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TREATMENT OF MIGRAINE ATTACKS BY DRUG AEROSOL INHALATION

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
61194
Program Year/Program:
2002 / SBIR
Agency Tracking Number:
NS044800
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Alexza Molecular Delivery Corporation
Alexza Molecular Delivery Corporation 1001 E Meadow Cir Palo Alto, CA 94303
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2002
Title: TREATMENT OF MIGRAINE ATTACKS BY DRUG AEROSOL INHALATION
Agency: HHS
Contract: 1R43NS044800-01
Award Amount: $270,089.00
 

Abstract:

DESCRIPTION (provided by applicant): Migraine is a serious condition affecting millions of Americans. Patients with migraine strongly desire more rapid headache relief than current medications provide. A promising approach to expediting pain relief is delivery of existing drugs to the systemic circulation more rapidly via aerosol inhalation. The major technical hurdle in this rapid delivery approach is generation of is aerosols of sufficiently small particle size. This obstacle is overcome by ALEXZA's novel aerosol generation approach, which can produce very small particle aerosols without using any excipients or entrainers. Our technique has already proven to be successful on several FDA drugs. Production of the aerosol occurs nearly instantaneously, making it ideal for inhalation drug delivery. The mass median aerodynamic diameter of the aerosol is typically about one micron, an ideal size for transmission through the tracheobronchial airways and deposition onto the alveoli. In this phase of the grant, we will demonstrate the ability to aerosolize one or more drugs for migraine without degradation or impurities and confirm the small particle size and in vitro biological activity of the evolved aerosol. Completion of the aims of Phase I will launch us into Phase II studies and towards the commercialization of an improved migraine treatment.

Principal Investigator:

Joshua D. Rabinowitz
6506873903
JRABINOWITZ@ALEXZA.COM

Business Contact:

Joshua Rabinowitz
6506873909
JRABINOWITZ@ALEXZA.COM
Small Business Information at Submission:

ALEXZA MOLECULAR DELIVERY CORPORATION
ALEXZA MOLECULAR DELIVERY CORPORATION 1001 E MEADOW CIR PALO ALTO, CA 94303

EIN/Tax ID: 770567768
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No