain and pediatric imaging are also emerging where this technology would be applicable. The proposed technology can also play a role in combined PET/CT and PET/MRI imaging instruments under development.

Principal Investigator:

Kanai S. Shah

Business Contact:

Gerald Entine
Small Business Information at Submission:

44 Hunt Street Watertown, MA 02472

EIN/Tax ID: 042546395
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No