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Microfluidic Cytometer for Complete Blood Count Analysis

Award Information

Agency:
National Aeronautics and Space Administration
Branch:
N/A
Award ID:
77696
Program Year/Program:
2007 / SBIR
Agency Tracking Number:
053889
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Radiation Monitoring Devices, Inc.
44 Hunt Street Watertown, MA 02472-4699
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 2007
Title: Microfluidic Cytometer for Complete Blood Count Analysis
Agency: NASA
Contract: NNJ07JA11C
Award Amount: $599,965.00
 

Abstract:

We will fabricate and test microfluidic designs for a micro-electromechanical system based complete blood count (CBC) analysis in separate modules and integrate them into a working prototype. A first module constitutes a hydrodynamic focusing injector and cell impedance meter. A second module takes hydrodynamically focused cells and measures light scatter in the forward and orthogonal directions, as well as of fluorescence emission intensities from specific cell types using novel signal collection designs and micrometer scale, and Geiger-mode avalanche photodiodes that produce time-correlated photocount statistics from multiple optical sources. The third module will serve for blood sample dilution, routing, automated lysing and removal of human erythrocytes. This unit will also incorporate a sensor for measuring hemoglobin (Hgb) concentration. The proposed blood analyzer will utilize innovative optical and fluidic designs on a modular platform that enable compactness, high sensitivity, and robust service, while requiring no operator intervention.

Principal Investigator:

Louis B. Strong
Principal Investigator
6176686801
lstrong@rmdinc.com

Business Contact:

Nancy S. Marshall
Business Official
6176686801
NMarshall@RMDInc.com
Small Business Information at Submission:

Radiation Monitoring Devices, Inc.
44 Hunt Street Watertown, MA 02472

EIN/Tax ID: 042546395
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No