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Migraine Headache Treatment by Drug Aerosol Inhalation

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
61194
Program Year/Program:
2003 / SBIR
Agency Tracking Number:
NS044800
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Alexza Molecular Delivery Corporation
Alexza Molecular Delivery Corporation 1001 E Meadow Cir Palo Alto, CA 94303
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 2003
Title: Migraine Headache Treatment by Drug Aerosol Inhalation
Agency: HHS
Contract: 2R44NS044800-02
Award Amount: $1,386,303.00
 

Abstract:

DESCRIPTION (provided by applicant): Migraine is a serious condition affecting millions of Americans. Patients with migraine strongly desire more rapid headache relief than current medications provide. A promising approach to expediting pain relief is delivery of existing drugs to the systemic circulation more rapidly via aerosol inhalation. In Phase I of this grant, Alexza MDC demonstrated the ability to form high purity, small particle size aerosols of several leading migraine medications. In addition, we have demonstrated rapid, reliable systemic absorption and quick onset of pharmacological activity of drug delivered as such aerosols to dogs. In Phase II, we will conduct the toxicology studies required to initiate human trials of such a fast-acting, inhaled migraine medication. In addition, we will optimize the convenience and reliability of the delivery device, and produce a sufficient supply of handheld, breath-actuated delivery devices to carryout a human safety and tolerability trial. Accomplishment of the goals of Phase II will lead directly to human clinical testing of a commercially viable device that could improve the lives of millions of people every year.

Principal Investigator:

Joshua D. Rabinowitz
6506873903
JRABINOWITZ@ALEXZA.COM

Business Contact:


6506873902
Small Business Information at Submission:

ALEXZA MOLECULAR DELIVERY CORPORATION
ALEXZA MOLECULAR DELIVERY CORPORATION 1001 E MEADOW CIR PALO ALTO, CA 94303

EIN/Tax ID: 770567768
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No