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Continuous Phoswich Detector for Molecular Imaging

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R43EB008937-01
Agency Tracking Number: EB008937
Amount: $179,999.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: PHS2007-2
Timeline
Solicitation Year: 2008
Award Year: 2008
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
44 Hunt Street
Watertown, MA 02472
United States
DUNS: 073804411
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 VIVEK NAGARKAR
 (617) 668-6937
 VNAGARKAR@RMDINC.COM
Business Contact
Phone: (617) 668-6801
Email: gentine@rmdinc.com
Research Institution
N/A
Abstract

DESCRIPTION (provided by applicant): Positron Emission Tomography (PET) imaging systems used in Nuclear Medicine can suffer from loss of spatial resolution due to parallax effects, called radial elongation. A scintillation detector that allows depth-of- in
teraction (DOI) determination would be an important advance. Previous attempts were made to develop DOI scintillators for PET, but all of them had significant performance limitations. The goal of the proposed Phase I research is to demonstrate the feasibil
ity of developing a novel DOI scintillator in which the decay time of the light emission varies continuously with depth. The material processing techniques will be used to form a continuous phoswich detector, which will create a structure where the decay t
ime of the light emission varies continuously with depth. Our approach is likely applicable to a number of new scintillators that are actively under development because of their superior properties, as well as to other scintillators known to show dramatic
variations in decay times with dopant concentration. A number of most likely candidates will be initially investigated. Scintillator fabrication and initial characterization will be performed at RMD, and tests pertinent to molecular imaging will be perform
ed at our collaborator's facilities at the University of Arizona. Molecular imaging techniques are well suited for imaging radiolabeled antibodies and other substances that can be used to localize and characterize tumors, and are well suited to the develop
ment of new radiolabeled agents for diagnosing and treating diseases in humans. The development of this detector will significantly improve the resolution and sensitivity with which measurements can be made. In turn, this will encourage the development of
superior drugs and technologies to diagnose, stage and treat to curtail the progression of and even cure certain cancers, diseases of the heart and disorders of the circulatory system. Outside medical imaging, the proposed development will have widespread
applications in industrial radiography, nondestructive evaluations, homeland security, and advanced imaging systems. PUBLIC HEALTH RELEVANCE: Positron Emission Tomography (PET) imaging systems used in nuclear medicine can suffer from loss of spatial resolu
tion due to parallax effects, called radial elongation. A scintillation detector that allows depth-of- interaction (DOI) determination would be an important advance. Previous attempts were made to develop DOI scintillators for PET, but all of them had sign
ificant performance limitations. The proposed research will demonstrate the feasibility of developing a novel DOI scintillator in which the decay time of the light emission varies continuously with depth. The successful completion of the research will lead
to widespread applications in medical imaging, industrial radiography, nondestructive evaluations, homeland security, and advanced imaging systems.

* Information listed above is at the time of submission. *

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