Blood coagulation factor IX is absent or deficient in hemophilia B patients. Current therapy, thetransfusion of human whole blood components, is effective, but it is not prophylactic or free of risk.Our long term objective is the development of a somatic cell gene therapy for hemophilia B.… More

We will systematically examine whether complement activation plays a significant role in theplatelet storage lesion (PSL). The goals of the project are four-fold: (1) to assess the etiology of PSL bydepleting complement factor 8 from platelet storage plasma; (2) determine if monoclonal… More

The inactivation of retroviral vectors derived from murine cells in human serum represents a formidmany potential applications of in vivo retroviral-mediated gene therapy. We have recently demonstratof amphotropic retroviral vector particles in human serum is primarily mediated by complement… More

Coronary artery disease is associated with extensive morbidity and mortality as well as substantial financial cost. An estimated 11.2 million people in the USA have coronary artery disease that leads to approximately 1.5 million acute myocardial infarctions (AMI) annually. The mechanism by which… More

DESCRIPTION (provided by applicant): The complement component C5 is common to all three pathways of complement activation. Its involvement in the pathogenesis of asthma is controversial. We have recently shown that the intrapulmonary activation of C5 is critical in animal models of asthma… More